Cholesterol Dysmetabolism in Alzheimer’s Disease: A Starring Role for Astrocytes?

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

Corder, E. H., Saunders, A. M., Strittmatter, W. J., Schmechel, D. E., Gaskell, P. C., Small, G. W., Roses, A. D., Haines, J. L., & Pericak-Vance, M. A. (1993) · Science · doi:10.1126/science.8346443 · Cited by 9,429 · see citing works

Neurotoxic reactive astrocytes are induced by activated microglia

Liddelow, S. A., Guttenplan, K. A., Clarke, L. E., Bennett, F. C., Bohlen, C. J., Schirmer, L., Bennett, M. L., Münch, A. E., Chung, W.-S., Peterson, T. C., et al. (2017) · Nature · doi:10.1038/nature21029 · Cited by 7,971 · see citing works

Reactive astrocyte nomenclature, definitions, and future directions

Escartin, C., Galea, E., Lakatos, A., O’Callaghan, J. P., Petzold, G. C., Serrano-Pozo, A., Steinhäuser, C., Volterra, A., Carmignoto, G., Agarwal, A., et al. (2021) · Nature Neuroscience · doi:10.1038/s41593-020-00783-4 · Cited by 2,533 · cited 1× · see citing works

Genomic analysis of reactive astrogliosis

Zamanian, J. L., Xu, L., Foo, L. C., Nouri, N., Zhou, L., Giffard, R. G., & Barres, B. A. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.6221-11.2012 · Cited by 2,404 · see citing works

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

Zhang, Y., Sloan, S. A., Clarke, L. E., Caneda, C., Plaza, C. A., Blumenthal, P. D., Vogel, H., Steinberg, G. K., Edwards, M. S. B., Li, G., et al. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.013 · Cited by 2,295 · see citing works

Mechanisms and regulation of cholesterol homeostasis

Luo, J., Yang, H., & Song, B.-L. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0190-7 · Cited by 1,980 · see citing works

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

Butterfield, D. A., & Halliwell, B. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0132-6 · Cited by 1,954 · see citing works

Astrocyte scar formation aids central nervous system axon regeneration

Anderson, M. A., Burda, J. E., Ren, Y., Ao, Y., O’Shea, T. M., Kawaguchi, R., Coppola, G., Khakh, B. S., Deming, T. J., & Sofroniew, M. V. (2016) · Nature · doi:10.1038/nature17623 · Cited by 1,851 · see citing works

Uniquely Hominid Features of Adult Human Astrocytes

Oberheim, N. A., Takano, T., Han, X., He, W., Lin, J. H. C., Wang, F., Xu, Q., Wyatt, J. D., Pilcher, W., Ojemann, J. G., et al. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4707-08.2009 · Cited by 1,488 · see citing works

An english translation of alzheimer’s 1907 paper, “über eine eigenartige erkankung der hirnrinde”

Stelzmann, R. A., Norman Schnitzlein, H., & Reed Murtagh, F. (1995) · Clinical Anatomy · doi:10.1002/ca.980080612 · Cited by 1,455 · see citing works

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

Yamazaki, Y., Zhao, N., Caulfield, T. R., Liu, C.-C., & Bu, G. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-019-0228-7 · Cited by 1,425 · see citing works

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

Strittmatter, W. J., Weisgraber, K. H., Huang, D. Y., Dong, L. M., Salvesen, G. S., Pericak-Vance, M., Schmechel, D., Saunders, A. M., Goldgaber, D., & Roses, A. D. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.17.8098 · Cited by 1,363 · see citing works

Cerebral blood flow regulation and neurovascular dysfunction in Alzheimer disease

Kisler, K., Nelson, A. R., Montagne, A., & Zlokovic, B. V. (2017) · Nature Reviews Neuroscience · doi:10.1038/nrn.2017.48 · Cited by 1,243 · see citing works

Normal aging induces A1-like astrocyte reactivity

Clarke, L. E., Liddelow, S. A., Chakraborty, C., Münch, A. E., Heiman, M., & Barres, B. A. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1800165115 · Cited by 1,237 · see citing works

Human ApoE isoforms differentially regulate brain amyloid-β peptide clearance

Castellano, J. M., Kim, J., Stewart, F. R., Jiang, H., DeMattos, R. B., Patterson, B. W., Fagan, A. M., Morris, J. C., Mawuenyega, K. G., Cruchaga, C., et al. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002156 · Cited by 1,227 · see citing works

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

Bu, G. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2620 · Cited by 1,168 · see citing works

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

Lin, Y.-T., Seo, J., Gao, F., Feldman, H. M., Wen, H.-L., Penney, J., Cam, H. P., Gjoneska, E., Raja, W. K., Cheng, J., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.05.008 · Cited by 1,125 · see citing works

Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions

William Rebeck, G., Reiter, J. S., Strickland, D. K., & Hyman, B. T. (1993) · Neuron · doi:10.1016/0896-6273(93)90070-8 · Cited by 1,107 · see citing works

Thematic review series: brain lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal

Dietschy, J. M., & Turley, S. D. (2004) · Journal of Lipid Research · doi:10.1194/jlr.r400004-jlr200 · Cited by 1,095 · see citing works

ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models

Cramer, P. E., Cirrito, J. R., Wesson, D. W., Lee, C. Y. D., Karlo, J. C., Zinn, A. E., Casali, B. T., Restivo, J. L., Goebel, W. D., James, M. J., et al. (2012) · Science · doi:10.1126/science.1217697 · Cited by 1,050 · see citing works

APOE and Alzheimer’s disease: Advances in genetics, pathophysiology, and therapeutic approaches

Serrano-Pozo, A., Das, S., & Hyman, B. T. (2021) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30412-9 · Cited by 1,037 · see citing works

Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXRα

Venkateswaran, A., Laffitte, B. A., Joseph, S. B., Mak, P. A., Wilpitz, D. C., Edwards, P. A., & Tontonoz, P. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.200367697 · Cited by 1,005 · see citing works

Sterol-dependent Transactivation of theABC1 Promoter by the Liver X Receptor/Retinoid X Receptor

Costet, P., Luo, Y., Wang, N., & Tall, A. R. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m003337200 · Cited by 981 · see citing works

Apolipoprotein E isoform-dependent amyloid deposition and neuritic degeneration in a mouse model of Alzheimer's disease

Holtzman, D. M., Bales, K. R., Tenkova, T., Fagan, A. M., Parsadanian, M., Sartorius, L. J., Mackey, B., Olney, J., McKeel, D., Wozniak, D., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.050004797 · Cited by 937 · see citing works

<i>APOE</i> predicts amyloid‐beta but not tau Alzheimer pathology in cognitively normal aging

Morris, J. C., Roe, C. M., Xiong, C., Fagan, A. M., Goate, A. M., Holtzman, D. M., & Mintun, M. A. (2010) · Annals of Neurology · doi:10.1002/ana.21843 · Cited by 830 · see citing works

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system.

Boyles, J. K., Pitas, R. E., Wilson, E., Mahley, R. W., & Taylor, J. M. (1985) · Journal of Clinical Investigation · doi:10.1172/jci112130 · Cited by 829 · see citing works

Glutamate exocytosis from astrocytes controls synaptic strength

Jourdain, P., Bergersen, L. H., Bhaukaurally, K., Bezzi, P., Santello, M., Domercq, M., Matute, C., Tonello, F., Gundersen, V., & Volterra, A. (2007) · Nature Neuroscience · doi:10.1038/nn1849 · Cited by 806 · see citing works

The Epidemiology of Alzheimer's Disease Modifiable Risk Factors and Prevention

Zhang, X.-X., Tian, Y., Wang, Z.-T., Ma, Y.-H., Tan, L., & Yu, J.-T. (2021) · The Journal of Prevention of Alzheimer's Disease · doi:10.14283/jpad.2021.15 · Cited by 789 · see citing works

Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence

Chai, H., Diaz-Castro, B., Shigetomi, E., Monte, E., Octeau, J. C., Yu, X., Cohn, W., Rajendran, P. S., Vondriska, T. M., Whitelegge, J. P., et al. (2017) · Neuron · doi:10.1016/j.neuron.2017.06.029 · Cited by 769 · see citing works

Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity

Ioannou, M. S., Jackson, J., Sheu, S.-H., Chang, C.-L., Weigel, A. V., Liu, H., Pasolli, H. A., Xu, C. S., Pang, S., Matthies, D., et al. (2019) · Cell · doi:10.1016/j.cell.2019.04.001 · Cited by 760 · see citing works

Modeling Alzheimer’s Disease with iPSCs Reveals Stress Phenotypes Associated with Intracellular Aβ and Differential Drug Responsiveness

Kondo, T., Asai, M., Tsukita, K., Kutoku, Y., Ohsawa, Y., Sunada, Y., Imamura, K., Egawa, N., Yahata, N., Okita, K., et al. (2013) · Cell Stem Cell · doi:10.1016/j.stem.2013.01.009 · Cited by 741 · see citing works

The aging astrocyte transcriptome from multiple regions of the mouse brain.

Boisvert, M. M., Erikson, G. A., Shokhirev, M. N., & Allen, N. J. (2018) · Cell Reports · doi:10.1016/j.celrep.2017.12.039 · Cited by 702 · see citing works

NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease

Lian, H., Yang, L., Cole, A., Sun, L., Chiang, A. C.-A., Fowler, S. W., Shim, D. J., Rodriguez-Rivera, J., Taglialatela, G., Jankowsky, J. L., et al. (2015) · Neuron · doi:10.1016/j.neuron.2014.11.018 · Cited by 697 · see citing works

Redefining the concept of reactive astrocytes as cells that remain within their unique domains upon reaction to injury

Wilhelmsson, U., Bushong, E. A., Price, D. L., Smarr, B. L., Phung, V., Terada, M., Ellisman, M. H., & Pekny, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0602841103 · Cited by 643 · cited 1× · see citing works

Heterogeneity of astrocytic form and function.

