Neurons derived from radial glial cells establish radial units in neocortex
Abstract
The neocortex of the adult brain consists of neurons and glia that are generated by precursor cells of the embryonic ventricular zone. In general, glia are generated after neurons during development, but radial glia are an exception to this rule. Radial glia are generated before neurogenesis and guide neuronal migration. Radial glia are mitotically active throughout neurogenesis, and disappear or become astrocytes when neuronal migration is complete. Although the lineage relationships of cortical neurons and glia have been explored, the clonal relationship of radial glia to other cortical cells remains unknown. It has been suggested that radial glia may be neuronal precursors, but this has not been demonstrated in vivo. We have used a retroviral vector encoding enhanced green fluorescent protein to label precursor cells in vivo and have examined clones 1-3 days later using morphological, immunohistochemical and electrophysiological techniques. Here we show that clones consist of mitotic radial glia and postmitotic neurons, and that neurons migrate along clonally related radial glia. Time-lapse images show that proliferative radial glia generate neurons. Our results support the concept that a lineage relationship between neurons and proliferative radial glia may underlie the radial organization of neocortex.
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Pyramidal excitatory neurons born in the ventricular and subventricular zones of prefrontal subdomains migrate radially toward the cortical plate under the influence of Fgfs.
“The pyramidal excitatory neurons born in the VZ and SVZ of the prefrontal subdomains, similar to other cortical areas, start to migrate radially toward the proper position in the CP under the influence of Fgfs [50, 59, 60].”
From Development of prefrontal cortex (2022) · cites this paper as [50]
After symmetric divisions, radial glia divide asymmetrically, generating postmitotic excitatory neurons that migrate to their final location in the cerebral cortex by using the basal process of the radial glial cell as a scaffold.
“After this period of symmetric divisions, these progenitor cells — also known as radial glia — divide asymmetrically, generating postmitotic excitatory neurons that will migrate to their final location in the cerebral cortex by using the basal process of the radial glial cell as a scaffold55–58.”
From Consequences of trisomy 21 for brain development in Down syndrome (2024) · cites this paper as [56]
Cites
Specification of Cerebral Cortical Areas
Rakic, P. (1988) · Science · doi:10.1126/science.3291116 · Cited by 3,127 · see citing works
Mode of cell migration to the superficial layers of fetal monkey neocortex
Rakic, P. (1972) · Journal of Comparative Neurology · doi:10.1002/cne.901450105 · Cited by 2,170 · see citing works
Gould, E., McEwen, B. S., Tanapat, P., Galea, L. A. M., & Fuchs, E. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-07-02492.1997 · Cited by 1,496 · see citing works
Interneuron Migration from Basal Forebrain to Neocortex: Dependence on <i>Dlx</i> Genes
Anderson, S. A., Eisenstat, D. D., Shi, L., & Rubenstein, J. L. R. (1997) · Science · doi:10.1126/science.278.5337.474 · Cited by 1,462 · see citing works
Isolation of radial glial cells by fluorescent-activated cell sorting reveals a neuronal lineage
Malatesta, P., Hartfuss, E., & Götz, M. (2000) · Development · doi:10.1242/dev.127.24.5253 · Cited by 1,157 · see citing works
Whole cell recording from neurons in slices of reptilian and mammalian cerebral cortex
Blanton, M. G., Turco, J. J. L., & Kriegstein, A. R. (1989) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(89)90131-3 · Cited by 945 · see citing works
Self-citationThe columnar organization of the neocortex.
