Rapid Seizure-Induced Reduction of Benzodiazepine and Zn 2+ Sensitivity of Hippocampal Dentate Granule Cell GABA A Receptors
Open accessAbstract
Fast synaptic inhibition in the forebrain is mediated primarily by GABA acting on GABAA receptors (GABARs). GABARs are regulated by numerous positive (barbiturates, benzodiazepines, and neurosteroids) and negative (picrotoxin, bicuculline, and Zn2+) allosteric modulators. The sensitivity of GABARs to GABA and to allosteric modulators changes gradually during normal development, during development of chronic epilepsy, and after prolonged exposure to GABAR agonists. Here we report the development of rapid functional plasticity of GABARs occurring over 45 min of continuous seizures (status epilepticus) in rats. Seizures induced in rats by administration of lithium followed by pilocarpine were readily terminated by the benzodiazepine diazepam when administered early during the seizures (after 10 min of seizures). However, during status epilepticus, there was a substantial reduction of diazepam potency for termination of the seizures. To determine whether the loss of sensitivity of the animals to diazepam was caused by an alteration of GABAR functional properties, we obtained whole-cell GABAR currents from hippocampal dentate granule cells isolated acutely from control rats and from rats undergoing status epilepticus. GABAR properties were characterized by determining GABA sensitivity and the sensitivity of GABARs to regulation by benzodiazepines, barbiturates, and Zn2+. When compared with those from naive controls, GABAR currents from rats undergoing status epilepticus were less sensitive to diazepam and Zn2+ but retained their sensitivity to GABA and pentobarbital. We conclude that the prolonged seizures of status epilepticus rapidly altered the functional properties of hippocampal dentate granule cell GABARs.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Seizure threshold shows a hyperbolic relationship to benzodiazepine dose in zebrafish, rats, and non-human primates.
“Seizure threshold shows a hyperbolic relationship to dose in zebrafish (Gupta, Khobragade, & Shingatgeri, 2014), rats (Kapur & Macdonald, 1997), and non-human primates (Bottlaender et al., 1994) (Figure 3b).”
From Pharmacological principles for safe benzodiazepine and Z-drug dose reduction (2026) · cites this paper as Kapur & Macdonald, 1997
Cites
Hamill, O. P., Marty, A., Neher, E., Sakmann, B., & Sigworth, F. J. (1981) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00656997 · Cited by 18,436 · see citing works
Down-Regulation of Na+/K+ATPase Activity by Human Parvovirus B19 Capsid Protein VP1
Almilaji, A., Szteyn, K., Fein, E., Pakladok, T., Muñoz, C., Elvira, B., Towhid, S. T., Alesutan, I., Shumilina, E. V., Bock, C. –., et al. (2013) · Cellular Physiology and Biochemistry · doi:10.1159/000350083 · Cited by 8,675 · see citing works
Modification of seizure activity by electrical stimulation: II. Motor seizure
Racine, R. J. (1972) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(72)90177-0 · Cited by 7,141 · see citing works
Regulation of the Voltage Gated K+ Channel Kv1.3 by Recombinant Human Klotho Protein
Almilaji, A., Honisch, S., Liu, G., Elvira, B., Ajay, S. S., Hosseinzadeh, Z., Ahmed, M., Muñoz, C., Sopjani, M., & Lang, F. (2014) · Kidney & Blood Pressure Research · doi:10.1159/000368472 · Cited by 5,592 · see citing works
Proposal for Revised Clinical and Electroencephalographic Classification of Epileptic Seizures
(1981) · Epilepsia · doi:10.1111/j.1528-1157.1981.tb06159.x · Cited by 3,433 · see citing works
GABA<sub>A</sub> Receptor Channels
Macdonald, R. L., & Olsen, R. W. (1994) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.17.030194.003033 · Cited by 1,975 · see citing works
Self-citationImportance of a novel GABAA receptor subunit for benzodiazepine pharmacology
Pritchett, D. B., Sontheimer, H. W., Shivers, B. D., Ymer, S., Kettenmann, H., Schofield, P. R., & Seeburg, P. H. (1989) · Nature · doi:10.1038/338582a0 · Cited by 1,293 · see citing works
A prospective, population-based epidemiologic study of status epilepticus in Richmond, Virginia
