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Differential Gating and Recruitment of P/Q-, N-, and R-Type Ca2+Channels in Hippocampal Mossy Fiber Boutons
Open accessAbstract
Voltage-gated Ca 2+channels in presynaptic terminals initiate the Ca 2+inflow necessary for transmitter release. At a variety of synapses, multiple Ca 2+channel subtypes are involved in synaptic transmission and plasticity. However, it is unknown whether presynaptic Ca 2+channels differ in gating properties and whether they are differentially activated by action potentials or subthreshold voltage signals. We examined Ca 2+channels in hippocampal mossy fiber boutons (MFBs) by presynaptic recording, using the selective blockers ω-agatoxin IVa, ω-conotoxin GVIa, and SNX-482 to separate P/Q-, N-, and R-type components. Nonstationary fluctuation analysis combined with blocker application revealed a single MFB contained on average ∼2000 channels, with 66% P/Q-, 26% N-, and 8% R-type channels. Whereas both P/Q-type and N-type Ca 2+channels showed high activation threshold and rapid activation and deactivation, R-type Ca 2+channels had a lower activation threshold and slower gating kinetics. To determine the efficacy of activation of different Ca 2+channel subtypes by physiologically relevant voltage waveforms, a six-state gating model reproducing the experimental observations was developed. Action potentials activated P/Q-type Ca 2+channels with high efficacy, whereas N- and R-type channels were activated less efficiently. Action potential broadening selectively recruited N- and R-type channels, leading to an equalization of the efficacy of channel activation. In contrast, subthreshold presynaptic events activated R-type channels more efficiently than P/Q- or N-type channels. In conclusion, single MFBs coexpress multiple types of Ca 2+channels, which are activated differentially by subthreshold and suprathreshold presynaptic voltage signals.
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“we targeted CaV2.1, the major type of presynaptic Ca2+ channel in MFBs [58,59]”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [59]
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Metadata
- Authors
- Li, L., Bischofberger, J., & Jonas, P.
- Affiliations
- University of Freiburg (DE)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-12-05
- Volume
- 27
- Issue
- 49
- Pages
- 13420-13429
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6673086
- OpenAlex
- W2084434180
- Cited by
- 206
- References
- 59
- Citations by year
- 2026: 10 · 2025: 7 · 2024: 13 · 2023: 18 · 2022: 9 · 2021: 8 · 2020: 6 · 2019: 13 · 2018: 10 · 2017: 10 · 2016: 4 · 2015: 6 · 2014: 16 · 2013: 8 · 2012: 15
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft (SFB 505)
- Leibniz-Gemeinschaft
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
- Keywords
- voltage-gated calcium channels, P/Q-type calcium channels, N-type calcium channels, R-type calcium channels, presynaptic terminals, channel gating kinetics, action potential broadening, synaptic transmission, omega-agatoxin IVA, omega-conotoxin GVIA, SNX-482, hippocampus
- MeSH terms
- Animals, Electric Stimulation, Synaptic Transmission, Recruitment, Neurophysiological, Calcium Channels, Ion Channel Gating, Rats, Wistar, Presynaptic Terminals, Mossy Fibers, Hippocampal, Calcium Channels, N-Type, Calcium Channels, P-Type, Calcium Channels, R-Type, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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