Mountcastle, V. B. (1997) · Brain : a journal of neurology · doi:10.1093/brain/120.4.701 · Cited by 941 · see citing works
Identification of major cell classes in the developing mammalian nervous system
Hockfield, S. J., & McKay, R. D. G. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-12-03310.1985 · Cited by 792 · see citing works
Radial Glial Identity Is Promoted by Notch1 Signaling in the Murine Forebrain
Gaiano, N., Nye, J. S., & Fishell, G. (2000) · Neuron · doi:10.1016/s0896-6273(00)81172-1 · Cited by 727 · see citing works
Embryonic vertebrate central nervous system: Revised terminology
Angevine, J. B., Bodian, D., Coulombre, A. J., Edds, M. V., Hamburger, V., Jacobson, M., Lyser, K. M., Prestige, M. C., Sidman, R. L., Varon, S. S., et al. (1970) · The Anatomical Record · doi:10.1002/ar.1091660214 · Cited by 727 · see citing works
Luskin, M. B., Pearlman, A., & Sanes, J. (1988) · Neuron · doi:10.1016/0896-6273(88)90163-8 · Cited by 554 · see citing works
Pixley, S. K., & de Vellis, J. (1984) · Developmental Brain Research · doi:10.1016/0165-3806(84)90097-x · Cited by 534 · see citing works
Cell lineage in the rat cerebral cortex: a study using retroviral-mediated gene transfer
Price, J., & Thurlow, L. (1988) · Development · doi:10.1242/dev.104.3.473 · Cited by 424 · see citing works
Notch signalling and the control of cell fate choices in vertebrates
Lewis, J. (1998) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.1998.0266 · Cited by 411 · see citing works
Vertebrate retinal ganglion cells are selected from competent progenitors by the action of Notch
Austin, C. P., Feldman, D. E., Ida, J. A., & Cepko, C. L. (1995) · Development · doi:10.1242/dev.121.11.3637 · Cited by 407 · see citing works
Anton, E. S., Kreidberg, J. A., & RAKIC, P. T. (1999) · Neuron · doi:10.1016/s0896-6273(00)81089-2 · Cited by 351 · see citing works
Takahashi, T., Nowakowski, R. S., & Caviness, V. S. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00820.1993 · Cited by 334 · see citing works
Proliferation “hot spots” in adult avian ventricular zone reveal radial cell division
Álvarez-Buylla, A., Theelen, M., & Nottebohm, F. (1990) · Neuron · doi:10.1016/0896-6273(90)90038-h · Cited by 331 · see citing works
Clusters of Coupled Neuroblasts in Embryonic Neocortex
Turco, J. J. L., & Kriegstein, A. R. (1991) · Science · doi:10.1126/science.1850552 · Cited by 314 · see citing works
Self-citationLuskin, M., Parnavelas, J., & Barfield, J. A. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-04-01730.1993 · Cited by 307 · see citing works
Ontogeny of radial and other astroglial cells in murine cerebral cortex
Misson, J., Takahashi, T., & Caviness, V. S. (1991) · Glia · doi:10.1002/glia.440040205 · Cited by 235 · see citing works
Systematic widespread clonal organization in cerebral cortex
Reid, C. B., Llang, I., & Walsh, C. (1995) · Neuron · doi:10.1016/0896-6273(95)90035-7 · Cited by 232 · see citing works
Cell Coupling and Uncoupling in the Ventricular Zone of Developing Neocortex
Bittman, K. S., Owens, D. F., Kriegstein, A. R., & LoTurco, J. J. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-18-07037.1997 · Cited by 225 · see citing works
Self-citationCellular migration patterns in the developing mouse cerebral cortex
Austin, C. P., & Cepko, C. L. (1990) · Development · doi:10.1242/dev.110.3.713 · Cited by 200 · see citing works
Lineage of radial glia in the chicken optic tectum
Gray, G. E., & Sanes, J. R. (1992) · Development · doi:10.1242/dev.114.1.271 · Cited by 189 · see citing works
The origins of cellular diversity in the mammalian central nervous system
McKay, R. D. G. (1989) · Cell · doi:10.1016/0092-8674(89)90934-3 · Cited by 174 · see citing works
Misson, J., Edwards, M. A., Yamamoto, M., & Caviness, V. S. (1988) · Developmental Brain Research · doi:10.1016/0165-3806(88)90043-0 · Cited by 151 · see citing works
Cai, L., Hayes, N. L., & Nowakowski, R. S. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-06-02088.1997 · Cited by 63 · see citing works
Gressèns, P., & Evrard, P. (1993) · Developmental Brain Research · doi:10.1016/0165-3806(93)90218-y · Cited by 54 · see citing works
Proteasome inhibition results in increased poly-ADP-ribosylation: Implications for neuron death