Oberheim, N. A., Goldman, S. A., & Nedergaard, M. (2012) · Methods in Molecular Biology · doi:10.1007/978-1-61779-452-0_3 · Cited by 638 · see citing works

Oxidative stress in the progression of Alzheimer disease in the frontal cortex

Ansari, M. A., & Scheff, S. W. (2010) · Journal of Neuropathology &amp; Experimental Neurology · doi:10.1097/nen.0b013e3181cb5af4 · Cited by 605 · see citing works

Sterol-regulated transport of SREBPs from endoplasmic reticulum to Golgi: Oxysterols block transport by binding to Insig

Radhakrishnan, A., Ikeda, Y., Kwon, H. J., Brown, M. S., & Goldstein, J. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700899104 · Cited by 593 · see citing works

β-Amyloid Peptides Induce Mitochondrial Dysfunction and Oxidative Stress in Astrocytes and Death of Neurons through Activation of NADPH Oxidase

Abramov, A. Y., Canevari, L., & Duchen, M. R. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.4042-03.2004 · Cited by 587 · see citing works

Neurotoxic reactive astrocytes induce cell death via saturated lipids

Guttenplan, K. A., Weigel, M. K., Prakash, P., Wijewardhane, P. R., Hasel, P., Rufen-Blanchette, U., Münch, A. E., Blum, J. A., Fine, J., Neal, M. C., et al. (2021) · Nature · doi:10.1038/s41586-021-03960-y · Cited by 578 · see citing works

In vivo evidence for a lactate gradient from astrocytes to neurons

Mächler, P., Wyss, M. T., Elsayed, M., Stobart, J., Gutierrez, R., von Faber-Castell, A., Kaelin, V., Zuend, M., San Martín, A., Romero-Gómez, I., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.10.010 · Cited by 571 · see citing works

Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides

Koistinaho, M., Lin, S., Wu, X., Esterman, M., Koger, D., Hanson, J., Higgs, R., Liu, F., Malkani, S., Bales, K. R., et al. (2004) · Nature Medicine · doi:10.1038/nm1058 · Cited by 571 · see citing works

ApoE influences amyloid-β (Aβ) clearance despite minimal apoE/Aβ association in physiological conditions

Verghese, P. B., Castellano, J. M., Garai, K., Wang, Y., Jiang, H., Shah, A., Bu, G., Frieden, C., & Holtzman, D. M. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220484110 · Cited by 556 · see citing works

Astrocytes mediate neurovascular signaling to capillary pericytes but not to arterioles

Mishra, A., Reynolds, J. R., Chen, Y., Gourine, A. V., Rusakov, D. A., & Attwell, D. (2016) · Nature Neuroscience · doi:10.1038/nn.4428 · Cited by 535 · see citing works

Involvement of Astrocytes in Alzheimer’s Disease from a Neuroinflammatory and Oxidative Stress Perspective

González-Reyes, R. E., Nava-Mesa, M. O., Vargas-Sánchez, K., Ariza-Salamanca, D. F., & Mora-Muñoz, L. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00427 · Cited by 525 · see citing works

Profile and Regulation of Apolipoprotein E (ApoE) Expression in the CNS in Mice with Targeting of Green Fluorescent Protein Gene to the ApoE Locus

Xu, Q., Bernardo, A., Walker, D., Kanegawa, T., Mahley, R. W., & Huang, Y. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5476-05.2006 · Cited by 524 · see citing works

Astrocytic neuroligins control astrocyte morphogenesis and synaptogenesis

Stogsdill, J. A., Ramirez, J., Liu, D., Kim, Y. H., Baldwin, K. T., Enustun, E., Ejikeme, T., Ji, R.-R., & Eroglu, C. (2017) · Nature · doi:10.1038/nature24638 · Cited by 506 · see citing works

Oxysterols direct immune cell migration via EBI2

Hannedouche, S., Zhang, J., Yi, T., Shen, W., Nguyen, D. G., Pereira, J. P., Guerini, D., Baumgarten, B. U., Roggo, S. P., Wen, B. G., et al. (2011) · Nature · doi:10.1038/nature10280 · Cited by 489 · see citing works

Reactive Glia not only Associates with Plaques but also Parallels Tangles in Alzheimer’s Disease

Serrano-Pozo, A., Mielke, M. L., Gómez-Isla, T., Betensky, R. A., Growdon, J. H., Frosch, M. P., & Hyman, B. T. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.05.047 · Cited by 488 · see citing works

Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema

Kitchen, P., Salman, M. M., Halsey, A. M., Clarke-Bland, C., MacDonald, J. A., Ishida, H., Vogel, H. J., Almutiri, S., Logan, A., Kreida, S., et al. (2020) · Cell · doi:10.1016/j.cell.2020.03.037 · Cited by 452 · see citing works

ApoE4 Accelerates Early Seeding of Amyloid Pathology

Liu, C.-C., Zhao, N., Fu, Y., Wang, N., Linares, C., Tsai, C.-W., & Bu, G. (2017) · Neuron · doi:10.1016/j.neuron.2017.11.013 · Cited by 451 · see citing works

The mitochondria-targeted antioxidant MitoQ prevents loss of spatial memory retention and early neuropathology in a transgenic mouse model of Alzheimer’s disease

McManus, M. J., Murphy, M. P., & Franklin, J. L. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.0552-11.2011 · Cited by 432 · see citing works

Human astrocytes: structure and functions in the healthy brain

Vasile, F., Dossi, E., & Rouach, N. (2017) · Brain Structure and Function · doi:10.1007/s00429-017-1383-5 · Cited by 428 · see citing works

Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover

Lund, E. G., Xie, C., Kotti, T., Turley, S. D., Dietschy, J. M., & Russell, D. W. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m303415200 · Cited by 421 · see citing works

Major Shifts in Glial Regional Identity Are a Transcriptional Hallmark of Human Brain Aging

Soreq, L., Rose, J., Soreq, E., Hardy, J., Trabzuni, D., Cookson, M. R., Smith, C., Ryten, M., Patani, R., & Ule, J. (2017) · Cell Reports · doi:10.1016/j.celrep.2016.12.011 · Cited by 419 · see citing works

Astrocytes accumulate Aβ42 and give rise to astrocytic amyloid plaques in Alzheimer disease brains

Nagele, R. G., D’Andrea, M. R., Lee, H., Venkataraman, V., & Wang, H.-Y. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02361-8 · Cited by 416 · see citing works

Human Astrocytes: Secretome Profiles of Cytokines and Chemokines

Choi, S. S., Lee, H. J., Lim, I., Satoh, J., & Kim, S. U. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092325 · Cited by 411 · see citing works

Isolation of glia from Alzheimer’s mice reveals inflammation and dysfunction

Orre, M., Kamphuis, W., Osborn, L. M., Jansen, A. H. P., Kooijman, L., Bossers, K., & Hol, E. M. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.06.004 · Cited by 394 · see citing works

Induction of Glial Fibrillary Acidic Protein Expression in Astrocytes by Nitric Oxide

Brahmachari, S., Fung, Y. K., & Pahan, K. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.5480-05.2006 · Cited by 390 · see citing works

Dissecting phenotypic traits linked to human resilience to Alzheimer’s pathology

Perez-Nievas, B. G., Stein, T. D., Tai, H.-C., Dols-Icardo, O., Scotton, T. C., Barroeta-Espar, I., Fernandez-Carballo, L., de Munain, E. L., Perez, J., Marquie, M., et al. (2013) · Brain · doi:10.1093/brain/awt171 · Cited by 387 · see citing works

Astrocytes phagocytose adult hippocampal synapses for circuit homeostasis

Lee, J.-H., Kim, J. S., Noh, S., Lee, H., Lee, S. Y., Mun, J. Y., Park, H., & Chung, W. (2020) · Nature · doi:10.1038/s41586-020-03060-3 · Cited by 387 · see citing works

Role of cholesterol and sphingolipids in brain development and neurological diseases

Hussain, G., Wang, J., Rasul, A., Anwar, H., Imran, A., Qasim, M., Zafar, S., Kamran, S., Razzaq, A., Aziz, N., et al. (2019) · Lipids in Health and Disease · doi:10.1186/s12944-019-0965-z · Cited by 383 · see citing works

Crossing the barrier: oxysterols as cholesterol transporters and metabolic modulators in the brain

Björkhem, I. (2006) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2006.01725.x · Cited by 381 · see citing works

Matrix Metalloproteinases Expressed by Astrocytes Mediate Extracellular Amyloid-β Peptide Catabolism

Yin, K.-J., Cirrito, J. R., Yan, P., Hu, X., Xiao, Q., Pan, X., Bateman, R., Song, H., Hsu, F.-F., Turk, J., et al. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2085-06.2006 · Cited by 381 · see citing works

Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture

Garwood, C. J., Pooler, A. M., Atherton, J., Hanger, D. P., & Noble, W. (2011) · Cell Death &amp; Disease · doi:10.1038/cddis.2011.50 · Cited by 379 · see citing works

ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism

Qi, G., Mi, Y., Shi, X., Gu, H., Brinton, R. D., & Yin, F. (2021) · Cell Reports · doi:10.1016/j.celrep.2020.108572 · Cited by 379 · see citing works

