The DOI matches its Crossref record; 55 of the 55 references it cites were found in a registry or an index.
Cyclin Dependent Kinase Inhibitors and Dominant Negative Cyclin Dependent Kinase 4 and 6 Promote Survival of NGF-Deprived Sympathetic Neurons
Open accessAbstract
Neuronal apoptosis plays a critical role in both normal development and disease. However, the precise molecular events controlling neuronal apoptosis are not well understood. Previously, we hypothesized that cell cycle regulatory molecules function in controlling the apoptotic pathways of trophic factor-deprived neurons. To test this hypothesis, we used the RNA alphavirus Sindbis to express three known cyclin dependent kinase inhibitors (CKIs), p16 ink4, p21 waf/cip, and p27 kip1, and dominant negative mutant forms of four known G 1 cyclin dependent kinases (CDKs), Cdk2, Cdk3, Cdk4, and Cdk6, in primary cultured rat superior cervical ganglion sympathetic neurons. We demonstrate that expression of each of the CKIs protects the postmitotic cultured neurons from apoptotic death evoked by withdrawal of NGF. In addition, we show that expression of dominant negative forms of Cdk4 or Cdk6, but not Cdk2 or Cdk3, protects NGF-deprived sympathetic neurons from death. Such findings suggest the participation of several CDKs and their cognate cyclins in a neuronal apoptotic pathway.
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Cites
Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis
Xia, Z., Dickens, M., Raingeaud, J., Davis, R. J., & Greenberg, M. E. (1995) · Science · doi:10.1126/science.270.5240.1326 · Cited by 5,287
The retinoblastoma protein and cell cycle control
Weinberg, R. A. (1995) · Cell · doi:10.1016/0092-8674(95)90385-2 · Cited by 4,862 · cited 2×
“…is unknown, it is interesting to note that one well studied substrate of Cdk4 and Cdk6 is the retinoblastoma gene (RB). pRB, the product of the retinoblastoma tumor suppressor gene, is thought to play a role in regulating the G1 phase of the cell cycle (Chellepan et al., 1991; Weinberg, 1995).”
Inhibitors of mammalian G1 cyclin-dependent kinases.
Sherr, C. J., & Roberts, J. M. (1995) · Genes & Development · doi:10.1101/gad.9.10.1149 · Cited by 3,243
Cell death during development of the nervous system
Oppenheim, R. W. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.002321 · Cited by 3,084
Effects of an Rb mutation in the mouse
Jacks, T., Fazeli, A., Schmitt, E. M., Bronson, R. T., Goodell, M. A., & Weinberg, R. A. (1992) · Nature · doi:10.1038/359295a0 · Cited by 1,755
The E2F transcription factor is a cellular target for the RB protein
Chellappan, S. P., Hiebert, S., Mudryj, M., Horowitz, J. M., & Nevins, J. R. (1991) · Cell · doi:10.1016/0092-8674(91)90557-f · Cited by 1,412
Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control
van den Heuvel, S., & Harlow, E. (1993) · Science · doi:10.1126/science.8266103 · Cited by 1,092
Martin, D. P., Schmidt, R. E., DiStefano, P. S., Lowry, O. H., Carter, J. G., & Johnson, E. M. (1988) · The Journal of cell biology · doi:10.1083/jcb.106.3.829 · Cited by 901
Estus, S., Zaks, W. J., Freeman, R. S., Gruda, M., Bravo, R., & Johnson, E. M. (1994) · The Journal of cell biology · doi:10.1083/jcb.127.6.1717 · Cited by 820
A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death
Ham, J., Babij, C., Whitfield, J., Pfarr, C. M., Lallemand, D., Yaniv, M., & Rubin, L. L. (1995) · Neuron · doi:10.1016/0896-6273(95)90331-3 · Cited by 796
Cited by
Ischemic Cell Death in Brain Neurons
Lipton, P. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.4.1431 · Cited by 3,043
Neurotrophin signal transduction in the nervous system
Kaplan, D. R., & Miller, F. D. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00092-1 · Cited by 1,944
Mitochondrial fragmentation in neurodegeneration.
Knott, A. B., Perkins, G., Schwarzenbacher, R., & Bossy-Wetzel, E. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2417 · Cited by 1,002
Neurotrophin Signaling Through the P75 Neurotrophin Receptor
Roux, P. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00016-3 · Cited by 717
Cell cycle regulation in the postmitotic neuron: oxymoron or new biology?
Herrup, K., & Yang, Y. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2124 · Cited by 507
Metadata
- Authors
- Park, D. S., Levine, B., Ferrari, G., & Greene, L. A.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1997-12-01
- Volume
- 17
- Issue
- 23
- Pages
- 8975-8983
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1646788158
- Cited by
- 265
- References
- 55
- FWCI
- 5.74
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Park, D. S., Levine, B., Ferrari, G., & Greene, L. A. (1997). Cyclin Dependent Kinase Inhibitors and Dominant Negative Cyclin Dependent Kinase 4 and 6 Promote Survival of NGF-Deprived Sympathetic Neurons. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.17-23-08975.1997
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