The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Role of IL-1α and IL-1β in Ischemic Brain Damage
Open accessAbstract
The cytokine interleukin-1 (IL-1) has been strongly implicated in the pathogenesis of ischemic brain damage. Evidence to date suggests that the major form of IL-1 contributing to ischemic injury is IL-1beta rather than IL-1alpha, but this has not been tested directly. The objective of the present study was to compare the effects of transient cerebral ischemia [30 min middle cerebral artery occlusion (MCAO)] on neuronal injury in wild-type (WT) mice and in IL-1alpha, IL-1beta, or both IL-1alpha and IL-1beta knock-out (KO) mice. Mice lacking both forms of IL-1 exhibited dramatically reduced ischemic infarct volumes compared with wild type (total volume, 70%; cortex, 87% reduction). Ischemic damage compared with WT mice was not significantly altered in mice lacking either IL-1alpha or IL-1beta alone. IL-1beta mRNA, but not IL-1alpha or the IL-1 type 1 receptor, was strongly induced by MCAO in WT and IL-1alpha KO mice. Administration (intracerebroventricularly) of recombinant IL-1 receptor antagonist significantly reduced infarct volume in WT (-32%) and IL-1alpha KO (-48%) mice, but had no effect on injury in IL-1beta or IL-1alpha/beta KO mice. These data confirm that IL-1 plays a major role in ischemic brain injury. They also show that chronic deletion of IL-1alpha or IL-1beta fails to influence brain damage, probably because of compensatory changes in the IL-1 system in IL-1alpha KO mice and changes in IL-1-independent mediators of neuronal death in IL-1beta KO mice.
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Cites
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Cytokines and acute neurodegeneration
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Self-citationInterleukin-1 and neuronal injury
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Self-citationSignaling pathways involved in ischemic stroke: molecular mechanisms and therapeutic interventions
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Metadata
- Authors
- Boutin, H., LeFeuvre, R. A., Horai, R., Asano, M., Iwakura, Y., & Rothwell, N. J.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2001-08-01
- Volume
- 21
- Issue
- 15
- Pages
- 5528-5534
- ISSN
- 0270-6474
- 1529-2401
- OpenAlex
- W2139112966
- Cited by
- 477
- References
- 38
- FWCI
- 11.60
- Type
- journal article
- Language
- en
- Open access
- green
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- Boutin, H., LeFeuvre, R. A., Horai, R., Asano, M., Iwakura, Y., & Rothwell, N. J. (2001). Role of IL-1α and IL-1β in Ischemic Brain Damage. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.21-15-05528.2001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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