Basolateral amygdala-nucleus accumbens interactions in mediating glucocorticoid enhancement of memory consolidation
Open accessAbstract
Systemic or intracerebral administration of glucocorticoids enhances memory consolidation in several tasks. Previously, we reported that these effects depend on an intact basolateral nucleus of the amygdala (BLA) and efferents from the BLA that run through the stria terminalis (ST). The BLA projects directly to the nucleus accumbens (NAc) via this ST pathway. The NAc also receives direct projections from the hippocampus and, therefore, may be a site of convergence of BLA and hippocampal influences in modulating memory consolidation. In support of this view, we found previously that lesions of either the NAc or the ST also block the memory-modulatory effect of systemically administered glucocorticoids. The present experiments examined the effects of lesions of the NAc or the ST on the memory-modulatory effects of intracerebral glucocorticoids on inhibitory avoidance training. Microinfusions of the specific glucocorticoid receptor agonist 11beta,17beta-dihydroxy-6,21-dimethyl-17alpha-pregna-4,6-trien-20yn-3-one (RU 28362; 1.0 or 3.0 ng) into either the BLA or the hippocampus of male Sprague Dawley rats administered immediately after training enhanced the 48 hr retention performance in a dose-dependent manner. Bilateral lesions of the NAc or the ST alone did not affect retention performance but blocked the memory enhancement induced by intra-BLA or intrahippocampal glucocorticoid receptor agonist administration. These findings indicate that the BLA-NAc pathway plays an essential role in mediating glucocorticoid effects on memory consolidation and suggest that the BLA interacts with hippocampal effects on memory consolidation via this pathway.
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The findings add support to the idea that memory enhancement requires coactivation of arousal and stress systems.
“our results provide further evidence that the arousal and stress systems must be coactivated for memory enhancement to occur (Roozendaal et al. 2001(Roozendaal et al. , 2006)).”
From Stress administered prior to encoding impairs neutral but enhances emotional long-term episodic memories. (2007) · cites this paper as Roozendaal et al. 2001
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References 82 · Cited by 128
- Authors
- Roozendaal, B., de Quervain, D. J.-F., Ferry, B., Setlow, B., & McGaugh, J. L.
- Affiliations
- University of California, Irvine (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2001-04-01
- Volume
- 21
- Issue
- 7
- Pages
- 2518-2525
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6762383
- OpenAlex
- W2169990926
- Cited by
- 128
- References
- 82
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 2 · 2023: 1 · 2022: 7 · 2021: 3 · 2019: 1 · 2018: 2 · 2017: 5 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 6 · 2012: 5
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- U.S. Public Health Service
- National Institute of Mental Health (R01MH012526, MH12526, R56MH012526)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
- Keywords
- glucocorticoids, memory consolidation, basolateral amygdala, nucleus accumbens, stria terminalis, hippocampus, glucocorticoid receptor agonists, RU 28362, passive avoidance, memory enhancement, brain lesions
- MeSH terms
- Amygdala, Animals, Avoidance Learning, Glucocorticoids, Hippocampus, Male, Memory, Nucleus Accumbens, Rats
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