Cited by 636Neurogenesis and neuroplasticity mechanismsMemory and Neural MechanismsNeuroscience and Neuropharmacology Research

Regulation and function of adult neurogenesis: from genes to cognition.

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Aimone, James B., Li, Yan, Lee, Star W., Clemenson, Gregory D., Deng, Wei, Gage, Fred H.·2014·Physiological Reviews

Abstract

Adult neurogenesis in the hippocampus is a notable process due not only to its uniqueness and potential impact on cognition but also to its localized vertical integration of different scales of neuroscience, ranging from molecular and cellular biology to behavior. This review summarizes the recent research regarding the process of adult neurogenesis from these different perspectives, with particular emphasis on the differentiation and development of new neurons, the regulation of the process by extrinsic and intrinsic factors, and their ultimate function in the hippocampus circuit. Arising from a local neural stem cell population, new neurons progress through several stages of maturation, ultimately integrating into the adult dentate gyrus network. The increased appreciation of the full neurogenesis process, from genes and cells to behavior and cognition, makes neurogenesis both a unique case study for how scales in neuroscience can link together and suggests neurogenesis as a potential target for therapeutic intervention for a number of disorders.

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Crossref · 10.1152/physrev.00004.2014

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Authors
Aimone, J. B., Li, Y., Lee, S. W., Clemenson, G. D., Deng, W., & Gage, F. H.
Affiliations
Salk Institute for Biological Studies (US)
Venue
Physiological Reviews
Published
2014-10
Volume
94
Issue
4
Pages
991-1026
ISSN
  • 0031-9333 (ISSN-L)
  • 1522-1210
OpenAlex
W2149901479
Cited by
635
References
420
Citations by year
2026: 32 · 2025: 44 · 2024: 28 · 2023: 47 · 2022: 43 · 2021: 53 · 2020: 50 · 2019: 52 · 2018: 64 · 2017: 86 · 2016: 70 · 2015: 60 · 2014: 6
FWCI
7.70
Type
journal article
Language
en
Open access
Locations
  • Physiological Reviews (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) (submittedVersion)
Funders
National Institute of Mental Health (R01MH090258, R01-MH090258-04)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
adult neurogenesis, hippocampus, dentate gyrus, neural stem cells, neuronal differentiation, neurogenesis regulation, intrinsic and extrinsic factors, cognitive function, neural circuit integration
MeSH terms
Animals, Brain, Gene Expression Regulation, Humans, Dentate Gyrus, Neurogenesis, Neural Stem Cells

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