Keller, J. N., & Markesbery, W. R. (2000) · Journal of Neuroscience Research · doi:10.1002/1097-4547(20000815)61:4 · Cited by 54 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Astrocytes: Biology and pathology
Sofroniew, M. V., & Vinters, H. V. (2010) · Acta Neuropathologica · doi:10.1007/s00401-009-0619-8 · Cited by 5,196 · see citing works
Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions
Ming, G.-L., & Song, H. (2011) · Neuron · doi:10.1016/j.neuron.2011.05.001 · Cited by 2,651 · see citing works
The Glial Nature of Embryonic and Adult Neural Stem Cells
Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475 · see citing works
Self-citationNoctor, S. C., Martínez-Cerdeño, V., Ivic, L., & Kriegstein, A. R. (2004) · Nature Neuroscience · doi:10.1038/nn1172 · Cited by 2,229 · see citing works
Self-citationThe cell biology of neurogenesis
Götz, M., & Huttner, W. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1739 · Cited by 2,130 · see citing works
The basics of brain development
Stiles, J., & Jernigan, T. L. (2010) · Neuropsychology Review · doi:10.1007/s11065-010-9148-4 · Cited by 2,009 · see citing works
Evolution of the neocortex: a perspective from developmental biology
Rakic, P. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2719 · Cited by 1,565 · see citing works
Astrocytes give rise to new neurons in the adult mammalian hippocampus
Seri, B., Garcı́a-Verdugo, J. M., McEwen, B. S., & Alvarez-Buylla, A. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07153.2001 · Cited by 1,495 · see citing works
Astroglia induce neurogenesis from adult neural stem cells
Song, H., Stevens, C. F., & Gage, F. H. (2002) · Nature · doi:10.1038/417039a · Cited by 1,452 · see citing works
Normal development of brain circuits
Tau, G. Z., & Peterson, B. S. (2010) · Neuropsychopharmacology · doi:10.1038/npp.2009.115 · Cited by 1,391 · see citing works
Development and Evolution of the Human Neocortex
Lui, J. H., Hansen, D. V., & Kriegstein, A. R. (2011) · Cell · doi:10.1016/j.cell.2011.06.030 · Cited by 1,342 · see citing works
Self-citationNeurogenic radial glia in the outer subventricular zone of human neocortex
Hansen, D. V., Lui, J. H., Parker, P. R. L., & Kriegstein, A. R. (2010) · Nature · doi:10.1038/nature08845 · Cited by 1,388 · see citing works
Self-citationEnglund, C., Fink, A., Lau, C., Pham, D., Daza, R. A. M., Bulfone, A., Kowalczyk, T., & Hevner, R. F. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2899-04.2005 · Cited by 1,261 · see citing works
Neurogenesis in the adult hippocampus
Kempermann, G., Song, H., & Gage, F. H. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018812 · Cited by 1,072 · see citing works
Microglia Regulate the Number of Neural Precursor Cells in the Developing Cerebral Cortex
Cunningham, C. L., Martínez-Cerdeño, V., & Noctor, S. C. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.3441-12.2013 · Cited by 976 · see citing works
Self-citationMirzadeh, Z., Merkle, F. T., Soriano-Navarro, M., Garcia-Verdugo, J. M., & Alvarez-Buylla, A. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.07.004 · Cited by 1,015 · see citing works
Development of the human cerebral cortex: Boulder Committee revisited
Bystron, I., Blakemore, C., & Rakic, P. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2252 · Cited by 977 · see citing works
Origin of oligodendrocytes in the subventricular zone of the adult brain
Menn, B., Garcia-Verdugo, J. M., Yaschine, C., Gonzalez-Perez, O., Rowitch, D., & Alvarez-Buylla, A. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.1299-06.2006 · Cited by 972 · see citing works
Molecular logic of neocortical projection neuron specification, development and diversity
Greig, L. C., Woodworth, M. B., Galazo, M. J., Padmanabhan, H., & Macklis, J. D. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3586 · Cited by 863 · see citing works
In vivo clonal analysis reveals self-renewing and multipotent adult neural stem cell characteristics
Bonaguidi, M. A., Wheeler, M. A., Shapiro, J. S., Stadel, R. P., Sun, G. J., Ming, G.-L., & Song, H. (2011) · Cell · doi:10.1016/j.cell.2011.05.024 · Cited by 831 · see citing works
Patterns of neural stem and progenitor cell division may underlie evolutionary cortical expansion
Kriegstein, A., Noctor, S., & Martínez-Cerdeño, V. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn2008 · Cited by 738 · see citing works
