The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.
Calcium Channel Types with Distinct Presynaptic Localization Couple Differentially to Transmitter Release in Single Calyx-Type Synapses
Open accessAbstract
We studied how Ca 2+influx through different subtypes of Ca 2+channels couples to release at a calyx-type terminal in the rat medial nucleus of the trapezoid body by simultaneously measuring the presynaptic Ca 2+influx evoked by a single action potential and the EPSC. Application of subtype-specific toxins showed that Ca 2+channels of the P/Q-, N-, and R-type controlled glutamate release at a single terminal. The Ca 2+influx through the P/Q-type channels triggered release more effectively than Ca 2+influx through N- or R-type channels. We investigated mechanisms that contributed to these differences in effectiveness. Electrophysiological experiments suggested that individual release sites were controlled by all three subtypes of Ca 2+channels. Immunocytochemical staining indicated, however, that a substantial fraction of N- and R-type channels was located distant from release sites. Although these distant channels contributed to the Ca 2+influx into the terminal, they may not contribute to release. Taken together, the results suggest that the Ca 2+influx into the calyx via N- and R-type channels triggers release less effectively than that via P/Q-type because a substantial fraction of the N- and R-type channels in the calyx is localized distant from release sites.
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Cites
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Cited by
Calcium Channel Regulation and Presynaptic Plasticity
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Self-citationRIM proteins tether Ca2+ channels to presynaptic active zones via a direct PDZ-domain interaction
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Metadata
- Authors
- Wu, L.-G., Westenbroek, R. E., Borst, J. G. G., Catterall, W. A., & Sakmann, B.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1999-01-15
- Volume
- 19
- Issue
- 2
- Pages
- 726-736
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2158561409
- Cited by
- 428
- References
- 45
- FWCI
- 8.81
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Wu, L.-G., Westenbroek, R. E., Borst, J. G. G., Catterall, W. A., & Sakmann, B. (1999). Calcium Channel Types with Distinct Presynaptic Localization Couple Differentially to Transmitter Release in Single Calyx-Type Synapses. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.19-02-00726.1999
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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