The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Transgenic Mice Expressing the Intracellular Domain of the p75 Neurotrophin Receptor Undergo Neuronal Apoptosis
Open accessAbstract
We have asked whether p75 NTR may play a role in neuronal apoptosis by producing transgenic mice that express the p75 NTR intracellular domain within peripheral and central neurons. These animals showed profound reductions in numbers of sympathetic and peripheral sensory neurons as well as cell loss in the neocortex, where there is normally little or no p75 NTR expression. Developmental loss of facial motor neurons was not observed, but induced expression of the p75 NTR intracellular domain within adult animals led to increased motor neuron death after axotomy. Biochemical analyses suggest that these effects were not attributable to a p75 NTR-dependent reduction in trk activation but instead indicate that the p75 NTR intracellular domain may act as a constitutive activator of signaling cascades that regulate apoptosis in both peripheral and central neurons.
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Boldin, M. P., Varfolomeev, E. E., Pancer, Z., Mett, I. L., Camonis, J. H., & Wallach, D. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.14.7795 · Cited by 993
Gene transfer and molecular cloning of the rat nerve growth factor receptor
Radeke, M. J., Misko, T. P., Hsu, C., Herzenberg, L. A., & Shooter, E. M. (1987) · Nature · doi:10.1038/325593a0 · Cited by 938
Cited by
Neurotrophin-regulated signalling pathways
Reichardt, L. F. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1894 · Cited by 2,195
Neurotrophin signal transduction in the nervous system
Kaplan, D. R., & Miller, F. D. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00092-1 · Cited by 1,944
Self-citationNerve Growth Factor Signaling, Neuroprotection, and Neural Repair
Sofroniew, M. V., Howe, C. L., & Mobley, W. C. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.1217 · Cited by 1,284
Neurotrophin Signaling Through the P75 Neurotrophin Receptor
Roux, P. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00016-3 · Cited by 717
Competitive Signaling Between TrkA and p75 Nerve Growth Factor Receptors Determines Cell Survival
Yoon, S. O., Casaccia-Bonnefil, P., Carter, B., & Chao, M. V. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-09-03273.1998 · Cited by 482
Metadata
- Authors
- Majdan, M., Lachance, C., Gloster, A., Aloyz, R., Zeindler, C., Bamji, S., Bhakar, A., Belliveau, D., Fawcett, J., Miller, F. D., & Barker, P. A.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1997-09-15
- Volume
- 17
- Issue
- 18
- Pages
- 6988-6998
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1551390553
- Cited by
- 210
- References
- 2
- FWCI
- 7.72
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Majdan, M., Lachance, C., Gloster, A., Aloyz, R., Zeindler, C., Bamji, S., Bhakar, A., Belliveau, D., Fawcett, J., Miller, F. D., & Barker, P. A. (1997). Transgenic Mice Expressing the Intracellular Domain of the p75 Neurotrophin Receptor Undergo Neuronal Apoptosis. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.17-18-06988.1997
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