The DOI matches its Crossref record; 102 of the 102 references it cites were found in a registry or an index.
Exacerbation of Pain by Anxiety Is Associated with Activity in a Hippocampal Network
Open accessAbstract
It is common clinical experience that anxiety about pain can exacerbate the pain sensation. Using event-related functional magnetic resonance imaging (FMRI), we compared activation responses to noxious thermal stimulation while perceived pain intensity was manipulated by changes in either physical intensity or induced anxiety. One visual signal, which reliably predicted noxious stimulation of moderate intensity, came to evoke low anxiety about the impending pain. Another visual signal was followed by the same, moderate-intensity stimulation on most of the trials, but occasionally by discriminably stronger noxious stimuli, and came to evoke higher anxiety. We found that the entorhinal cortex of the hippocampal formation responded differentially to identical noxious stimuli, dependent on whether the perceived pain intensity was enhanced by pain-relevant anxiety. During this emotional pain modulation, entorhinal responses predicted activity in closely connected, affective (perigenual cingulate), and intensity coding (mid-insula) areas. Our finding suggests that accurate preparatory information during medical and dental procedures alleviates pain by disengaging the hippocampus. It supports the proposal that during anxiety, the hippocampal formation amplifies aversive events to prime behavioral responses that are adaptive to the worst possible outcome.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Previous neuroimaging studies have also shown that nocebo effects are mediated by the hippocampus and regions involved in anticipatory anxiety processing (Bingel et al., 2011; Kong et al., 2008; Ploghaus et al., 2001).”
From Distinct neural representations of placebo and nocebo effects (2015) · cites this paper as Ploghaus et al., 2001
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Results indicated that activation in the entorhinal cortex of the hippocampal formation differed depending on whether pain intensity was increased by the anxiety manipulation.”
From Psychological aspects of persistent pain: Current state of the science (2004) · cites this paper as [94]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798
Statistical parametric maps in functional imaging: A general linear approach
Friston, K. J., Holmes, A. P., Worsley, K. J., Poline, J. ‐., Frith, C. D., & Frackowiak, R. S. J. (1994) · Human Brain Mapping · doi:10.1002/hbm.460020402 · Cited by 9,688
A global optimisation method for robust affine registration of brain images
Jenkinson, M., & Smith, S. M. (2001) · Medical Image Analysis · doi:10.1016/s1361-8415(01)00036-6 · Cited by 7,018
Cognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259
Contributions of anterior cingulate cortex to behaviour
Devinsky, O., Morrell, M. J., & Vogt, B. A. (1995) · Brain · doi:10.1093/brain/118.1.279 · Cited by 3,377
Temporal Autocorrelation in Univariate Linear Modeling of FMRI Data
Woolrich, M. W., Ripley, B. D., Brady, M., & Smith, S. M. (2001) · NeuroImage · doi:10.1006/nimg.2001.0931 · Cited by 2,859
Pain Affect Encoded in Human Anterior Cingulate But Not Somatosensory Cortex
Rainville, P., Duncan, G. H., Price, D. D., Carrier, B., & Bushnell, M. C. (1997) · Science · doi:10.1126/science.277.5328.968 · Cited by 2,629
Functional imaging of brain responses to pain. A review and meta-analysis (2000)
Peyron, R., Laurent, B., & García-Larrea, L. (2000) · Neurophysiologie Clinique/Clinical Neurophysiology · doi:10.1016/s0987-7053(00)00227-6 · Cited by 2,171
