The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Differential Modulation of Proliferation in the Neocortical Ventricular and Subventricular Zones
Open accessAbstract
Recent studies have implicated the classical neurotransmitters GABA and glutamate in the regulation of neural progenitor proliferation. We now show that GABA and glutamate have opposite effects on the two neural progenitor populations in the ventricular zones (VZs) and subventricular zones (SVZs) of the embryonic cerebrum. Application of either molecule to organotypic slice cultures dramatically increases proliferation in the VZ by shortening the cell cycle, whereas proliferation in the SVZ is decreased. These disparate effects, measured both by bromodeoxyuridine uptake and the expansion of retrovirally labeled progenitor clones, are mimicked by the application of specific GABA and glutamate agonists and are blocked by antagonists. Thus, the relative contributions of the VZ and SVZ to neocortical growth may be regulated by differential responsiveness to GABA and glutamate.
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Cites
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GABA and glutamate depolarize cortical progenitor cells and inhibit DNA synthesis
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Cited by
GABA: A Pioneer Transmitter That Excites Immature Neurons and Generates Primitive Oscillations
Ben-Ari, Y., Gaiarsa, J.-L., Tyzio, R., & Khazipov, R. (2007) · Physiological Reviews · doi:10.1152/physrev.00017.2006 · Cited by 1,304
Is there more to gaba than synaptic inhibition?
Owens, D. F., & Kriegstein, A. R. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn919 · Cited by 1,156
Wichterle, H., Turnbull, D. H., Nery, S., Fishell, G., & Alvarez-Buylla, A. (2001) · Development · doi:10.1242/dev.128.19.3759 · Cited by 722
Cell-cycle control and cortical development
Dehay, C., & Kennedy, H. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2097 · Cited by 655
Weissman, T. A., Riquelme, P. A., Ivic, L., Flint, A. C., & Kriegstein, A. R. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.015 · Cited by 578
Metadata
- Authors
- Haydar, T. F., Wang, F., Schwartz, M. L., & Rakic, P.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2000-08-01
- Volume
- 20
- Issue
- 15
- Pages
- 5764-5774
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2095802030
- Cited by
- 419
- References
- 56
- FWCI
- 4.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Haydar, T. F., Wang, F., Schwartz, M. L., & Rakic, P. (2000). Differential Modulation of Proliferation in the Neocortical Ventricular and Subventricular Zones. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.20-15-05764.2000
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
