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Cholinergic Modulation of Excitatory Synaptic Transmission in the CA3 Area of the Hippocampus
Open accessAbstract
Cholinergic innervation of the hippocampus has been implicated in memory formation and retrieval. Here we study cholinergic modulation of excitatory transmission in the CA3 area of the rat hippocampus. We used a combination of optical measurements of presynaptic calcium and electrophysiological measurements of synaptic currents to study associational–commissural (A/C) and mossy fiber (MF) synapses in brain slices. Direct synaptic modulation mediated by ACh receptors is only evident at the A/C synapse, where synaptic inhibition primarily reflects presynaptic calcium channel inhibition mediated by muscarinic receptors. MF synapses can, however, be indirectly modulated by muscarinic receptor activation. Muscarine elevates the firing rate of inhibitory cells, which increases GABA release and inhibits MF synapses by activating presynaptic GABA B receptors. Muscarine also depolarizes dentate granule cells and elevates their rate of firing. This leads to synaptic enhancement when combined with the use-dependent facilitation of MF synapses. In addition we were unable to evoke an increase in presynaptic calcium levels in MF boutons with local application of nicotinic receptor agonists. This finding does not support a leading hypothesis for MF modulation in which activation of presynaptic nicotinic receptors enhances transmission directly by elevating presynaptic calcium levels. However, indirect synaptic modulation could arise from nicotinic excitation of inhibitory neurons. Thus, to understand cholinergic modulation within the CA3 region, it is necessary to take into account secondary actions on synapses arising from other chemical messengers released by other cell types and to consider effects on firing patterns of presynaptic cells, which in turn influence release via use-dependent synaptic plasticity.
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“Several neuromodulators, such as acetylcholine [97], dopamine [98], and noradrenaline [54] have been reported to affect mossy fiber synaptic transmission.”
From Presynaptic cAMP-PKA-mediated potentiation induces reconfiguration of synaptic vesicle pools and channel-vesicle coupling at hippocampal mossy fiber boutons (2024) · cites this paper as [97]
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Cites
A new generation of Ca2+ indicators with greatly improved fluorescence properties.
Grynkiewicz, G., Poenie, M., & Tsien, R. Y. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83641-4 · Cited by 21,562
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023
The cholinergic hypothesis of geriatric memory dysfunction
Bartus, R. T., Dean, R. L., Beer, B., & Lippa, A. S. (1982) · Science · doi:10.1126/science.7046051 · Cited by 5,545
Alzheimer's Disease: A Disorder of Cortical Cholinergic Innervation
Coyle, J. T., Price, D. L., & DeLong, M. R. (1983) · Science · doi:10.1126/science.6338589 · Cited by 3,052
The three-dimensional organization of the hippocampal formation: A review of anatomical data
Amaral, D. G., & Witter, M. P. (1989) · Neuroscience · doi:10.1016/0306-4522(89)90424-7 · Cited by 2,180
Séguéla, P., Wadiche, J. I., Dineley‐Miller, K., Dani, J., & Jw, P. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-02-00596.1993 · Cited by 1,471
Hulme, E. C., Birdsall, N. J. M., & Buckley, N. J. (1990) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.30.040190.003221 · Cited by 1,366
Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors
McGehee, D. S., Heath, M. J. S., Gelber, S., Devay, P., & Role, L. W. (1995) · Science · doi:10.1126/science.7569895 · Cited by 1,070
Hippocampal synaptic transmission enhanced by low concentrations of nicotine
Gray, R. G. F., Rajan, A. S., Radcliffe, K. A., Yakehiro, M., & Dani, J. A. (1996) · Nature · doi:10.1038/383713a0 · Cited by 947
Spatial selectivity of unit activity in the hippocampal granular layer
Jung, M. W., & McNaughton, B. L. (1993) · Hippocampus · doi:10.1002/hipo.450030209 · Cited by 789
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Chu, Y. (2014) · Digital Access to Scholarship at Harvard (DASH) (Harvard University)
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Roshan‐Milani, S., Saboory, E., & Cobb, S. (2009) · Iranian journal of basic medical sciences. · doi:10.22038/ijbms.2009.5185
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Zemankovics, R., & Szentágothai, J. (2011) · Semmelweis University Repository (Semmelweis University) · doi:10.14753/se.2012.1696
Thirugnanasambandam, N. (2011) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-3251
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Eom, K., Lee, H., Hyun, J. H., Ryu, H.-H., Lee, Y., Lee, I., Ho, W., & Lee, S. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.07.21.213538
Grosmark, A., Milstein, A. D., Losonczy, A., & Soltész, I. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780190065324.003.0007
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Dobryakova, Y. V., Bolshakov, A. P., Rozov, A. V., & Markevich, V. A. (2025) · Neurochemical Journal · doi:10.1134/s1819712425700011
Malézieux, M. (2018) · theses.fr (ABES) · doi:10.70675/a57fb9f7z01b7z450bza4ccz168a5b84253c
BindingDB (2021) · UC San Diego · doi:10.7270/q29s1vc0
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Metadata
- Authors
- Vogt, K. E., & Regehr, W. G.
- Affiliations
- Harvard University (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2001-01-01
- Volume
- 21
- Issue
- 1
- Pages
- 75-83
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6762445
- OpenAlex
- W2125706064
- Cited by
- 149
- References
- 49
- Citations by year
- 2025: 4 · 2024: 5 · 2023: 5 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 2 · 2018: 6 · 2017: 4 · 2016: 2 · 2015: 4 · 2014: 6 · 2013: 5 · 2012: 10
- FWCI
- 4.56
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- National Institutes of Health
- U.S. Public Health Service (P01-N538312)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nicotinic Acetylcholine Receptors Study
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- cholinergic modulation, excitatory synaptic transmission, hippocampal CA3, muscarinic receptors, nicotinic acetylcholine receptors, mossy fiber synapses, presynaptic calcium, GABAergic inhibition, GABAB receptors, dentate gyrus granule cells, synaptic plasticity, acetylcholine
- MeSH terms
- Animals, Calcium, Cholinergic Fibers, Fluorescent Dyes, Hippocampus, Muscarine, Synaptic Transmission, Nicotine, Synapses, Fura-2, Rats, Sprague-Dawley, Pyramidal Cells, Receptors, Metabotropic Glutamate, Patch-Clamp Techniques, Cholinergic Agonists, Glutamic Acid, Nicotinic Agonists, Mossy Fibers, Hippocampal, Excitatory Postsynaptic Potentials, Rats, GABA-B Receptor Agonists, GABA-A Receptor Antagonists, GABA-B Receptor Antagonists, In Vitro Techniques
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