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Receptors with Different Affinities Mediate Phasic and Tonic GABAAConductances in Hippocampal Neurons
Open accessAbstract
A tonic inhibitory conductance mediated by GABA(A) receptors that supplements the phasic inhibition produced by IPSCs has been identified in the hippocampus and cerebellum. It is presently unknown whether tonic and phasic inhibitions are mediated by GABA(A) receptors with different subunit assemblies. Here we demonstrate that a low concentration (200 nm) of the highly specific competitive GABA(A) antagonist SR95531 (gabazine) reduces phasic inhibition in hippocampal granule cells by 71% but has no effect on tonic inhibition, whereas a high concentration (10 microm) of the antagonist blocked both conductances. These findings are consistent with tonic and phasic conductances being mediated by different GABA(A) receptor subtypes with different affinities for GABA.
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Citations
Cited by
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Millan, M. J. (2003) · Progress in Neurobiology · doi:10.1016/s0301-0082(03)00087-x · Cited by 965
Reducing excessive GABA-mediated tonic inhibition promotes functional recovery after stroke
Clarkson, A. N., Huang, B. S., MacIsaac, S. E., Mody, I., & Carmichael, S. T. (2010) · Nature · doi:10.1038/nature09511 · Cited by 869
Regulation and function of adult neurogenesis: from genes to cognition.
Aimone, J. B., Li, Y., Lee, S. W., Clemenson, G. D., Deng, W., & Gage, F. H. (2014) · Physiological Reviews · doi:10.1152/physrev.00004.2014 · Cited by 635
The sedative component of anesthesia is mediated by GABAA receptors in an endogenous sleep pathway
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Metadata
- Authors
- Stell, B. M., & Mody, I.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-05-15
- Volume
- 22
- Issue
- 10
- Pages
- RC223-RC223
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1926479678
- Cited by
- 326
- References
- 0
- FWCI
- 8.17
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Stell, B. M., & Mody, I. (2002). Receptors with Different Affinities Mediate Phasic and Tonic GABAAConductances in Hippocampal Neurons. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.22-10-j0003.2002
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