The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Late-stage neuronal progenitors in the retina are radial Müller glia that function as retinal stem cells
Open accessAbstract
Neuronal progenitors in the mammalian brain derive from radial glia or specialized astrocytes. In developing neural retina, radial glia-like Müller cells are generated late in neurogenesis and are not considered to be neuronal progenitors, but they do proliferate after injury and can express neuronal markers, suggesting a latent neurogenic capacity. To examine the neurogenic capacity of retinal glial cells, we used lineage tracing in transgenic zebrafish with a glial-specific promoter (gfap, for glial fibrillary acid protein) driving green fluorescent protein in differentiated Müller glia. We found that all Müller glia in the zebrafish retina express low levels of the multipotent progenitor marker Pax6 (paired box gene 6), and they proliferate at a low frequency in the intact, uninjured retina. Müller glia-derived progenitors express Crx (cone rod homeobox) and are late retinal progenitors that generate the rod photoreceptor lineage in the postembryonic retina. These Müller glia-derived progenitors also remain competent to produce earlier neuronal lineages, in that they respond to loss of cone photoreceptors by specifically regenerating the missing neurons. We conclude that zebrafish Müller glia function as multipotent retinal stem cells that generate retinal neurons by homeostatic and regenerative developmental mechanisms.
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“The zebrafish retina is an important model for revealing these mechanisms since the retina is able to mount a robust regenerative response following injury and this response is dependent on the dedifferentiation of Müller glia (MG)”
From HB-EGF is Necessary and Sufficient for Müller Glia Dedifferentiation and Retina Regeneration (2012) · cites this paper as Bernardos et al., 2007
In the citing paper
“Key to successful retina regeneration are Müller glia (MG), the major glial cell-type in the retina (Bernardos et al., 2007; Fausett and Goldman, 2006; Fimbel et al., 2007).”
From Retinal injury, growth factors, and cytokines converge on β-catenin and pStat3 signaling to stimulate retina regeneration (2014) · cites this paper as Bernardos et al., 2007
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Neurons derived from radial glial cells establish radial units in neocortex
Noctor, S. C., Flint, A. C., Weissman, T. A., Dammerman, R. S., & Kriegstein, A. R. (2001) · Nature · doi:10.1038/35055553 · Cited by 2,016
Müller cells in the healthy and diseased retina
Bringmann, A., Pannicke, T., Grosche, J., Francke, M., Wiedemann, P., Skatchkov, S. N., Osborne, N. N., & Reichenbach, A. (2006) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2006.05.003 · Cited by 1,967
A common progenitor for neurons and glia persists in rat retina late in development
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Álvarez-Buylla, A., & Lim, D. A. (2004) · Neuron · doi:10.1016/s0896-6273(04)00111-4 · Cited by 1,348
Vertebrate neural cell-fate determination: Lessons from the retina
Livesey, F. J., & Cepko, C. L. (2001) · Nature reviews. Neuroscience · doi:10.1038/35053522 · Cited by 948
Pax6 Is Required for the Multipotent State of Retinal Progenitor Cells
Marquardt, T., Ashery‐Padan, R., Andrejewski, N., Scardigli, R., Guillemot, F., & Gruß, P. (2001) · Cell · doi:10.1016/s0092-8674(01)00295-1 · Cited by 926
Radial Glia Serve as Neuronal Progenitors in All Regions of the Central Nervous System
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The molecular basis of retinal ganglion cell death in glaucoma
Almasieh, M., Wilson, A. M., Morquette, B., Vargas, J. L. C., & Polo, A. D. (2011) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2011.11.002 · Cited by 990
Bringmann, A., Iandiev, I., Pannicke, T., Wurm, A., Hollborn, M., Wiedemann, P., Osborne, N. N., & Reichenbach, A. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.07.001 · Cited by 761
Reichenbach, A., & Bringmann, A. (2013) · Glia · doi:10.1002/glia.22477 · Cited by 756
Müller glial cell reprogramming and retina regeneration
Goldman, D. J. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3723 · Cited by 652
The zebrafish as a model for complex tissue regeneration
Gemberling, M. P., Bailey, T. J., Hyde, D. R., & Poss, K. D. (2013) · Trends in Genetics · doi:10.1016/j.tig.2013.07.003 · Cited by 596
Metadata
- Authors
- Bernardos, R. L., Barthel, L. K., Meyers, J. R., & Raymond, P. A.
- Affiliations
- University of Michigan (US)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-06-27
- Volume
- 27
- Issue
- 26
- Pages
- 7028-7040
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6672216
- OpenAlex
- W2016508121
- Cited by
- 647
- References
- 60
- Citations by year
- 2026: 28 · 2025: 22 · 2024: 32 · 2023: 40 · 2022: 39 · 2021: 38 · 2020: 38 · 2019: 33 · 2018: 31 · 2017: 27 · 2016: 36 · 2015: 32 · 2014: 33 · 2013: 45 · 2012: 33
- FWCI
- 13.23
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Eye Institute (R01EY004318, F32EY017251)
- National Institute of Neurological Disorders and Stroke (F31NS047909)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Development and Disorders
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- Müller cells, retinal stem cells, neuronal precursors, retinal neurogenesis, zebrafish retina, Pax6, CRX, rod photoreceptors, photoreceptor regeneration, glial fibrillary acidic protein, lineage tracing, retinal homeostasis, multipotent progenitors
- MeSH terms
- Aging, Animals, Cell Differentiation, Homeostasis, Neuroglia, Neurons, Regeneration, Retina, Species Specificity, Stem Cells, Zebrafish, Cell Lineage
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