Cited by 568Ion channel regulation and functionNeuroscience and Neuropharmacology ResearchCardiac electrophysiology and arrhythmias

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Resurgent Sodium Current and Action Potential Formation in Dissociated Cerebellar Purkinje Neurons

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Raman, Indira M., Bean, Bruce P.·1997·The Journal of Neuroscience

DOI 10.1523/jneurosci.17-12-04517.1997PMC PMC6573347

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Abstract

Voltage-dependent sodium channels were studied in dissociated cerebellar Purkinje neurons from rats. In whole-cell recordings, a tetrodotoxin (TTX)-sensitive inward current was elicited when the membrane was repolarized to voltages between −60 and −20 mV after depolarizations to +30 mV long enough to produce maximal inactivation. At −40 mV, this “resurgent” current peaked in 8 msec and decayed with a time constant of 30 msec. With 50 m m sodium as a charge carrier, the resurgent current was on average ∼120 pA. CA3 pyramidal neurons had no such current. The current may reflect recovery of inactivated channels through open states, because in Purkinje neurons (but not CA3 neurons) there was partial recovery from inactivation at −40 mV, coinciding with the rise of resurgent current. In single-channel recordings, individual channels gave openings corresponding to resurgent and conventional transient current. Action potentials were recorded from dissociated neurons under current clamp to investigate the role of the resurgent current in action potential formation. Purkinje neurons fired spontaneously at ∼30 Hz. Hyperpolarization to −85 mV prevented spontaneous firing, and brief depolarization then induced all-or-none firing of conglomerate action potentials comprising three to four spikes. When conglomerate action potentials were used as command voltages in voltage-clamp experiments, TTX-sensitive sodium current was elicited between spikes. The falling phase of an action potential is similar to voltage patterns that activate resurgent sodium current, and thus, resurgent sodium current likely contributes to the formation of conglomerate action potentials in Purkinje neurons.

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Authors: Raman, I. M., & Bean, B. P.
Affiliations: Harvard University (US)
ORCID: Raman, Indira M.
Bean, Bruce P.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 1997-06-15
Volume: 17
Issue: 12
Pages: 4517-4526
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.17-12-04517.1997
PMC: PMC6573347
OpenAlex: W1537888364
Cited by: 568
References: 27
Citations by year: 2026: 6 · 2025: 8 · 2024: 19 · 2023: 15 · 2022: 13 · 2021: 22 · 2020: 23 · 2019: 29 · 2018: 22 · 2017: 19 · 2016: 37 · 2015: 21 · 2014: 30 · 2013: 16 · 2012: 33
FWCI: 3.67
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 183 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01hl035034-19, HL 35034)
National Heart, Lung, and Blood Institute (HL 35034)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords: resurgent sodium current, voltage-gated sodium channels, Purkinje cells, tetrodotoxin-sensitive sodium current, CA3 pyramidal cells, spontaneous firing, single-channel recording
MeSH terms: Action Potentials, Animals, Cell Adhesion, Evoked Potentials, Hippocampus, Purkinje Cells, Tetrodotoxin, Time Factors, Sodium Channels, Pyramidal Cells, Patch-Clamp Techniques, Rats, In Vitro Techniques

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Resurgent Sodium Current and Action Potential Formation in Dissociated Cerebellar Purkinje Neurons

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