Voluntary Exercise Promotes Glymphatic Clearance of Amyloid Beta and Reduces the Activation of Astrocytes and Microglia in Aged Mice

He, X.-F., Liu, D.-X., Zhang, Q., Liang, F.-Y., Dai, G.-Y., Zeng, J.-S., Pei, Z., Xu, G.-Q., & Lan, Y. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00144 · Cited by 371 · see citing works

The contribution of activated astrocytes to Aβ production: Implications for Alzheimer's disease pathogenesis

Zhao, J. J., O’Connor, T., & Vassar, R. J. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-150 · Cited by 370 · see citing works

Autophagy failure in A lzheimer's disease and the role of defective lysosomal acidification

Wolfe, D. M., Lee, J., Kumar, A. R., Lee, S., Orenstein, S. J., & Nixon, R. A. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12169 · Cited by 348 · see citing works

Dopamine-Evoked Synaptic Regulation in the Nucleus Accumbens Requires Astrocyte Activity

Corkrum, M., Covelo, A., Lines, J., Bellocchio, L., Pisansky, M., Loke, K., Quintana, R., Rothwell, P. E., Lujan, R., Marsicano, G., et al. (2020) · Neuron · doi:10.1016/j.neuron.2019.12.026 · Cited by 327 · see citing works

Changes in the levels of cerebral and extracerebral sterols in the brain of patients with Alzheimer's disease

Heverin, M., Bogdanović, N., Lütjohann, D., Bayer, T. A., Pikuleva, I. A., Brétillon, L., Diczfalusy, U., Winblad, B. G., & Björkhem, I. (2004) · Journal of Lipid Research · doi:10.1194/jlr.m300320-jlr200 · Cited by 325 · see citing works

The role of astrocytes in oxidative stress of central nervous system: A mixed blessing

Chen, Y., Chen, Q., Huang, J., Tang, X., Liu, C., Huang, K., Xu, J., Guo, G. F., Tong, A., & Zhou, L. (2020) · Cell Proliferation · doi:10.1111/cpr.12781 · Cited by 308 · see citing works

Marked differences in cholesterol synthesis between neurons and glial cells from postnatal rats

Nieweg, K., Schaller, H., & Pfrieger, F. W. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05917.x · Cited by 307 · see citing works

Oxysterols and neurodegenerative diseases

Björkhem, I., Cedazo-Mı́nguez, Á., Leoni, V., & Meaney, S. (2009) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2009.02.001 · Cited by 302 · see citing works

Apolipoprotein E–dependent accumulation of Alzheimer disease–related lesions begins in middle age

Kok, E., Haikonen, S., Luoto, T., Huhtala, H., Goebeler, S., Haapasalo, H., & Karhunen, P. J. (2009) · Annals of Neurology · doi:10.1002/ana.21696 · Cited by 299 · see citing works

Characterization of four lipoprotein classes in human cerebrospinal fluid

Koch, S., Donarski, N., Goetze, K., Kreckel, M., Stuerenburg, H.-J., Buhmann, C., & Beisiegel, U. (2001) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31605-9 · Cited by 298 · see citing works

Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis

Chen, Y., Strickland, M. R., Soranno, A., & Holtzman, D. M. (2021) · Neuron · doi:10.1016/j.neuron.2020.10.008 · Cited by 298 · see citing works

Changes in brain oxysterols at different stages of Alzheimer's disease: Their involvement in neuroinflammation

Testa, G., Staurenghi, E., Zerbinati, C., Gargiulo, S., Iuliano, L., Giaccone, G., Fantò, F., Poli, G., Leonarduzzi, G., & Gamba, P. (2016) · Redox Biology · doi:10.1016/j.redox.2016.09.001 · Cited by 293 · see citing works

Deciphering the astrocyte reaction in Alzheimer's disease

Perez-Nievas, B. G., & Serrano-Pozo, A. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00114 · Cited by 282 · see citing works

Questions and (some) answers on reactive astrocytes

Escartin, C., Guillemaud, O., & Carrillo‐de Sauvage, M. (2019) · Glia · doi:10.1002/glia.23687 · Cited by 275 · see citing works

Human<i>APOE</i>Isoform-Dependent Effects on Brain β-Amyloid Levels in PDAPP Transgenic Mice

Bales, K. R., Liu, F., Wu, S., Lin, S., Koger, D., DeLong, C., Hansen, J. C., Sullivan, P. M., & Paul, S. M. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.0887-09.2009 · Cited by 274 · see citing works

Differential Expression of Cholesterol Hydroxylases in Alzheimer's Disease

Brown, J. A., Theisler, C. M., Silberman, S., Magnuson, D. J., Gottardi-Littell, N. R., Lee, J. M., Yager, D., Crowley, J., Sambamurti, K., Rahman, M. M., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m402324200 · Cited by 268 · see citing works

24(S)-Hydroxycholesterol Participates in a Liver X Receptor-controlled Pathway in Astrocytes That Regulates Apolipoprotein E-mediated Cholesterol Efflux

Abildayeva, K., Jansen, P. J., Hirsch-Reinshagen, V., Bloks, V. W., Bakker, A. H. F., Ramaekers, F. C. S., de Vente, J., Groen, A. K., Wellington, Kuipers, F., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m601019200 · Cited by 267 · see citing works

Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons

Söllvander, S., Nikitidou, E., Brolin, R., Söderberg, L., Sehlin, D., Lannfelt, L., & Erlandsson, A. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0098-z · Cited by 267 · see citing works

Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition

Liu, C.-C., Hu, J., Zhao, N., Wang, J., Wang, N., Cirrito, J. R., Kanekiyo, T., Holtzman, D. M., & Bu, G. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.3442-16.2017 · Cited by 267 · see citing works

Enhancing Astrocytic Lysosome Biogenesis Facilitates Aβ Clearance and Attenuates Amyloid Plaque Pathogenesis

Xiao, Q., Yan, P., Ma, X., Liu, H., Perez, R., Zhu, A., Gonzales, E., Burchett, J. M., Schuler, D. R., Cirrito, J. R., et al. (2014) · The Journal of Neuroscience · doi:10.1523/jneurosci.3788-13.2014 · Cited by 266 · see citing works

Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease

Ceyzériat, K., Ben Haim, L., Denizot, A., Pommier, D., Matos, M., Guillemaud, O., Palomares, M.-A., Abjean, L., Petit, F., Gipchtein, P., et al. (2018) · Acta Neuropathologica Communications · doi:10.1186/s40478-018-0606-1 · Cited by 256 · see citing works

The Blood–Cerebrospinal Fluid Barrier: Structure and Functional Significance

Johanson, C. E., Stopa, E. G., & McMillan, P. N. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-938-3_4 · Cited by 249 · see citing works

Glial fibrillary acidic protein isoform expression in plaque related astrogliosis in Alzheimer's disease

Kamphuis, W., Middeldorp, J., Kooijman, L., Sluijs, J. A., Kooi, E., Moeton, M., Freriks, M., Mizee, M. R., & Hol, E. M. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.09.035 · Cited by 244 · see citing works

Septal Cholinergic Neuromodulation Tunes the Astrocyte-Dependent Gating of Hippocampal NMDA Receptors to Wakefulness

Papouin, T., Dunphy, J. M., Tolman, M., Dineley, K. T., & Haydon, P. G. (2017) · Neuron · doi:10.1016/j.neuron.2017.04.021 · Cited by 243 · see citing works

Role of ATP‐binding cassette transporters in brain lipid transport and neurological disease

Kim, W. S., Weickert, C. S., & Garner, B. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05099.x · Cited by 237 · see citing works

Alterations in cholesterol metabolism as a risk factor for developing Alzheimer’s disease: Potential novel targets for treatment

Loera‐Valencia, R., Goikolea, J., Parrado‐Fernández, C., Merino‐Serrais, P., & Maioli, S. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.03.003 · Cited by 228 · see citing works

Differential Relationships of Reactive Astrocytes and Microglia to Fibrillar Amyloid Deposits in Alzheimer Disease

Serrano-Pozo, A., Muzikansky, A., Gómez-Isla, T., Growdon, J. H., Betensky, R. A., Frosch, M. P., & Hyman, B. T. (2013) · Journal of Neuropathology &amp; Experimental Neurology · doi:10.1097/nen.0b013e3182933788 · Cited by 226 · see citing works

Cholesterol and Alzheimer’s Disease; From Risk Genes to Pathological Effects

Feringa, F. M., & van der Kant, R. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.690372 · Cited by 226 · see citing works

APOE genotype alters glial activation and loss of synaptic markers in mice

Zhu, Y., Nwabuisi‐Heath, E., Dumanis, S. B., Tai, L. M., Yu, C., Rebeck, G. W., & Ladu, M. J. (2012) · Glia · doi:10.1002/glia.22289 · Cited by 224 · see citing works

Calcium signals induced by amyloid β peptide and their consequences in neurons and astrocytes in culture

Abramov, A. Y., Canevari, L., & Duchen, M. R. (2004) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2004.09.006 · Cited by 223 · see citing works

APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes

Zhao, J., Davis, M. D., Martens, Y. A., Shinohara, M., Graff-Radford, N. R., Younkin, S. G., Wszolek, Z. K., Kanekiyo, T., & Bu, G. (2017) · Human Molecular Genetics · doi:10.1093/hmg/ddx155 · Cited by 221 · see citing works

On the turnover of brain cholesterol in patients with Alzheimer's disease. Abnormal induction of the cholesterol-catabolic enzyme CYP46 in glial cells

