The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
A Distinct Subgroup of Small DRG Cells Express GDNF Receptor Components and GDNF Is Protective for These Neurons after Nerve Injury
Open accessAbstract
Several lines of evidence suggest that neurotrophin administration may be of some therapeutic benefit in the treatment of peripheral neuropathy. However, a third of sensory neurons do not express receptors for the neurotrophins. These neurons are of small diameter and can be identified by the binding of the lectin IB4 and the expression of the enzyme thiamine monophosphatase (TMP). Here we show that these neurons express the receptor components for glial-derived neurotrophic factor (GDNF) signaling (RET, GFRα-1, and GFRα-2). In lumbar dorsal root ganglia, virtually all IB4-labeled cells express RET mRNA, and the majority of these cells (79%) also express GFRα-1, GFRα-2, or GFRα-1 plus GFRα-2. GDNF, but not nerve growth factor (NGF), can prevent several axotomy-induced changes in these neurons, including the downregulation of IB4 binding, TMP activity, and somatostatin expression. GDNF also prevents the slowing of conduction velocity that normally occurs after axotomy in a population of small diameter DRG cells and the A-fiber sprouting into lamina II of the dorsal horn. GDNF therefore may be useful in the treatment of peripheral neuropathies and may protect peripheral neurons that are refractory to neurotrophin treatment.
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Neurturin, a relative of glial-cell-line-derived neurotrophic factor
Kotzbauer, P. T., Lampe, P. A., Heuckeroth, R. O., Golden, J. P., Creedon, D. J., Johnson Jr, E. M., & Milbrandt, J. (1996) · Nature · doi:10.1038/384467a0 · Cited by 710
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Self-citationFunctional regeneration of sensory axons into the adult spinal cord
Ramer, M. S., Priestley, J. V., & McMahon, S. B. (2000) · Nature · doi:10.1038/35002084 · Cited by 517
Self-citationMannion, R. J., Costigan, M., Decosterd, I., Amaya, F., Ma, Q.-P., Holstege, J. C., Ji, R.-R., Acheson, A., Lindsay, R. M., Wilkinson, G. A., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.16.9385 · Cited by 435
Widenfalk, J., Lundströmer, K., Jubran, M., Brené, S., & Olson, L. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-10-03457.2001 · Cited by 289
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Metadata
- Authors
- Bennett, D. L. H., Michael, G. J., Ramachandran, N., Munson, J. B., Averill, S., Yan, Q., McMahon, S. B., & Priestley, J. V.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1998-04-15
- Volume
- 18
- Issue
- 8
- Pages
- 3059-3072
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2145277005
- Cited by
- 627
- References
- 1
- FWCI
- 14.87
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Bennett, D. L. H., Michael, G. J., Ramachandran, N., Munson, J. B., Averill, S., Yan, Q., McMahon, S. B., & Priestley, J. V. (1998). A Distinct Subgroup of Small DRG Cells Express GDNF Receptor Components and GDNF Is Protective for These Neurons after Nerve Injury. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.18-08-03059.1998
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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