Psychological and neural mechanisms of the affective dimension of pain
Price, D. D. (2000) · Science · doi:10.1126/science.288.5472.1769 · Cited by 2,092
Research works printed but not linked: 1
- 10.1002/1098-1063(2000)10:4<398::AID-HIPO6>3.0.CO;2-K · DOI
Cited by
Sorted by citations
The cognitive control of emotion
OCHSNER, K., & GROSS, J. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.03.010 · Cited by 4,495
Human brain mechanisms of pain perception and regulation in health and disease
Apkarian, A. V., Bushnell, M. C., Treede, R., & Zubieta, J. (2005) · European Journal of Pain · doi:10.1016/j.ejpain.2004.11.001 · Cited by 3,126
Placebo-Induced Changes in fMRI in the Anticipation and Experience of Pain
Wager, T. D., Rilling, J. K., Smith, E. E., Sokolik, A., Casey, K. L., Davidson, R. J., Kosslyn, S. M., Rose, R. M., & Cohen, J. D. (2004) · Science · doi:10.1126/science.1093065 · Cited by 1,992
The Neuropsychology of Anxiety
Gray, J. A., & McNaughton, N. (2003) · doi:10.1093/acprof:oso/9780198522713.001.0001 · Cited by 1,953
The Cerebral Signature for Pain Perception and Its Modulation
Tracey, I., & Mantyh, P. W. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.012 · Cited by 1,843
Self-citationThe effect of pain on cognitive function: A review of clinical and preclinical research
Moriarty, O., McGuire, B. E., & Finn, D. P. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.01.002 · Cited by 1,122
Predictors of Postoperative Pain and Analgesic Consumption: A Qualitative Systematic Review
Ip, H. Y. V., Abrishami, A., Peng, P. W. H., Wong, J., & Chung, F. (2009) · Anesthesiology · doi:10.1097/aln.0b013e3181aae87a · Cited by 1,055
What we know about primary dysmenorrhea today: a critical review.
Iacovides, S., Avidon, I., & Baker, F. (2015) · Human Reproduction Update · doi:10.1093/humupd/dmv039 · Cited by 973
Keeping pain out of mind: The role of the dorsolateral prefrontal cortex in pain modulation
Lorenz, J., Minoshima, S., & Casey, K. L. (2003) · Brain · doi:10.1093/brain/awg102 · Cited by 952
Models and Mechanisms of Hyperalgesia and Allodynia
Sandkühler, J. (2009) · Physiological Reviews · doi:10.1152/physrev.00025.2008 · Cited by 1,148
Psychological aspects of persistent pain: Current state of the science
Keefe, F. J., Rumble, M. E., Scipio, C. D., Giordano, L. A., & Perri, L. M. (2004) · The Journal of Pain · doi:10.1016/j.jpain.2004.02.576 · Cited by 954
Bingel, U., Wanigasekera, V., Wiech, K., Ni Mhuircheartaigh, R., Lee, M. C., Ploner, M., & Tracey, I. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3001244 · Cited by 810
Self-citationClinical biomarkers in drug discovery and development
Frank, R., & Hargreaves, R. J. (2003) · Nature Reviews Drug Discovery · doi:10.1038/nrd1130 · Cited by 807
Synaptic plasticity in the anterior cingulate cortex in acute and chronic pain
Bliss, T., Collingridge, G. L., Kaang, B., & Zhuo, M. (2016) · Nature reviews. Neuroscience · doi:10.1038/nrn.2016.68 · Cited by 790
A common neurobiology for pain and pleasure
Leknes, S., & Tracey, I. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2333 · Cited by 784
Self-citationThe subjective experience of pain: where expectations become reality
Koyama, T., McHaffie, J. G., Laurienti, P. J., & Coghill, R. C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0408576102 · Cited by 747
Paulus, M. P., Rogalsky, C., Simmons, A., Feinstein, J. S., & Stein, M. B. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00251-9 · Cited by 745
Cognitive modulation of pain: how do attention and emotion influence pain processing?
