The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Glutamate Transmission in the Nucleus Accumbens Mediates Relapse in Cocaine Addiction
Open accessAbstract
Elevated dopamine transmission in the nucleus accumbens is thought to be a primary mediator of addiction to cocaine. However, repeated exposure to cocaine is associated with the recruitment of glutamate transmission. This poses the possibility that the behaviors characterizing cocaine addiction, such as craving-induced relapse, may not be preferentially mediated by dopamine transmission. An animal model of relapse was used to demonstrate that glutamate, and not dopamine transmission in the nucleus accumbens, is a primary mediator of cocaine-induced reinstatement of drug-seeking behavior. Reinstatement was produced by a systemic injection of cocaine or by the microinjection of the glutamate receptor agonist AMPA or dopamine into the nucleus accumbens. It was found that microinjection of an AMPA receptor antagonist into the nucleus accumbens blocked reinstatement by all compounds, whereas a dopamine receptor antagonist was effective only in blocking reinstatement by intra-accumbens dopamine administration. These data suggest an important role for nucleus accumbens glutamate and not dopamine transmission in cocaine-induced relapse to drug-seeking behavior.
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Citations
Cites
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“In addition to dopaminergic innervation from the ventral tegmental area (Swanson, 1982), the nucleus accumbens receives dense glutamatergic inputs from the prefrontal cortex, hippocampus, periventricular thalamus, and amygdala (Kelley et al., 1982; Phillipson and Griffiths, 1985; Groenewegen et…”
BackgroundActivation of memory circuits during cue-elicited cocaine craving.
Grant, S., London, E. D., Newlin, D. B., Villemagne, V. L., Liu, X., Contoreggi, C., Phillips, R. L., Kimes, A. S., & Margolin, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.12040 · Cited by 936
Associative processes in addiction and reward. The role of amygdala-ventral striatal subsystems
EVERITT, B. J., PARKINSON, J. A., OLMSTEAD, M. C., ARROYO, M., ROBLEDO, P., & ROBBINS, T. W. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09280.x · Cited by 708 · cited 1×
“…an emerging literature that dopaminergic afferents to the amygdala modulate the reinstatement of cocaine-seeking behavior (Tran-Nguyen et al., 1998; Everitt et al., 1999) and that the systemic administration of a dopamine receptor antagonist has been shown to inhibit cocaine-seeking…”
BackgroundOpposite Modulation of Cocaine-Seeking Behavior by D 1 - and D 2 -Like Dopamine Receptor Agonists
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Rewarding Actions of Phencyclidine and Related Drugs in Nucleus Accumbens Shell and Frontal Cortex
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Cited by
Dopamine, learning and motivation.
Wise, R. A. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1406 · Cited by 3,379
The Neural Basis of Addiction: A Pathology of Motivation and Choice
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Self-citationThe reinstatement model of drug relapse: history, methodology and major findings
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Synaptic plasticity and addiction
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The glutamate homeostasis hypothesis of addiction
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Metadata
- Authors
- Cornish, J. L., & Kalivas, P. W.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2000-08-01
- Volume
- 20
- Issue
- 15
- Pages
- RC89-RC89
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2112824246
- Cited by
- 545
- References
- 7
- FWCI
- 9.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Glutamate Transmission in the Nucleus Accumbens Mediates Relapse in Cocaine Addiction. https://app.cochat.ai/papers/10.1523/jneurosci.20-15-j0006.2000
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- Cornish, J. L., & Kalivas, P. W. (2000). Glutamate Transmission in the Nucleus Accumbens Mediates Relapse in Cocaine Addiction. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.20-15-j0006.2000
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
