The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Essential Role for dlg in Synaptic Clustering of Shaker K+Channels In Vivo
Open accessAbstract
The assemblage of specific ion channels and receptors at synaptic sites is crucial for signaling between pre- and postsynaptic cells. However, the mechanisms by which proteins are targeted to and clustered at synapses are poorly understood. Here we show that the product of the Drosophila discs-large gene, DLG, is colocalized with Shaker K+channels, which are clustered at glutamatergic synapses at the larval neuromuscular junction. In heterologous cells, DLG can cluster Shaker-type K+channels, and, in the yeast two-hybrid system, the DLG PDZ1–2 domains bind directly to the C-terminal tail of Shaker proteins. We also demonstrate that DLG-Shaker interactions are required in vivo for Shaker clustering at the neuromuscular junction. Synaptic clustering of Shaker channels is abolished not only by mutations in dlg but also by a mutation in Shaker that deletes its C-terminal DLG binding motif. Analyses of various dlg mutant alleles suggest that channel clustering and synaptic targeting functions depend on distinct DLG domains. These studies demonstrate for the first time that DLG plays an important role in synaptic organization in vivo that correlates with its ability to bind directly to specific membrane proteins of the synapse.
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Cites
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Migaud, M., Charlesworth, P., Dempster, M., Webster, L. C., Watabe, A. M., Makhinson, M., He, Y., Ramsay, M. F., Morris, R. G. M., Morrison, J. H., et al. (1998) · Nature · doi:10.1038/24790 · Cited by 1,160
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Chung, H. J., Xia, J., Scannevin, R. H., Zhang, X., & Huganir, R. L. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-19-07258.2000 · Cited by 558
Clustering of AMPA Receptors by the Synaptic PDZ Domain–Containing Protein PICK1
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Metadata
- Authors
- Tejedor, F. J., Bokhari, A., Rogero, O., Gorczyca, M., Zhang, J., Kim, E., Sheng, M., & Budnik, V.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1997-01-01
- Volume
- 17
- Issue
- 1
- Pages
- 152-159
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2128703002
- Cited by
- 264
- References
- 42
- FWCI
- 15.19
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Tejedor, F. J., Bokhari, A., Rogero, O., Gorczyca, M., Zhang, J., Kim, E., Sheng, M., & Budnik, V. (1997). Essential Role for dlg in Synaptic Clustering of Shaker K+Channels In Vivo. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.17-01-00152.1997
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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