Villemure, C., & Bushnell, C. M. (2002) · Pain · doi:10.1016/s0304-3959(02)00007-6 · Cited by 728
Butler, R. K., & Finn, D. P. (2009) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2009.04.003 · Cited by 768
The influence of negative emotions on pain: Behavioral effects and neural mechanisms
Wiech, K., & Tracey, I. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.05.059 · Cited by 614
Self-citationSystematic Review and Meta-analysis of Virtual Reality in Pediatrics: Effects on Pain and Anxiety
Eijlers, R., Utens, E. M. W. J., Staals, L. M., de Nijs, P. F. A., Berghmans, J. M., Wijnen, R. M. H., Hillegers, M. H. J., Dierckx, B., & Legerstee, J. S. (2019) · Anesthesia & Analgesia · doi:10.1213/ane.0000000000004165 · Cited by 628
Getting the pain you expect: mechanisms of placebo, nocebo and reappraisal effects in humans
Tracey, I. (2010) · Nature Medicine · doi:10.1038/nm.2229 · Cited by 553
Self-citationBrain generators of laser-evoked potentials: from dipoles to functional significance
Garcia-Larrea, L., Frot, M., & Valeriani, M. (2003) · Neurophysiologie Clinique/Clinical Neurophysiology · doi:10.1016/j.neucli.2003.10.008 · Cited by 541
Atlas, L. Y., & Wager, T. D. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.03.039 · Cited by 463
How neuroimaging studies have challenged us to rethink: Is chronic pain a disease?
Tracey, I., & Bushnell, M. C. (2009) · The Journal of Pain · doi:10.1016/j.jpain.2009.09.001 · Cited by 455
Self-citationHow Placebos Change the Patient's Brain
Benedetti, F., Carlino, E., & Pollo, A. (2011) · Neuropsychopharmacology · doi:10.1038/npp.2010.81 · Cited by 446
Placebo analgesia induced by social observational learning
Colloca, L., & Benedetti, F. (2009) · Pain · doi:10.1016/j.pain.2009.01.033 · Cited by 416
The role of learning in nocebo and placebo effects
Colloca, L., Sigaudo, M., & Benedetti, F. (2008) · Pain · doi:10.1016/j.pain.2008.02.006 · Cited by 411
Cortical thickness and pain sensitivity in zen meditators.
Grant, J. A., Courtemanche, J., Duerden, E. G., Duncan, G. H., & Rainville, P. (2010) · Emotion · doi:10.1037/a0018334 · Cited by 395
Mood Influences Supraspinal Pain Processing Separately from Attention
Villemure, C., & Bushnell, M. C. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.3822-08.2009 · Cited by 415
Wilder‐Smith, C. H., Schindler, D., Lövblad, K., Redmond, S. M., & Nirkko, A. (2004) · Gut · doi:10.1136/gut.2003.028514 · Cited by 396
Neural circuitry underlying pain modulation: expectation, hypnosis, placebo
Ploghaus, A., Becerra, L. R., Borras, C., & Borsook, D. (2003) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(03)00061-5 · Cited by 385
Self-citationDrabant, E. M., Hariri, A. R., Meyer‐Lindenberg, A., Muñoz, K. E., Mattay, V. S., Kolachana, B. S., Egan, M. F., & Weinberger, D. R. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.12.1396 · Cited by 387
Indovina, P., Barone, D., Gallo, L., Chirico, A., De Pietro, G., & Giordano, A. (2018) · The Clinical Journal of Pain · doi:10.1097/ajp.0000000000000599 · Cited by 388
REVIEW: From nociception to pain perception: imaging the spinal and supraspinal pathways
Brooks, J. C. W., & Tracey, I. (2005) · Journal of Anatomy · doi:10.1111/j.1469-7580.2005.00428.x · Cited by 400
Self-citationEffects of odors on pain perception: deciphering the roles of emotion and attention
Villemure, C., Slotnick, B. M., & Bushnell, C. M. (2003) · Pain · doi:10.1016/s0304-3959(03)00297-5 · Cited by 369
