Mechanisms and Functional Implications of Adult Neurogenesis

Zhao, Chunmei; Deng, Wei; Gage, Fred H.

doi:10.1016/j.cell.2008.01.033

Cited by 3,007Neurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology ResearchNeuroinflammation and Neurodegeneration Mechanisms

Mechanisms and Functional Implications of Adult Neurogenesis

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Zhao, Chunmei, Deng, Wei, Gage, Fred H.·2008·Cell

DOI 10.1016/j.cell.2008.01.033

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Abstract

The generation of new neurons is sustained throughout adulthood in the mammalian brain due to the proliferation and differentiation of adult neural stem cells. In this review, we discuss the factors that regulate proliferation and fate determination of adult neural stem cells and describe recent studies concerning the integration of newborn neurons into the existing neural circuitry. We further address the potential significance of adult neurogenesis in memory, depression, and neurodegenerative disorders such as Alzheimer's and Parkinson's disease.

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The dentate gyrus of the hippocampus is the brain region where the most active neurogenesis has been documented to take place.
“The dentate gyrus of the hippocampus is the brain region where the most active neurogenesis has been documented to take place23–25.”
From Therapeutically viable generation of neurons with antisense oligonucleotide suppression of PTB (2021) · cites this paper as [25]
The Main Text (indexed as Abstract; no page available) identifies the subgranular zone of the hippocampal dentate gyrus as a site where adult neurogenesis is clearly demonstrated. It also identifies the subventricular zone as such a site, but does not say that neurogenesis is most active in the dentate gyrus. (LLM, conf=0.86)
Experimental — accuracy not yet measured
Newly generated neuroblasts in the SVZ migrate to the olfactory bulb, and those in the SGZ migrate into the dentate gyrus granule cell layer, affecting memory and behavior.
“Newly generated neuroblasts in the SVZ migrate to become granule and periglomerular neurons in the olfactory bulb and neurons born in the SGZ migrate into the granule cell layer of the DG and. become dentate granule cells, contributing to the maintenance and reorganization of the existing circuitry and affecting memory and behavior (Imayoshi et al., 2008; reviewed in Zhao et al., 2008).”
From FoxOs Cooperatively Regulate Diverse Pathways Governing Neural Stem Cell Homeostasis (2009) · cites this paper as Zhao et al., 2008
In adult mice, relatively quiescent neural stem cells give rise to transit-amplifying progenitors that divide rapidly and contribute to neuroblasts.
“In adult mice, relatively quiescent NSC give rise to transit-amplifying progenitor cells which rapidly divide and contribute to neuroblasts (Morshead et al., 1994; reviewed in Zhao et al., 2008).”
From FoxOs Cooperatively Regulate Diverse Pathways Governing Neural Stem Cell Homeostasis (2009) · cites this paper as Zhao et al., 2008

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Authors: Zhao, C., Deng, W., & Gage, F. H.
Affiliations: Salk Institute for Biological Studies (US)
Corresponding author: Gage, Fred H.
ORCID: Deng, Wei
Gage, Fred H.
Venue: Cell
Publisher: Elsevier BV
Published: 2008-02
Volume: 132
Issue: 4
Pages: 645-660
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2008.01.033
OpenAlex: W2057608998
Cited by: 3,007
References: 22
Citations by year: 2026: 43 · 2025: 63 · 2024: 78 · 2023: 94 · 2022: 102 · 2021: 124 · 2020: 115 · 2019: 137 · 2018: 171 · 2017: 184 · 2016: 218 · 2015: 211 · 2014: 258 · 2013: 253 · 2012: 206
FWCI: 17.23
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1993 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Council
National Institutes of Health
Topics: Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: adult neurogenesis, adult neural stem cells, neural stem cell proliferation, fate determination, neural integration, memory, depression, Alzheimer's disease, Parkinson's disease, neurodegenerative diseases
MeSH terms: Animals, Brain, Cell Differentiation, Humans, Nervous System Diseases, Neurons, Stem Cells

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Mechanisms and Functional Implications of Adult Neurogenesis

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