Bogdanović, N., Brétillon, L., Lund, E. G., Diczfalusy, U., Lannfelt, L., Winblad, B. G., Russell, D. W., & Björkhem, I. (2001) · Neuroscience Letters · doi:10.1016/s0304-3940(01)02277-7 · Cited by 213 · see citing works

Tau accumulation in astrocytes of the dentate gyrus induces neuronal dysfunction and memory deficits in Alzheimer’s disease

Richetin, K., Steullet, P., Pachoud, M., Perbet, R., Parietti, E., Maheswaran, M., Eddarkaoui, S., Bégard, S., Pythoud, C., Rey, M. J., et al. (2020) · Nature Neuroscience · doi:10.1038/s41593-020-00728-x · Cited by 212 · see citing works

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

Lin, Y.-T., Seo, J., Gao, F., Feldman, H. M., Wen, H.-L., Penney, J., Cam, H. P., Gjoneska, E., Raja, W. K., Cheng, J., et al. (2018) · Neuron · doi:10.1016/j.neuron.2018.06.011 · Cited by 210 · see citing works

Diverse human astrocyte and microglial transcriptional responses to Alzheimer’s pathology

Smith, A. M., Davey, K., Tsartsalis, S., Khozoie, C., Fancy, N., Tang, S. S., Liaptsi, E., Weinert, M., McGarry, A., Muirhead, R. C. J., et al. (2022) · Acta Neuropathologica · doi:10.1007/s00401-021-02372-6 · Cited by 209 · cited 1× · see citing works

Glucose metabolic crosstalk and regulation in brain function and diseases

Zhang, S., Lachance, B. B., Mattson, M. P., & Jia, X. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102089 · Cited by 205 · see citing works

Oxidized cholesterol as the driving force behind the development of Alzheimer’s disease

Gamba, P., Testa, G., Gargiulo, S., Staurenghi, E., Poli, G., & Leonarduzzi, G. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00119 · Cited by 202 · see citing works

Astrocyte lipid metabolism is critical for synapse development and function in vivo

van Deijk, A. F., Camargo, N., Timmerman, J., Heistek, T., Brouwers, J. F., Mogavero, F., Mansvelder, H. D., Smit, A. B., & Verheijen, M. H. G. (2017) · Glia · doi:10.1002/glia.23120 · Cited by 201 · see citing works

Amyloid clearance defect in ApoE4 astrocytes is reversed by epigenetic correction of endosomal pH

Prasad, H., & Rao, R. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1801612115 · Cited by 200 · see citing works

Alzheimer’s disease is associated with altered expression of genes involved in immune response and mitochondrial processes in astrocytes

Sekar, S., McDonald, J., Cuyugan, L., Aldrich, J., Kurdoglu, A., Adkins, J., Serrano, G., Beach, T. G., Craig, D. W., Valla, J., et al. (2015) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.09.027 · Cited by 199 · see citing works

Cholesterol Metabolism in Neurodegenerative Diseases: Molecular Mechanisms and Therapeutic Targets

Dai, L., Zou, L. B., Meng, L., Qiang, G., Yan, M., & Zhang, Z. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02232-6 · Cited by 195 · see citing works

Cholesterol as a causative factor in Alzheimer's disease: a debatable hypothesis

Wood, W. G., Li, L., Müller, W. E., & Eckert, G. P. (2014) · Journal of Neurochemistry · doi:10.1111/jnc.12637 · Cited by 194 · see citing works

Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition

Rodriguez, G. A., Tai, L. M., LaDu, M. J., & Rebeck, G. W. (2014) · Journal of Neuroinflammation · doi:10.1186/1742-2094-11-111 · Cited by 193 · see citing works

Low-density Lipoprotein Receptor Represents an Apolipoprotein E-independent Pathway of Aβ Uptake and Degradation by Astrocytes

Basak, J. M., Verghese, P. B., Yoon, H., Kim, J., & Holtzman, D. M. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.288746 · Cited by 192 · see citing works

Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients

Ji, Y., Gong, Y., Gan, W., Beach, T., Holtzman, D. M., & Wisniewski, T. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.08.007 · Cited by 189 · see citing works

Conservation and divergence of vulnerability and responses to stressors between human and mouse astrocytes

Li, J., Pan, L., Pembroke, W. G., Rexach, J. E., Godoy, M. I., Condro, M. C., Alvarado, A. G., Harteni, M., Chen, Y., Stiles, L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24232-3 · Cited by 187 · see citing works

Chronic oxidative stress causes increased tau phosphorylation in M17 neuroblastoma cells

Su, B., Wang, X., Lee, H., Tabaton, M., Perry, G. L., Smith, M. A., & Zhu, X. (2009) · Neuroscience Letters · doi:10.1016/j.neulet.2009.11.010 · Cited by 178 · see citing works

Apolipoprotein E ε4 is associated with disease-specific effects on brain atrophy in Alzheimer's disease and frontotemporal dementia

Agosta, F., Vossel, K. A., Miller, B. L., Migliaccio, R., Bonasera, S. J., Filippi, M., Boxer, A. L., Karydas, A., Possin, K. L., & Gorno-Tempini, M. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812697106 · Cited by 178 · see citing works

Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation

Liao, F., Li, A., Xiong, M., Bien-Ly, N., Jiang, H., Zhang, Y., Finn, M. B., Hoyle, R., Keyser, J., Lefton, K. B., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci96429 · Cited by 178 · see citing works

On the rate of translocation in vitro and kinetics in vivo of the major oxysterols in human circulation

Meaney, S., Bodin, K., Diczfalusy, U., & Björkhem, I. (2002) · Journal of Lipid Research · doi:10.1194/jlr.m200293-jlr200 · Cited by 173 · see citing works

Lipid Biomarkers in Alzheimer's Disease

Zarrouk, A., Debbabi, M., Bezine, M., Karym, E. M., Badreddine, A., Rouaud, O., Moreau, T., Cherkaoui-Malki, M., El Ayeb, M., Nasser, B., et al. (2018) · Current Alzheimer Research · doi:10.2174/1567205014666170505101426 · Cited by 170 · see citing works

Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression

Tyzack, G. E., Sitnikov, S., Barson, D. G., Adams-Carr, K. L., Lau, N. K., Kwok, J. C. F., Zhao, C., Franklin, R. J. M., Káradóttir, R. T., Fawcett, J. W., et al. (2014) · Nature Communications · doi:10.1038/ncomms5294 · Cited by 166 · see citing works

Angiotensin-converting enzyme levels and activity in Alzheimer's disease: differences in brain and CSF ACE and association with ACE1 genotypes.

(2009) · PubMed Central · Cited by 165 · see citing works

ApoE4 Alters ABCA1 Membrane Trafficking in Astrocytes

Rawat, V., Wang, S., Sima, J., Bar, R., Liraz, O., Gundimeda, U., Parekh, T., Chan, J., Johansson, J. O., Tang, C., et al. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.1400-19.2019 · Cited by 165 · see citing works

Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory

Li, X., Zhang, J., Li, D., He, C., He, K., Xue, T., Wan, L., Zhang, C., & Liu, Q. (2021) · Neuron · doi:10.1016/j.neuron.2021.01.005 · Cited by 165 · see citing works

Apolipoprotein E and cholesterol in aging and disease in the brain

de Chaves, E. P., Narayanaswami, V., Christoffersen, C., & Nielsen, L. B. (2008) · Future Lipidology · doi:10.2217/17460875.3.5.505 · Cited by 164 · see citing works

GLT-1 Loss Accelerates Cognitive Deficit Onset in an Alzheimer's Disease Animal Model

Mookherjee, P., Green, P. S., Watson, G. S., Marques, M. A., Tanaka, K., Meeker, K. D., Meabon, J. S., Li, N., Zhu, P., Olson, V. G., et al. (2011) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110503 · Cited by 164 · see citing works

Apolipoprotein E4 Alters Astrocyte Fatty Acid Metabolism and Lipid Droplet Formation

Farmer, B., Kluemper, J., & Johnson, L. (2019) · Cells · doi:10.3390/cells8020182 · Cited by 164 · see citing works

Transplanted astrocytes internalize deposited β‐amyloid peptides in a transgenic mouse model of Alzheimer's disease

Pihlaja, R., Koıstınaho, J., Malm, T., Sikkilä, H., Vainio, S. J., & Koistinaho, M. (2007) · Glia · doi:10.1002/glia.20599 · Cited by 162 · see citing works

Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

Hu, J., Liu, C.-C., Chen, X.-F., Zhang, Y.-W., Xu, H., & Bu, G. (2015) · Molecular Neurodegeneration · doi:10.1186/s13024-015-0001-3 · Cited by 161 · see citing works

Astrocytic expression of the Alzheimer's disease β‐secretase (BACE1) is stimulus‐dependent

Hartlage‐Rübsamen, M., Zeitschel, U., Apelt, J., Gärtner, U., Franke, H., Stahl, T., Günther, A., Schliebs, R., Penkowa, M., Bigl, V., et al. (2002) · Glia · doi:10.1002/glia.10178 · Cited by 160 · see citing works

Quantitation of ATP-binding cassette subfamily-A transporter gene expression in primary human brain cells

Kim, W., Guillemin, G., Glaros, E., Lim, C. K., & Garner, B. (2006) · NeuroReport · doi:10.1097/01.wnr.0000221833.41340.cd · Cited by 158 · see citing works

Mapping synaptic glutamate transporter dysfunction in vivo to regions surrounding Aβ plaques by iGluSnFR two-photon imaging