DeLorenzo, R. J., Hauser, W. A., Towne, A. R., Boggs, J. G., Pellock, J. M., Penberthy, L., Garnett, L. K., Fortner-Burton, C. A., & Ko, D. (1996) · Neurology · doi:10.1212/wnl.46.4.1029 · Cited by 1,058 · see citing works
Sloviter, R. S. (1991) · Hippocampus · doi:10.1002/hipo.450010106 · Cited by 707 · see citing works
Antiepileptic Drug Mechanisms of Action
Macdonald, R. L., & Kelly, K. M. (1995) · Epilepsia · doi:10.1111/j.1528-1157.1995.tb05996.x · Cited by 592 · see citing works
Self-citationFrom ion currents to genomic analysis: Recent advances in GABAA receptor research
Rabow, L. E., Russek, S. J., & Farb, D. H. (1995) · Synapse · doi:10.1002/syn.890210302 · Cited by 469 · see citing works
Cavazos, J. E., Das, I., & Sutula, T. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-05-03106.1994 · Cited by 462 · see citing works
Systemic Factors and Epileptic Brain Damage
Meldrum, B. S. (1973) · Archives of Neurology · doi:10.1001/archneur.1973.00490260026003 · Cited by 441 · see citing works
Isolation of neurons suitable for patch-clamping from adult mammalian central nervous systems
Kay, A. R., & Wong, R. K. S. (1986) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(86)90040-3 · Cited by 409 · see citing works
Zinc-Induced Collapse of Augmented Inhibition by GABA in a Temporal Lobe Epilepsy Model
Buhl, E. H., Otis, T. S., & Módy, I. (1996) · Science · doi:10.1126/science.271.5247.369 · Cited by 409 · see citing works
The functional anatomy and pathology of lithium-pilocarpine and high-dose pilocarpine seizures
Clifford, D. B., Olney, J. W., Maniotis, A. J., Collins, R. C., & Zorumski, C. F. (1987) · Neuroscience · doi:10.1016/0306-4522(87)90171-0 · Cited by 377 · see citing works
Functional and molecular distinction between recombinant rat GABAA receptor subtypes by Zn2+
Draguhn, A., Verdoorn, T. A., Ewert, M., Seeburg, P. H., & Sakmann, B. J. (1990) · Neuron · doi:10.1016/0896-6273(90)90337-f · Cited by 376 · see citing works
Systemic Cholinergic Agents Induce Seizures and Brain Damage in Lithium-Treated Rats
Honchar, M. P., Olney, J. W., & Sherman, W. R. (1983) · Science · doi:10.1126/science.6301005 · Cited by 368 · see citing works
Functional anatomy of hippocampal seizures
Lothman, E. W., Bertram, E. H., & Stringer, J. L. (1991) · Progress in Neurobiology · doi:10.1016/0301-0082(91)90011-o · Cited by 356 · see citing works
Physiology of Status Epilepticus in Primates
Meldrum, B. S., & Horton, R. W. (1973) · Archives of Neurology · doi:10.1001/archneur.1973.00490190019001 · Cited by 341 · see citing works
Properties of putative cerebellar gamma-aminobutyric acid A receptor isoforms.
Saxena, N., & Macdonald, R. L. (1996) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)08745-0 · Cited by 293 · see citing works
Self-citationLothman, E. W., Bertram, E. H., Bekenstein, J. W., & Perlin, J. B. (1989) · Epilepsy Research · doi:10.1016/0920-1211(89)90038-7 · Cited by 293 · see citing works
Otis, T. S., De Koninck, Y., & Mody, I. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.16.7698 · Cited by 257 · see citing works
Gibbs, J. W., Shumate, M. D., & Coulter, D. A. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.77.4.1924 · Cited by 248 · see citing works
GABAA receptors are differentially sensitive to zinc: dependence on subunit composition
Smart, T. G., Moss, S. J., Xie, X., & Huganir, R. L. (1991) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1991.tb12337.x · Cited by 226 · see citing works
Hippocampal Pyramidal Cell Loss in Human Status Epilepticus
DeGiorgio, C. M., Tomiyasu, U., Gott, P. S., & Treiman, D. M. (1992) · Epilepsia · doi:10.1111/j.1528-1157.1992.tb02278.x · Cited by 218 · see citing works
Response of status epilepticus induced by lithium and pilocarpine to treatment with diazepam
Walton, N. Y., & Treiman, D. M. (1988) · Experimental Neurology · doi:10.1016/0014-4886(88)90010-6 · Cited by 196 · see citing works
Shin, C., Pedersen, H., & McNamara, J. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-10-02696.1985 · Cited by 163 · see citing works
Repeated seizures induce long-term increase in hippocampal benzodiazepine receptors.
