Cited by 822Pain Management and Placebo EffectPain Mechanisms and TreatmentsMemory and Neural Mechanisms

The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.

Exacerbation of Pain by Anxiety Is Associated with Activity in a Hippocampal Network

Open access

Ploghaus, Alexander, Narain, Charvy, Beckmann, Christian F., Clare, Stuart, Bantick, Susanna, Wise, Richard, Matthews, Paul M., Rawlins, J. Nicholas P., Tracey, Irene·2001·The Journal of Neuroscience

DOI 10.1523/jneurosci.21-24-09896.2001PMC PMC6763058

Open this paper in CoChat — free account Open PDF

Abstract

It is common clinical experience that anxiety about pain can exacerbate the pain sensation. Using event-related functional magnetic resonance imaging (FMRI), we compared activation responses to noxious thermal stimulation while perceived pain intensity was manipulated by changes in either physical intensity or induced anxiety. One visual signal, which reliably predicted noxious stimulation of moderate intensity, came to evoke low anxiety about the impending pain. Another visual signal was followed by the same, moderate-intensity stimulation on most of the trials, but occasionally by discriminably stronger noxious stimuli, and came to evoke higher anxiety. We found that the entorhinal cortex of the hippocampal formation responded differentially to identical noxious stimuli, dependent on whether the perceived pain intensity was enhanced by pain-relevant anxiety. During this emotional pain modulation, entorhinal responses predicted activity in closely connected, affective (perigenual cingulate), and intensity coding (mid-insula) areas. Our finding suggests that accurate preparatory information during medical and dental procedures alleviates pain by disengaging the hippocampus. It supports the proposal that during anxiety, the hippocampal formation amplifies aversive events to prime behavioral responses that are adaptive to the worst possible outcome.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1523/jneurosci.21-24-09896.2001

Cites

102 of 102 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688
A global optimisation method for robust affine registration of brain images
Jenkinson, M., & Smith, S. M. (2001) · Medical Image Analysis · doi:10.1016/s1361-8415(01)00036-6 · Cited by 7,018
Cognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259
Contributions of anterior cingulate cortex to behaviour
Devinsky, O., Morrell, M. J., & Vogt, B. A. (1995) · Brain · doi:10.1093/brain/118.1.279 · Cited by 3,377
Temporal Autocorrelation in Univariate Linear Modeling of FMRI Data
Woolrich, M. W., Ripley, B. D., Brady, M., & Smith, S. M. (2001) · NeuroImage · doi:10.1006/nimg.2001.0931 · Cited by 2,859
Pain Affect Encoded in Human Anterior Cingulate But Not Somatosensory Cortex
Rainville, P., Duncan, G. H., Price, D. D., Carrier, B., & Bushnell, M. C. (1997) · Science · doi:10.1126/science.277.5328.968 · Cited by 2,629
Functional imaging of brain responses to pain. A review and meta-analysis (2000)
Peyron, R., Laurent, B., & García-Larrea, L. (2000) · Neurophysiologie Clinique/Clinical Neurophysiology · doi:10.1016/s0987-7053(00)00227-6 · Cited by 2,171
Psychological and neural mechanisms of the affective dimension of pain
Price, D. D. (2000) · Science · doi:10.1126/science.288.5472.1769 · Cited by 2,092