Hefendehl, J. K., LeDue, J. M., Ko, R. W. Y., Mahler, J., Murphy, T. H., & MacVicar, B. A. (2016) · Nature Communications · doi:10.1038/ncomms13441 · Cited by 157 · see citing works

Predictive value of APOE- 4 allele for progression from MCI to AD-type dementia: a meta-analysis

Elias-Sonnenschein, L. S., Viechtbauer, W., Ramakers, I. H. G. B., Verhey, F. R. J., & Visser, P. J. (2011) · Journal of Neurology, Neurosurgery &amp; Psychiatry · doi:10.1136/jnnp.2010.231555 · Cited by 154 · see citing works

Abnormal brain cholesterol homeostasis in Alzheimer’s disease-a targeted metabolomic and transcriptomic study

Varma, V. R., Büşra Lüleci, H., Oommen, A. M., Varma, S., Blackshear, C. T., Griswold, M. E., An, Y., Roberts, J. A., O’Brien, R., Pletnikova, O., et al. (2021) · npj Aging and Mechanisms of Disease · doi:10.1038/s41514-021-00064-9 · Cited by 153 · see citing works

Novel route for elimination of brain oxysterols across the blood-brain barrier: conversion into 7α-hydroxy-3-oxo-4-cholestenoic acid

Meaney, S., Heverin, M., Panzenboeck, U., Ekström, L., Axelsson, M., Andersson, U., Diczfalusy, U., Pikuleva, I. A., Wahren, J., Sattler, W., et al. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m600529-jlr200 · Cited by 144 · see citing works

Side chain oxidized oxysterols in cerebrospinal fluid and the integrity of blood-brain and blood-cerebrospinal fluid barriers

Leoni, V., Masterman, T., Patel, P., Meaney, S., Diczfalusy, U., & Björkhem, I. (2003) · Journal of Lipid Research · doi:10.1194/jlr.m200434-jlr200 · Cited by 144 · see citing works

Glial Cell Calcium Signaling Mediates Capillary Regulation of Blood Flow in the Retina

Biesecker, K. R., Srienc, A. I., Shimoda, A. M., Agarwal, A., Bergles, D. E., Kofuji, P., & Newman, E. A. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.1782-16.2016 · Cited by 144 · see citing works

Neuronal LRP1 Regulates Glucose Metabolism and Insulin Signaling in the Brain

Liu, C., Hu, J., Tsai, C., Yue, M., Melrose, H. L., Kanekiyo, T., & Bu, G. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.5180-14.2015 · Cited by 140 · see citing works

Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology.

Wang, C., Wilson, W. A., Moore, S. D., Mace, B. E., Maeda, N., Schmechel, D. E., & Sullivan, P. M. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.10.013 · Cited by 138 · see citing works

Oxidative stress and altered mitochondrial protein expression in the absence of amyloid-β and tau pathology in iPSC-derived neurons from sporadic Alzheimer's disease patients

Birnbaum, J. H., Wanner, D., Gietl, A. F., Saake, A., Kündig, T. M., Hock, C., Nitsch, R. M., & Tackenberg, C. (2018) · Stem Cell Research · doi:10.1016/j.scr.2018.01.019 · Cited by 135 · see citing works

Cholesterol and Alzheimer’s Disease Risk: A Meta-Meta-Analysis

Sáiz-Vazquez, O., Puente-Martínez, A., Ubillos-Landa, S., Pacheco-Bonrostro, J., & Santabárbara, J. (2020) · Brain Sciences · doi:10.3390/brainsci10060386 · Cited by 135 · see citing works

Young APOE4 targeted replacement mice exhibit poor spatial learning and memory, with reduced dendritic spine density in the medial entorhinal cortexPreprint

Rodriguez, G. A., Burns, M. P., Weeber, E. J., & Rebeck, G. W. (2013) · Learning & Memory · doi:10.1101/lm.030031.112 · Cited by 134 · see citing works

Localization of Human Acyl-Coenzyme A:Cholesterol Acyltransferase-1 (ACAT-1) in Macrophages and in Various Tissues

Sakashita, N., Miyazaki, A., Takeya, M., Horiuchi, S., Chang, C. C. Y., Chang, T., & Takahashi, K. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64723-2 · Cited by 126 · see citing works

Cross‐talk between monocyte invasion and astrocyte proliferation regulates scarring in brain injury

Frik, J., Merl‐Pham, J., Plesnila, N., Mattugini, N., Kjell, J., Kraska, J., Gomez, R. M., Hauck, S. M., Sirko, S., & Götz, M. (2018) · EMBO Reports · doi:10.15252/embr.201745294 · Cited by 126 · see citing works

Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease

Shinohara, M., Murray, M. E., Frank, R. D., Shinohara, M., DeTure, M., Yamazaki, Y., Tachibana, M., Atagi, Y., Davis, M. D., Liu, C.-C., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1580-y · Cited by 123 · see citing works

ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice

Liraz, O., Boehm-Cagan, A., & Michaelson, D. M. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-16 · Cited by 118 · see citing works

The impairment of cholesterol metabolism in Huntington disease

Leoni, V., & Caccia, C. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.12.018 · Cited by 118 · see citing works

Reactive Oxygen Species from Human Astrocytes Induced Functional Impairment and Oxidative Damage

Sheng, W. S., Hu, S., Feng, A., & Rock, R. B. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1123-z · Cited by 116 · see citing works

Soluble apoE/Aβ complex: mechanism and therapeutic target for APOE4-induced AD risk

Tai, L. M., Mehra, S., Shete, V., Estus, S., Rebeck, G. W., Bu, G., & LaDu, M. J. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-2 · Cited by 116 · see citing works

Oxidative injury triggers autophagy in astrocytes: The role of endogenous zinc

Lee, S., Cho, K. S., & Koh, J. (2009) · Glia · doi:10.1002/glia.20854 · Cited by 115 · see citing works

Astrocytes from old Alzheimer's disease mice are impaired in Aβ uptake and in neuroprotection

Iram, T., Trudler, D., Kain, D., Kanner, S., Galron, R., Vassar, R. J., Barzilai, A., Blinder, P., Fishelson, Z., & Frenkel, D. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.08.001 · Cited by 115 · see citing works

Associations of cortical astrogliosis with cognitive performance and dementia status

Kashon, M. L., Ross, G. W., O'Callaghan, J. P., Miller, D. B., Petrovitch, H., Burchfiel, C. M., Sharp, D. S., Markesbery, W. R., Davis, D. G., Hardman, J. M., et al. (2005) · Journal of Alzheimer s Disease · doi:10.3233/jad-2004-6604 · Cited by 114 · see citing works

High resolution dissection of reactive glial nets in Alzheimer’s disease

Bouvier, D. S., Jones, E. V., Quesseveur, G., Davoli, M. A., A. Ferreira, T., Quirion, R., Mechawar, N., & Murai, K. K. (2016) · Scientific Reports · doi:10.1038/srep24544 · Cited by 111 · see citing works

ApoE4-Induced Cholesterol Dysregulation and Its Brain Cell Type-Specific Implications in the Pathogenesis of Alzheimer's Disease.

Jeong, W., Lee, H. G., Cho, S., & Seo, J. (2019) · PubMed Central · doi:10.14348/molcells.2019.0200 · Cited by 104 · see citing works

Constitutive hippocampal cholesterol loss underlies poor cognition in old rodents

Martín, M. G., Ahmed, T., Korovaichuk, A., Venero, C., Menchón, S. A., Salas, I. H., Munck, S., Herreras, Ó., Balschun, D., & Dotti, C. G. (2014) · EMBO Molecular Medicine · doi:10.15252/emmm.201303711 · Cited by 98 · see citing works

Activated forms of astrocytes with higher GLT-1 expression are associated with cognitive normal subjects with Alzheimer pathology in human brain

Kobayashi, E., Nakano, M., Kubota, K., Himuro, N., Mizoguchi, S., Chikenji, T., Otani, M., Mizue, Y., Nagaishi, K., & Fujimiya, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-19442-7 · Cited by 98 · see citing works

Direct Observation of Rapid Internalization and Intracellular Transport of Sterol by Macrophage Foam Cells

Wüstner, D., Mondal, M., Tabas, I. A., & Maxfield, F. R. (2005) · Traffic · doi:10.1111/j.1600-0854.2005.00285.x · Cited by 97 · see citing works

Binding and uptake of Aβ1‐42 by primary human astrocytes <i>in vitro</i>

Nielsen, H. M., Veerhuis, R., Holmqvist, B., & Janciauskiene, S. (2009) · Glia · doi:10.1002/glia.20822 · Cited by 96 · see citing works

Cholesterol metabolites exported from human brain

Iuliano, L., Crick, P. J., Zerbinati, C., Tritapepe, L., Abdel‐Khalik, J., Poirot, M., Wang, Y., & Griffiths, W. J. (2015) · Steroids · doi:10.1016/j.steroids.2015.01.026 · Cited by 91 · see citing works

Cholesterol homeostasis: a key to prevent or slow down neurodegeneration

Anchisi, L., Dessı̀, S., Pani, A., & Mandas, A. (2013) · Frontiers in Physiology · doi:10.3389/fphys.2012.00486 · Cited by 88 · see citing works

Does the oxysterol 27-hydroxycholesterol underlie Alzheimer's disease–Parkinson's disease overlap?

