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Inducible Genetic Suppression of Neuronal Excitability
Open accessAbstract
Graded, reversible suppression of neuronal excitability represents a logical goal of therapy for epilepsy and intractable pain. To achieve such suppression, we have developed the means to transfer “electrical silencing” genes into neurons with sensitive control of transgene expression. An ecdysone-inducible promoter drives the expression of inwardly rectifying potassium channels in polycistronic adenoviral vectors. Infection of superior cervical ganglion neurons did not affect normal electrical activity but suppressed excitability after the induction of gene expression. These experiments demonstrate the feasibility of controlled ion channel expression after somatic gene transfer into neurons and serve as the prototype for a novel generalizable approach to modulate excitability.
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Citations
Cited by
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Lima, S. Q., & Miesenböck, G. (2005) · Cell · doi:10.1016/j.cell.2005.02.004 · Cited by 562
Burrone, J., O'Byrne, M., & Murthy, V. N. (2002) · Nature · doi:10.1038/nature01242 · Cited by 487
Neural activity and the dynamics of central nervous system development
Hua, J. Y., & Smith, S. J. (2004) · Nature Neuroscience · doi:10.1038/nn1218 · Cited by 450
Automated monitoring and analysis of social behavior in Drosophila
Dankert, H., Wang, L., Hoopfer, E. D., Anderson, D. J., & Perona, P. (2009) · Nature Methods · doi:10.1038/nmeth.1310 · Cited by 382
ON and OFF pathways in Drosophila motion vision
Joesch, M., Schnell, B., Raghu, S. V., Reiff, D. F., & Borst, A. (2010) · Nature · doi:10.1038/nature09545 · Cited by 352
Metadata
- Authors
- Johns, D. C., Marx, R., Mains, R. E., O’Rourke, B., & Marbán, E.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1999-03-01
- Volume
- 19
- Issue
- 5
- Pages
- 1691-1697
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1562764236
- Cited by
- 264
- References
- 0
- FWCI
- 11.65
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Johns, D. C., Marx, R., Mains, R. E., O’Rourke, B., & Marbán, E. (1999). Inducible Genetic Suppression of Neuronal Excitability. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.19-05-01691.1999
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