Show all 99 references

Research works printed but not linked: 1

10.1002/1098-1063(2000)10:4<398::AID-HIPO6>3.0.CO;2-K · DOI

Sorted by citations

Items 501–600 of 821

Involvement of the endocannabinoid system in attentional modulation of nociceptive behaviour in rats
Ford, G. K., Moriarty, O., Okine, B. N., TULLY, E. R., Mulcahy, A., Harhen, B., & Finn, D. P. (2014) · European Journal of Pain · doi:10.1002/ejp.646 · Cited by 14
Imagerie fonctionnelle cérébrale appliquée à l’analyse des phénomènes douloureux
Peyron, R., & Faillenot, I. (2011) · médecine/sciences · doi:10.1051/medsci/201127182 · Cited by 15
Pain Perception Associated with Mini‐Implants and Interventions for Pain Management: A Cross‐Sectional Questionnaire‐Based Survey
Sreenivasagan, S., Subramanian, A. K., Selvaraj, A., & Marya, A. (2021) · BioMed Research International · doi:10.1155/2021/4842865 · Cited by 14
Cerebral responses to innocuous somatic pressure stimulation following aerobic exercise rehabilitation in chronic pain patients: a functional magnetic resonance imaging study
Micalos, P. S., Korgaonkar, M. S., Drinkwater, E. J., Cannon, J., & Marino, F. E. (2014) · International Journal of General Medicine · doi:10.2147/ijgm.s55169 · Cited by 14
Untersuchungen zur zerebralen Verarbeitung von Schmerzen mit funktioneller Bildgebung
Valet, M., Sprenger, T., & Tölle, T. R. (2010) · Der Schmerz · doi:10.1007/s00482-010-0896-0 · Cited by 15
Intra-hippocampal tonic inhibition influences formalin pain-induced pyramidal cell suppression, but not excitation in dorsal field CA1 of rat
Zheng, F., & Khanna, S. (2008) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2008.09.004 · Cited by 14
Recent advances and future prospects in neuroimaging of acute and chronic pain
Davis, K. D. (2006) · Future Neurology · doi:10.2217/14796708.1.2.203 · Cited by 14
Participation of the GABA/benzodiazepine receptor and the NO-cyclicGMP pathway in the “antinociceptive-like effects” of diazepam
Jiménez-Velázquez, G., López‐Muñoz, F. J., & Fernández‐Guasti, A. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.06.021 · Cited by 14
Neuropathie Pain-Definition and Implications for Research and Therapy
Backonja, M. M., & Argoff, C. E. (2005) · Journal of Neuropathic Pain & Symptom Palliation · doi:10.1300/j426v01n02_03 · Cited by 14
Integration of prior expectations and suppression of prediction errors during expectancy-induced pain modulation: the influence of anxiety and pleasantness
Tsai, H.-Y., Lapanan, K., Lin, Y., Huang, C., Lin, W., Lin, M., Lu, Z., Lin, F.-S., & Tseng, M. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.1627-23.2024 · Cited by 14
Headache and Treatment of Unruptured Intracranial Aneurysms
Arena, J., Hawkes, M. A., Farez, M., Pertierra, L., Köhler, A., Marrodán, M., Benito, D. C., Goicochea, M. T., Miranda, J. C., & Ameriso, S. F. (2017) · Journal of Stroke and Cerebrovascular Diseases · doi:10.1016/j.jstrokecerebrovasdis.2016.12.026 · Cited by 13
Preparing for the Worst: Evidence that Older Adults Proactively Downregulate Negative Affect
Corbett, B., Rajah, M. N., & Duarte, A. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhz166 · Cited by 13
Time-Frequency Intracranial Source Localization of Feedback-Related EEG Activity in Hypothesis Testing
Papo, D., Douiri, A., Bouchet, F., Bourzeix, J.-C., Caverni, J.-P., & Baudonnière, P.-M. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl042 · Cited by 12
Neurological Evidence of a Mind-Body Connection: Mindfulness and Pain Control
Marie, R. S., & Talebkhah, K. S. (2018) · American Journal of Psychiatry Residents Journal · doi:10.1176/appi.ajp-rj.2018.130401 · Cited by 13
A narrative review of the literature on illness uncertainty in hypermobile ehlers-danlos syndrome: implications for research and clinical practice
Feldman, E. C. H., Homan, K. J., Williams, S. E., Ting, T. V., Goldschneider, K. R., & Kashikar‐Zuck, S. (2023) · Pediatric Rheumatology · doi:10.1186/s12969-023-00908-6 · Cited by 15
Mechanical pain sensitivity is associated with hippocampal structural integrity
Ayoub, L. J., Honigman, L., Barnett, A. J., McAndrews, M. P., & Moayedi, M. (2024) · Pain · doi:10.1097/j.pain.0000000000003221 · Cited by 12