McNamara, J. O., Peper, A., & Patrone, V. (1980) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.77.5.3029 · Cited by 148 · see citing works
Prognostic factors of pentobarbital therapy for refractory generalized status epilepticus
Yaffe, K. S., & Lowenstein, D. H. (1993) · Neurology · doi:10.1212/wnl.43.5.895 · Cited by 147 · see citing works
Kapur, J., Stringer, J. L., & Lothman, E. W. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.2.417 · Cited by 143 · see citing works
Self-citationAkaike, N., Hattori, K., Inomata, N., & Oomura, Y. (1985) · The Journal of Physiology · doi:10.1113/jphysiol.1985.sp015622 · Cited by 141 · see citing works
Watanabe, Y., Johnson, R. S., Butler, L. S., Binder, D. K., Spiegelman, B. M., Papaioannou, V. E., & McNamara, J. O. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-12-03827.1996 · Cited by 139 · see citing works
Morrisett, R. A., Jope, R. S., & Snead, O. C. (1987) · Experimental Neurology · doi:10.1016/0014-4886(87)90293-7 · Cited by 131 · see citing works
Kapur, J., & Coulter, D. A. (1995) · Annals of Neurology · doi:10.1002/ana.410380609 · Cited by 129 · see citing works
Self-citationMagnetic Resonance Imaging Evidence of Hippocampal Sclerosis in Progression: A Case Report
Nohria, V., Lee, N., Tien, R. D., Heinz, E. R., Smith, J. S., DeLong, G. R., Skeen, M. B., Resnick, T., Crain, B. J., & Lewis, D. V. (1994) · Epilepsia · doi:10.1111/j.1528-1157.1994.tb01807.x · Cited by 124 · see citing works
Changes in plasma catecholamines after tonic‐clonic seizures
Simon, R. P., Aminoff, M. J., & Benowitz, N. L. (1984) · Neurology · doi:10.1212/wnl.34.2.255 · Cited by 123 · see citing works
Valdés, F., Dasheiff, R. M., Birmingham, F., Crutcher, K. A., & McNamara, J. O. (1982) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.79.1.193 · Cited by 112 · see citing works
Fujikawa, D. G., Daniels, A. H., & Kim, J. S. (1994) · Epilepsy Research · doi:10.1016/0920-1211(94)90051-5 · Cited by 105 · see citing works
Otis, T. (1994) · Medical Entomology and Zoology · Cited by 99 · see citing works
Bertmam, E. H., & Lothman, E. W. (1993) · Brain Research · doi:10.1016/0006-8993(93)91295-4 · Cited by 90 · see citing works
Self‐sustaining limbic status epilepticus.
van Landingham, K. E., & Lothman, E. W. (1991) · Neurology · doi:10.1212/wnl.41.12.1942 · Cited by 77 · see citing works
Ethanol, gamma-aminobutyrate type A receptors, and protein kinase C phosphorylation.
Macdonald, R. L. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.9.3633 · Cited by 73 · see citing works
Self-citationThe Imaging of Individual Atoms
Jefferson, D. A. (1996) · Science · doi:10.1126/science.274.5286.369 · Cited by 73 · see citing works
Treatment of Status Epilepticus
Ramsay, R. E. (1993) · Epilepsia · doi:10.1111/j.1528-1157.1993.tb05908.x · Cited by 72 · see citing works
Kapur, J., & Lothman, E. W. (1989) · Journal of Neurophysiology · doi:10.1152/jn.1989.61.2.427 · Cited by 70 · see citing works
Self-citationLin, Y., Browning, M. D., Dudek, E. M., & Macdonald, R. L. (1994) · Neuron · doi:10.1016/0896-6273(94)90427-8 · Cited by 65 · see citing works
Self-citationOh, K. S., Lee, C., Gibbs, J. W., & Coulter, D. A. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-02-01341.1995 · Cited by 54 · see citing works
Greenfield, L. J., & Macdonald, R. L. (1996) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s004240050238 · Cited by 50 · see citing works
Self-citationCoulter, D. A., Huguenard, J. R., & Prince, D. A. (1990) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1990.tb14096.x · Cited by 49 · see citing works
Inositol triphosphate, cyclic AMP, and cyclic GMP in rat brain regions after lithium and seizures
Jope, R. S., Song, L., & Kolasa, K. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90261-w · Cited by 44 · see citing works
Perlin, J. B., Churn, S. B., Lothman, E. W., & DeLorenzo, R. J. (1992) · Epilepsy Research · doi:10.1016/0920-1211(92)90045-u · Cited by 43 · see citing works
The Effects of Raising Intracellular Calcium on Synaptic GABA A Receptor-channels
Koninck, Y. D., & Módy, I. (1996) · Neuropharmacology · doi:10.1016/s0028-3908(96)00063-9 · Cited by 43 · see citing works
The balance between excitation and inhibition in dentate granule cells and its role in epilepsy.
Módy, I., Otis, T. S., Staley, K. J., & Köhr, G. (1992) · PubMed · Cited by 41 · see citing works
Intracellular Ca2+ suppressed a transient potassium current in hippocampal neurons
Chen, Q., & Wong, R. K. S. (1991) · Journal of Neuroscience · doi:10.1523/jneurosci.11-02-00337.1991 · Cited by 39 · see citing works
Status Epilepticus: Concepts in Diagnosis and Treatment
DeLorenzo, R. J. (1990) · Seminars in Neurology · doi:10.1055/s-2008-1063984 · Cited by 37 · see citing works
Loss of GABA A receptors during partial status epilepticus
Kapur, J., Lothman, E. W., & DeLorenzo, R. J. (1994) · Neurology · doi:10.1212/wnl.44.12.2407 · Cited by 37 · see citing works
Self-citationBizon, J. L., Lauterborn, J. C., Isackson, P. J., & Gall, C. M. (1996) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19960311)366:3 · Cited by 22 · see citing works
Regulation of GABAA receptor channels by anticonvulsant and convulsant drugs and by phosphorylation.