Self-citationAdult Ependymal Cells Are Postmitotic and Are Derived from Radial Glial Cells during Embryogenesis
Spassky, N., Merkle, F. T., Flames, N., Tramontin, A. D., García-Verdugo, J. M., & Alvarez-Buylla, A. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1108-04.2005 · Cited by 717 · see citing works
Smart, I. H. M. (2002) · Cerebral Cortex · doi:10.1093/cercor/12.1.37 · Cited by 687 · see citing works
Patterns of neuronal migration in the embryonic cortex
Kriegstein, A. R., & Noctor, S. C. (2004) · Trends in Neurosciences · doi:10.1016/j.tins.2004.05.001 · Cited by 648 · see citing works
Self-citationCell-cycle control and cortical development
Dehay, C., & Kennedy, H. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2097 · Cited by 655 · see citing works
Bernardos, R. L., Barthel, L. K., Meyers, J. R., & Raymond, P. A. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1624-07.2007 · Cited by 647 · see citing works
Establishing Cerebral Organoids as Models of Human-Specific Brain Evolution
Pollen, A. A., Bhaduri, A., Andrews, M. G., Nowakowski, T. J., Meyerson, O. S., Mostajo-Radji, M. A., Di Lullo, E., Alvarado, B., Bedolli, M., Dougherty, M. L., et al. (2019) · Cell · doi:10.1016/j.cell.2019.01.017 · Cited by 600 · see citing works
Self-citationThe Adult Ventricular–Subventricular Zone (V-SVZ) and Olfactory Bulb (OB) Neurogenesis
Lim, D. A., & Alvarez-Buylla, A. (2016) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a018820 · Cited by 571 · see citing works
Neural stem cells: origin, heterogeneity and regulation in the adult mammalian brain
Obernier, K., & Alvarez-Buylla, A. (2019) · Development · doi:10.1242/dev.156059 · Cited by 578 · see citing works
Expression Analysis Highlights AXL as a Candidate Zika Virus Entry Receptor in Neural Stem Cells
Nowakowski, T. J., Pollen, A. A., Di Lullo, E., Sandoval-Espinosa, C., Bershteyn, M., & Kriegstein, A. R. (2016) · Cell Stem Cell · doi:10.1016/j.stem.2016.03.012 · Cited by 529 · see citing works
Self-citationThe transcription factor NFIA controls the onset of gliogenesis in the developing spinal cord
Deneen, B., Ho, R., Lukaszewicz, A., Hochstim, C. J., Gronostajski, R. M., & Anderson, D. J. (2006) · Neuron · doi:10.1016/j.neuron.2006.11.019 · Cited by 514 · see citing works
A new subtype of progenitor cell in the mouse embryonic neocortex
Wang, X., Tsai, J.-W., LaMonica, B., & Kriegstein, A. R. (2011) · Nature Neuroscience · doi:10.1038/nn.2807 · Cited by 507 · see citing works
Self-citationHypothalamic tanycytes: a key component of brain-endocrine interaction
RODRIGUEZ, E., BLAZQUEZ, J., PASTOR, F., PELAEZ, B., PENA, P., PERUZZO, B., & AMAT, P. (2005) · International review of cytology · doi:10.1016/s0074-7696(05)47003-5 · Cited by 475 · see citing works
Potential for neural regeneration after neurotoxic injury in the adult mammalian retina
Ooto, S., Akagi, T., Kageyama, R., Akita, J., Mandai, M., Honda, Y., & Takahashi, M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402129101 · Cited by 454 · see citing works
A Role for 1 Tubulin-Expressing Muller Glia in Regeneration of the Injured Zebrafish Retina
Fausett, B. V., & Goldman, D. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0332-06.2006 · Cited by 435 · see citing works
Development and arealization of the cerebral cortex
Cadwell, C. R., Bhaduri, A., Mostajo-Radji, M. A., Keefe, M. G., & Nowakowski, T. J. (2019) · Neuron · doi:10.1016/j.neuron.2019.07.009 · Cited by 408 · see citing works
Guiding Neuronal Cell Migrations
Marin, O., Valiente, M., Ge, X., & Tsai, L.-H. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001834 · Cited by 417 · see citing works
Mori, T., Tanaka, K., Buffo, A., Wurst, W., Kühn, R., & Götz, M. (2006) · Glia · doi:10.1002/glia.20350 · Cited by 398 · see citing works
Generating Neuronal Diversity in the Mammalian Cerebral Cortex
Lodato, S., & Arlotta, P. (2015) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100814-125353 · Cited by 389 · see citing works
Development of prefrontal cortex
Kolk, S. M., & Rakic, P. (2022) · Neuropsychopharmacology · doi:10.1038/s41386-021-01137-9 · Cited by 378 · see citing works
“Through close interplay between cell-autonomous events and local as well as external cues, neurons generated close to the ventricle start migrating in radial columns [45, 46, 50, 51].”
