Integrin Subunit Gene Expression Is Regionally Differentiated in Adult Brain
Open accessAbstract
Integrins are a diverse family of heterodimeric (αβ) adhesion receptors recently shown to be concentrated within synapses and involved in the consolidation of long-term potentiation. Whether neuronal types or anatomical systems in the adult rat brain are coded by integrin type was studied in the present experiments by mapping the relative densities of mRNAs for nine α and four β subunits. Expression patterns were markedly different and in some regions complementary. General results and areas of notable labeling were as follows: α1—limited neuronal expression, neocortical layer V, hippocampal CA3; α3 and α5—diffuse neuronal and glial labeling, Purkinje cells, hippocampal stratum pyramidale, locus coeruleus (α3); α4— discrete limbic regions, olfactory cortical layer II, hippocampal CA2; α6—most prominently neuronal, neocortical subplate, endopiriform, subiculum; α7—discrete, all neocortical layers, hippocampal granule cells and CA3, cerebellar granule and Purkinje cells, all efferent cranial nerve nuclei; α8—discrete neuronal, deep cortex, hippocampal CA1, basolateral amygdala, striatum; αV—all cortical layers, striatum, Purkinje cells; β4—dentate gyrus granule cells; β5—broadly distributed, neocortex, medial amygdala, cerebellar granule and Purkinje cells, efferent cranial nerve nuclei; α2, β2, and β3—mRNAs not detected. These results establish that brain subfields express different balances of integrin subunits and thus different integrin receptors. Such variations will determine which matrix proteins are recognized by neurons and the types of intraneuronal signaling generated by matrix binding. They also could generate important differences in synaptic plasticity across brain systems.
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β1 integrins are the predominant integrin subunit in the central nervous system.
“β1 integrins are the predominant integrin subunit in the central nervous system.”
From The Serine/Threonine Kinase <scp>NDR2</scp> Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus (2025) · cites this paper as Pinkstaff et al. 1999
The Discussion (page unavailable) says that all α subunits studied can associate with β1, supporting a broad role for β1-containing integrins in adult brain. It does not establish that β1 is the predominant integrin subunit by abundance across the central nervous system. (LLM, conf=0.78)
Experimental — accuracy not yet measuredβ1 integrins are developmentally upregulated.
“They are developmentally upegulated (Pinkstaff et al. 1999; Ikeshima‐Kataoka et al. 2022; Milner and Campbell 2002)”
From The Serine/Threonine Kinase <scp>NDR2</scp> Regulates Integrin Signaling, Synapse Formation, and Synaptic Plasticity in the Hippocampus (2025) · cites this paper as Pinkstaff et al. 1999
The Discussion reports β1 integrin expression in adult brain, but does not compare expression across developmental stages. Searches for developmental upregulation and postnatal changes found no passage establishing that β1 integrins increase during development; page numbers were unavailable in our copy. (LLM, conf=0.72)
Experimental — accuracy not yet measured
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- Authors
- Pinkstaff, J. K., Detterich, J., Lynch, G., & Gall, C.
- Affiliations
- University of California, Irvine (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1999-03-01
- Volume
- 19
- Issue
- 5
- Pages
- 1541-1556
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6782158
- OpenAlex
- W2107012136
- Cited by
- 250
- References
- 2
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 5 · 2023: 1 · 2022: 6 · 2021: 4 · 2019: 2 · 2018: 4 · 2017: 3 · 2016: 10 · 2015: 3 · 2014: 7 · 2013: 14 · 2012: 12
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01ns026748-10)
- National Institute of Neurological Disorders and Stroke (NS-26748, NS 37799, R01NS037799)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- integrin subunits, alpha-integrin, beta-integrin, neocortex, hippocampus, cerebellum, Purkinje cells, locus coeruleus, amygdala, striatum, synapses, extracellular matrix binding, synaptic plasticity, long-term potentiation
- MeSH terms
- Animals, Autoradiography, Brain, Male, Organ Specificity, RNA, Messenger, Tissue Distribution, Gene Expression, Integrins, Rats, Sprague-Dawley, In Situ Hybridization, Rats
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