The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
The Meissner Corpuscle Revised: A Multiafferented Mechanoreceptor with Nociceptor Immunochemical Properties
Open accessAbstract
Meissner corpuscles (MCs) in the glabrous skin of monkey digits have at least three types of innervation as revealed by immunofluorescence. The previously well known Aalphabeta-fiber terminals are closely intertwined with endings from peptidergic C-fibers. These intertwined endings are segregated into zones that alternate with zones containing a third type of ending supplied by nonpeptidergic C-fibers. Although MCs are widely regarded as low-threshold mechanoreceptors, all three types of innervation express immunochemical properties associated with nociception. The peptidergic C-fiber endings have readily detectable levels of immunoreactivity (IR) for calcitonin gene-related peptide (CGRP) and substance P (SP). The Aalphabeta endings have relatively lower levels of IR for CGRP and SP as well as the SP neurokinin 1 receptor and vanilloid-like receptor 1. Both the Aalphabeta and peptidergic C-fiber endings were also labeled with antibodies for different combinations of adrenergic, opioid, and purinergic receptors. The nonpeptidergic C-fiber endings express IR for vanilloid receptor 1, which has also been implicated in nociception. Thus, MCs are multiafferented receptor organs that may have nociceptive capabilities in addition to being low-threshold mechanoreceptors.
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Citations
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Johansson, R. S. (1978) · The Journal of Physiology · doi:10.1113/jphysiol.1978.sp012411 · Cited by 430 · cited 2×
“The glabrous skin of mammals is supplied by many primary afferents that have rapidly adapting responses within sharply defined receptive fields (Lindblom, 1965; Talbot et al., 1968; Knibestöl and Vallbo, 1970; Pubols et al., 1971; Johansson, 1978; Turnbull and Rasmusson, 1986; Proske et al., 1998).”
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Self-citationQuantification of myelinated endings and mechanoreceptors in human digital skin
Nolano, M., Provitera, V., Crisci, C., Stancanelli, A., Wendelschafer‐Crabb, G., Kennedy, W. R., & Santoro, L. (2003) · Annals of Neurology · doi:10.1002/ana.10615 · Cited by 201
Metadata
- Authors
- Paré, M., Elde, R., Mazurkiewicz, J. E., Smith, A. M., & Rice, F. L.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2001-09-15
- Volume
- 21
- Issue
- 18
- Pages
- 7236-7246
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1949260838
- Cited by
- 181
- References
- 1
- FWCI
- 4.61
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Paré, M., Elde, R., Mazurkiewicz, J. E., Smith, A. M., & Rice, F. L. (2001). The Meissner Corpuscle Revised: A Multiafferented Mechanoreceptor with Nociceptor Immunochemical Properties. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.21-18-07236.2001
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