The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Reduced Striatal Dopamine Transporter Density in Abstinent Methamphetamine and Methcathinone Users: Evidence from Positron Emission Tomography Studies with [11C]WIN-35,428
Open accessAbstract
Methamphetamine and methcathinone are psychostimulant drugs with high potential for abuse. In animals, methamphetamine and related drugs are known to damage brain dopamine (DA) neurons, and this damage has recently been shown to be detectable in living nonhuman primates by means of positron emission tomography (PET) with [11C]WIN-35,428, a DA transporter (DAT) ligand. The present studies determined whether living humans with a history of methamphetamine or methcathinone abuse showed evidence of lasting decrements in brain DAT density. PET studies were performed in 10 control subjects, six abstinent methamphetamine users, four abstinent methcathinone users, and three patients with Parkinson's disease (PD). On average, subjects had abstained from amphetamine use for approximately 3 years. Before PET studies, all subjects underwent urine and blood toxicology screens to rule out recent drug use. Compared with controls, abstinent methamphetamine and methcathinone users had significant decreases in DAT density in the caudate nucleus (-23 and -24%, respectively) and putamen (-25 and -16%, respectively). Larger decreases in DAT density were evident in patients with PD (47 and 68% in caudate and putamen, respectively). Neither methamphetamine nor methcathinone users showed clinical signs of parkinsonism. Persistent reductions of DAT density in methamphetamine and methcathinone users are suggestive of loss of DAT or loss of DA terminals and raise the possibility that as these individuals age, they may be at increased risk for the development of parkinsonism or neuropsychiatric conditions in which brain DA neurons have been implicated.
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“Alternatively, studies in methamphetamine abusers show a consistent and long lasting decrease in the dopamine transporter, which is the main target of this drug (Chou et al., 2007; Johanson et al., 2006; McCann et al., 1998; McCann et al., 2008; Sekine et al., 2001; Volkow et al., 2001b).”
From Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity (2014) · cites this paper as McCann et al., 1998
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Cites
Uneven Pattern of Dopamine Loss in the Striatum of Patients with Idiopathic Parkinson's Disease
Kish, S. J., Shannak, K. S., & Hornykiewicz, O. (1988) · New England Journal of Medicine · doi:10.1056/nejm198804073181402 · Cited by 1,945 · cited 1×
“…reduction in [ 11 C]WIN-35,428 BP in the putamen compared with the caudate nucleus is in keeping with previous observations of greater DA terminal loss in the putamen than in the caudate of patients with PD (Kish et al., 1988; Tedroff et al., 1988; Kaufman and Madras, 1991; Frost et al., 1993).”
ResultDopamine (3-hydroxytyramine) and brain function.
Hornykiewicz, O. (1966) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)07154-6 · Cited by 1,389 · cited 2×
“…more severe, decreases in [ 11 C]W I N-35,428 binding are evident in the striata of patients with PD (Kaufman and Madras, 1991; Frost et al., 1993; Table 3), a neurodegenerative disorder in which nigrostriatal DA neuronal degeneration is well documented (Hornykiewicz, 1966; K ish et al., 1988).”
BackgroundStriatal dopamine nerve terminal markers in human, chronic methamphetamine users
Wilson, J. M., Kalasinsky, K. S., Levey, A. I., Bergeron, C., Reiber, G. D., Anthony, R. M., Schmunk, G. A., Shannak, K. S., Haycock, J. W., & Kish, S. J. (1996) · Nature Medicine · doi:10.1038/nm0696-699 · Cited by 718 · cited 2×
“…for detecting severe DA cell loss, such as in PD (Hornykiewicz, 1966; Tedroff et al., 1988; Wilson et al., 1996b), they appear to be less sensitive for detecting milder degrees of nigrostriatal DA injury, such as that in olivopontocerebellar atrophy (Zhong et al., 1995; Wilson et al., 1996b).”
BackgroundWagner, G. C., Ricaurte, G. A., Seiden, L. S., Schuster, C. R., Miller, R. J., & Westley, J. (1980) · Brain Research · doi:10.1016/0006-8993(80)91265-2 · Cited by 523 · cited 3×
“After administration of methamphetamine or methcathinone, animals develop long-lasting decreases in brain DA and 5-HT axonal markers, including the neurotransmitters themselves (i.e., DA and 5-HT), their rate-limiting synthetic enzymes (tyrosine hydroxylase and tryptophan hydroxylase), and their transporter sites (Sei…”
BackgroundRole for Excitatory Amino Acids in Methamphetamine-Induced Nigrostriatal Dopaminergic Toxicity
Sonsalla, P. K., Nicklas, W. J., & Heikkila, R. E. (1989) · Science · doi:10.1126/science.2563176 · Cited by 483 · cited 1×
“, two to four times at 2 hr intervals) (Sonsalla et al., 1989; Melega et al., 1993).”