BackgroundBortone, D., & Polleux, F. (2009) · Neuron · doi:10.1016/j.neuron.2009.01.034 · Cited by 387 · see citing works
The determination of projection neuron identity in the developing cerebral cortex
Leone, D. P., Srinivasan, K., Chen, B., Alcamo, E., & McConnell, S. K. (2008) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2008.05.006 · Cited by 382 · see citing works
Role of Intermediate Progenitor Cells in Cerebral Cortex Development
Pontious, A., Kowalczyk, T., Englund, C., & Hevner, R. F. (2008) · Developmental Neuroscience · doi:10.1159/000109848 · Cited by 378 · see citing works
G1 Phase Regulation, Area-Specific Cell Cycle Control, and Cytoarchitectonics in the Primate Cortex
Lukaszewicz, A., Savatier, P., Cortay, V., Giroud, P., Huissoud, C., Berland, M., Kennedy, H., & Dehay, C. (2005) · Neuron · doi:10.1016/j.neuron.2005.06.032 · Cited by 315 · see citing works
Oligodendrocyte development and the onset of myelination in the human fetal brain
Jakovcevski, I. (2009) · Frontiers in Neuroanatomy · doi:10.3389/neuro.05.005.2009 · Cited by 323 · see citing works
Specific synapses develop preferentially among sister excitatory neurons in the neocortex
Yu, Y.-C., Bultje, R. S., Wang, X., & Shi, S.-H. (2009) · Nature · doi:10.1038/nature07722 · Cited by 305 · see citing works
GABA Regulates Excitatory Synapse Formation in the Neocortex via NMDA Receptor Activation
Wang, D. D., & Kriegstein, A. R. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.5599-07.2008 · Cited by 299 · see citing works
Self-citationBuilding a lineage from single cells: genetic techniques for cell lineage tracking
Woodworth, M. B., Girskis, K. M., & Walsh, C. A. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2016.159 · Cited by 236 · see citing works
Molecular and behavioral aspects of the actions of alcohol on the adult and developing brain
Alfonso-Loeches, S., & Guerri, C. (2011) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2011.580567 · Cited by 254 · see citing works
Preferential electrical coupling regulates neocortical lineage-dependent microcircuit assembly
Yu, Y.-C., He, S., Chen, S., Fu, Y., Brown, K. N., Yao, X.-H., Ma, J., Gao, K. P., Sosinsky, G. E., Huang, K., et al. (2012) · Nature · doi:10.1038/nature10958 · Cited by 219 · see citing works
Pucilowska, J., Vithayathil, J., Tavares, E. J., Kelly, C., Karlo, J. C., & Landreth, G. E. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.4864-13.2015 · Cited by 207 · see citing works
Regulation of cerebral cortex size and folding by expansion of basal progenitors
Nonaka‐Kinoshita, M., Reillo, I., Artegiani, B., Ángeles Martínez‐Martínez, M., Nelson, M., Borrell, V., & Calegari, F. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.96 · Cited by 221 · see citing works
Cell transplantation therapies for spinal cord injury focusing on induced pluripotent stem cells
Nakamura, M., & Okano, H. (2013) · Cell Research · doi:10.1038/cr.2012.171 · Cited by 214 · see citing works
Martínez-Cerdeño, V., Cunningham, C. L., Camacho, J., Antczak, J. L., Prakash, A. N., Cziep, M. E., Walker, A. I., & Noctor, S. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030178 · Cited by 203 · see citing works
