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Glial Cell Line-Derived Neurotrophic Factor Alters Axon Schwann Cell Units and Promotes Myelination in Unmyelinated Nerve Fibers
Open accessAbstract
Glial cell line-derived neurotrophic factor (GDNF) plays an important role in the development and maintenance of a subset of dorsal root ganglion sensory neurons. We administered high-dose exogenous recombinant human GDNF (rhGDNF) daily to adult rats to examine its effect on unmyelinated axon-Schwann cell units in intact peripheral nerves. In rhGDNF-treated animals, there was a dramatic proliferation in the Schwann cells of unmyelinated fibers, which resulted in the segregation of many unmyelinated axons into a 1:1 relationship with Schwann cells and myelination of normally unmyelinated small axons. This study demonstrates that the administration of high doses of a growth factor to adult rats can change the phenotype of nerve fibers from unmyelinated to myelinated.
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Cites
Progesterone synthesis and myelin formation by Schwann cells
Koenig, H. L., Schumacher, M., Ferzaz, B., Thi, A. N. D., Ressouches, A., Guennoun, R., Jung-Testas, I., Robel, P., Akwa, Y., & Baulieu, E.-E. (1995) · Science · doi:10.1126/science.7770777 · Cited by 480
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Taveggia, C., Zanazzi, G., Petrylak, A., Yano, H., Rosenbluth, J., Einheber, S., Xu, X., Esper, R. M., Loeb, J. A., Shrager, P., et al. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.017 · Cited by 730
Axon-Glial Signaling and the Glial Support of Axon Function
Nave, K.-A., & Trapp, B. D. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094309 · Cited by 658
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Chew, S. Y., Mi, R., Hoke, A., & Leong, K. W. (2008) · Biomaterials · doi:10.1016/j.biomaterials.2007.10.025 · Cited by 521
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Linking oligodendrocyte and myelin dysfunction to neurocircuitry abnormalities in schizophrenia
Takahashi, N., Sakurai, T., Davis, K. L., & Buxbaum, J. D. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.09.004 · Cited by 337
Metadata
- Authors
- Höke, A., Ho, T., Crawford, T. O., LeBel, C., Hilt, D., & Griffin, J. W.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-01-15
- Volume
- 23
- Issue
- 2
- Pages
- 561-567
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1505236598
- Cited by
- 168
- References
- 1
- FWCI
- 3.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Höke, A., Ho, T., Crawford, T. O., LeBel, C., Hilt, D., & Griffin, J. W. (2003). Glial Cell Line-Derived Neurotrophic Factor Alters Axon Schwann Cell Units and Promotes Myelination in Unmyelinated Nerve Fibers. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.23-02-00561.2003
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