Macdonald, R. L., Twyman, R. E., Ryan‐Jastrow, T., & Angelotti, T. P. (1992) · PubMed · Cited by 21 · see citing works
Self-citation(1995) · Epilepsia · doi:10.1111/j.1528-1157.1995.tb01643.x · Cited by 19 · see citing works
Deyn, P. P. D., & Macdonald, R. L. (1988) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1988.tb16554.x · Cited by 11 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
The neurobiology of zinc in health and disease
Frederickson, C. J., Koh, J., & Bush, A. I. (2005) · Nature reviews. Neuroscience · doi:10.1038/nrn1671 · Cited by 1,841 · see citing works
Guidelines for the Evaluation and Management of Status Epilepticus
Brophy, G. M., BELL, R. D., Claassen, J., Alldredge, B. K., Bleck, T. P., Glauser, T. A., LaRoche, S. M., Riviello, J. J., Shutter, L., Sperling, M. R., et al. (2012) · Neurocritical Care · doi:10.1007/s12028-012-9695-z · Cited by 1,630 · see citing works
Petit‐Pedrol, M., Armangué, T., Peng, X., Bataller, L., Cellucci, T., Davis, R. A., McCracken, L., Martínez‐Hernández, E., Mason, W. P., Kruer, M. C., et al. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(13)70299-0 · Cited by 616 · see citing works
Scharfman, H. E., Goodman, J. H., & Sollas, A. L. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06144.2000 · Cited by 605 · see citing works
Lowenstein, D. H., & Alldredge, B. K. (1998) · New England Journal of Medicine · doi:10.1056/nejm199804023381407 · Cited by 594 · see citing works
Naylor, D. E., Liu, H., & Wasterlain, C. G. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4944-04.2005 · Cited by 549 · see citing works
Ilic, T. V., Meintzschel, F., Cleff, U., Ruge, D., Kessler, K. R., & Ziemann, U. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.030122 · Cited by 547 · see citing works
Status epilepticus: pathophysiology and management in adults
Chen, J. W. Y., & Wasterlain, C. G. (2006) · The Lancet Neurology · doi:10.1016/s1474-4422(06)70374-x · Cited by 499 · see citing works
Betjemann, J. P., & Lowenstein, D. H. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00042-3 · Cited by 501 · see citing works
Drug Resistance in Epilepsy: Putative Neurobiologic and Clinical Mechanisms
Schmidt, D., & Löscher, W. (2005) · Epilepsia · doi:10.1111/j.1528-1167.2005.54904.x · Cited by 483 · see citing works
The structural basis of function in Cys-loop receptors
Thompson, A. J., Lester, H. A., & Lummis, S. C. R. (2010) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583510000168 · Cited by 340 · see citing works
Status Epilepticus Increases the Intracellular Accumulation of GABAA Receptors
Goodkin, H. P. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0900-05.2005 · Cited by 336 · see citing works
Subunit-Specific Trafficking of GABAAReceptors during Status Epilepticus
Goodkin, H. P., Joshi, S., Mtchedlishvili, Z., Brar, J., & Kapur, J. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.3426-07.2008 · Cited by 324 · see citing works
Self-citationManford, M. (2017) · Journal of Neurology · doi:10.1007/s00415-017-8394-2 · Cited by 302 · see citing works
Brain, aging and neurodegeneration: Role of zinc ion availability
Mocchegiani, E., Bertoni–Freddari, C., Marcellini, F., & Malavolta, M. (2005) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2005.04.005 · Cited by 280 · see citing works
Non-convulsive status epilepticus in adults: clinical forms and treatment
Meierkord, H., & Holtkamp, M. (2007) · The Lancet Neurology · doi:10.1016/s1474-4422(07)70074-1 · Cited by 260 · see citing works
Reddy, D. S., & Kuruba, R. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms140918284 · Cited by 252 · see citing works
Sutula, T. P., & Dudek, F. E. (2007) · Progress in brain research · doi:10.1016/s0079-6123(07)63029-5 · Cited by 251 · see citing works
Mazarati, A. M., Baldwin, R. A., Sankar, R., & Wasterlain, C. G. (1998) · Brain Research · doi:10.1016/s0006-8993(98)01080-4 · Cited by 237 · see citing works
Chin, R., Neville, B. G. R., Peckham, C. S., Wade, A. M., Bedford, H. E., & Scott, R. C. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70141-8 · Cited by 236 · see citing works
Kullmann, D. M., Moreau, A. W., Bakiri, Y., & Nicholson, E. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.030 · Cited by 234 · see citing works