Self-citationChai, X., Förster, E., Zhao, S., Bock, H. H., & Frotscher, M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2934-08.2009 · Cited by 202 · see citing works
Wu, S.-X., Goebbels, S., Nakamura, K., Nakamura, K., Kometani, K., Minato, N., Kaneko, T., Nave, K.-A., & Tamamaki, N. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0508560102 · Cited by 198 · see citing works
Stancik, E. K., Navarro-Quiroga, I., Sellke, R., & Haydar, T. F. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.6131-09.2010 · Cited by 186 · see citing works
Emerging roles of neural stem cells in cerebral cortex development and evolution
Borrell, V., & Reillo, I. (2012) · Developmental Neurobiology · doi:10.1002/dneu.22013 · Cited by 185 · see citing works
Hevner, R. F., Daza, R. A. M., Englund, C., Kohtz, J., & Fink, A. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.11.033 · Cited by 180 · see citing works
González, M., Cabrera‐Socorro, A., Pérez‐García, C. G., Fraser, J. D., López, F. J., Alonso, R., & Meyer, G. (2007) · Journal of Comparative Neurology · doi:10.1002/cne.21419 · Cited by 167 · see citing works
Regulation of Protein Tyrosine Kinase Signaling by Substrate Degradation during Brain Development
Arnaud, L., Ballif, B. A., & Cooper, J. A. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.24.9293-9302.2003 · Cited by 164 · see citing works
Wang, D. D., & Kriegstein, A. R. (2011) · Cerebral Cortex · doi:10.1093/cercor/bhq124 · Cited by 148 · see citing works
Self-citationClonal production and organization of inhibitory interneurons in the neocortex
Brown, K. N., Chen, S., Han, Z., Lu, C.-H., Tan, X., Zhang, X.-J., Ding, L., Lopez-Cruz, A., Saur, D., Anderson, S. A., et al. (2011) · Science · doi:10.1126/science.1208884 · Cited by 152 · see citing works
Rash, B. G., Duque, A., Morozov, Y. M., Arellano, J. I., Micali, N., & Rakic, P. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1822169116 · Cited by 156 · see citing works
A Stem Cell Niche for Intermediate Progenitor Cells of the Embryonic Cortex
Javaherian, A., & Kriegstein, A. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp029 · Cited by 155 · see citing works
Self-citationCiliary ectosomes: transmissions from the cell's antenna
Wood, C. R., & Rosenbaum, J. L. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.12.008 · Cited by 153 · see citing works
Regulation of cerebral cortical neurogenesis by the Pax6 transcription factor
Manuel, M. N., Mi, D., Mason, J. O., & Price, D. J. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00070 · Cited by 153 · see citing works
Martini, F. J., Valiente, M., López Bendito, G., Szabó, G., Moya, F., Valdeolmillos, M., & Marín, O. (2009) · Development · doi:10.1242/dev.025502 · Cited by 147 · see citing works
Geldmacher-Voss, B., Reugels, A. M., Pauls, S., & Campos-Ortega, J. A. (2003) · Development · doi:10.1242/dev.00603 · Cited by 144 · see citing works
Cortical interneuron specification: the juncture of genes, time and geometry
Bandler, R. C., Mayer, C., & Fishell, G. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.10.003 · Cited by 125 · see citing works
