Activation of memory circuits during cue-elicited cocaine craving.

Grant, S; London, E D; Newlin, D B; Villemagne, V L; Liu, X; Contoreggi, C; Phillips, R L; Kimes, A S; Margolin, A

doi:10.1073/pnas.93.21.12040

Cited by 936Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesSubstance Abuse Treatment and Outcomes

Activation of memory circuits during cue-elicited cocaine craving.

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Grant, S, London, E D, Newlin, D B, Villemagne, V L, Liu, X, Contoreggi, C, Phillips, R L, Kimes, A S +1 more·1996·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.93.21.12040PMC PMC38179

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Abstract

Evidence accumulated over more than 45 years has indicated that environmental stimuli can induce craving for drugs of abuse in individuals who have addictive disorders. However, the brain mechanisms that subserve such craving have not been elucidated. Here a positron emission tomographic study shows increased glucose metabolism in cortical and limbic regions implicated in several forms of memory when human volunteers who abuse cocaine are exposed to drug-related stimuli. Correlations of metabolic increases in the dorsolateral prefrontal cortex, medial temporal lobe (amygdala), and cerebellum with self-reports of craving suggest that a distributed neural network, which integrates emotional and cognitive aspects of memory, links environmental cues with cocaine craving.

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Authors: Grant, S., London, E. D., Newlin, D. B., Villemagne, V. L., Liu, X., Contoreggi, C., Phillips, R. L., Kimes, A. S., & Margolin, A.
Affiliations: National Institute on Drug Abuse (US)
ORCID: London, E D
Villemagne, V L
Phillips, R L
Kimes, A S
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1996-10-15
Volume: 93
Issue: 21
Pages: 12040-12045
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.93.21.12040
PMC: PMC38179
OpenAlex: W2022235619
Cited by: 936
References: 38
Citations by year: 2026: 4 · 2025: 5 · 2024: 16 · 2023: 18 · 2022: 9 · 2021: 18 · 2020: 17 · 2019: 19 · 2018: 27 · 2017: 30 · 2016: 28 · 2015: 35 · 2014: 30 · 2013: 54 · 2012: 27
FWCI: 6.48
Type: journal article
Language: en
Open access: green
europepmc.org
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Keywords: cocaine craving, drug-related cues, memory circuits, cocaine dependence, glucose metabolism, dorsolateral prefrontal cortex, amygdala, medial temporal lobe, cerebellum, emotional memory, cognitive memory, cue reactivity, artificial neural networks
MeSH terms: Adult, Analysis of Variance, Brain, Cocaine, Deoxyglucose, Female, Fluorine Radioisotopes, Glucose, Humans, Functional Laterality, Male, Memory, Opioid-Related Disorders, Tomography, Emission-Computed, Fluorodeoxyglucose F18, Substance-Related Disorders

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Activation of memory circuits during cue-elicited cocaine craving.

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