The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Regulation of Neurogenesis in Adult Mouse Hippocampus by cAMP and the cAMP Response Element-Binding Protein
Open accessAbstract
The cAMP cascade, including the cAMP response element-binding protein (CREB), is known to play an important role in neuronal survival and plasticity. Here the influence of this cascade on neurogenesis in adult hippocampus was determined. Activation of the cAMP cascade by administration of rolipram, an inhibitor of cAMP breakdown, increased the proliferation of newborn cells in adult mouse hippocampus. In addition, rolipram induction of cell proliferation resulted in mature granule cells that express neuronal-specific markers. Increased cell proliferation is accompanied by activation of CREB phosphorylation in dentate gyrus granule cells, suggesting a role for this transcription factor. This possibility is supported by studies demonstrating that cell proliferation is decreased in conditional transgenic mice that express a dominant negative mutant of CREB in hippocampus. The results suggest that the cAMP-CREB cascade could contribute to the actions of neurotransmitters and neurotrophic factors on adult neurogenesis.
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Cites
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The Neuroendocrinology of Stress: A Never Ending Story
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More hippocampal neurons in adult mice living in an enriched environment
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Chronic antidepressant treatment increases neurogenesis in adult rat hippocampus
Malberg, J. E., Eisch, A. J., Nestler, E. J., & Duman, R. S. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-24-09104.2000 · Cited by 3,111
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Self-citationTrkB Regulates Hippocampal Neurogenesis and Governs Sensitivity to Antidepressive Treatment
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Self-citation
Metadata
- Authors
- Nakagawa, S., Kim, J.-E., Lee, R., Malberg, J. E., Chen, J., Steffen, C., Zhang, Y.-J., Nestler, E. J., & Duman, R. S.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-05-01
- Volume
- 22
- Issue
- 9
- Pages
- 3673-3682
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2167089957
- Cited by
- 485
- References
- 42
- FWCI
- 5.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nakagawa, S., Kim, J.-E., Lee, R., Malberg, J. E., Chen, J., Steffen, C., Zhang, Y.-J., Nestler, E. J., & Duman, R. S. (2002). Regulation of Neurogenesis in Adult Mouse Hippocampus by cAMP and the cAMP Response Element-Binding Protein. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.22-09-03673.2002
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