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Impact of Self-Administered Cocaine and Cocaine Cues on Extracellular Dopamine in Mesolimbic and Sensorimotor Striatum in Rhesus Monkeys
Open accessAbstract
Studies were conducted to determine the impact of self-administered cocaine on extracellular striatal dopamine in four rhesus monkeys. The extent to which external cue conditioning contributed to the effects of cocaine and whether there is activation of striatal dopaminergic neurotransmission during drug-seeking behavior was also examined. Microdialysis measurements were made at 2 min intervals in sensorimotor (dorsolateral) and mesolimbic (central and ventromedial) striatum. A fixed-ratio schedule of reinforcement was used, with cocaine availability signaled by a visual cue. Studies examined the effects of cocaine or cocaine cues against a drug-free baseline. Large (fivefold to eightfold) increases in extracellular dopamine after a self-administered infusion of 0.5 mg/kg cocaine were quite rapid and matched the time course of reported subjective effects in human laboratory studies. To determine if conditioning to external cues contributed to the cocaine-induced increases, saline was substituted for cocaine in the infusion, leaving all other visual and auditory stimuli unchanged. No increase in extracellular dopamine in either sensorimotor or mesolimbic striatal subdivisions was observed. Extracellular dopamine during extended periods of drug-seeking behavior triggered by a visual cue was determined in both central and ventromedial striatum. This procedure also did not result in any measurable changes in extracellular dopamine. These studies demonstrate rapid and pronounced pharmacological actions of self-administered cocaine. No apparent conditioned component of those actions was associated with external environmental cues, suggesting that cues that trigger drug-seeking behavior in nonhuman primates do not cause conditioned increases in mesolimbic striatal dopamine.
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“Animal evidence suggests that the ability to increase dopamine in ventral striatum, involved with reward circuitry, is a common pharmacological effect underlying the reinforcing properties of virtually all drugs of abuse (Di Chiara and Imperato, 1988; Bradberry et al., 2000).”
From A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment (2013) · cites this paper as Bradberry et al., 2000
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Cites
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564
A psychomotor stimulant theory of addiction.
Wise, R. A., & Bozarth, M. A. (1987) · Psychological Review · doi:10.1037/0033-295x.94.4.469 · Cited by 2,747
Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine
Ritz, M. C., Lamb, R. J., Goldberg, S. R., & Kuhar, M. J. (1987) · Science · doi:10.1126/science.2820058 · Cited by 2,180
Relative reward preference in primate orbitofrontal cortex
Tremblay, L., & Schultz, W. (1999) · Nature · doi:10.1038/19525 · Cited by 1,314
Schultz, W., Apicella, P., & Ljungberg, T. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-03-00900.1993 · Cited by 1,291
Acute effects of cocaine on human brain activity and emotion
Breiter, H. C., Gollub, R. L., Weisskoff, R. M., Kennedy, D. N., Makris, N., Berke, J. D., Goodman, J. M., Kantor, H. L., Gastfriend, D. R., Riorden, J. P., et al. (1997) · Neuron · doi:10.1016/s0896-6273(00)80374-8 · Cited by 1,270
Stewart, J., de Wit, H., & Eikelboom, R. (1984) · Psychological Review · doi:10.1037/0033-295x.91.2.251 · Cited by 1,261
Fallon, J. H., & Moore, R. Y. (1978) · The Journal of Comparative Neurology · doi:10.1002/cne.901800310 · Cited by 1,190
Longitudinal topography and interdigitation of corticostriatal projections in the rhesus monkey
Selemon, L. D., & Goldman-Rakic, P. S. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-03-00776.1985 · Cited by 1,074
The Rhesus Monkey Brain in Stereotaxic Coordinates
Paxinos, G., Huang, X., & Toga, A. W. (1999) · Research Online (University of Wollongong) · Cited by 1,070
Research works printed but not linked: 2
- Erb, 1998, Effect of clonidine on stress- and drug-induced relapse to heroin and cocaine seeking., Soc Neurosci Abstr, 24, 498
- 10.1037//1064-1297.3.3.219 · DOI
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Hurd, Y. L., & Hall, H. (2005) · Handbook of chemical neuroanatomy · doi:10.1016/s0924-8196(05)80013-2 · Cited by 14
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Jenkins, B. G., Chen, Y. I., & Mandeville, J. B. (2002) · Frontiers in neuroscience · doi:10.1201/9781420042153.ch6 · Cited by 13
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Howell, L. L., Wilcox, K. M., Lindsey, K. P., & Kimmel, H. L. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300828 · Cited by 12
Bradberry, C. W. (2010) · Neurotoxicity Research · doi:10.1007/s12640-010-9156-4 · Cited by 12
Self-citationLi, Y., Partridge, J. G., Berger, C., Sepulveda‐Rodriguez, A., Vicini, S., & Conant, K. E. (2015) · European Journal of Neuroscience · doi:10.1111/ejn.13146 · Cited by 11
Chiuccariello, L., Boileau, I., Guranda, M., Rusjan, P., Wilson, A. A., Zawertailo, L. A., Houle, S., Busto, U. E., & Foll, B. L. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060382 · Cited by 12