Ketamine controls prolonged status epilepticus
Borris, D. J., Bertram, E. H., & Kapur, J. (2000) · Epilepsy Research · doi:10.1016/s0920-1211(00)00175-3 · Cited by 218 · see citing works
Self-citationNaylor, D. E., Liu, H., Niquet, J., & Wasterlain, C. G. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.12.015 · Cited by 215 · see citing works
Gaínza‐Lein, M., Fernández, I. S., Jackson, M. C., Abend, N. S., Arya, R., Brenton, J. N., Carpenter, J. L., Chapman, K. E., Gaillard, W. D., Glauser, T. A., et al. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2017.4382 · Cited by 210 · see citing works
Molecular mechanisms of antiseizure drug activity at GABAA receptors
Greenfield, L. J. (2013) · Seizure · doi:10.1016/j.seizure.2013.04.015 · Cited by 205 · see citing works
GABA and Its Receptors in Epilepsy
Sperk, G., Fürtinger, S., Schwarzer, C., & Pirker, S. (2004) · Advances in experimental medicine and biology · doi:10.1007/978-1-4757-6376-8_7 · Cited by 195 · see citing works
EFNS guideline on the management of status epilepticus
Meierkord, H., Boon, P., Engelsen, B. A., Göcke, K., Shorvon, S. D., Tinuper, P., & Holtkamp, M. (2006) · European Journal of Neurology · doi:10.1111/j.1468-1331.2006.01397.x · Cited by 182 · see citing works
Prognostic factors, morbidity and mortality in tonic–clonic status epilepticus: A review
Neligan, A., & Shorvon, S. D. (2010) · Epilepsy Research · doi:10.1016/j.eplepsyres.2010.09.003 · Cited by 169 · see citing works
Serrano, G. E., Lelutiu, N. B., Rojas, A., Cochi, S., Shaw, R. N., Makinson, C. D., Wang, D., FitzGerald, G. A., & Dingledine, R. J. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3922-11.2011 · Cited by 169 · see citing works
Phenomenology of prolonged febrile seizures
Shinnar, S., Hesdorffer, D. C., Nordli, D. R., Pellock, J. M., O’Dell, C., Lewis, D. V., Frank, L. M., Moshé, S. L., Epstein, L. G., Marmarou, A., et al. (2008) · Neurology · doi:10.1212/01.wnl.0000310774.01185.97 · Cited by 167 · see citing works
Mazarati, A. M., & Wasterlain, C. G. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00238-4 · Cited by 162 · see citing works
Pathophysiology of status epilepticus
Walker, M. C. (2016) · Neuroscience Letters · doi:10.1016/j.neulet.2016.12.044 · Cited by 160 · see citing works
Jones, D. M., Esmaeil, N., Maren, S., & Macdonald, R. L. (2002) · Epilepsy Research · doi:10.1016/s0920-1211(02)00085-2 · Cited by 154 · see citing works
Self-citationPerks, A., Cheema, S., & Mohanraj, R. (2012) · British Journal of Anaesthesia · doi:10.1093/bja/aes027 · Cited by 146 · see citing works
Coulter, D. A. (2001) · International review of neurobiology · doi:10.1016/s0074-7742(01)45013-6 · Cited by 140 · see citing works
Kienitz, R., Kay, L., Beuchat, I., Gelhard, S., von Brauchitsch, S., Mann, C., Lucaciu, A., Schäfer, J.-H., Siebenbrodt, K., Zöllner, J.-P., et al. (2022) · CNS Drugs · doi:10.1007/s40263-022-00940-2 · Cited by 139 · see citing works
A “Malignant” Variant of Status Epilepticus
Holtkamp, M., Othman, J., Buchheim, K., Masuhr, F., Schielke, E., & Meierkord, H. (2005) · Archives of Neurology · doi:10.1001/archneur.62.9.1428 · Cited by 139 · see citing works
Kang, J., & Macdonald, R. L. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.0449 · Cited by 139 · see citing works
Self-citationDrislane, F. W., Blum, A. S., Lopez, M., Gautam, S., & Schomer, D. L. (2009) · Epilepsia · doi:10.1111/j.1528-1167.2008.01993.x · Cited by 139 · see citing works
Racine, R. J., Steingart, M., & McIntyre, D. (1999) · Epilepsy Research · doi:10.1016/s0920-1211(99)00013-3 · Cited by 136 · see citing works
Review: Epilepsy as an Example of Neural Plasticity
Scharfman, H. E. (2002) · The Neuroscientist · doi:10.1177/107385840200800211 · Cited by 136 · see citing works
Navarro, V., Dagron, C., Elie, C., Lamhaut, L., Demeret, S., Urien, S., An, K., Bolgert, F., Tréluyer, J., Baulac, M., et al. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00296-3 · Cited by 134 · see citing works
Pitkänen, A., Kharatishvili, I., Narkilahti, S., Łukasiuk, K., & Nissinen, J. (2004) · Epilepsy Research · doi:10.1016/j.eplepsyres.2004.10.003 · Cited by 120 · see citing works