The effect of weighted blankets on sleep and related disorders: a brief review
Yu, J., Yang, Z., Sun, S., Sun, K., Chen, W., Zhang, L., Xu, J., Xu, Q., Liu, Z., Ke, J., et al. (2024) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2024.1333015 · Cited by 21
Functional characterization of nociceptive mechanisms involved in fibromyalgia and electroacupuncture
Lottering, B. J., & Lin, Y. (2021) · Brain Research · doi:10.1016/j.brainres.2020.147260 · Cited by 12
Regional cerebral blood flow as predictor of response to occipital nerve block in cluster headache
Medina, S., Bakar, N. A., O’Daly, O., Miller, S., Makovac, E., Renton, T. F., Williams, S., Matharu, M. S., & Howard, M. A. (2021) · The Journal of Headache and Pain · doi:10.1186/s10194-021-01304-9 · Cited by 12
Sex-specific associations between grey matter volume and phobic symptoms in dental phobia
Wabnegger, A., Scharmüller, W., & Schienle, A. (2014) · Neuroscience Letters · doi:10.1016/j.neulet.2014.07.054 · Cited by 12
The Asymmetrical Contributions of Pleasure and Pain to Subjective Well-Being
Shriver, A. (2014) · Review of Philosophy and Psychology · doi:10.1007/s13164-013-0171-2 · Cited by 12
Pain anticipatory phenomena in patients with central poststroke pain: a magnetoencephalography study
Gopalakrishnan, R., Burgess, R. C., Lempka, S. F., Gale, J. T., Floden, D. P., & Machado, A. G. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00215.2016 · Cited by 12
Evidence for pain attenuation by the motor system-based judgment of agency
Karsh‬‏, ‪., Goldstein, O. C., & Eitam, B. (2017) · Consciousness and Cognition · doi:10.1016/j.concog.2017.11.012 · Cited by 13
Abnormalities in pain sensitivity among individuals with autism spectrum disorder: Evidence from meta-analysis
Zhang, W., Li, X., Yao, J., Ye, Q., & Peng, W. (2021) · Acta Psychologica Sinica · doi:10.3724/sp.j.1041.2021.00613 · Cited by 12
Dyspnea, Relative Youth and Low Daily Doses of Opioids Predict Increased Opioid Dosage in the Last Week of a Terminal Cancer Patient's Life
Miura, T., Matsumoto, Y., Motonaga, S., Hasuo, H., Abe, K., & Kinoshita, H. (2014) · Japanese Journal of Clinical Oncology · doi:10.1093/jjco/hyu137 · Cited by 12
Sex dimorphism in a mediatory role of the posterior midcingulate cortex in the association between anxiety and pain sensitivity
Kisler, L. B., Granovsky, Y., Sinai, A., Sprecher, E., Shamay‐Tsoory, S., & Weissman‐Fogel, I. (2016) · Experimental Brain Research · doi:10.1007/s00221-016-4710-9 · Cited by 11
A role of cognitive and emotional factors in formation of pain
Koberskaya, N. N., & Tabeeva, G. R. (2021) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro2021121111111 · Cited by 11
Mapping the associations of daily pain, sleep, and psychological distress in a U.S. sample
Anderson, A. R., & Holliday, D. (2023) · Journal of Behavioral Medicine · doi:10.1007/s10865-023-00432-8 · Cited by 11
Effect of High-Definition Transcranial Direct Current Stimulation on Headache Severity and Central µ-Opioid Receptor Availability in Episodic Migraine
DaSilva, A. F., Kim, D. J., Lim, M., Nascimento, T., Scott, P. J. H., Smith, Y., Koeppe, R., Zubieta, J., & Kaciroti, N. (2023) · Journal of Pain Research · doi:10.2147/jpr.s407738 · Cited by 12
Is implicit memory associated with the hippocampus?
Steinkrauss, A. C., & Slotnick, S. D. (2024) · Cognitive Neuroscience · doi:10.1080/17588928.2024.2315816 · Cited by 14
Somatic burden and perceived cognitive problems in trauma‐exposed adults with posttraumatic stress symptoms or pain
Bartel, A., Jordan, J. T., Correll, D., Devane, A., & Samuelson, K. W. (2019) · Journal of Clinical Psychology · doi:10.1002/jclp.22855 · Cited by 12
Placebo and nocebo effects in the neurological practice
Bittar, C., & Nascimento, O. J. M. (2015) · Arquivos de Neuro-Psiquiatria · doi:10.1590/0004-282x20140180 · Cited by 12
Evaluation of anxiolytic effects of aripiprazole and hydroxyzine as a combination in mice
Kale, P. P., Sawantdesai, N., & Savai, J. (2016) · Journal of Basic and Clinical Pharmacy · doi:10.4103/0976-0105.189429 · Cited by 11
