The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Truncated Soluble Nogo Receptor Binds Nogo-66 and Blocks Inhibition of Axon Growth by Myelin
Open accessAbstract
CNS myelin contains axon outgrowth inhibitors, such as Nogo, that restrict regenerative growth after injury. An understanding of the mechanism of Nogo signaling through its receptor (NgR) is critical to developing strategies for overcoming Nogo-mediated inhibition. Here we analyze the function of NgR domains in outgrowth inhibition. Analysis of alkaline phosphatase (AP)-Nogo binding in COS-7 cells reveals that the leucine-rich repeat domain is necessary and sufficient for Nogo binding and NgR multimerization. Viral infection of embryonic day 7 chick retinal ganglion cells with mutated NgR demonstrates that the NgR C-terminal domain is required for inhibitory signaling but not ligand binding. The NgR glycosylphosphatidylinositol domain is not essential for inhibitory signaling but may facilitate Nogo responses. From this analysis, we have developed a soluble, truncated version of the Nogo receptor that antagonizes outgrowth inhibition on both myelin and Nogo substrates. These data suggest that NgR mediates a significant fraction of myelin inhibition of axon outgrowth.
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Cites
Functional rafts in cell membranes
Simons, K., & Ikonen, E. (1997) · Nature · doi:10.1038/42408 · Cited by 9,757
Cited by
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PirB is a Functional Receptor for Myelin Inhibitors of Axonal Regeneration
Atwal, J. K., Pinkston-Gosse, J., Syken, J., Stawicki, S., Wu, Y., Shatz, C., & Tessier-Lavigne, M. (2008) · Science · doi:10.1126/science.1161151 · Cited by 502
Guidance Molecules in Axon Regeneration
Giger, R. J., Hollis, E. R., & Tuszynski, M. H. (2010) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001867 · Cited by 346
Budel, S., Padukkavidana, T., Liu, B. P., Feng, Z., Hu, F., Johnson, S., Lauren, J., Park, J. H., McGee, A. W., Liao, J., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.3828-08.2008 · Cited by 107
Self-citationGopalakrishnan, S. M., Teusch, N., Imhof, C., Bakker, M. H. M., Schurdak, M., Burns, D. J., & Warrior, U. (2008) · Journal of Neuroscience Research · doi:10.1002/jnr.21671 · Cited by 62
Metadata
- Authors
- Fournier, A. E., Gould, G. C., Liu, B. P., & Strittmatter, S. M.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2002-10-15
- Volume
- 22
- Issue
- 20
- Pages
- 8876-8883
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1939985926
- Cited by
- 207
- References
- 1
- FWCI
- 5.52
- Type
- journal article
- Language
- en
- Open access
- green
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- Fournier, A. E., Gould, G. C., Liu, B. P., & Strittmatter, S. M. (2002). Truncated Soluble Nogo Receptor Binds Nogo-66 and Blocks Inhibition of Axon Growth by Myelin. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.22-20-08876.2002
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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