The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Altered Hippocampal Synaptic Potentiation in P2X4Knock-Out Mice
Open accessAbstract
P2X 4 purinergic receptors are calcium-permeable, ATP-activated ion channels. In the CA1 area of the hippocampus, they are located at the subsynaptic membrane somewhat peripherally to AMPA receptors. The possible role of P2X 4 receptors has been difficult to elucidate because of the lack of selective antagonists. Here we report the generation of a P2X 4 receptor knock-out mouse and show that long-term potentiation (LTP) at Schaffer collateral synapses is reduced relative to that in wild-type mice. Ivermectin, which selectively potentiates currents at P2X 4, was found to increase LTP in wild-type mice but had no effect in P2X 4 knock-out mice. We suggest that calcium entry through subsynaptic P2X 4 receptors during high-frequency stimulation contributes to synaptic strengthening.
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Cites
Molecular Physiology of P2X Receptors
North, R. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00015.2002 · Cited by 2,919
Self-citationReanalysis of P2X7Receptor Expression in Rodent Brain
Sim, J. A., Young, M. T., Sung, H.-Y., North, R. A., & Surprenant, A. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1469-04.2004 · Cited by 264
Cited by
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McCutcheon, J. E., & Marinelli, M. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06648.x · Cited by 280
Exocytosis of ATP From Astrocytes Modulates Phasic and Tonic Inhibition in the Neocortex
Lalo, U., Palygin, O., Rasooli-Nejad, S., Andrew, J., Haydon, P. G., & Pankratov, Y. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001747 · Cited by 270
P2X4 receptor controls microglia activation and favors remyelination in autoimmune encephalitis
Zabala, A., Vazquez‐Villoldo, N., Rissiek, B., Gejo, J., Martin, A., Palomino, A., Perez‐Samartín, A., Pulagam, K. R., Lukowiak, M., Capetillo‐Zarate, E., et al. (2018) · EMBO Molecular Medicine · doi:10.15252/emmm.201708743 · Cited by 192
Self-citationRibeiro, D. E., Casarotto, P. C., Staquini, L., Pinto e Silva, M. A., Biojone, C., Wegener, G., & Joca, S. (2019) · PeerJ · doi:10.7717/peerj.7834 · Cited by 21
Metadata
- Authors
- Sim, J. A., Chaumont, S., Jo, J., Ulmann, L., Young, M. T., Cho, K., Buell, G., North, R. A., & Rassendren, F.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2006-08-30
- Volume
- 26
- Issue
- 35
- Pages
- 9006-9009
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2033948582
- Cited by
- 180
- References
- 2
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Sim, J. A., Chaumont, S., Jo, J., Ulmann, L., Young, M. T., Cho, K., Buell, G., North, R. A., & Rassendren, F. (2006). Altered Hippocampal Synaptic Potentiation in P2X4Knock-Out Mice. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.2370-06.2006
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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