Effects of sensitization on the detection of an instrumental contingency
Phillips, G. D., & Vugler, A. (2011) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2011.07.009 · Cited by 10
Li, Y., Chen, X., Dzakpasu, R., & Conant, K. E. (2016) · Journal of Neurochemistry · doi:10.1111/jnc.13915 · Cited by 9
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Baeg, E., Jedema, H. P., & Bradberry, C. W. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0499-0 · Cited by 10
Self-citationNeural Basis of Pleasure and Reward
Knapp, C. M., & Kornetsky, C. H. (2009) · Wiley eBooks · doi:10.1002/9780470478509.neubb002040 · Cited by 9
Mass spectrometry-based neurochemical analysis: perspectives for primate research
Zhang, X., Rauch, A., Xiao, H., Rainer, G., & Logothetis, N. K. (2008) · Expert Review of Proteomics · doi:10.1586/14789450.5.5.641 · Cited by 8
Cortes, J. A., Gomez, G. A. G., Ehnerd, C., Gurnsey, K., Nicolazzo, J., Bradberry, C. W., & Jedema, H. P. (2016) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2016.04.014 · Cited by 8
Self-citationChapter VI Dopamine, motivation and reward
Chiara, G. D. (2005) · Handbook of chemical neuroanatomy · doi:10.1016/s0924-8196(05)80010-7 · Cited by 7
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Porrino, L. J., Huston-Lyons, D., Letchworth, S. R., Freedland, C. S., & Nader, M. A. (2002) · Humana Press eBooks · doi:10.1007/978-1-59259-165-7_16 · Cited by 5
Mayer, S., Saxena, P., Crayen, M. A., & Treue, S. (2025) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2025.110361 · Cited by 4
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de Moura, F. B., Kohut, S. J., & Bergman, J. (2019) · Advances in pharmacology · doi:10.1016/bs.apha.2019.04.005 · Cited by 2
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Huertas, A., Wessinger, W. D., Kucheryavykh, Y. V., Sanabria, P., Eaton, M. J., Skatchkov, S. N., Rojas, L. V., Maldonado-Martínez, G., & Inyushin, M. Y. (2014) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2014.11.021 · Cited by 3
Brain fMRI in Clinical Pharmacological Studies
Beckman, N. (2006) · CRC Press eBooks · doi:10.3109/9781420004526-16 · Cited by 2
Nonhuman Primate Self-Administration in Assessments of Abuse Potential
Czoty, P. W., Banks, M. L., Nader, M. A., & France, C. P. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420172-9.00004-7 · Cited by 1
Cocaine effects on striatal dynorphin and CART neuropeptides : Association to mood disorder
Fagergren, P. (2003) · Figshare · Cited by 1
Ikegami, A. (2003) · Texas ScholarWorks (Texas Digital Library) · Cited by 1
Brain fMRI in clinical pharmacological studies
Tracey, I., Schweinhardt, P., & Bountra, C. (2006) · Cited by 1
Bradberry, C. W. (2010) · Springer eBooks · doi:10.1007/978-1-4614-0785-0_25 · Cited by 1
Self-citationWilloughby, B. M. (2007) · D-Scholarship@Pitt (University of Pittsburgh)
Chapter 5.2 The use of microdialysis in neuropsychiatric disease models
O'Connor, W. T. (2006) · Handbook of behavioral neuroscience · doi:10.1016/s1569-7339(06)16022-1
Shu, Z. (2014) · D-Scholarship@Pitt (University of Pittsburgh)
The Neural Basis of Drug Stimulus Processing and Craving: An Activation Likelihood Estimation
Chase, M.-A. W., Eickhoff, S. B., Laird, A. R., & Hogarth, L. (2011)
Garcia, K. L. P. (2016) · TSpace (University of Toronto)
The Role of Dopamine in Cue-induced Craving: A [11C]-(+)-PHNO PET Study in Tobacco-dependent Smokers
Chiuccariello, L. (2010) · TSpace (University of Toronto)
Early Life Adversity, Traits and Opioid Addiction
Zumbusch, A. S. (2018) · Libraries and Cultural Resources (University of Calgary) · doi:10.11575/prism/32817
Briand, L. A. (2007) · Deep Blue (University of Michigan)
Bradberry, C. W. (2013) · Springer eBooks · doi:10.1007/978-1-4614-7264-3_30
Self-citationIncreased Response Variability and Attentional Lapses After Chronic Cocaine Self-Administration
Olsen, A. S. (2009) · D-Scholarship@Pitt (University of Pittsburgh)
Metadata
- Authors
- Bradberry, C. W., Barrett-Larimore, R. L., Jatlow, P., & Rubino, S. R.
- Affiliations
- Yale University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2000-05-15
- Volume
- 20
- Issue
- 10
- Pages
- 3874-3883
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6772692
- OpenAlex
- W1888424353
- Cited by
- 137
- References
- 66
- Citations by year
- 2025: 1 · 2021: 1 · 2019: 4 · 2018: 1 · 2016: 3 · 2015: 6 · 2014: 3 · 2013: 7 · 2012: 6
- FWCI
- 4.77
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Yale University
- National Institutes of Health (5p50da004060-13, 5r29da008073-02)
- National Institute on Drug Abuse (DA 10331, R01DA010331, DA04060, DA 08073)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- cocaine self-administration, extracellular dopamine, sensorimotor striatum, cocaine cues, drug-seeking behavior, fixed-ratio schedules, rhesus monkeys, microdialysis, dopamine signaling
- MeSH terms
- Animals, Behavior, Animal, Cocaine, Conditioning, Psychological, Corpus Striatum, Dopamine, Extracellular Space, Macaca mulatta, Magnetic Resonance Imaging, Male, Nucleus Accumbens, Self Administration, Microdialysis, Dopamine Uptake Inhibitors, Cocaine-Related Disorders
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