The perception and categorisation of emotional stimuli: A review
Brosch, T., Pourtois, G., & Sander, D. (2009) · Cognition & Emotion · doi:10.1080/02699930902975754 · Cited by 412
Keltner, J. R., Furst, A., Fan, C., Redfern, R., Inglis, B., & Fields, H. L. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4463-05.2006 · Cited by 346
Neural Mechanisms Underlying Anxiety–Chronic Pain Interactions
Zhuo, M. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.01.006 · Cited by 350
Hippocampal NMDA receptors and anxiety: At the interface between cognition and emotion
Barkus, C., McHugh, S. B., Sprengel, R., Seeburg, P. H., Rawlins, J. N. P., & Bannerman, D. M. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.10.014 · Cited by 339
Self-citationBrain indoleamine 2,3-dioxygenase contributes to the comorbidity of pain and depression
Kim, H., Chen, L. L., Lim, G., Sung, B., Wang, S., McCabe, M. F., Rusanescu, G., Yang, L., Tian, Y., & Mao, J. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61884 · Cited by 329
Schedlowski, M., Enck, P., Rief, W., & Bingel, U. (2015) · Pharmacological Reviews · doi:10.1124/pr.114.009423 · Cited by 323
Common brain mechanisms of chronic pain and addiction
Elman, I., & Borsook, D. (2016) · Neuron · doi:10.1016/j.neuron.2015.11.027 · Cited by 303
Anxiety Reduction through Detachment: Subjective, Physiological, and Neural Effects
Kalisch, R., Wiech, K., Critchley, H. D., Seymour, B., O'Doherty, J. P., Oakley, D. A., Allen, P., & Dolan, R. J. (2005) · Journal of Cognitive Neuroscience · doi:10.1162/0898929054021184 · Cited by 303
Berna, C., Leknes, S., Holmes, E. A., Edwards, R. R., Goodwin, G. M., & Tracey, I. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.01.014 · Cited by 305
Self-citationVachon‐Presseau, É., Roy, M., Martel, M. O., Caron, E., Marin, M., Chen, J.-I., Albouy, G., Plante, I., Sullivan, M. J. L., LUPIEN, S. J., et al. (2013) · Brain · doi:10.1093/brain/aws371 · Cited by 294
Cerebral and Spinal Modulation of Pain by EmotionsPreprint
Roy, M., Piché, M., Chen, J.-I., Peretz, I., & Rainville, P. (2009) · Nature Precedings · doi:10.1073/pnas.0904706106 · Cited by 283
Central changes associated with chronic pelvic pain and endometriosis
Brawn, J., Morotti, M., Zondervan, K. T., Becker, C. M., & Vincent, K. (2014) · Human Reproduction Update · doi:10.1093/humupd/dmu025 · Cited by 274
“Thus anxiety amplifies pain by increasing activity within the hippocampus and entorhinal cortex (Ploghaus et al., 2001), whilst depression enhances the affective component of pain, increasing unpleasantness, and appears to disrupt activity within a network of brain regions including the amygdala and inferior frontal g…”
Structural Brain Anomalies and Chronic Pain: A Quantitative Meta-Analysis of Gray Matter Volume
Smallwood, R. F., Laird, A. R., Ramage, A. E., Parkinson, A. L., Lewis, J. D., Clauw, D. J., Williams, D. A., Schmidt‐Wilcke, T., Farrell, M. J., Eickhoff, S. B., et al. (2013) · Journal of Pain · doi:10.1016/j.jpain.2013.03.001 · Cited by 281
A functional magnetic resonance imaging study on the neural mechanisms of hyperalgesic nocebo effect
Kong, J., Gollub, R. L., Polich, G., Kirsch, I., LaViolette, P., Vangel, M., Rosen, B., & Kaptchuk, T. J. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.2944-08.2008 · Cited by 263
