The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Contribution of 5-HT2Receptor Subtypes to Sleep–Wakefulness and Respiratory Control, and Functional Adaptations in Knock-Out Mice Lacking 5-HT2AReceptors
Open accessAbstract
Serotonin (5-hydroxytryptamine; 5-HT) plays key roles in sleep–wakefulness regulation. Evidence indicates that 5-HT 2 receptors are involved mainly in non-rapid eye movement sleep (NREMS) regulation and respiratory control. Here, we investigated the relative contribution of 5-HT 2A, 5-HT 2B, and 5-HT 2C receptor subtypes to NREMS and breathing during sleep, using 5-HT 2 subtype-selective ligands in wild-type (5-HT 2A+/+) and knock-out (5-HT 2A–/–) mice that do not express 5-HT 2A receptors. Acute blockade of 5-HT 2A receptors induced an increase in NREMS in 5-HT 2A+/+ mice, but not 5-HT 2A–/– mutants, which spontaneously expressed less NREMS than wild-type animals. In 5-HT 2A+/+ mice, 5-HT 2B receptor blockade produced a reduction of NREMS, whereas receptor activation induced an increase in this sleep stage. These effects were less pronounced in 5-HT 2A–/– mice, indicating a lower sensitivity of 5-HT 2B receptors in mutants, with no change in 5-HT 2B mRNA. Blockade of 5-HT 2C receptors had no effect on NREMS in both strains. In addition, an increase in EEG power density after sleep deprivation was observed in 5-HT 2A+/+ mice but not in 5-HT 2A–/– mice. Whole-body plethysmographic recordings indicated that 5-HT 2A receptor blockade in 5-HT 2A+/+ mice reduced NREMS apneas and bradypneas that occurred after sighs. In contrast, in 5-HT 2A–/– mutants, NREMS apneas were not modified, and bradypnea after sighs were more pronounced. Our results demonstrate that 5-HT exerts a 5-HT 2B-mediated facilitation of NREMS, and an influence respectively inhibitory on NREMS and facilitatory on sleep apnea generation, via 5-HT 2A receptors. Moreover, 5-HT 2A gene knock-out leads to functional compensations yielding adaptive changes opposite to those caused by pharmacological blockade of 5-HT 2A receptors in 5-HT 2A+/+ mice.
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Citations
Cites
The Neurobiology of Sleep: Genetics, cellular physiology and subcortical networks
Pace-Schott, E. F., & Hobson, J. A. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn895 · Cited by 937
Early-Life Blockade of the 5-HT Transporter Alters Emotional Behavior in Adult Mice
Ansorge, M. S., Zhou, M., Lira, A., Hen, R., & Gingrich, J. A. (2004) · Science · doi:10.1126/science.1101678 · Cited by 817
Self-citationSerotonin Agonists and Antagonists in Obstructive Sleep Apnea: Therapeutic Potential
Veasey, S. C. (2003) · American Journal of Respiratory Medicine · doi:10.1007/bf03256636 · Cited by 129
Karashima, A., Nakao, M., Honda, K., Iwasaki, N., Katayama, N., & Yamamoto, M. (2004) · Neuroscience Research · doi:10.1016/j.neures.2004.07.007 · Cited by 44
Cited by
Control of sleep and wakefulness
Brown, R. E., Basheer, R., McKenna, J. T., Strecker, R. E., & McCarley, R. W. (2012) · Physiological Reviews · doi:10.1152/physrev.00032.2011 · Cited by 1,477
Molecular biology of 5-HT receptors
Hannon, J., & Hoyer, D. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.03.020 · Cited by 815
Serotonin control of sleep-wake behavior
Monti, J. M. (2011) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2010.11.003 · Cited by 614
Drugs for Insomnia beyond Benzodiazepines: Pharmacology, Clinical Applications, and Discovery
Atkin, T., Comai, S., & Gobbi, G. (2018) · Pharmacological Reviews · doi:10.1124/pr.117.014381 · Cited by 391
A Sleep-Promoting Role for the Drosophila Serotonin Receptor 1A
Yuan, Q., Joiner, W. J., & Sehgal, A. (2006) · Current Biology · doi:10.1016/j.cub.2006.04.032 · Cited by 301
Metadata
- Authors
- Popa, D., Léna, C., Fabre, V., Prenat, C., Gingrich, J., Escourrou, P., Hamon, M., & Adrien, J.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2005-12-07
- Volume
- 25
- Issue
- 49
- Pages
- 11231-11238
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2053591992
- Cited by
- 170
- References
- 4
- FWCI
- 5.14
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Popa, D., Léna, C., Fabre, V., Prenat, C., Gingrich, J., Escourrou, P., Hamon, M., & Adrien, J. (2005). Contribution of 5-HT2Receptor Subtypes to Sleep–Wakefulness and Respiratory Control, and Functional Adaptations in Knock-Out Mice Lacking 5-HT2AReceptors. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.1724-05.2005
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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