The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Glutamine Uptake by Neurons: Interaction of Protons with System A Transporters
Open accessAbstract
Astrocytes provide the glutamine required by neurons to synthesize glutamate and GABA. However, the mechanisms involved in glutamine transfer from glia to neurons have remained poorly understood. Recent work has implicated the System N transporter SN1 in the efflux of glutamine from astrocytes and the very closely related System A transporters SA1 and SA2 in glutamine uptake by neurons. To understand how these closely related proteins mediate flux in different directions, we have examined their ionic coupling. In contrast to the electroneutral exchange of H+for Na+and neutral amino acid catalyzed by SN1, we now show that SA1 and SA2 do not couple H+movement to amino acid flux. As a result, SA1 and SA2 are electrogenic and do not mediate flux reversal as readily as SN1. Differences between System N and A transporters in coupling to H+thus contribute to the delivery of glutamine from glia to neurons. Nonetheless, although they are not transported, H+inhibit SA1 and SA2 by competing with Na+.
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Citations
Cites
Nitrogen shuttling between neurons and glial cells during glutamate synthesis
Lieth, E., LaNoue, K. F., Berkich, D. A., Xu, B., Ratz, M., Taylor, C., & Hutson, S. M. (2001) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2001.00156.x · Cited by 192
Cited by
Bak, L. K., Schousboe, A., & Waagepetersen, H. S. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.03913.x · Cited by 1,114
Chen, Y., & Swanson, R. A. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200302000-00001 · Cited by 912
Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family
Mackenzie, B., & Erickson, J. D. (2004) · Pfl�gers Archiv European Journal of Physiology · doi:10.1007/s00424-003-1117-9 · Cited by 515
Neuronal-glial glucose oxidation and glutamatergic-GABAergic function.
Hyder, F., Patel, A. B., Gjedde, A., Rothman, D. L., Behar, K. L., & Shulman, R. G. (2006) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600263 · Cited by 408
The implications of IDH mutations for cancer development and therapy
Pirozzi, C. J., & Yan, H. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00521-0 · Cited by 382
Metadata
- Authors
- Chaudhry, F. A., Schmitz, D., Reimer, R. J., Larsson, P., Gray, A. T., Nicoll, R., Kavanaugh, M., & Edwards, R. H.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-01-01
- Volume
- 22
- Issue
- 1
- Pages
- 62-72
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2120139857
- Cited by
- 213
- References
- 1
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Chaudhry, F. A., Schmitz, D., Reimer, R. J., Larsson, P., Gray, A. T., Nicoll, R., Kavanaugh, M., & Edwards, R. H. (2002). Glutamine Uptake by Neurons: Interaction of Protons with System A Transporters. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.22-01-00062.2002
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