“) We selected the left hippocampus as a seed region because it (1) showed significant differences in group analysis; (2) played an important role in the correlation between anxiety and pain intensity ratings, as indicated by a previous study (Ploghaus et al., 2001); (3) has not been reported in the substantial placebo…”
InfluentialThe neurobiology of irritable bowel syndrome
Mayer, E. A., Ryu, H. J., & Bhatt, R. R. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-01972-w · Cited by 304
Subcortical structures involved in pain processing: evidence from single-trial fMRI
Bingel, U., Quante, M., Knab, R., Bromm, B., Weiller, C., & Büchel, C. (2002) · Pain · doi:10.1016/s0304-3959(02)00157-4 · Cited by 267
Dunckley, P., Wise, R. G., Fairhurst, M. T., Hobden, P., Aziz, Q., Chang, L., & Tracey, I. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1100-05.2005 · Cited by 262
Self-citationJensen, K. B., Loitoile, R., Kosek, E., Petzke, F. W., Carville, S. F., Fransson, P., Marcus, H. E., Williams, S., Choy, E., Mainguy, Y., et al. (2012) · Molecular Pain · doi:10.1186/1744-8069-8-32 · Cited by 276
The placebo effect: From concepts to genes
Colagiuri, B., Schenk, L. A., Keßler, M., Dorsey, S. G., & Colloca, L. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.08.017 · Cited by 278
Painful Heat Reveals Hyperexcitability of the Temporal Pole in Interictal and Ictal Migraine States
Moulton, E. A., Becerra, L. R., Maleki, N., Pendse, G., Tully, S., Hargreaves, R. J., Burstein, R., & Borsook, D. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq109 · Cited by 241
Composite Pain Biomarker Signatures for Objective Assessment and Effective Treatment
Tracey, I., Woolf, C. J., & Andrews, N. A. (2019) · Neuron · doi:10.1016/j.neuron.2019.02.019 · Cited by 246
Self-citationAnticipatory brainstem activity predicts neural processing of pain in humans
Fairhurst, M., Wiech, K., Dunckley, P., & Tracey, I. (2007) · Pain · doi:10.1016/j.pain.2006.09.001 · Cited by 231
Self-citationAversion-Related Circuitry in the Cerebellum: Responses to Noxious Heat and Unpleasant Images
Moulton, E. A., Elman, I., Pendse, G., Schmahmann, J. D., Becerra, L. R., & Borsook, D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.6709-10.2011 · Cited by 228
Pain imaging in health and disease — how far have we come?
Schweinhardt, P., & Bushnell, M. C. (2010) · Journal of Clinical Investigation · doi:10.1172/jci43498 · Cited by 237
Quantifying cerebral contributions to pain beyond nociception
Woo, C., Schmidt, L., Krishnan, A., Jepma, M., Roy, M., Lindquist, M. A., Atlas, L. Y., & Wager, T. D. (2017) · Nature Communications · doi:10.1038/ncomms14211 · Cited by 233
Tracey, I. (2008) · British Journal of Anaesthesia · doi:10.1093/bja/aen102 · Cited by 223
Self-citationSeifert, F. C., & Maihöfner, C. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8428-0 · Cited by 218
Predictability modulates the affective and sensory-discriminative neural processing of pain
Carlsson, K., Andersson, J., Petrovic, P., Petersson, K. M., Öhman, A., & Ingvar, M. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.05.027 · Cited by 208
Peyron, R., Frot, M., Schneider, F., Garcia-Larrea, L., Mertens, P., Barral, F. G., Sindou, M., Laurent, B., & Mauguière, F. (2002) · NeuroImage · doi:10.1006/nimg.2002.1315 · Cited by 209
Brain imaging of pain: state of the art
Morton, D. L., Jones, A. K. P., & Sandhu, J. (2016) · Journal of Pain Research · doi:10.2147/jpr.s60433 · Cited by 211
Levels of appraisal: a medial prefrontal role in high-level appraisal of emotional material.