The impact of preoperative pain-related psychological factors on pain intensity post-surgery in Jordan
Khalil, H., Shajrawi, A. M., Al-Dweik, G. A., Zaghmouri, A. A., & Henker, R. (2020) · Journal of Health Psychology · doi:10.1177/1359105320937067 · Cited by 11
Impaired pain processing in Parkinson's disease and its relative association with the sense of smell
Hara, T., Hirayama, M., Mizutani, Y., Hama, T., Hori, N., Nakamura, T., Kato, S., Watanabe, H., & Sobue, G. (2012) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2012.06.020 · Cited by 11
Topological Alterations of the Intrinsic Brain Network in Patients with Functional Dyspepsia
Nan, J., Zhang, L., Zhu, F., Tian, X., Zheng, Q., von Deneen, K. M., Liu, J., & Zhang, M. (2015) · Journal of Neurogastroenterology and Motility · doi:10.5056/jnm15118 · Cited by 11
Exploring women’s sensory experiences of undergoing colposcopy and related procedures: implications for preparatory sensory information provision
O’Connor, M., Waller, J., Gallagher, P., Martin, C. M., JO’Leary, J., D’Arcy, T., Prendiville, W. J., Flannelly, G., & Sharp, L. (2016) · Journal of Psychosomatic Obstetrics & Gynecology · doi:10.1080/0167482x.2016.1197905 · Cited by 11
Investigation of health care workers’ stress, depression and anxiety levels in terms of work-related violence
Biçkes, D. M., Çİ̇ZMECİ̇, B., GÖVER, İ. H., & Pomak, İ. (2017) · Journal of Human Sciences · doi:10.14687/jhs.v14i3.4495 · Cited by 11
A novel rat model of extremity trauma for prehospital pain management research
Xiang, L., Klemcke, H. G., Wienandt, N., Ryan, K. L., & Hinojosa‐Laborde, C. (2018) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000001833 · Cited by 11
Chapter 7 The role of secondary somatosensory cortex and insula in pain
Mauguı̀ere, F. (2004) · Supplements to Clinical neurophysiology · doi:10.1016/s1567-424x(09)70343-5 · Cited by 11
Predictive Factors for Anxiety during Blood Sampling and Insertion of Peripheral Intravenous Catheters in Paediatric Patients in Spain
Ferraz‐Torres, M., Escalada‐Hernández, P., Martín‐Rodríguez, L. S., Delarosa, R., Saenz, R., & Soto‐Ruiz, N. (2021) · Journal of Pediatric Nursing · doi:10.1016/j.pedn.2021.04.009 · Cited by 10
Topographically selective motor inhibition under threat of pain
Betti, S., Badioli, M., Dalbagno, D., Garofalo, S., di Pellegrino, G., & Starita, F. (2024) · Pain · doi:10.1097/j.pain.0000000000003301 · Cited by 10
The influence of expectations and attention on conditioned pain modulation: A systematic review and meta-analysis
Billens, A., Oosterwijck, S. V., Dhondt, E., Meeus, M., Greef, I. D., Damme, S. V., & Oosterwijck, J. V. (2024) · Clinical Psychology Review · doi:10.1016/j.cpr.2024.102517 · Cited by 10
Increased sensitivity to supra-threshold painful stimuli in patients with multiple functional somatic symptoms (MFS)
Kuzminskyte, R., Kupers, R. C., Videbech, P., GJEDDE, A. H., & Fink, P. (2010) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2010.03.002 · Cited by 10
Is structural hydroxyapatite tricalcium-phosphate graft or tricortical iliac crest autograft better for calcaneal lengthening osteotomy in childhood?
Martinkevich, P., Rahbek, O., Stilling, M., Pedersen, L. K., Gottliebsen, M., Søballé, K., & Møller‐Madsen, B. (2016) · The Bone & Joint Journal · doi:10.1302/0301-620x.98b11.bjj-2016-0095.r1 · Cited by 10
HO-CO pathway activation may be associated with hippocampal μ and δ opioid receptors in inhibiting inflammatory pain aversiveness and nociception in WT but not NOS2-KO mice
Cazuza, R. A., Arantes, A. L. F., Pol, O., & Leite‐Panissi, C. R. A. (2021) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2021.01.002 · Cited by 10
Anterior Cingulate Cortex Activity During Rest Is Related to Alterations in Pain Perception in Aging
Terrasa, J. L., Montoya, P., Sitges, C., van der Meulen, M., Anton, F., & González‐Roldán, A. M. (2021) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2021.695200 · Cited by 10
Mechanical Affective Touch Therapy for Anxiety Disorders: Effects on Resting State Functional Connectivity