Wasterlain, C. G., & Chen, J. W. Y. (2008) · Epilepsia · doi:10.1111/j.1528-1167.2008.01928.x · Cited by 120 · see citing works
Self-sustaining status epilepticus after brief electrical stimulation of the perforant path
Mazarati, A. M., Wasterlain, C. G., Sankar, R., & Shin, D. H. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00606-4 · Cited by 116 · see citing works
Anticonvulsant properties of hypothermia in experimental status epilepticus
Schmitt, F. C., Buchheim, K., Meierkord, H., & Holtkamp, M. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.05.008 · Cited by 115 · see citing works
Perucca, E., Bialer, M., & White, H. S. (2023) · CNS Drugs · doi:10.1007/s40263-023-01027-2 · Cited by 114 · see citing works
Trends in Status Epilepticus—Related Hospitalizations and Mortality
Betjemann, J. P., Josephson, S. A., Lowenstein, D. H., & Burke, J. F. (2015) · JAMA Neurology · doi:10.1001/jamaneurol.2015.0188 · Cited by 113 · see citing works
Advances in the pathophysiology of status epilepticus
Chen, J. W. Y., Naylor, D. E., & Wasterlain, C. G. (2007) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2007.00803.x · Cited by 112 · see citing works
Treatment of Refractory and Super-refractory Status Epilepticus
Rai, S., & Drislane, F. W. (2018) · Neurotherapeutics · doi:10.1007/s13311-018-0640-5 · Cited by 111 · see citing works
Nolte, C., Gore, A., Sekler, I., Kresse, W., Hershfinkel, M., Hoffmann, A., Kettenmann, H., & Moran, A. (2004) · Glia · doi:10.1002/glia.20065 · Cited by 107 · see citing works
The Management of Status Epilepticus
Marik, P. E., & Varón, J. (2004) · CHEST Journal · doi:10.1378/chest.126.2.582 · Cited by 107 · see citing works
Bankstahl, J. P., & Löscher, W. (2008) · Epilepsy Research · doi:10.1016/j.eplepsyres.2008.07.007 · Cited by 106 · see citing works
Ketamine successfully terminates malignant status epilepticus
Prüß, H., & Holtkamp, M. (2008) · Epilepsy Research · doi:10.1016/j.eplepsyres.2008.08.005 · Cited by 104 · see citing works
Pathophysiology of convulsive status epilepticus
Fernández, I. S., Goodkin, H. P., & Scott, R. C. (2018) · Seizure · doi:10.1016/j.seizure.2018.08.002 · Cited by 103 · see citing works
Possible alterations in GABAAreceptor signaling that underlie benzodiazepine‐resistant seizures
Deeb, T. Z., Maguire, J. L., & Moss, S. J. (2012) · Epilepsia · doi:10.1111/epi.12037 · Cited by 103 · see citing works
Fisher, J. L., & Macdonald, R. L. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-08-02944.1998 · Cited by 102 · see citing works
Self-citationEndogenous Zinc Inhibits GABAAReceptors in a Hippocampal Pathway
Ruiz, A. J., Walker, M. C., Fabian‐Fine, R., & Kullmann, D. M. (2004) · Journal of Neurophysiology · doi:10.1152/jn.00755.2003 · Cited by 100 · see citing works
Distribution of the zinc transporter ZnT‐1 in comparison with chelatable zinc in the mouse brain
Sekler, I., Moran, A., Hershfinkel, M., Dori, A., Margulis, A., Birenzweig, N., Nitzan, Y. B., & Silverman, W. F. (2002) · The Journal of Comparative Neurology · doi:10.1002/cne.10224 · Cited by 98 · see citing works
Nishimura, T., Schwarzer, C., Gasser, E., Kato, N., Vezzani, A., & Sperk, G. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.04.013 · Cited by 96 · see citing works
GABAA receptor epilepsy mutations
Macdonald, R. L., Gallagher, M. J., Feng, H., & Kang, J. (2004) · Biochemical Pharmacology · doi:10.1016/j.bcp.2004.07.029 · Cited by 94 · see citing works
Self-citationPatterns of benzodiazepine underdosing in the Established Status Epilepticus Treatment Trial
Sathe, A. G., Underwood, E., Coles, L. D., Elm, J., Silbergleit, R., Chamberlain, J. M., Kapur, J., Cock, H. R., Fountain, N. B., Shinnar, S., et al. (2021) · Epilepsia · doi:10.1111/epi.16825 · Cited by 93 · see citing works
Self-citationReduced Excitatory Drive onto Interneurons in the Dentate Gyrus after Status Epilepticus
Doherty, J., & Dingledine, R. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-06-02048.2001 · Cited by 90 · see citing works
Pharmacologic treatment of status epilepticus
Trinka, E., Höfler, J., Leitinger, M., Rohracher, A., Kalss, G., & Brigo, F. (2015) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2016.1127354 · Cited by 88 · see citing works
