Cited by 144Barrier Structure and Function StudiesNeuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

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Glial Cell Calcium Signaling Mediates Capillary Regulation of Blood Flow in the Retina

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Biesecker, Kyle R., Srienc, Anja I., Shimoda, Angela M., Agarwal, Amit, Bergles, Dwight E., Kofuji, Paulo, Newman, Eric A.·2016·The Journal of Neuroscience

DOI 10.1523/jneurosci.1782-16.2016PMC PMC5013190

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Abstract

The brain is critically dependent on the regulation of blood flow to nourish active neurons. One widely held hypothesis of blood flow regulation holds that active neurons stimulate Ca 2+ increases in glial cells, triggering glial release of vasodilating agents. This hypothesis has been challenged, as arteriole dilation can occur in the absence of glial Ca 2+ signaling. We address this controversy by imaging glial Ca 2+ signaling and vessel dilation in the mouse retina. We find that sensory stimulation results in Ca 2+ increases in the glial endfeet contacting capillaries, but not arterioles, and that capillary dilations often follow spontaneous Ca 2+ signaling. In IP3R2 −/− mice, where glial Ca 2+ signaling is reduced, light-evoked capillary, but not arteriole, dilation is abolished. The results show that, independent of arterioles, capillaries actively dilate and regulate blood flow. Furthermore, the results demonstrate that glial Ca 2+ signaling regulates capillary but not arteriole blood flow. SIGNIFICANCE STATEMENT We show that a Ca 2+ -dependent glial cell signaling mechanism is responsible for regulating capillary but not arteriole diameter. This finding resolves a long-standing controversy regarding the role of glial cells in regulating blood flow, demonstrating that glial Ca 2+ signaling is both necessary and sufficient to dilate capillaries. While the relative contributions of capillaries and arterioles to blood flow regulation remain unclear, elucidating the mechanisms that regulate capillary blood flow may ultimately lead to the development of therapies for treating diseases where blood flow regulation is disrupted, including Alzheimer's disease, stroke, and diabetic retinopathy. This finding may also aid in revealing the underlying neuronal activity that generates BOLD fMRI signals.

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Authors: Biesecker, K. R., Srienc, A. I., Shimoda, A. M., Agarwal, A., Bergles, D. E., Kofuji, P., & Newman, E. A.
Affiliations: University of Minnesota (US)
Johns Hopkins University (US)
ORCID: Biesecker, Kyle R.
Srienc, Anja I.
Agarwal, Amit
Bergles, Dwight E.
Kofuji, Paulo
Newman, Eric A.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2016-09-07
Volume: 36
Issue: 36
Pages: 9435-9445
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.1782-16.2016
PMC: PMC5013190
OpenAlex: W2516254780
Cited by: 144
References: 57
Citations by year: 2026: 6 · 2025: 13 · 2024: 10 · 2023: 15 · 2022: 19 · 2021: 23 · 2020: 11 · 2019: 10 · 2018: 19 · 2017: 16 · 2016: 2
FWCI: 8.58
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 181 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (UL1TR000114, NS050274)
National Institute of Mental Health (P50MH100024, P50MH084020)
National Eye Institute (R01EY026882, R01EY004077, R01EY026514, P30EY011374)
National Institute of General Medical Sciences (T32GM008471)
National Institute of Neurological Disorders and Stroke (P30NS050274)
National Institute of Dental and Craniofacial Research (T90DE022732)
National Center for Advancing Translational Sciences
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: retinal capillaries, arterioles, IP3R2, sensory stimulation, vasodilation, BOLD fMRI, diabetic retinopathy, stroke
MeSH terms: Chondroitin Sulfate Proteoglycan 4, Animals, Antigens, Calcium, Capillaries, Female, Glial Fibrillary Acidic Protein, Glycosaminoglycans, Male, Mice, Inbred C57BL, Mice, Transgenic, Proteoglycans, Regional Blood Flow, Retina, Transcription Factors, Visual Pathways, Calcium Signaling, Excitatory Amino Acid Transporter 1, Mice, Inositol 1,4,5-Trisphosphate Receptors, LIM-Homeodomain Proteins, Ependymoglial Cells, In Vitro Techniques

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Glial Cell Calcium Signaling Mediates Capillary Regulation of Blood Flow in the Retina

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