The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Reorganization and Movement of Microtubules in Axonal Growth Cones and Developing Interstitial Branches
Open accessAbstract
Local changes in microtubule organization and distribution are required for the axon to grow and navigate appropriately; however, little is known about how microtubules (MTs) reorganize during directed axon outgrowth. We have used time-lapse digital imaging of developing cortical neurons microinjected with fluorescently labeled tubulin to follow the movements of individual MTs in two regions of the axon where directed growth occurs: the terminal growth cone and the developing interstitial branch. In both regions, transitions from quiescent to growth states were accompanied by reorganization of MTs from looped or bundled arrays to dispersed arrays and fragmentation of long MTs into short MTs. We also found that long-term redistribution of MTs accompanied the withdrawal of some axonal processes and the growth and stabilization of others. Individual MTs moved independently in both anterograde and retrograde directions to explore developing processes. Their velocities were inversely proportional to their lengths. Our results demonstrate directly that MTs move within axonal growth cones and developing interstitial branches. Our findings also provide the first direct evidence that similar reorganization and movement of individual MTs occur in the two regions of the axon where directed outgrowth occurs. These results suggest a model whereby short exploratory MTs could direct axonal growth cones and interstitial branches toward appropriate locations.
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Cites
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Cited by
Microtubule assembly, organization and dynamics in axons and dendrites
Conde, C., & Cáceres, A. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2631 · Cited by 1,086
Cytoskeletal Dynamics and Transport in Growth Cone Motility and Axon Guidance
Dent, E. W., & Gertler, F. B. (2003) · Neuron · doi:10.1016/s0896-6273(03)00633-0 · Cited by 893
Self-citationStepanova, T., Slemmer, J., Hoogenraad, C. C., Lansbergen, G., Dortland, B., De Zeeuw, C. I., Grosveld, F., van Cappellen, G., Akhmanova, A., & Galjart, N. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-07-02655.2003 · Cited by 698
Activity-Dependent Dynamic Microtubule Invasion of Dendritic Spines
Hu, X., Viesselmann, C., Nam, S., Merriam, E., & Dent, E. W. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3074-08.2008 · Cited by 290
Self-citationTodd, P. K., Mack, K. J., & Malter, J. S. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2336265100 · Cited by 280
Metadata
- Authors
- Dent, E. W., Callaway, J. L., Szebenyi, G., Baas, P. W., & Kalil, K.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 1999-10-15
- Volume
- 19
- Issue
- 20
- Pages
- 8894-8908
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2107673711
- Cited by
- 264
- References
- 66
- FWCI
- 4.47
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Dent, E. W., Callaway, J. L., Szebenyi, G., Baas, P. W., & Kalil, K. (1999). Reorganization and Movement of Microtubules in Axonal Growth Cones and Developing Interstitial Branches. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.19-20-08894.1999
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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