Timing in the treatment of status epilepticus: From basics to the clinic
Gaínza‐Lein, M., Fernández, I. S., Ulate-Campos, A., Loddenkemper, T., & Ostendorf, A. P. (2018) · Seizure · doi:10.1016/j.seizure.2018.05.021 · Cited by 88 · see citing works
The role of mammalian ionotropic receptors in synaptic plasticity: LTP, LTD and epilepsy
Kullmann, D., Asztely, F., & Walker, M. (2000) · Cellular and Molecular Life Sciences (CMLS) · doi:10.1007/pl00000640 · Cited by 92 · see citing works
The Role of Benzodiazepines in the Treatment of Epilepsy
Ochoa, J. G., & Kilgo, W. A. (2016) · Current Treatment Options in Neurology · doi:10.1007/s11940-016-0401-x · Cited by 88 · see citing works
Pirker, S., Schwarzer, C., Czech, T., Baumgartner, C., Pockberger, H., Maier, H., Hauer, B., Sieghart, W., Fürtinger, S., & Sperk, G. (2003) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/62.8.820 · Cited by 86 · see citing works
Leroy, C., Poisbeau, P., Keller, A. F., & Nehlig, A. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.059246 · Cited by 85 · see citing works
Hellier, J. L., Patrylo, P. R., Dou, P., Nett, M., Rose, G. M., & Dudek, F. E. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-22-10053.1999 · Cited by 84 · see citing works
GABAA Receptor Internalization during Seizures
Goodkin, H. P., Sun, C., Yeh, J., Mangan, P. S., & Kapur, J. (2007) · Epilepsia · doi:10.1111/j.1528-1167.2007.01297.x · Cited by 83 · see citing works
Self-citationThe evolution of the pilocarpine animal model of status epilepticus
Juvale, I. I. A., & Has, A. T. C. (2020) · Heliyon · doi:10.1016/j.heliyon.2020.e04557 · Cited by 82 · see citing works
Detection and Treatment of Refractory Status Epilepticus in the Intensive Care Unit
Drislane, F. W., Lopez, M., Blum, A. S., & Schomer, D. L. (2008) · Journal of Clinical Neurophysiology · doi:10.1097/wnp.0b013e31817be70e · Cited by 82 · see citing works
Doboszewska, U., Młyniec, K., Wlaź, A., Poleszak, E., Nowak, G., & Wlaź, P. (2019) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.08.013 · Cited by 81 · see citing works
Holtkamp, M., & Meierkord, H. (2011) · Therapeutic Advances in Neurological Disorders · doi:10.1177/1756285611403826 · Cited by 81 · see citing works
Niquet, J., Baldwin, R. A., Norman, K. M., Suchomelová, L., Lumley, L. A., & Wasterlain, C. G. (2016) · Epilepsia · doi:10.1111/epi.13480 · Cited by 78 · see citing works
GABA receptor function and pharmacology in epilepsy and status epilepticus
Jones, D. M., & MACDONALD, R. (2003) · Current Opinion in Pharmacology · doi:10.1016/s1471-4892(02)00015-2 · Cited by 78 · see citing works
Self-citationBernard, C., Esclapez, M., Hirsch, J. C., & Ben‐Ari, Y. (1998) · Epilepsy Research · doi:10.1016/s0920-1211(98)00043-6 · Cited by 78 · see citing works
Benzodiazepine‐refractory status epilepticus: pathophysiology and principles of treatment
Niquet, J., Baldwin, R. A., Suchomelová, L., Lumley, L. A., Naylor, D. E., Eavey, R., & Wasterlain, C. G. (2016) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.13147 · Cited by 77 · see citing works
Mtchedlishvili, Z., Lepsveridze, E., Xu, H., Kharlamov, E. A., Lu, B., & Kelly, K. M. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.03.012 · Cited by 77 · see citing works
Chapman, M., Smith, M. C. F., & Hirsch, N. P. (2001) · Anaesthesia · doi:10.1046/j.1365-2044.2001.02115.x · Cited by 76 · see citing works
Blair, R. E., Sombati, S., Lawrence, D. C., McCay, B. D., & DeLorenzo, R. J. (2004) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.104.068478 · Cited by 76 · see citing works
The impact of diazepam’s discovery on the treatment and understanding of status epilepticus
Goodkin, H. P., & Kapur, J. (2009) · Epilepsia · doi:10.1111/j.1528-1167.2009.02257.x · Cited by 75 · see citing works
Self-citationPhelan, K. D., Shwe, U. T., Williams, D. K., Greenfield, L. J., & Zheng, F. (2015) · Epilepsy Research · doi:10.1016/j.eplepsyres.2015.09.008 · Cited by 75 · see citing works
Diazepam Terminates Brief but Not Prolonged Seizures in Young, Naïve Rats
Goodkin, H. P., Liu, X., & Holmes, G. L. (2003) · Epilepsia · doi:10.1046/j.1528-1157.2003.62402.x · Cited by 73 · see citing works
