Extracellular matrix and matrix receptors in blood–brain barrier formation and stroke

Baeten, Kim M.; Akassoglou, Katerina

doi:10.1002/dneu.20954

Cited by 398Barrier Structure and Function StudiesCell Adhesion Molecules ResearchCellular Mechanics and Interactions

Extracellular matrix and matrix receptors in blood–brain barrier formation and stroke

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Baeten, Kim M., Akassoglou, Katerina·2011·Developmental Neurobiology

DOI 10.1002/dneu.20954PMC PMC3482610

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Abstract

The blood–brain barrier (BBB) is formed primarily to protect the brain microenvironment from the influx of plasma components, which may disturb neuronal functions. The BBB is a functional unit that consists mainly of specialized endothelial cells (ECs) lining the cerebral blood vessels, astrocytes, and pericytes. The BBB is a dynamic structure that is altered in neurologic diseases, such as stroke. ECs and astrocytes secrete extracellular matrix (ECM) proteins to generate and maintain the basement membranes (BMs). ECM receptors, such as integrins and dystroglycan, are also expressed at the brain microvasculature and mediate the connections between cellular and matrix components in physiology and disease. ECM proteins and receptors elicit diverse molecular signals that allow cell adaptation to environmental changes and regulate growth and cell motility. The composition of the ECM is altered upon BBB disruption and directly affects the progression of neurologic disease. The purpose of this review is to discuss the dynamic changes of ECM composition and integrin receptor expression that control BBB functions in physiology and pathology. © 2011 Wiley Periodicals, Inc. Develop Neurobiol 71: 1018‐1039, 2011

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Integrins mediate cell signaling by activating extracellular matrix ligands, growth factors, and growth factor receptors, regulating endothelial cell survival, migration, differentiation, adhesion, and polarity.
“Integrins mediate cell signaling by activating ECM ligands, growth factors, and growth factor receptors, which regulates multiple endothelial cell functions including survival, migration, differentiation, adhesion, and polarity (35).”
From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [35]
In “Matrix Receptors of the BBB” (page unavailable), the paper says integrins signal upon binding ECM ligands, activating latent growth factors, and transactivating growth factor receptors. It links integrins to survival, migration, differentiation, and aspects of endothelial adhesion, but does not say integrins activate ECM ligands or regulate endothelial polarity; its “Endothelial cells” section instead attributes polarization to tight junctions. (LLM, conf=0.87)
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Authors: Baeten, K. M., & Akassoglou, K.
Affiliations: University of California, San Francisco (US)
Corresponding author: Akassoglou, Katerina
ORCID: Baeten, Kim M.
Akassoglou, Katerina
Venue: Developmental Neurobiology
Publisher: Wiley
Published: 2011-10-11
Volume: 71
Issue: 11
Pages: 1018-1039
ISSN: 1932-8451 (ISSN-L)
1932-846X
DOI: 10.1002/dneu.20954
PMC: PMC3482610
OpenAlex: W2067935721
Cited by: 397
References: 232
Citations by year: 2026: 8 · 2025: 27 · 2024: 32 · 2023: 48 · 2022: 38 · 2021: 44 · 2020: 39 · 2019: 32 · 2018: 38 · 2017: 22 · 2016: 20 · 2015: 11 · 2014: 14 · 2013: 13 · 2012: 7
FWCI: 1.07
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Developmental Neurobiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Neurological Disorders and Stroke (R01NS066361, R01NS052189, R01NS051470)
National Center for Research Resources (P41RR004050)
Topics: Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Keywords: blood-brain barrier, extracellular matrix, integrins, dystroglycan, basement membrane, endothelial cells, astrocytes, pericytes, stroke, blood-brain barrier disruption, ECM receptors, cell motility, neurovascular unit
MeSH terms: Animals, Blood-Brain Barrier, Brain, Humans, Microcirculation, Receptors, Cell Surface, Extracellular Matrix Proteins, Stroke

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Extracellular matrix and matrix receptors in blood–brain barrier formation and stroke

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