The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
Cyclooxygenase-2 Contributes to Functional Hyperemia in Whisker-Barrel Cortex
Open accessAbstract
The prostanoid-synthesizing enzyme cyclooxygenase-2 (COX-2) is expressed in selected cerebral cortical neurons and is involved in synaptic signaling. We sought to determine whether COX-2 participates in the increase in cerebral blood flow produced by synaptic activity in the somatosensory cortex. In anesthetized mice, the vibrissae were stimulated mechanically, and cerebral blood flow was recorded in the contralateral somatosensory cortex by a laser–Doppler probe. We found that the COX-2 inhibitor NS-398 attenuates the increase in somatosensory cortex blood flow produced by vibrissal stimulation. Furthermore, the flow response was impaired in mice lacking the COX-2 gene, whereas the associated increase in whisker-barrel cortex glucose use was not affected. The increases in cerebral blood flow produced by hypercapnia, acetylcholine, or bradykinin were not attenuated by NS-398, nor did they differ between wild-type and COX-2 null mice. The findings provide evidence for a previously unrecognized role of COX-2 in the mechanisms coupling synaptic activity to neocortical blood flow and provide an insight into one of the functions of constitutive COX-2 in the CNS.
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Cyclooxygenase in biology and disease
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Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse
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Self-citationCerebral Blood Flow and Metabolism
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Behind the scenes of functional brain imaging: A historical and physiological perspective
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The Neurovascular Unit Coming of Age: A Journey through Neurovascular Coupling in Health and Disease
Iadecola, C. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.030 · Cited by 2,480
Self-citationNeurovascular regulation in the normal brain and in Alzheimer's disease
Iadecola, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1387 · Cited by 2,213
Self-citationNeuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation
Zonta, M., Angulo, M. C., Gobbo, S., Rosengarten, B., Hossmann, K.-A., Pozzan, T., & Carmignoto, G. (2003) · Nature Neuroscience · doi:10.1038/nn980 · Cited by 1,455
Neuroinflammation: friend and foe for ischemic stroke
Jayaraj, R. L., Azimullah, S., Beiram, R., Jalal, F. Y., & Rosenberg, G. A. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1516-2 · Cited by 1,428
Metadata
- Authors
- Niwa, K., Araki, E., Morham, S. G., Ross, M. E., & Iadecola, C.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2000-01-15
- Volume
- 20
- Issue
- 2
- Pages
- 763-770
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2114516724
- Cited by
- 261
- References
- 53
- FWCI
- 10.53
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Niwa, K., Araki, E., Morham, S. G., Ross, M. E., & Iadecola, C. (2000). Cyclooxygenase-2 Contributes to Functional Hyperemia in Whisker-Barrel Cortex. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.20-02-00763.2000
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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