Characterization of status epilepticus induced by two organophosphates in rats
Todorovic, M. S., Cowan, M. L., Balint, C. A., Sun, C., & Kapur, J. (2012) · Epilepsy Research · doi:10.1016/j.eplepsyres.2012.04.014 · Cited by 73 · see citing works
Self-citationMtchedlishvili, Z., Bertram, E. H., & Kapur, J. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.00453.x · Cited by 71 · see citing works
Self-citationRefractory and Super-Refractory Status Epilepticus—an Update
Hocker, S. E., Tatum, W. O., LaRoche, S. M., & Freeman, W. D. (2014) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-014-0452-x · Cited by 70 · see citing works
Fritsch, B., Stott, J. J., Donofrio, J. J., & Rogawski, M. A. (2009) · Epilepsia · doi:10.1111/j.1528-1167.2009.02205.x · Cited by 70 · see citing works
Ragozzino, D., Palma, E., Angelantonio, S. D., Amici, M., Mascia, A., Arcella, A., Giangaspero, F., Cantore, G., Gennaro, G. D., Manfredi, M., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507339102 · Cited by 67 · see citing works
Li, W., Tian, X., Huang, B., Li, H., Zhao, X., Gao, S., Zheng, J., Zhang, X., Zhou, H., Tian, Y., et al. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.09.059 · Cited by 66 · see citing works
Enhanced AMPA receptor-mediated neurotransmission on CA1 pyramidal neurons during status epilepticus
Joshi, S., Rajasekaran, K., Sun, H., Williamson, J., & Kapur, J. (2017) · Neurobiology of Disease · doi:10.1016/j.nbd.2017.03.017 · Cited by 65 · see citing works
Self-citationAndré, V., Ferrandon, A., Marescaux, C., & Nehlig, A. (2000) · Neuroscience · doi:10.1016/s0306-4522(00)00209-8 · Cited by 65 · see citing works
Acute Cellular Alterations in the Hippocampus After Status Epilepticus
Macdonald, R. L., & Kapur, J. (1999) · Epilepsia · doi:10.1111/j.1528-1157.1999.tb00873.x · Cited by 65 · see citing works
Self-citationManagement of Prolonged Seizures and Status Epilepticus in Childhood: A Systematic Review
Sofou, K., Kristjánsdóttir, R., Papachatzakis, N. E., Ahmadzadeh, A., & Uvebrant, P. (2009) · Journal of Child Neurology · doi:10.1177/0883073809332768 · Cited by 63 · see citing works
Chandler, K. E., Princivalle, A. P., Fabian‐Fine, R., Bowery, N. G., Kullmann, D. M., & Walker, M. C. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-36-11382.2003 · Cited by 64 · see citing works
Simeone, T. A., Donevan, S. D., & Rho, J. M. (2003) · Journal of Child Neurology · doi:10.1177/08830738030180012101 · Cited by 64 · see citing works
Status EpilepticusPreprint
Seinfeld, S. A., Goodkin, H. P., & Shinnar, S. (2016) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a022830 · Cited by 63 · see citing works
Mechanisms of drug resistance in status epilepticus
Löscher, W. (2007) · Epilepsia · doi:10.1111/j.1528-1167.2007.01357.x · Cited by 62 · see citing works
Żółkowska, D., Wu, C., & Rogawski, M. A. (2018) · Epilepsia · doi:10.1111/epi.13999 · Cited by 61 · see citing works
- Authors
- Kapur, J., & Macdonald, R. L.
- Affiliations
- Pediatrics and Genetics (US)
- University of Michigan (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1997-10-01
- Volume
- 17
- Issue
- 19
- Pages
- 7532-7540
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2892718
- OpenAlex
- W1909177474
- Cited by
- 427
- References
- 61
- Citations by year
- 2026: 5 · 2025: 10 · 2024: 12 · 2023: 12 · 2022: 13 · 2021: 16 · 2020: 11 · 2019: 16 · 2018: 21 · 2017: 28 · 2016: 18 · 2015: 26 · 2014: 14 · 2013: 11 · 2012: 18
- FWCI
- 3.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Epilepsy Foundation
- U.S. Public Health Service (R01 33300)
- National Institute of Neurological Disorders and Stroke (KO8-NS01748, K08NS001748, R01NS033300)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- GABAA receptor, status epilepticus, benzodiazepine sensitivity, diazepam, zinc, allosteric modulation, barbiturates, pentobarbital, functional plasticity, chronic epilepsy
- MeSH terms
- Animals, Benzodiazepines, Diazepam, Electric Conductivity, Female, Male, Neurons, Pentobarbital, Receptors, GABA-A, Seizures, Time Factors, Zinc, Rats, Sprague-Dawley, Dentate Gyrus, Rats, GABA-A Receptor Antagonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