BackgroundDopamine nerve terminal degeneration produced by high doses of methylamphetamine in the rat brain
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“, 1996; Hirata and Cadet, 1997) but not in rats (Ricaurte et al., 1982) or monkeys (Woolverton et al.”
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“…reduction in [ 11 C]WIN-35,428 BP in the putamen compared with the caudate nucleus is in keeping with previous observations of greater DA terminal loss in the putamen than in the caudate of patients with PD (Kish et al., 1988; Tedroff et al., 1988; Kaufman and Madras, 1991; Frost et al., 1993).”
BackgroundResultPresynaptic monoaminergic vesicles in Parkinson's disease and normal aging
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“Although agerelated reductions in the DAT are known to occur (Evans et al., 1991; Volkow et al., 1994; van Dyck et al., 1995; Frey et al., 1996), the reported age-related decreases are not of the degree observed in the present study nor do they occur from ages 30 to 37, the mean ages of…”
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Cited by
Sorted by citations
Dopamine in drug abuse and addiction: results from imaging studies and treatment implications
Volkow, N. D., Fowler, J. S., Wang, G.-J., & Swanson, J. M. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001507 · Cited by 1,101
Association of Dopamine Transporter Reduction With Psychomotor Impairment in Methamphetamine Abusers
Volkow, N. D., Chang, L. L., Wang, G., Fowler, J. S., Leonido–Yee, M., Franceschi, D., Sedler, M. J., Gatley, S. J., HITZEMANN, R. J., Ding, Y. ‐., et al. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.3.377 · Cited by 984
Volkow, N. D., Chang, L., Wang, G.-J., Fowler, J. S., Ding, Y.-S., Sedler, M., Logan, J., Franceschi, D., Gatley, J., Hitzemann, R., et al. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.12.2015 · Cited by 916
A review of the clinical pharmacology of methamphetamine
Cruickshank, C., & Dyer, K. R. (2009) · Addiction · doi:10.1111/j.1360-0443.2009.02564.x · Cited by 802
“Signs of PD are associated with striatal DAT deficits of 47% [131], but DAT deficits among recently abstinent methamphetamine users are typically 20–30% of normal levels [104,105,112,131].”
BackgroundStructural Abnormalities in the Brains of Human Subjects Who Use Methamphetamine
Thompson, P. M., Hayashi, K. M., Simon, S. L., Geaga, J. A., Hong, M., Sui, Y., Lee, J. Y., Toga, A. W., Ling, W. W., & London, E. D. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0713-04.2004 · Cited by 770
“Positron emission tomography (PET) has demonstrated that compared with corresponding measures in control subjects, MA abusers exhibit lower levels of dopamine transporters in the striatum (McCann et al., 1998; Sekine et al., 2001; Volkow et al., 2001) and prefrontal cortex (Sekine et al.”
Background
Metadata
- Authors
- McCann, U. D., Wong, D. F., Yokoi, F., Villemagne, V., Dannals, R. F., & Ricaurte, G. A.
- Affiliations
- National Institute of Mental Health (US)
- Johns Hopkins University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1998-10-15
- Volume
- 18
- Issue
- 20
- Pages
- 8417-8422
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6792853
- OpenAlex
- W2106287416
- Cited by
- 602
- References
- 46
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 8 · 2023: 12 · 2022: 10 · 2021: 19 · 2020: 11 · 2019: 12 · 2018: 14 · 2017: 16 · 2016: 16 · 2015: 27 · 2014: 32 · 2013: 38 · 2012: 34
- FWCI
- 8.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01da009482-05, 5r01da006275-03)
- National Institute of Mental Health
- National Institute on Drug Abuse (F32DA005707, DA05707, DA09482, DA-06275, R01DA005707)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- methamphetamine, methcathinone, amphetamine abuse, dopamine transporter density, striatum, caudate nucleus, putamen, dopamine neuron loss, Parkinson's disease, psychostimulants, neurotoxicity
- MeSH terms
- Adult, Central Nervous System Stimulants, Brain Chemistry, Carbon Radioisotopes, Carrier Proteins, Cocaine, Female, Humans, Male, Membrane Glycoproteins, Methamphetamine, Middle Aged, Nerve Tissue Proteins, Parkinson Disease, Secondary, Propiophenones, Tomography, Emission-Computed, Neostriatum, Dopamine Uptake Inhibitors, Amphetamine-Related Disorders, Membrane Transport Proteins, Dopamine Plasma Membrane Transport Proteins
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