Regulation of Radial Glial Survival by Signals from the Meninges
Radakovits, R., Barros, C. S., Belvindrah, R., Patton, B., & Muller, U. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.5537-08.2009 · Cited by 135 · see citing works
Emerging topics in Reelin function
Förster, E., Bock, H. H., Herz, J., Chai, X., Frotscher, M., & Zhao, S. (2010) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2010.07222.x · Cited by 130 · see citing works
Notch2 signaling maintains NSC quiescence in the murine ventricular-subventricular zone
Engler, A., Rolando, C., Giachino, C., Saotome, I., Erni, A., Brien, C., Zhang, R., Zimber-Strobl, U., Radtke, F., Artavanis-Tsakonas, S., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.094 · Cited by 125 · see citing works
Lineage-specific laminar organization of cortical GABAergic interneurons
Ciceri, G., Dehorter, N., Sols, I., Huang, Z. J., Maravall, M., & Marín, O. (2013) · Nature Neuroscience · doi:10.1038/nn.3485 · Cited by 124 · see citing works
Toward a Genetic Dissection of Cortical Circuits in the Mouse
Huang, Z. J. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.041 · Cited by 123 · see citing works
Mayer, C., Jaglin, X. H., Cobbs, L. V., Bandler, R. C., Streicher, C., Cepko, C. L., Hippenmeyer, S., & Fishell, G. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.011 · Cited by 113 · see citing works
Reelin in the years: controlling neuronal migration and maturation in the mammalian brain
D'Arcangelo, G. (2014) · Advances in Neuroscience · doi:10.1155/2014/597395 · Cited by 120 · see citing works
Wide dispersion and diversity of clonally related inhibitory interneurons
Harwell, C. C., Fuentealba, L. C., Gonzalez-Cerrillo, A., Parker, P. R. L., Gertz, C. C., Mazzola, E., Garcia, M. T., Alvarez-Buylla, A., Cepko, C. L., & Kriegstein, A. R. (2015) · Neuron · doi:10.1016/j.neuron.2015.07.030 · Cited by 106 · see citing works
Self-citationCordaro, M., Cuzzocrea, S., & Crupi, R. (2020) · Antioxidants · doi:10.3390/antiox9030216 · Cited by 98 · see citing works
Radial glia cells in the developing human brain
Howard, B. M., Mo, Z., Filipovic, R., Moore, A. R., Antic, S. D., & Zecevic, N. (2008) · The Neuroscientist · doi:10.1177/1073858407313512 · Cited by 97 · see citing works
Evolution and development of the mammalian cerebral cortex
Molnár, Z., Kaas, J. H., de Carlos, J. A., Hevner, R. F., Lein, E., & Němec, P. (2014) · Brain Behavior and Evolution · doi:10.1159/000357753 · Cited by 93 · see citing works
Najas, S., Arranz, J., Lochhead, P. A., Ashford, A. L., Oxley, D., Delabar, J. M., Cook, S. J., Barallobre, M. J., & Arbonés, M. L. (2015) · EBioMedicine · doi:10.1016/j.ebiom.2015.01.010 · Cited by 92 · see citing works
Distinct Lineage-Dependent Structural and Functional Organization of the Hippocampus
Xu, H.-T., Han, Z., Gao, P., He, S., Li, Z., Shi, W., Kodish, O., Shao, W., Brown, K. N., Huang, K., et al. (2014) · Cell · doi:10.1016/j.cell.2014.03.067 · Cited by 80 · see citing works
Aberrant differentiation of glutamatergic cells in neocortex of mouse model for fragile X syndrome.