Kalisch, R., Wiech, K., Critchley, H. D., & Dolan, R. J. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.11.011 · Cited by 206
Tomasi, D. G., Ernst, T., Caparelli, E. C., & Chang, L. (2006) · Human Brain Mapping · doi:10.1002/hbm.20211 · Cited by 201
A neuroimaging biomarker for sustained experimental and clinical pain
Lee, J., Kim, H. J., Čeko, M., Park, B., Lee, S. A., Park, H., Roy, M., Kim, S., Wager, T. D., & Woo, C. (2021) · Nature Medicine · doi:10.1038/s41591-020-1142-7 · Cited by 199
Hubbard, C. S., Khan, S. A., Keaser, M. L., Mathur, V. A., Goyal, M., & Seminowicz, D. A. (2014) · eneuro · doi:10.1523/eneuro.0006-14.2014 · Cited by 184
Foreman, R. D., Garrett, K. M., & Blair, R. W. (2015) · Comprehensive physiology · doi:10.1002/cphy.c140032 · Cited by 212
Dysmenorrhoea is associated with central changes in otherwise healthy women
Vincent, K., Warnaby, C. E., Stagg, C. J., Moore, J. A., Kennedy, S. M., & Tracey, I. (2011) · Pain · doi:10.1016/j.pain.2011.03.029 · Cited by 192
Self-citationWise, R. G. (2002) · NeuroImage · doi:10.1006/nimg.2002.1146 · Cited by 192
Self-citationPain, decisions, and actions: a motivational perspective
Wiech, K., & Tracey, I. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00046 · Cited by 188
Self-citationTriberti, S., Repetto, C., & Riva, G. (2014) · Cyberpsychology Behavior and Social Networking · doi:10.1089/cyber.2014.0054 · Cited by 205
Brain imaging approaches to the study of functional GI disorders: A Rome Working Team Report
Mayer, E. A., Aziz, Q., Coen, S., Kern, M., Labus, J. S., Lane, R., Kuo, B., Naliboff, B., & Tracey, I. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01304.x · Cited by 204
Self-citationFunctional connectivity of the frontoparietal network predicts cognitive modulation of pain
Kong, J., Jensen, K. B., Loiotile, R. E., Cheetham, A., Wey, H., Tan, Y. H. V., Rosen, B. R., Smoller, J. W., Kaptchuk, T. J., & Gollub, R. L. (2012) · Pain · doi:10.1016/j.pain.2012.12.004 · Cited by 191
The interaction between stress and chronic pain through the lens of threat learning
Timmers, I., Quaedflieg, C. W. E. M., Hsu, C., Heathcote, L. C., Rovnaghi, C. R., & Simons, L. E. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.10.007 · Cited by 205
The Effect of Virtual Reality on Pain and Range of Motion in Adults With Burn Injuries
Carrougher, G. J., Hoffman, H. G., Nakamura, D. Y., Lezotte, D., Soltani, M., Leahy, L., Engrav, L. H., & Patterson, D. R. (2009) · Journal of Burn Care & Research · doi:10.1097/bcr.0b013e3181b485d3 · Cited by 178
Disrupted Brain Circuitry for Pain‐Related Reward/Punishment in Fibromyalgia
Loggia, M. L., Berna, C., Kim, J., Cahalan, C. M., Gollub, R. L., Wasan, A. D., Harris, R. E., Edwards, R. R., & Napadow, V. (2013) · Arthritis & Rheumatology · doi:10.1002/art.38191 · Cited by 188
Kil, H., Kim, W. O., Chung, W. Y., Kim, G. H., Seo, H., & Hong, J.-Y. (2011) · British Journal of Anaesthesia · doi:10.1093/bja/aer305 · Cited by 176
Dissociable Influences of Opiates and Expectations on Pain
Atlas, L. Y., Whittington, R. A., Lindquist, M. A., Wielgosz, J., Sonty, N., & Wager, T. D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0383-12.2012 · Cited by 177
Affective Influence on Judgments and Decisions: Moving towards Core Mechanisms
Winkielman, P., Knutson, B. D., Paulus, M. P., & Trujillo, J. L. (2007) · Review of General Psychology · doi:10.1037/1089-2680.11.2.179 · Cited by 181
Roles of the hippocampal formation in pain information processing
Liu, M., & Chen, J. (2009) · Neuroscience Bulletin · doi:10.1007/s12264-009-0905-4 · Cited by 178
Pain Pathways and Nervous System Plasticity: Learning and Memory in Pain
McCarberg, B. H., & Peppin, J. F. (2019) · Pain Medicine · doi:10.1093/pm/pnz017 · Cited by 192
Yoshida, W., Seymour, B., Koltzenburg, M., & Dolan, R. J. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.4984-12.2013 · Cited by 165
Coxon, L., Horne, A. W., & Vincent, K. (2018) · Best Practice & Research Clinical Obstetrics & Gynaecology · doi:10.1016/j.bpobgyn.2018.01.014 · Cited by 170
Lang, S., Kroll, A., Lipinski, S. J., Wessa, M., Ridder, S., Christmann, C., Schad, L. R., & Flor, H. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06624.x · Cited by 171
Larsson, M., Tillisch, K., Craig, A. D., Engström, M., Labus, J. S., Naliboff, B. D., Lundberg, P., Ström, M., Mayer, E. A., & Walter, S. A. (2011) · Gastroenterology · doi:10.1053/j.gastro.2011.11.022 · Cited by 170
Kalisch, R., Wiech, K., Herrmann, K., & Dolan, R. J. (2006) · Journal of Cognitive Neuroscience · doi:10.1162/jocn.2006.18.8.1266 · Cited by 173
Valet, M., Gündel, H., Sprenger, T., Sorg, C., Mühlau, M., Zimmer, C., Henningsen, P., & Tölle, T. R. (2008) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31818d1e02 · Cited by 171
Common hippocampal structural and functional changes in migraine
Maleki, N., Becerra, L. R., Brawn, J., McEwen, B. S., Burstein, R., & Borsook, D. (2012) · Brain Structure and Function · doi:10.1007/s00429-012-0437-y · Cited by 170
Can neuroimaging studies identify pain endophenotypes in humans?