Gonsalves, M. A., Beck, Q. M., Fukuda, A. M., Tirrell, E., Kokdere, F., Kronenberg, E. F., Iadarola, N. D., Hagberg, S., Carpenter, L. L., & Barredo, J. (2022) · Neuromodulation Technology at the Neural Interface · doi:10.1016/j.neurom.2021.10.007 · Cited by 11
Attention and pain: are auditory distractors special?
Sloan, P., & Hollins, M. (2017) · Experimental Brain Research · doi:10.1007/s00221-017-4903-x · Cited by 10
The Localization Research of Brain Plasticity Changes after Brachial Plexus Pain: Sensory Regions or Cognitive Regions?
Wang, S., Ma, Z., Lu, Y.-C., Wu, J., Hua, X., Zheng, M., & Xu, J. (2019) · Neural Plasticity · doi:10.1155/2019/7381609 · Cited by 10
Recognizing pain as an early warning symptom of ischemic cardiovascular disease: A qualitative artistic representation of the journey
O’Keefe-McCarthy, S., Taplay, K., Flynn-Bowman, A., Keeping‐Burke, L., Sjaarda, V., McCleary, L., Abernethy, J., Prentice, M. B., Tyrer, K., & Salfi, J. (2020) · Canadian Journal of Pain · doi:10.1080/24740527.2020.1801339 · Cited by 10
Pain and the Placebo/Nocebo Effect
Pollo, A., & Benedetti, F. (2011) · Springer eBooks · doi:10.1007/978-1-4419-1651-8_20 · Cited by 10
Strategies for Assessing and Minimizing Pain
Karas, A. Z., Danneman, P. J., & Cadillac, J. M. (2008) · Elsevier eBooks · doi:10.1016/b978-012373898-1.50012-7 · Cited by 10
Memory and the septo-hippocampal system
Gray, J. A., & McNaughton, N. (2003) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198522713.003.0008 · Cited by 10
Past Pain Experience and Experimentally induced Pain Perception
Paquet, A., Plansont, B., Labrunie, A., Malauzat, D., & Girard, M. F. (2017) · Issues in Mental Health Nursing · doi:10.1080/01612840.2017.1354103 · Cited by 10
Uncertainty about the intensity of impending pain increases ensuing pain responses in congenital blindness
Holten-Rossing, S., Slimani, H., Ptito, M., Danti, S., & Kupers, R. C. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.12.005 · Cited by 10
Anesthesiology and pain medicine
de Barros, G. A. M., Kraychete, D. C., Lineburger, E. B., & Módolo, N. S. P. (2022) · Brazilian Journal of Anesthesiology (English Edition) · doi:10.1016/j.bjane.2022.07.007 · Cited by 10
Acupuncture: Specific and Non-Specific Effects
Endres, H. G. (2008) · Forschende Komplementärmedizin / Research in Complementary Medicine · doi:10.1159/000113416 · Cited by 10
Harmaline potentiates morphine-induced antinociception via affecting the ventral hippocampal GABA-A receptors in mice
Alijanpour, S., Jafaripour, S., Ghasemzadeh, Z., Khakpai, F., & Zarrindast, M. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173806 · Cited by 9
Associations between postoperative analgesic consumption and distress tolerance, anxiety, depression, and pain catastrophizing: a prospective observational study
Tapar, H., Özsoy, Z., Balta, M. G., Daşıran, F., Tapar, G. G., & Karaman, T. (2021) · Brazilian Journal of Anesthesiology (English Edition) · doi:10.1016/j.bjane.2021.07.007 · Cited by 9
The Effect of Preoperative Oral Melatonin on Postoperative Pain after Lumbar Disc Surgery: A Double-Blinded Randomized Clinical Trial
Baradari, A. G., Habibi, M. R., Aarabi, M., Sobhani, S., Babaei, A., Zeydi, A. E., & Ghayoumi, F. (2022) · Ethiopian Journal of Health Sciences · doi:10.4314/ejhs.v32i6.17 · Cited by 9
Testosterone administration enhances the expectation and perception of painful and non-painful somatosensory stimuli
Zhuo, S., Zhang, Y., Lin, C., & Peng, W. (2023) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2023.106081 · Cited by 9
Predictability and probability modulate the neural responses to other’s pain: An event-related potential investigation
Liao, C., Wu, H., Guan, Q., Luo, Y., & Cui, F. (2018) · Biological Psychology · doi:10.1016/j.biopsycho.2018.08.002 · Cited by 10
Effects of intravenous propranolol on heat pain sensitivity in healthy men
Schweinhardt, P., Abulhasan, Y. B., Koeva, V., Balderi, T., Kim, D. J., Alhujairi, M., & Carli, F. (2012) · European Journal of Pain · doi:10.1002/j.1532-2149.2012.00231.x · Cited by 9
“First Pain” in Humans: Convergent and Specific Forebrain Responses
Matre, D., Hernández-García, L., Tran, T. D., & Casey, K. L. (2010) · Molecular Pain · doi:10.1186/1744-8069-6-81 · Cited by 9
