Cited by 337Schizophrenia research and treatmentNeurogenesis and neuroplasticity mechanismsNeuroscience and Neuropharmacology Research

Linking oligodendrocyte and myelin dysfunction to neurocircuitry abnormalities in schizophrenia

Open access
Takahashi, Nagahide, Sakurai, Takeshi, Davis, Kenneth L., Buxbaum, Joseph D.·2011·Progress in Neurobiology

Abstract

Multiple lines of evidence in schizophrenia, from brain imaging, studies in postmortem brains, and genetic association studies, have implicated oligodendrocyte and myelin dysfunction in this disease. Recent studies suggest that oligodendrocyte and myelin dysfunction leads to changes in synaptic formation and function, which could lead to cognitive dysfunction, a core symptom of schizophrenia. Furthermore, there is accumulating data linking oligodendrocyte and myelin dysfunction with dopamine and glutamate abnormalities, both of which are found in schizophrenia. These findings implicate oligodendrocyte and myelin dysfunction as a primary change in schizophrenia, not only as secondary consequences of the illness or treatment. Strategies targeting oligodendrocyte and myelin abnormalities could therefore provide therapeutic opportunities for patients suffering from schizophrenia.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1016/j.pneurobio.2010.09.004

Cites

167 of 167 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. Safferman AZ Kane JM Aronowitz JS Gordon MF Pollack S Lieberman JA 1994 The use of clozapine in neurologic disorders The Journal of clinical psychiatry 55 Suppl B 98 101 7961585

Cited by

Sorted by citations

Authors
Takahashi, N., Sakurai, T., Davis, K. L., & Buxbaum, J. D.
Affiliations
Icahn School of Medicine at Mount Sinai (US)
Corresponding author
Buxbaum, Joseph D.
Venue
Progress in Neurobiology
Publisher
Elsevier BV
Published
2011-01
Volume
93
Issue
1
Pages
13-24
ISSN
0301-0082 (ISSN-L)
OpenAlex
W2091960711
Cited by
337
References
167
Citations by year
2026: 15 · 2025: 19 · 2024: 21 · 2023: 36 · 2022: 25 · 2021: 26 · 2020: 26 · 2019: 19 · 2018: 16 · 2017: 23 · 2016: 15 · 2015: 19 · 2014: 24 · 2013: 20 · 2012: 17
FWCI
2.28
Type
journal article
Language
en
Open access
Locations
  • Progress in Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Mental Health (P50MH066392)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
schizophrenia, oligodendrocytes, synaptic dysfunction, cognitive impairment, therapeutic target
MeSH terms
Animals, Humans, Myelin Sheath, Nerve Net, Oligodendroglia, Schizophrenia

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review