Tracey, I. (2011) · Nature Reviews Neurology · doi:10.1038/nrneurol.2011.4 · Cited by 170
Self-citationCognitive impairment in patients with chronic pain: The significance of stress
Hart, R. P., Wade, J. B., & Martelli, M. F. (2003) · Current Pain and Headache Reports · doi:10.1007/s11916-003-0021-5 · Cited by 177
Pissiota, A., Frans, Ö., Michelgård, Å., Appel, L., Långström, B., Flaten, M. A., & Fredrikson, M. G. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02855.x · Cited by 168
Collard, V., Mistraletti, G., Taqi, A., Asenjo, J. F., Feldman, L. S., Fried, G. M., & Carli, F. (2007) · Anesthesia & Analgesia · doi:10.1213/01.ane.0000282822.07437.02 · Cited by 163
Current advances in orthodontic pain
Long, H., Wang, Y., Jian, F., Liao, L., Yang, X., & Lai, W. (2016) · International Journal of Oral Science · doi:10.1038/ijos.2016.24 · Cited by 169
Michael, J. R. (2009) · Frontiers in bioscience · doi:10.2741/3585 · Cited by 167
Cerebral and Cerebrospinal Processes Underlying Counterirritation Analgesia
Piché, M., Arsenault, M., & Rainville, P. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.2341-09.2009 · Cited by 169
Investigation into the neural correlates of emotional augmentation of clinical pain
Schweinhardt, P., Kalk, N. J., Wartolowska, K. A., Chessell, I. P., Wordsworth, B. P., & Tracey, I. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.12.016 · Cited by 160
Self-citation
Metadata
- Authors
- Ploghaus, A., Narain, C., Beckmann, C. F., Clare, S., Bantick, S., Wise, R., Matthews, P. M., Rawlins, J. N. P., & Tracey, I.
- Affiliations
- John Radcliffe Hospital (GB)
- University of Oxford (GB)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2001-12-15
- Volume
- 21
- Issue
- 24
- Pages
- 9896-9903
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6763058
- OpenAlex
- W1828259239
- Cited by
- 822
- References
- 99
- Citations by year
- 2026: 8 · 2025: 20 · 2024: 27 · 2023: 37 · 2022: 32 · 2021: 42 · 2020: 32 · 2019: 40 · 2018: 32 · 2017: 36 · 2016: 35 · 2015: 47 · 2014: 48 · 2013: 48 · 2012: 35
- FWCI
- 11.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (acceptedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Keywords
- pain modulation, hippocampal formation, entorhinal cortex, noxious thermal stimulation, pain intensity, insula, anticipatory anxiety, emotional pain
- MeSH terms
- Adult, Anxiety, Behavior, Brain Mapping, Conditioning, Classical, Heart Rate, Hot Temperature, Hippocampus, Humans, Hyperalgesia, Magnetic Resonance Imaging, Male, Nerve Net, Pain, Physical Stimulation, Entorhinal Cortex, Parahippocampal Gyrus
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