Anticipation of thermal pain in diverticular disease
Smith, J. K., Marciani, L., Humes, D. J., Francis, S., Gowland, P. A., & Spiller, R. E. (2016) · Neurogastroenterology & Motility · doi:10.1111/nmo.12790 · Cited by 10
Virtual Reality for Pain Management Among Children and Adolescents: Applicability in Clinical Settings and Limitations
Atzori, B., Vagnoli, L., Messeri, A., & Grotto, R. L. (2018) · Lecture notes in computer science · doi:10.1007/978-3-319-92052-8_2 · Cited by 9
Outcomes of a mind-body treatment program for chronic back pain with no distinct structural pathology--a case series of patients diagnosed and treated as tension myositis syndrome.
Schechter, D., Smith, A. P., Beck, J., Roach, J., Karim, R., & Azen, S. P. (2007) · PubMed · Cited by 9
Nociceptive Processing in the Hippocampus and Entorhinal Cortex, Neurophysiology and Pharmacology
Khanna, S. (2006) · Springer eBooks · doi:10.1007/978-3-540-29805-2_2761 · Cited by 9
Modulation of the sensory and affective dimensions of pain by expectations and uncertainty: a Bayesian modeling approachPreprint
Poublan‐Couzardot, A., Pagnoni, G., & Antoine Lutz, A. (2022) · OSF Preprints (OSF Preprints) · doi:10.31219/osf.io/nteg7 · Cited by 8
Comparison of brain activity within the sensorimotor network between sports players and patients with somatic symptom disorder
Kim, S. M., & Han, D. H. (2021) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2021.110534 · Cited by 8
Placebo comparator group selection and use in surgical trials: the ASPIRE project including expert workshop
Beard, D. J., Campbell, M., Blazeby, J. M., Carr, A. J., Weijer, C., Cuthbertson, B. H., Buchbinder, R., Pinkney, T. D., Bishop, F. L., Pugh, J., et al. (2021) · Health Technology Assessment · doi:10.3310/hta25530 · Cited by 9
Self-citation
A brief virtual reality intervention for pre-operative anxiety in adults
Martinez-Bernal, D., Cross, W. F., Hasselberg, M. J., Tapparello, C., Stenz, C. F. H., & Kolokythas, A. (2023) · Oral Surgery Oral Medicine Oral Pathology and Oral Radiology · doi:10.1016/j.oooo.2023.08.014 · Cited by 8
Imagerie de la douleur
Peyron, R. (2014) · Biologie Aujourd hui · doi:10.1051/jbio/2014003 · Cited by 8
Dissecting post-herniotomy pain – Scratching the surface?
Geber, C., & Birklein, F. (2010) · Pain · doi:10.1016/j.pain.2010.04.011 · Cited by 8
A theory of the septo-hippocampal system
Gray, J. A., & McNaughton, N. (2003) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198522713.003.0010 · Cited by 8
Identifying pain perceptual biases related to fear of pain and threat in a pain‐free sample
Yang, Z., & Bateer (2020) · European Journal of Pain · doi:10.1002/ejp.1553 · Cited by 8
Theory Without Theories: Well-Being, Ethics, and Medicine
Hawkins, J. (2021) · The Journal of Medicine and Philosophy A Forum for Bioethics and Philosophy of Medicine · doi:10.1093/jmp/jhab028 · Cited by 8
Investigating neuroepigenetic alterations in chronic low back pain with positron emission tomography
Yoo, C., Rani, N., Shen, S., Loggia, M. L., Gaynor, K., Moore, K. E., Bagdasarian, F. A., Lin, Y.-S., Edwards, R. R., Price, J. C., et al. (2024) · Pain · doi:10.1097/j.pain.0000000000003272 · Cited by 7
Effect of dry needling on pain and central sensitization in women with chronic pelvic pain: A randomized parallel-group controlled clinical trial
Sedighimehr, N., Razeghi, M., & Rezaei, I. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e31699 · Cited by 7
Effect of a controlled diaphragmatic breathing session on perceived pain and state anxiety in people with chronic pain
Serrano‐Ibáñez, E. R., Czub, M., Cordero, C. O., López-Martínez, A. E., Ramírez‐Maestre, C., Piskorz, J., & Esteve, R. (2024) · Current Psychology · doi:10.1007/s12144-024-06745-4 · Cited by 10
To Assess the Prevalence of Dental Anxiety and Assess the Efficacy of Vibraject and to Assess Prevalence of Dental Phobia
Sreenivasagan, S., Sneha, P., Ravi, P., & Vb, K. R. (2018) · Dentistry · doi:10.4172/2161-1122.1000491 · Cited by 7
Effects of arterial cannulation stress on regional cerebral blood flow in major depressive disorder