Marwarha, G., & Ghribi, O. (2014) · Experimental Gerontology · doi:10.1016/j.exger.2014.09.013 · Cited by 87 · see citing works

On the formation and possible biological role of 25-hydroxycholesterol

Diczfalusy, U. (2013) · Biochimie · doi:10.1016/j.biochi.2012.06.016 · Cited by 87 · see citing works

Astrocytes autophagy in aging and neurodegenerative disorders

Wang, J., & Xu, C. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109691 · Cited by 87 · see citing works

27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation

Ismail, M.-A.-M., Mateos, L., Maioli, S., Merino‐Serrais, P., Ali, Z., Lodeiro, M., Westman, E., Leitersdorf, E., Gulyás, B. Z., Wahlund, L., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20160534 · Cited by 84 · see citing works

Interferon γ stimulates β-secretase expression and sAPPβ production in astrocytes

Hong, H. S., Hwang, E. M., Sim, H. J., Cho, H.-J., Boo, J. H., Oh, S. S., Kim, S. U., & Mook-Jung, I. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(03)01270-1 · Cited by 81 · see citing works

Hypercholesterolaemia-induced oxidative stress at the blood–brain barrier

Dias, I. H. K., Polidori, M. C., & Griffiths, H. R. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140164 · Cited by 78 · see citing works

A Crosstalk Between Brain Cholesterol Oxidation and Glucose Metabolism in Alzheimer’s Disease

Gamba, P., Staurenghi, E., Testa, G., Giannelli, S., Sottero, B., & Leonarduzzi, G. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00556 · Cited by 77 · see citing works

Endogenous reactive oxygen species cause astrocyte defects and neuronal dysfunctions in the hippocampus: a new model for aging brain

Ishii, T., Takanashi, Y., Sugita, K., Miyazawa, M., Yanagihara, R., Yasuda, K., Onouchi, H., Kawabe, N., Nakata, M., Yamamoto, Y., et al. (2016) · Aging Cell · doi:10.1111/acel.12523 · Cited by 76 · see citing works

The Controversial Role of 24-S-Hydroxycholesterol in Alzheimer’s Disease

Gamba, P., Giannelli, S., Staurenghi, E., Testa, G., Sottero, B., Biasi, F., Poli, G., & Leonarduzzi, G. (2021) · Antioxidants · doi:10.3390/antiox10050740 · Cited by 76 · see citing works

Oxidation of Aβ and Plaque Biogenesis in Alzheimer's Disease and Down Syndrome

Head, E., Garzon-Rodriguez, W., Johnson, J. K., Lott, I. T., Cotman, C. W., & Glabe, C. (2001) · Neurobiology of Disease · doi:10.1006/nbdi.2001.0431 · Cited by 75 · see citing works

SIRT1 facilitates amyloid beta peptide degradation by upregulating lysosome number in primary astrocytes

Li, M., Ji, J., Zheng, L.-J., Shen, J., Li, X., Zhang, Q., Bai, X., & Wang, Q. (2018) · Neural Regeneration Research · doi:10.4103/1673-5374.239449 · Cited by 74 · see citing works

A High-Cholesterol Diet Increases 27-Hydroxycholesterol and Modifies Estrogen Receptor Expression and Neurodegeneration in Rabbit Hippocampus

Brooks, S. W., Dykes, A. C., & Schreurs, B. G. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-160725 · Cited by 68 · see citing works

Cholesterol homeostasis failure in the brain: Implications for synaptic dysfunction and cognitive decline

Segatto, M., Leboffe, L., Trapani, L., & Pallottini, V. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666140303142902 · Cited by 65 · see citing works

Oxysterols present in Alzheimer's disease brain induce synaptotoxicity by activating astrocytes: A major role for lipocalin-2

Staurenghi, E., Cerrato, V., Gamba, P., Testa, G., Giannelli, S., Leoni, V., Caccia, C., Buffo, A., Noble, W. J., Perez‐Nievas, B. G., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101837 · Cited by 63 · see citing works

Dual pathways mediate β-amyloid stimulated glutathione release from astrocytes

Ye, B., Shen, H., Zhang, J., Zhu, Y.-G., Ransom, B. R., Chen, X., & Ye, Z. (2015) · Glia · doi:10.1002/glia.22886 · Cited by 62 · see citing works

Control of Long-Term Plasticity by Glutamate Transporters

Valtcheva, S., & Venance, L. (2019) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2019.00010 · Cited by 62 · see citing works

Reduced Adult Neurogenesis and Altered Emotional Behaviors in Autoimmune-Prone B-Cell Activating Factor Transgenic Mice

Crupi, R., Cambiaghi, M., Spatz, L. A., Hen, R., Thorn, M., Friedman, E., Vita, G., & Battaglia, F. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.12.008 · Cited by 58 · see citing works

Don't forget astrocytes when targeting Alzheimer's disease

Sadick, J. S., & Liddelow, S. A. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14568 · Cited by 58 · see citing works

Regulation of cholesterol homeostasis by liver X receptors

Hu, Y., Zheng, L., & Wang, Q. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2009.12.027 · Cited by 57 · see citing works

Side Chain-oxidized Oxysterols Regulate the Brain Renin-Angiotensin System through a Liver X Receptor-dependent Mechanism

Mateos, L., Ismail, M.-A.-M., Gil-Bea, F. J., Schüle, R., Schöls, L. J., Heverin, M., Folkesson, R., Björkhem, I., & Cedazo-Mı́nguez, Á. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.236877 · Cited by 56 · see citing works

Cholesterol in the Pathogenesis of Alzheimer’s, Parkinson’s Diseases and Autism: Link to Synaptic Dysfunction

Petrov, A. M., Kasimov, M. R., & Zefirov, A. L. (2017) · Acta Naturae · doi:10.32607/20758251-2017-9-1-26-37 · Cited by 56 · see citing works

Association Between Oxidative Stress and Altered Cholesterol Metabolism in Alzheimer’s Disease Patients

Zarrouk, A., Hammouda, S., Ghzaiel, I., Hammami, S. O., Khamlaoui, W., Ahmed, S. H., Lizard, G., & Hammami, M. (2020) · Current Alzheimer Research · doi:10.2174/1567205017666201203123046 · Cited by 52 · see citing works

27-Hydroxycholesterol regulates cholesterol synthesis and transport in C6 glioma cells

An, Y., Zhang, D.-D., Yu, H., Ma, W., Lu, Y., Liu, Q.-R., & Xiao, R. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2017.02.001 · Cited by 48 · see citing works

The Oxysterol 27-Hydroxycholesterol Increases Oxidative Stress and Regulate Nrf2 Signaling Pathway in Astrocyte Cells

Ma, W., Li, C., Yu, H., Zhang, D.-D., Xi, Y., Han, J., Liu, Q.-R., & Xiao, R. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1524-2 · Cited by 47 · see citing works

A silver lining for 24-hydroxycholesterol in Alzheimer's disease: The involvement of the neuroprotective enzyme sirtuin 1

Testa, G., Staurenghi, E., Giannelli, S., Gargiulo, S., Guglielmotto, M., Tabaton, M., Tamagno, E., Gamba, P., & Leonarduzzi, G. (2018) · Redox Biology · doi:10.1016/j.redox.2018.05.009 · Cited by 46 · see citing works

Molecular Hydrogen Suppresses Reactive Astrogliosis Related to Oxidative Injury during Spinal Cord Injury in Rats

Liu, F., Xu, S., Xiang, Z., Li, X., Li, J., Yuan, H., & Sun, X. (2014) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12258 · Cited by 43 · see citing works

Topological analyses in APP/PS1 mice reveal that astrocytes do not migrate to amyloid-β plaques

Galea, E., Morrison, W., Hudry, E., Arbel‐Ornath, M., Bacskai, B. J., Gómez‐Isla, T., Stanley, E., & Hyman, B. T. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1516779112 · Cited by 42 · see citing works

Astrocytes contain amyloid-β annular protofibrils in Alzheimer's disease brains

Lasagna‐Reeves, C. A., & Kayed, R. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.08.027 · Cited by 40 · see citing works

Changes in astrocyte functional markers and β-amyloid metabolism-related proteins in the early stages of hypercholesterolemia

Chen, Y. L., Wang, L.-Y., Chen, Y., Gao, J. Y., Marshall, C., Cai, Z., Hu, G., & Xiao, M. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.12.039 · Cited by 40 · see citing works

Sensing and Regulating Synaptic Activity by Astrocytes at Tripartite Synapse

Noriega‐Prieto, J. A., & Araque, A. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03317-x · Cited by 38 · see citing works

Aβ-induced Ca2+ influx regulates astrocytic BACE1 expression via calcineurin/NFAT4 signals

Jin, S. M., Cho, H. J., Kim, Y. W., Hwang, J. Y., & Mook‐Jung, I. (2012) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2012.07.123 · Cited by 36 · see citing works

Improved synthesis and in vitro evaluation of the cytotoxic profile of oxysterols oxidized at C4 (4α- and 4β-hydroxycholesterol) and C7 (7-ketocholesterol, 7α- and 7β-hydroxycholesterol) on cells of the central nervous system

Nury, T., Samadi, M. H., Zarrouk, A., Riedinger, J. M., & Lizard, G. (2013) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2013.09.028 · Cited by 36 · see citing works

Hypercholesterolemia and 27-Hydroxycholesterol Increase S100A8 and RAGE Expression in the Brain: a Link Between Cholesterol, Alarmins, and Neurodegeneration

Loera‐Valencia, R., Ismail, M.-A.-M., Goikolea, J., Lodeiro, M., Mateos, L., Björkhem, I., Puerta, E., Romão, M. A., Gomes, C. M., Merino‐Serrais, P., et al. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02521-8 · Cited by 36 · see citing works