Tervonen, T. A., Louhivuori, V., Sun, X., Hokkanen, M.-E., Kratochwil, C. F., Zebryk, P., Castrén, E., & Castrén, M. L. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.10.010 · Cited by 82 · see citing works
Cellular and Molecular Mechanisms Linking Human Cortical Development and Evolution
Libé-Philippot, B., & Vanderhaeghen, P. (2021) · Annual Review of Genetics · doi:10.1146/annurev-genet-071719-020705 · Cited by 78 · see citing works
Radial glia in the ventral telencephalon
Turrero García, M., & Harwell, C. C. (2017) · FEBS Letters · doi:10.1002/1873-3468.12829 · Cited by 62 · see citing works
Glial Cells and Integrity of the Nervous System
von Bernhardi, R., Eugenín-von Bernhardi, J., Flores, B., & Eugenín León, J. (2016) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-319-40764-7_1 · Cited by 67 · see citing works
Martínez-Cerdeño, V., Camacho, J., Fox, E., Miller, E., Ariza, J., Kienzle, D., Plank, K., Noctor, S. C., & Van de Water, J. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhu291 · Cited by 63 · see citing works
Self-citationoRGs and mitotic somal translocation — a role in development and disease
Ostrem, B., Di Lullo, E., & Kriegstein, A. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2016.11.007 · Cited by 61 · see citing works
Self-citationAssessing the validity of current mouse genetic models of obsessive-compulsive disorder
Wang, L., Simpson, H. B., & Dulawa, S. C. (2009) · Behavioural Pharmacology · doi:10.1097/fbp.0b013e32832a80ad · Cited by 50 · see citing works
The G protein-coupled receptor GPRC5B contributes to neurogenesis in the developing mouse neocortex
Kurabayashi, N., Nguyen, M. D., & Sanada, K. (2013) · Development · doi:10.1242/dev.099754 · Cited by 46 · see citing works
Different astroglia permissivity controls the migration of olfactory bulb interneuron precursors
García‐Marqués, J., De Carlos, J. A., Greer, C. A., & López‐Mascaraque, L. (2010) · Glia · doi:10.1002/glia.20918 · Cited by 46 · see citing works
The Influence of Wiring Economy on Nervous System Evolution
Wang, I. E., & Clandinin, T. R. (2016) · Current Biology · doi:10.1016/j.cub.2016.08.053 · Cited by 45 · see citing works
Lineage Is a Poor Predictor of Interneuron Positioning within the Forebrain
Mayer, C., Bandler, R. C., & Fishell, G. (2016) · Neuron · doi:10.1016/j.neuron.2016.09.035 · Cited by 45 · see citing works
Harrison, S. J., Nishinakamura, R., Jones, K. R., & Monaghan, A. P. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.002873 · Cited by 42 · see citing works
Ye, W., Mairet‐Coello, G., Pasoreck, E., & DiCicco‐Bloom, E. (2009) · Developmental Neurobiology · doi:10.1002/dneu.20680 · Cited by 43 · see citing works
GluN2B-Containing NMDA Receptors Promote Wiring of Adult-Born Neurons into Olfactory Bulb Circuits
Kelsch, W., Li, Z., Eliava, M., Goengrich, C., & Monyer, H. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1459-12.2012 · Cited by 40 · see citing works
Micali, N., Kim, S.-K., Diaz-Bustamante, M., Stein-O’Brien, G., Seo, S., Shin, J.-H., Rash, B. G., Ma, S., Wang, Y., Olivares, N. A., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107599 · Cited by 31 · see citing works
Consequences of trisomy 21 for brain development in Down syndrome
Russo, M. L., Sousa, A. M. M., & Bhattacharyya, A. (2024) · Nature Reviews Neuroscience · doi:10.1038/s41583-024-00866-2 · Cited by 28 · see citing works
Endometriosis-Derived Thromboxane A2 Induces Neurite Outgrowth
Yan, D., Liu, X., & Guo, S.-W. (2017) · Reproductive Sciences · doi:10.1177/1933719116670037 · Cited by 17 · see citing works
- Authors
- Noctor, S. C., Flint, A. C., Weissman, T. A., Dammerman, R. S., & Kriegstein, A. R.
- Affiliations
- Columbia University Irving Medical Center (US)
- Columbia University (US)
- Corresponding author
- Kriegstein, Arnold R.
- Venue
- Nature
- Published
- 2001-02
- Volume
- 409
- Issue
- 6821
- Pages
- 714-720
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1503727145
- Cited by
- 2,016
- References
- 30
- Citations by year
- 2026: 41 · 2025: 44 · 2024: 42 · 2023: 64 · 2022: 56 · 2021: 68 · 2020: 108 · 2019: 89 · 2018: 57 · 2017: 75 · 2016: 71 · 2015: 91 · 2014: 90 · 2013: 98 · 2012: 103
- FWCI
- 21.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- radial glia, neocortex, neuronal migration, neuronal lineage, clonal analysis, neurogenesis, retroviral labeling, time-lapse imaging
- MeSH terms
- Animals, Antigens, Differentiation, Cell Differentiation, Cell Movement, Clone Cells, Luminescent Proteins, Mitosis, Neuroglia, Neurons, Rats, Sprague-Dawley, Microscopy, Video, Neocortex, Green Fluorescent Proteins, Rats
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