Cited by 206Ion channel regulation and functionNeuroscience and Neuropharmacology ResearchCardiac electrophysiology and arrhythmias

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Differential Gating and Recruitment of P/Q-, N-, and R-Type Ca2+Channels in Hippocampal Mossy Fiber Boutons

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Li, Liyi, Bischofberger, Josef, Jonas, Peter·2007·The Journal of Neuroscience

DOI 10.1523/jneurosci.1709-07.2007PMC PMC6673086

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Abstract

Voltage-gated Ca 2+channels in presynaptic terminals initiate the Ca 2+inflow necessary for transmitter release. At a variety of synapses, multiple Ca 2+channel subtypes are involved in synaptic transmission and plasticity. However, it is unknown whether presynaptic Ca 2+channels differ in gating properties and whether they are differentially activated by action potentials or subthreshold voltage signals. We examined Ca 2+channels in hippocampal mossy fiber boutons (MFBs) by presynaptic recording, using the selective blockers ω-agatoxin IVa, ω-conotoxin GVIa, and SNX-482 to separate P/Q-, N-, and R-type components. Nonstationary fluctuation analysis combined with blocker application revealed a single MFB contained on average ∼2000 channels, with 66% P/Q-, 26% N-, and 8% R-type channels. Whereas both P/Q-type and N-type Ca 2+channels showed high activation threshold and rapid activation and deactivation, R-type Ca 2+channels had a lower activation threshold and slower gating kinetics. To determine the efficacy of activation of different Ca 2+channel subtypes by physiologically relevant voltage waveforms, a six-state gating model reproducing the experimental observations was developed. Action potentials activated P/Q-type Ca 2+channels with high efficacy, whereas N- and R-type channels were activated less efficiently. Action potential broadening selectively recruited N- and R-type channels, leading to an equalization of the efficacy of channel activation. In contrast, subthreshold presynaptic events activated R-type channels more efficiently than P/Q- or N-type channels. In conclusion, single MFBs coexpress multiple types of Ca 2+channels, which are activated differentially by subthreshold and suprathreshold presynaptic voltage signals.

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Authors: Li, L., Bischofberger, J., & Jonas, P.
Affiliations: University of Freiburg (DE)
ORCID: Li, Liyi
Bischofberger, Josef
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2007-12-05
Volume: 27
Issue: 49
Pages: 13420-13429
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.1709-07.2007
PMC: PMC6673086
OpenAlex: W2084434180
Cited by: 206
References: 59
Citations by year: 2026: 10 · 2025: 7 · 2024: 13 · 2023: 18 · 2022: 9 · 2021: 8 · 2020: 6 · 2019: 13 · 2018: 10 · 2017: 10 · 2016: 4 · 2015: 6 · 2014: 16 · 2013: 8 · 2012: 15
FWCI: 5.70
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 183 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Deutsche Forschungsgemeinschaft (SFB 505)
Leibniz-Gemeinschaft
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion channel regulation and function
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac electrophysiology and arrhythmias
Keywords: voltage-gated calcium channels, P/Q-type calcium channels, N-type calcium channels, R-type calcium channels, presynaptic terminals, channel gating kinetics, action potential broadening, synaptic transmission, omega-agatoxin IVA, omega-conotoxin GVIA, SNX-482, hippocampus
MeSH terms: Animals, Electric Stimulation, Synaptic Transmission, Recruitment, Neurophysiological, Calcium Channels, Ion Channel Gating, Rats, Wistar, Presynaptic Terminals, Mossy Fibers, Hippocampal, Calcium Channels, N-Type, Calcium Channels, P-Type, Calcium Channels, R-Type, Rats

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Differential Gating and Recruitment of P/Q-, N-, and R-Type Ca2+Channels in Hippocampal Mossy Fiber Boutons

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