EBI2 regulates pro-inflammatory signalling and cytokine release in astrocytes

Rutkowska, A., Shimshek, D. R., Sailer, A. W., & Dev, K. K. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.01.029 · Cited by 33 · see citing works

Upregulation of Alzheimer’s Disease Amyloid-β Protein Precursor in Astrocytes Both in vitro and in vivo

Liang, Y., Raven, F., Ward, J. F., Zhen, S. Y., Zhang, S., Sun, H., Miller, S., Choi, S. H., Tanzi, R. E., & Zhang, C. M. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200128 · Cited by 29 · see citing works

Elevated GFAP isoform expression promotes protein aggregation and compromises astrocyte function

Lin, N., Yang, A., Chang, C., & Perng, M. (2021) · The FASEB Journal · doi:10.1096/fj.202100087r · Cited by 29 · see citing works

Astrocyte activation and neurotoxicity: A study in different rat brain regions and in rat C6 astroglial cells

Goswami, P., Gupta, S., Joshi, N., Sharma, S., & Singh, S. (2015) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2015.06.001 · Cited by 27 · see citing works

Extracellular ATP induces graded reactive response of astrocytes and strengthens their antioxidative defense in vitro

Adžić, M., Stevanović, I. D., Josipović, N., Laketa, D., Lavrnja, I. C., Bjelobaba, I. M., Bozic, I. D., Jovanović, M., Milosevic, M. M., & Nedeljković, N. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23950 · Cited by 26 · see citing works

Alternative Targets to Fight Alzheimer’s Disease: Focus on Astrocytes

Valenza, M., Facchinetti, R., Menegoni, G., Steardo, L., & Scuderi, C. (2021) · Biomolecules · doi:10.3390/biom11040600 · Cited by 25 · see citing works

24S-hydroxycholesterol affects redox homeostasis in human glial U-87 MG cells

Cigliano, L., Spagnuolo, M. S., Napolitano, G., Iannotta, L., Fasciolo, G., Barone, D., & Venditti, P. (2019) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2019.02.013 · Cited by 23 · see citing works

Astrocyte glutamate uptake coordinates experience‐dependent, eye‐specific refinement in developing visual cortex

Sipe, G. O., Petravicz, J., Rikhye, R. V., Garcia, R. I., Mellios, N., & Sur, M. (2021) · Glia · doi:10.1002/glia.23987 · Cited by 20 · see citing works

Beta-Secretase 1 Underlies Reactive Astrocytes and Endothelial Disruption in Neurodegeneration

Chacón-Quintero, M. V., Pineda-López, L. G., Villegas‐Lanau, C. A., Posada‐Duque, R., & Cardona‐Gómez, G. P. (2021) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2021.656832 · Cited by 15 · see citing works

Regulation of ABCG4 transporter expression by sterols and LXR ligands

Yang, A., Alrosan, A. Z., Sharpe, L. J., Brown, A. J., Callaghan, R., & Gelissen, I. C. (2020) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2020.129769 · Cited by 12 · see citing works

7β-hydroxycholesterol reduces the extent of reactive gliosis caused by iron deposition in the hippocampus but does not attenuate the iron-induced seizures in rats

Yao, Y., Sun, S., Kong, Q., & Tong, E. (2006) · Neuroscience · doi:10.1016/j.neuroscience.2005.12.011 · Cited by 2 · see citing works

Regulation of astrocyte lipid metabolism and ApoE secretion by the microglial oxysterol, 25-hydroxycholesterol

Cashikar, A. G., Toral-Rios, D., Timm, D., Romero, J., Strickland, M., Long, J. M., Han, X., Holtzman, D. M., & Paul, S. M. (2023) · Journal of Lipid Research · doi:10.1016/j.jlr.2023.100350 · Cited by 72 · see citing works

Lipidome disruption in Alzheimer’s disease brain: detection, pathological mechanisms, and therapeutic implications

He, S., Xu, Z., & Han, X. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00803-6 · Cited by 62 · see citing works

Functions of Stress-Induced Lipid Droplets in the Nervous System

Islimye, E., Girard, V., & Gould, A. P. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.863907 · Cited by 55 · see citing works

The translational potential of cholesterol-based therapies for neurological disease

Valenza, M., Birolini, G., & Cattaneo, E. F. (2023) · Nature Reviews Neurology · doi:10.1038/s41582-023-00864-5 · Cited by 48 · see citing works

HDL-like-Mediated Cell Cholesterol Trafficking in the Central Nervous System and Alzheimer’s Disease Pathogenesis

Borràs, C., Mercer, A., Sirisi, S., Alcolea, D. A., Escolá‐Gil, J. C., Blanco‐Vaca, F., & Tondo, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23169356 · Cited by 41 · see citing works

PCSK9 affects astrocyte cholesterol metabolism and reduces neuron cholesterol supplying in vitro: potential implications in Alzheimer’s disease

Papotti, B., Adorni, M. P., Marchi, C., Zimetti, F., Ronda, N., Panighel, G., Lupo, M. G., Vilella, A., Giuliani, D., Ferri, N., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012192 · Cited by 41 · see citing works

Astrocytic microRNAs and transcription factors in Alzheimer’s disease and therapeutic interventions

Nassar, A., Kodi, T., Satarker, S., Chowdari Gurram, P., Upadhya, D., SM, F., Mudgal, J., & Nampoothiri, M. (2022) · Cells · doi:10.3390/cells11244111 · Cited by 36 · see citing works

White matter injury, cholesterol dysmetabolism, and APP/Abeta dysmetabolism interact to produce Alzheimer’s disease (AD) neuropathology: A hypothesis and review

Sharp, F. R., DeCarli, C. S., Jin, L., & Zhan, X. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1096206 · Cited by 30 · see citing works

ApoE3 vs. ApoE4 Astrocytes: A Detailed Analysis Provides New Insights into Differences in Cholesterol Homeostasis

Staurenghi, E., Leoni, V., Iacono, M. L., Sottero, B., Testa, G., Giannelli, S., Leonarduzzi, G., & Gamba, P. (2022) · Antioxidants · doi:10.3390/antiox11112168 · Cited by 22 · see citing works

Remodeling of astrocyte secretome in amyotrophic lateral sclerosis: uncovering novel targets to combat astrocyte-mediated toxicity

Ng, W., & Ng, S. (2022) · Translational Neurodegeneration · doi:10.1186/s40035-022-00332-y · Cited by 21 · see citing works

Moxibustion improves hypothalamus Aqp4 polarization in APP/PS1 mice: Evidence from spatial transcriptomics

Liu, S., Li, H., Shen, Y., Zhu, W., Wang, Y., Wang, J., Zhang, N., Li, C., Xie, L., & Wu, Q. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1069155 · Cited by 17 · see citing works

APOE Lipoprotein Particles: Pathophysiology, Therapy, and the Crosstalk in Alzheimer’s Disease and Cardiovascular Disease

Лю, Ч., Liu, J., Wang, Y., Xu, S.-F., & Yu, L.-M. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-05629-3 · Cited by 21 · see citing works

27-Hydroxycholesterol-Induced Dysregulation of Cholesterol Metabolism Impairs Learning and Memory Ability in ApoE ε4 Transgenic Mice

Wang, Y., Hao, L., Wang, T., Liu, W., Wang, L., Ju, M., Feng, W., & Xiao, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911639 · Cited by 15 · see citing works

Impact of Oxysterols in Age-Related Disorders and Strategies to Alleviate Adverse Effects

Ghosh, S., Ghzaiel, I., Véjux, A., Meaney, S., Nag, S., Lizard, G., Tripathi, G., Naez, F., & Paul, S. (2023) · Advances in experimental medicine and biology · doi:10.1007/978-3-031-43883-7_9 · Cited by 16 · see citing works

The Emerging Role of PCSK9 in the Pathogenesis of Alzheimer’s Disease: A Possible Target for the Disease Treatment

Testa, G., Giannelli, S., Staurenghi, E., Cecci, R., Floro, L., Gamba, P., Sottero, B., & Leonarduzzi, G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252413637 · Cited by 14 · see citing works

Satellite glial cells: Shaping peripheral input into the brain-body axis?