Savitz, J. B., Nugent, A. C., Cannon, D. M., Carlson, P. J., Davis, R., Neumeister, A., Rallis-Frutos, D., Fromm, S., Herscovitch, P., & Drevets, W. C. (2012) · Scientific Reports · doi:10.1038/srep00308 · Cited by 6
Functional MRI-based identification of brain regions activated by mechanical noxious stimulation and modulatory effect of remifentanil in cats
Nagakubo, D., Hamamoto, Y., Hasegawa, D., Kamata, M., Iizuka, T., Muta, K., Fujita, N., Nakagawa, T., & Nishimura, R. (2017) · Research in Veterinary Science · doi:10.1016/j.rvsc.2017.07.024 · Cited by 7
Unpredictability impairs goal-directed target processing and performance
Dieterich, R., Endraß, T., Kathmann, N., & Weinberg, A. (2019) · Biological Psychology · doi:10.1016/j.biopsycho.2019.01.007 · Cited by 8
Analgesic, anxiolytic and sedative-like activities of leaves of Alpinia calcarata Roscoe in mice
Mahmuda, F., Francisco Montiel, A., Shahnaz, N., Farjana, Y., & Basher, M. A. (2020) · Journal of Medicinal Plants Research · doi:10.5897/jmpr2020.6913 · Cited by 7
Does Threat Enlarge Nociceptive Reflex Receptive Fields?
Lannon, E. W., Jure, F. A., Andersen, O. K., & Rhudy, J. L. (2020) · Journal of Pain · doi:10.1016/j.jpain.2020.10.006 · Cited by 7
Ethology and anxiety
Gray, J. A., & McNaughton, N. (2003) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780198522713.003.0002 · Cited by 7
Gray matter volume of limbic brain structures during the development of chronic back pain: a longitudinal cohort study
Neumann, N., Domín, M., & Lotze, M. (2024) · Pain · doi:10.1097/j.pain.0000000000003351 · Cited by 6
Virtual Reality as Active Distraction in Laceration Repair
McEvoy, A. O., Vincent, O. B., Vazifedan, T., Chang, T. P., Clingenpeel, J. M., & Kapoor, R. (2024) · Pediatric Emergency Care · doi:10.1097/pec.0000000000003319 · Cited by 6
Pain in Pets: Beyond Physiology
Downing, R. A., & Rocca, G. D. (2023) · Animals · doi:10.3390/ani13030355 · Cited by 6
Mental health markers and protective factors in students with symptoms of physical pain across WEIRD and non-WEIRD samples – a network analysis
Tandon, T., Piccolo, M., Ledermann, K., McNally, R. J., Gupta, R., Morina, N., & Martin-Söelch, C. (2024) · BMC Psychiatry · doi:10.1186/s12888-024-05767-3 · Cited by 7
Effects of hippocampal damage on pain perception in a rat model of Alzheimer's disease induced by amyloid-β and ibotenic acid injection into the hippocampus
Hayashi, M., Kudo, C., Hanamoto, H., Maegawa, H., Usami, N., & Niwa, H. (2024) · Physiology & Behavior · doi:10.1016/j.physbeh.2024.114652 · Cited by 6
Psychological Factors in Arthritis: Cause or Consequence?
Harris, M. L. (2015) · Springer eBooks · doi:10.1007/978-3-319-22858-7_4 · Cited by 7
Sodium salicylate enhances neural excitation via reducing GABAergic transmission in the dentate gyrus area of rat hippocampus in vivo
Tang, H., Gong, H., Zhang, X., Huang, Y., Wu, C., Tang, Z., Chen, L., & Wang, M. (2021) · Hippocampus · doi:10.1002/hipo.23312 · Cited by 6
Neuroplasticity of pain processing and motor control in CAI patients: A UK Biobank study with clinical validation
Wang, Y., Li, Q., Xue, X., Xu, X., Tao, W., Liu, S., Li, Y., Wang, H., & Hua, Y. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2023.1096930 · Cited by 7
Funktionelle Bildgebung in der Schmerzforschung
Somborski, K., & Bingel, U. (2010) · Der Schmerz · doi:10.1007/s00482-010-0917-z · Cited by 6
Relief Expectation and Sleep
Laverdure-Dupont, D., Rainville, P., Montplaisir, J. Y., & Lavigne, G. J. (2010) · Reviews in the Neurosciences · doi:10.1515/revneuro.2010.21.5.381 · Cited by 6
Role of hippocampal orexin receptors in antinociception elicited by chemical stimulation of the lateral hypothalamus in the tail-flick test
Zargarani, A., Karimi‐Haghighi, S., & Haghparast, A. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113492 · Cited by 6
Different transfer of nociceptive sensitivity from rats with postnatal hippocampal lesions to control rats
Yamamotová, A., Franěk, M., Vaculín, Š., Šťastný, F., Bubeníková‐Valešová, V., & Rokyta, R. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05666.x · Cited by 6

