Regulation and function of adult neurogenesis: from genes to cognition.
Open accessAbstract
Adult neurogenesis in the hippocampus is a notable process due not only to its uniqueness and potential impact on cognition but also to its localized vertical integration of different scales of neuroscience, ranging from molecular and cellular biology to behavior. This review summarizes the recent research regarding the process of adult neurogenesis from these different perspectives, with particular emphasis on the differentiation and development of new neurons, the regulation of the process by extrinsic and intrinsic factors, and their ultimate function in the hippocampus circuit. Arising from a local neural stem cell population, new neurons progress through several stages of maturation, ultimately integrating into the adult dentate gyrus network. The increased appreciation of the full neurogenesis process, from genes and cells to behavior and cognition, makes neurogenesis both a unique case study for how scales in neuroscience can link together and suggests neurogenesis as a potential target for therapeutic intervention for a number of disorders.
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Inhibition or ablation of neurogenesis impairs performance on spatial and contextual memory tasks.
“Animal models have demonstrated that the inhibition or ablation of neurogenesis impairs performance on spatial and contextual memory tasks while improved performances on these tasks are seen when neurogenesis is stimulated (Deng et al., 2010; Snyder and Cameron, 2012; Aimone et al., 2014; Vadodaria and Jessberger, 2014; Kent et al., 2015).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Aimone et al., 2014
Improved performances on spatial and contextual memory tasks are seen when neurogenesis is stimulated.
“Animal models have demonstrated that the inhibition or ablation of neurogenesis impairs performance on spatial and contextual memory tasks while improved performances on these tasks are seen when neurogenesis is stimulated (Deng et al., 2010; Snyder and Cameron, 2012; Aimone et al., 2014; Vadodaria and Jessberger, 2014; Kent et al., 2015).”
From Aerobic Exercise as a Tool to Improve Hippocampal Plasticity and Function in Humans: Practical Implications for Mental Health Treatment (2016) · cites this paper as Aimone et al., 2014
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BDNF: A Key Factor with Multipotent Impact on Brain Signaling and Synaptic Plasticity
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Adult Hippocampal Neurogenesis: Regulation and Possible Functional and Clinical Correlates
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Functional hypoxia drives neuroplasticity and neurogenesis via brain erythropoietin
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“…or ablation of neurogenesis impairs performance on spatial and contextual memory tasks while improved performances on these tasks are seen when neurogenesis is stimulated (Deng et al., 2010; Snyder and Cameron, 2012; Aimone et al., 2014; Vadodaria and Jessberger, 2014; Kent et al., 2015).”
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Neuroplasticity and Clinical Practice: Building Brain Power for Health
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Neurogenesis, neuronal migration, and axon guidance
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- Authors
- Aimone, J. B., Li, Y., Lee, S. W., Clemenson, G. D., Deng, W., & Gage, F. H.
- Affiliations
- Salk Institute for Biological Studies (US)
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2014-10
- Volume
- 94
- Issue
- 4
- Pages
- 991-1026
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- PMC
- PMC4280160
- OpenAlex
- W2149901479
- Cited by
- 635
- References
- 420
- Citations by year
- 2026: 32 · 2025: 44 · 2024: 28 · 2023: 47 · 2022: 43 · 2021: 53 · 2020: 50 · 2019: 52 · 2018: 64 · 2017: 86 · 2016: 70 · 2015: 60 · 2014: 6
- FWCI
- 7.70
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Physiological Reviews (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH090258, R01-MH090258-04)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- adult neurogenesis, hippocampus, dentate gyrus, neural stem cells, neuronal differentiation, neurogenesis regulation, intrinsic and extrinsic factors, cognitive function, neural circuit integration
- MeSH terms
- Animals, Brain, Gene Expression Regulation, Humans, Dentate Gyrus, Neurogenesis, Neural Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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