Meriau, P., Kuruvilla, R., & Cavalli, V. (2025) · Neuron · doi:10.1016/j.neuron.2025.05.031 · Cited by 13 · see citing works

Reexamining the Causes and Effects of Cholesterol Deposition in the Brains of Patients with Alzheimer’s Disease

Hu, Z., Yuan, Y.-Q., Tong, Z., Liao, M., Yuan, S., Jian, Y., Yang, J.-L., & Liu, W. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03529-y · Cited by 13 · see citing works

Isoform- and cell-state-specific APOE homeostasis and function

Lindner, K., & Gavin, A.-C. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01470 · Cited by 13 · see citing works

Effect and Mechanism of Rapamycin on Cognitive Deficits in Animal Models of Alzheimer’s Disease: A Systematic Review and Meta-analysis of Preclinical Studies

Cai, J., Xie, D., Kong, F., Zhai, Z., Zhu, Z., Zhao, Y., Xu, Y., & Sun, T. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231249 · Cited by 13 · see citing works

Low to moderate ethanol exposure reduces astrocyte-induced neuroinflammatory signaling and cognitive decline in presymptomatic APP/PS1 mice

Kang, S., Lee, J., Ali, D. N., Choi, S. H., Nesbitt, J. J., Min, H.-K. P., Trushina, E. V., & Choi, D. (2024) · Scientific Reports · doi:10.1038/s41598-024-75202-w · Cited by 15 · see citing works

Role of Scavenger Receptor B1 (SR-B1) in Improving Food Benefits for Human Health

Valacchi, G., & Pecorelli, A. (2025) · Annual Review of Food Science and Technology · doi:10.1146/annurev-food-111523-121935 · Cited by 11 · see citing works

Machine learning approaches for neurological disease prediction: A systematic review

Fatima, A., & Masood, S. (2024) · Expert Systems · doi:10.1111/exsy.13569 · Cited by 10 · see citing works

Modulation of cholesterol metabolism with Phytoremedies in Alzheimer’s disease: A comprehensive review

Koppula, S., Wankhede, N. L., Sammeta, S. S., Shende, P. V., Pawar, R. S., Chimthanawala, N. M. A., Umare, M. D., Taksande, B. G., Upaganlawar, A. B., Umekar, M. J., et al. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102389 · Cited by 10 · see citing works

Cholinergic neurodegeneration and cholesterol metabolism dysregulation by constitutive p75NTR signaling in the p75exonIII-KO mice

Baro, R. C., Benito-Martínez, A., Escribano-Saiz, J. J., Franco, M. L., Ceccarelli, L., Calatayud-Baselga, I., Mira, H., & Vilar, M. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1237458 · Cited by 10 · see citing works

Functional Specificity of Astrocyte Subtypes in Alzheimer’s Disease: Decoding Disease Mechanisms Through Network-based Analysis of Integrated Single-Nuclei Multi-Omic Data

İlgün, A., & Çakır, T. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04965-8 · Cited by 11 · see citing works

Anti-oxidative-initiated cognitive impairment amelioration in Alzheimer's disease model rats through preventive transcutaneous electrical acupoint stimulation

Weng, H., Wang, Q., Ye, R., Bai, Y., Yang, H., Xu, G., & Wang, Q. (2023) · Integrative Medicine Research · doi:10.1016/j.imr.2023.100946 · Cited by 9 · see citing works

The role of ATP‐binding cassette transporter G1 (ABCG1) in Alzheimer's disease: A review of the mechanisms

Yazdi, M. K., Alavi, M. S., & Roohbakhsh, A. (2024) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13981 · Cited by 9 · see citing works

The Regulation of Frontal Cortex Cholesterol Metabolism Abnormalities by NR3C1/NRIP1/NR1H2 Is Involved in the Occurrence of Stress-Induced Depression

Shi, R. H., Li, Y., Zhu, W., Xin, H., Yang, H., Feng, X., Wang, Z., Li, S., Cong, B., & Shi, W. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25158075 · Cited by 9 · see citing works

Epigenetic Regulation of Cholesterol and Oxysterol Homeostasis.

Feng, W., Yang, K., Ju, M., Wang, T., & Xiao, R. (2025) · Nutrition reviews · doi:10.1093/nutrit/nuaf082 · Cited by 8 · see citing works

Cholesterol alterations in fragile X syndrome, autism spectrum disorders and other neurodevelopmental disorders

Benachenhou, S., Laroui, A., Dionne, O., Rojas, D., Toupin, A., & Çaku, A. (2023) · International review of neurobiology · doi:10.1016/bs.irn.2023.08.011 · Cited by 8 · see citing works

Astrocyte response in Alzheimer’s disease: Good or bad?

Ismail, A., Al-Kuraishy, H. M., Al-Gareeb, A. I., Albuhadily, A. K., Yassen, A. S. A., Alexiou, A. T., Papadakis, M., & Batiha, G. E. (2025) · Brain Research · doi:10.1016/j.brainres.2025.149971 · Cited by 6 · see citing works

Effects of Phenols from Olive Vegetation Water on Mutagenicity and Genotoxicity of Stored-Cooked Beef Patties

Mercatante, D., Currò, S., Rosignoli, P., Cardenia, V., Sordini, B., Taticchi, A., Rodríguez‐Estrada, M. T., & Fabiani, R. (2024) · Antioxidants · doi:10.3390/antiox13060695 · Cited by 5 · see citing works

Acupuncture as a Complementary Therapy for Alzheimer’s Disease

Li, H., Xiang, Q., Ren, R., & Wang, G. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-231250 · Cited by 4 · see citing works

Moderate ethanol exposure reduces astrocyte-induced neuroinflammatorysignaling and cognitive decline in presymptomatic APP/PS1 micePreprint

Kang, S., Lee, J., Choi, S., Nesbitt, J. J., Min, P. H., Trushina, E., & Choi, D.-S. (2023) · Research Square · doi:10.21203/rs.3.rs-3627637/v1 · Cited by 2 · see citing works

Multiomic Evidence for a Unified Model of Alzheimer’s Disease Etiology Linking Microglial Flux Capacity and Astrocyte-Neuron Metabolic BreakdownPreprint

Paterson, T., Rohrs, J. A., Hohman, T. J., Mapstone, M. E., Meikle, P. J., Kaddurah‐Daouk, R., Levey, A. I., Hood, L., Initiative, A. D. N., & Funk, C. C. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.07.23.604835 · Cited by 3 · see citing works

Loganin Modulates Sigma‐1 Receptor to Alleviate Depression: Animal, Cellular, and Computational Evidence

Wang, M., Xia, C., Guo, Y., Zuo, G., Cheng, Y., Yang, H., Zhang, W., He, J., & Xu, J. (2025) · Phytotherapy Research · doi:10.1002/ptr.70141 · Cited by 3 · see citing works

Oxymatrine impedes Alzheimer’s progression via the attenuation of hypercholesterolemia and fibrosis

Das, A., Manna, R., Chowdhury, D., Sharma, D. P., & Bodakhe, S. H. (2025) · Metabolic Brain Disease · doi:10.1007/s11011-025-01606-w · Cited by 3 · see citing works

CK2 inhibition suppresses glial inflammation in models of neuroinflammation and neurodegeneration

Silva, I. I. N. D., Ramirez, D., Parylak, S., Wallace, L. A., Tucker, J. K., Erberich, J. M., Katariya, R., McDonald, A. H., Gallina, I. S., Tucker, A. L., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-71736-x · Cited by 2 · see citing works

The phytosterol 24(S)-saringosterol alters lipid homeostasis and inflammatory pathways in a cell-specific manner

Singh, M., Yu, J., Vanmierlo, T., Mulder, M. T., Paul, S. M., & Cashikar, A. G. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119506 · Cited by 1 · see citing works

CK2 inhibition suppresses glial inflammation in the brainPreprint

Silva, I. I. N. D., Ramirez, D., Parylak, S., Wallace, L. A., Tucker, J. K., Erberich, J. M., Katariya, R., McDonald, A. H., Gallina, I. S., Tucker, A. L., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.08.05.668554 · Cited by 1 · see citing works

The role of the α7 nicotinic acetylcholine receptor in a model of amyloid pathology

Santos, D. G. (2024) · theses.fr (ABES) · doi:10.70675/b3ed4de5zcd9ez4421za129z0a05130d86b9

Dynamic regional divergence of SV2A expression in a mouse model of primary tauopathy: A longitudinal multi-tracer PET study

Li, Y., Zatcepin, A., Palumbo, G., Oos, R., Wind-Mark, K., Lindner, S., Gildehaus, F., Gnörich, J. S., Werner, R. A., Brendel, M., et al. (2026) · NeuroImage · doi:10.1016/j.neuroimage.2026.121932

Deep interpretable learning of sample representations for characterizing disease states in single-cell transcriptomicsPreprint

Wagle, M. M., Wang, Y., Samanta, S., Liu, Z., Patrick, E., Yang, P., & Kellis, M. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.07.21.738207 · Cited by 1 · see citing works

Common metabolic, environmental, and molecular mechanisms underlying neurodevelopmental and neurodegenerative disorders

Vallés, A. S., & Barrantes, F. J. (2026) · Frontiers in Neurology · doi:10.3389/fneur.2026.1860052

Cholesterol Metabolism and Oxidative Stress in Alzheimer’s Disease

Iuliano, L., & Leoni, V. (2013) · Oxidative stress in applied basic research and clinical practice · doi:10.1007/978-1-62703-598-9_9

Oxysterols present in Alzheimer's disease brain induce synaptotoxicity by activating astrocytes: A major role for lipocalin-2

Staurenghi, E., Cerrato, V., Gamba, P., Testa, G., Giannelli, S., Leoni, V., Caccia, C., Buffo, A., Noble, W. J., Perez‐Nievas, B. G., et al. (2020) · Redox Biology · doi:10.1016/j.redox.2020.101837 · Cited by 63 · see citing works

Oxysterols Present in Alzheimer’s Disease Braininduce Synaptoxicity by Activating Astrocytes: A Major Role for Lipocalin-2Preprint

Staurenghi, E., Cerrato, V., Gamba, P., Testa, G., Giannelli, S., Leoni, V., Caccia, C., Buffo, A., Noble, W. J., Perez‐Nievas, B. G., et al. (2020) · doi:10.21203/rs.3.rs-52307/v1

The Role of Brain Cholesterol and its Oxidized Products in Alzheimer's Disease

Giudetti, A. M., Romano, A., Lavecchia, A. M., & Gaetani, S. (2015) · Current Alzheimer Research · doi:10.2174/1567205012666150921103426 · Cited by 41 · see citing works

Navigating the metabolic maze: anomalies in fatty acid and cholesterol processes in Alzheimer’s astrocytes

Zhang, X., Chen, C., & Liu, Y. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01430-x · Cited by 32 · see citing works