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Cited by 222Visual perception and processing mechanismsZebrafish Biomedical Research ApplicationsVestibular and auditory disorders

The DOI matches its Crossref record; 68 of the 68 references it cites were found in a registry or an index.

Visuomotor Behaviors in Larval Zebrafish after GFP-Guided Laser Ablation of the Optic Tectum

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Roeser, Tobias, Baier, Herwig·2003·The Journal of Neuroscience
DOI 10.1523/jneurosci.23-09-03726.2003PMC PMC6742205
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Abstract

The optic tectum is the largest visual center in most vertebrates and the main target for retinal ganglion cells (RGCs) conveying visual information from the eye to the brain. The retinotectal projection has served as an important model in many areas of developmental neuroscience. However, knowledge of the function of the tectum is limited. We began to address this issue using laser ablations and subsequent behavioral testing in zebrafish. We used a transgenic zebrafish line that expresses green-fluorescent protein in RGCs projecting to the tectum. By aiming a laser beam at the labeled retinal fibers demarcating the tectal neuropil, the larval tectum could be selectively destroyed. We tested whether tectum-ablated zebrafish larvae, when presented with large-field movements in their surroundings, displayed optokinetic responses (OKR) or optomotor responses (OMR), two distinct visuomotor behaviors that compensate for self-motion. Neither OKR nor OMR were found to be dependent on intact retinotectal connections. Also, visual acuity remained unaffected. Tectum ablation, however, slowed down the OKR by reducing the frequency of saccades but left tracking velocity, gain, and saccade amplitude unaffected. Removal of the tectum had no effect on the processing of second-order motion, to which zebrafish show both OKR and OMR, suggesting that the tectum is not an integral part of the circuit that extracts higher-order cues in the motion pathway.

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Metadata

Authors
Roeser, T., & Baier, H.
Affiliations
University of California, San Francisco (US)
ORCID
Baier, Herwig
Venue
The Journal of Neuroscience
Publisher
Society for Neuroscience
Published
2003-05-01
Volume
23
Issue
9
Pages
3726-3734
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
DOI
10.1523/jneurosci.23-09-03726.2003
PMC
PMC6742205
OpenAlex
W2150958067
Semantic Scholar
fe7a175f2bfdb09b95fe04e44714ab7c8b7a31ac
Cited by
222
References
67
Citations by year
2026: 12 · 2025: 10 · 2024: 8 · 2023: 3 · 2022: 14 · 2021: 7 · 2020: 9 · 2019: 7 · 2018: 7 · 2017: 12 · 2016: 7 · 2015: 11 · 2014: 10 · 2013: 17 · 2012: 11
FWCI
4.18
Type
journal article
Language
en
Open access
Licence
public-domain
Locations
  • Journal of Neuroscience (publishedVersion, public-domain)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Boehringer Ingelheim Fonds
  • National Institutes of Health
  • National Eye Institute (R01EY012406)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Zebrafish Biomedical Research Applications
  • Life Sciences › Neuroscience › Neurology › Vestibular and auditory disorders
Keywords
optic tectum, retinotectal projection, zebrafish larvae, optokinetic response, optomotor response, visuomotor behavior, laser ablation, retinal ganglion cells, saccades, visual acuity, second-order motion
MeSH terms
Animals, Behavior, Animal, Cues, Eye Movements, Larva, Luminescent Proteins, Motion Perception, Retinal Ganglion Cells, Saccades, Superior Colliculi, Visual Acuity, Visual Pathways, Zebrafish, Animals, Genetically Modified, Green Fluorescent Proteins, Laser Therapy

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