Authors: Ploghaus, A., Narain, C., Beckmann, C. F., Clare, S., Bantick, S., Wise, R., Matthews, P. M., Rawlins, J. N. P., & Tracey, I.
Affiliations: John Radcliffe Hospital (GB)
University of Oxford (GB)
ORCID: Beckmann, Christian F.
Clare, Stuart
Wise, Richard
Matthews, Paul M.
Tracey, Irene
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2001-12-15
Volume: 21
Issue: 24
Pages: 9896-9903
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.21-24-09896.2001
PMC: PMC6763058
OpenAlex: W1828259239
Cited by: 822
References: 99
Citations by year: 2026: 8 · 2025: 20 · 2024: 27 · 2023: 37 · 2022: 32 · 2021: 42 · 2020: 32 · 2019: 40 · 2018: 32 · 2017: 36 · 2016: 35 · 2015: 47 · 2014: 48 · 2013: 48 · 2012: 35
FWCI: 11.18
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 182 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: pain modulation, hippocampal formation, entorhinal cortex, noxious thermal stimulation, pain intensity, insula, anticipatory anxiety, emotional pain
MeSH terms: Adult, Anxiety, Behavior, Brain Mapping, Conditioning, Classical, Heart Rate, Hot Temperature, Hippocampus, Humans, Hyperalgesia, Magnetic Resonance Imaging, Male, Nerve Net, Pain, Physical Stimulation, Entorhinal Cortex, Parahippocampal Gyrus

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Exacerbation of Pain by Anxiety Is Associated with Activity in a Hippocampal Network

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks