Reanalysis of P2X7Receptor Expression in Rodent Brain

Molecular Physiology of P2X Receptors

North, R. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00015.2002 · Cited by 2,919 · see citing works

Altered Cytokine Production in Mice Lacking P2X7Receptors

Solle, M., Labasi, J. M., Perregaux, D. G., Stam, E. J., Petrushova, N., Koller, B. H., Griffiths, R., & Gabel, C. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m006781200 · Cited by 924 · see citing works

Rapid Secretion of Interleukin-1β by Microvesicle Shedding

Mackenzie, A. B., Wilson, H. L., Kiss‐Toth, E., Dower, S., North, R. A., & Surprenant, A. (2001) · Immunity · doi:10.1016/s1074-7613(01)00229-1 · Cited by 862 · see citing works

Nucleotide receptors: an emerging family of regulatory molecules in blood cells

Virgilio, F. D., Chiozzi, P., Ferrari, D., Falzoni, S., Sanz, J. M., Morelli, A., Torboli, M., Bolognesi, G., & Baricordi, O. R. (2001) · Blood · doi:10.1182/blood.v97.3.587 · Cited by 702 · see citing works

Tissue distribution of the P2X7 receptor

Collo, G., Neidhart, S., Kawashima, E. H., Kosco‐Vilbois, M. H., North, R. A., & Buell, G. N. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00140-8 · Cited by 493 · see citing works

Absence of the P2X7 Receptor Alters Leukocyte Function and Attenuates an Inflammatory Response

Labasi, J. M., Petrushova, N., Donovan, C. B., McCurdy, S. P., Lira, P. D., Payette, M. M., Brissette, W. H., Wicks, J. R., Audoly, L., & Gabel, C. A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.12.6436 · Cited by 490 · see citing works

Immunohistochemical study of the P2X2 and P2X3 receptor subunits in rat and monkey sensory neurons and their central terminals

Vulchanova, L., Riedl, M. S., Shuster, S. J., Buell, G. N., Surprenant, A., North, R. A., & Elde, R. (1997) · Neuropharmacology · doi:10.1016/s0028-3908(97)00126-3 · Cited by 417 · see citing works

Nucleotide receptors

North, R. A., & Barnard, E. A. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80062-1 · Cited by 414 · see citing works

P2X receptors in peripheral neurons

Dunn, P. M., Zhong, Y., & Burnstock, G. (2001) · Progress in Neurobiology · doi:10.1016/s0301-0082(01)00005-3 · Cited by 365 · see citing works

Molecular physiology of p2x receptors and atp signalling at synapses

Khakh, B. S. (2001) · Nature reviews. Neuroscience · doi:10.1038/35058521 · Cited by 363 · see citing works

Interleukin-1 and neuronal injury: mechanisms, modification, and therapeutic potential

Rothwell, N. J. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(02)00098-3 · Cited by 292 · see citing works

Neuronal P2X₇Receptors Are Targeted to Presynaptic Terminals in the Central and Peripheral Nervous Systems

Deuchars, S. A., Atkinson, L., Brooke, R. E., Musa, H., Milligan, C. J., Batten, T. F. C., Buckley, N. J., Parson, S. H., & Deuchars, J. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07143.2001 · Cited by 287 · see citing works

P2X Receptors and Nociception

Chizh, B. A., & Illés, P. (2001) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01512-6 · Cited by 271 · see citing works

Involvement of P2X₇ receptors in the regulation of neurotransmitter release in the rat hippocampus

Sperlágh, B., Köfalvi, A., Deuchars, J., Atkinson, L., J. Milligan, C., Buckley, N. J., & Vizi, E. S. (2002) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2002.00920.x · Cited by 264 · see citing works

Distinct Localization of P2X Receptors at Excitatory Postsynaptic Specializations

Rubio, M. E., & Soto, F. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-02-00641.2001 · Cited by 260 · see citing works

Neuronal P2X receptors: localisation and functional properties

Nörenberg, W., & Illés, P. (2000) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s002100000311 · Cited by 214 · see citing works

Priming of Macrophages with Lipopolysaccharide Potentiates P2X7-mediated Cell Death via a Caspase-1-dependent Mechanism, Independently of Cytokine Production

Feuvre, R. A. L., Brough, D., Iwakura, Y., Takeda, K., & Rothwell, N. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m104388200 · Cited by 192 · see citing works

P2X7 Receptor-Dependent Blebbing and the Activation of Rho-Effector Kinases, Caspases, and IL-1β Release

Verhoef, P. A., Estación, M., Schilling, W. P., & Dubyak, G. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.11.5728 · Cited by 173 · see citing works

The nucleotide receptor P2X7 mediates actin reorganization and membrane blebbing in RAW 264.7 macrophages via p38 MAP kinase and Rho

Pfeiffer, Z. A., Aga, M., Prabhu, U., Watters, J. J., Hall, D. J., & Bertics, P. J. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.1203648 · Cited by 159 · see citing works

Fast synaptic transmission mediated by P2X receptors in CA3 pyramidal cells of rat hippocampal slice cultures

Mori, M., Heuss, C., Gähwiler, B. H., & Gerber, U. R. (2001) · The Journal of Physiology · doi:10.1111/j.1469-7793.2001.t01-1-00115.x · Cited by 156 · see citing works

ATP Modulation of Excitatory Synapses onto Interneurons

Khakh, B. S., Gittermann, D., Cockayne, D. A., & Jones, A. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-19-07426.2003 · Cited by 155 · see citing works

Sensory presynaptic and widespread somatodendritic immunolocalization of central ionotropic P2X ATP receptors

Lê, K., Villeneuve, P., Ramjaun, A. R., McPherson, P. S., Beaudet, A., & Séguéla, P. (1998) · Neuroscience · doi:10.1016/s0306-4522(97)00365-5 · Cited by 148 · see citing works

Activation of Presynaptic P2X7-Like Receptors Depresses Mossy Fiber–CA3 Synaptic Transmission through p38 Mitogen-Activated Protein Kinase

Armstrong, J. N., Brust, T., Lewis, R. G., & MacVicar, B. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-14-05938.2002 · Cited by 136 · see citing works

Promoter Transgenics Reveal Multiple Gonadotropin-Releasing Hormone-I-Expressing Cell Populations of Different Embryological Origin in Mouse Brain

Skynner, M. J., Slater, R., Sim, J. A., Allen, N. D., & Herbison, A. E. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05955.1999 · Cited by 131 · see citing works

P2X7 Nucleotide Receptor Mediation of Membrane Pore Formation and Superoxide Generation in Human Promyelocytes and Neutrophils

Suh, B., Kim, J., Namgung, U., Ha, H., & Kim, K. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.11.6754 · Cited by 128 · see citing works

Role of P2X 7 Receptors in Ischemic and Excitotoxic Brain Injury In Vivo

Feuvre, R. A. L., Brough, D., Touzani, O., & Rothwell, N. J. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000048519.34839.97 · Cited by 122 · see citing works

Hit-to-Lead studies: The discovery of potent adamantane amide P2X7 receptor antagonists

Baxter, A., Bent, J., Bowers, K. C., Braddock, M., Brough, S., Fagura, M., Lawson, M., McInally, T., Mortimore, M., Robertson, M. J., et al. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2003.08.034 · Cited by 122 · see citing works

Cutting Edge: Purinergic Signaling Regulates Radical-Mediated Bacterial Killing Mechanisms in Macrophages Through a P2X7-Independent Mechanism

Sikora, A. G., Liu, J., Brosnan, C. F., Buell, G. N., Chessel, I., & Bloom, B. R. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.2.558 · Cited by 120 · see citing works

Synaptic P2X receptors

Robertson, S. J., Ennion, S. J., Evans, R. J., & Edwards, F. A. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00222-1 · Cited by 112 · see citing works

Differential Assembly of Rat Purinergic P2X7 Receptor in Immune Cells of the Brain and Periphery

Kim, M., Spelta, V., Sim, J. A., North, R. A., & Surprenant, A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m102253200 · Cited by 102 · see citing works

Neuron‐specific distribution of P2X7 purinergic receptors in the monkey retina

Ishii, K., Kaneda, M., Li, H., Rockland, K. S., & Hashikawa, T. (2003) · The Journal of Comparative Neurology · doi:10.1002/cne.10608 · Cited by 90 · see citing works

Detection of P2X purinergic receptors on human B lymphocytes

Sluyter, R., Barden, J. A., & Wiley, J. S. (2001) · Cell and Tissue Research · doi:10.1007/s004410100372 · Cited by 83 · see citing works

Differential co-localisation of the P2X7 receptor subunit with vesicular glutamate transporters VGLUT1 and VGLUT2 in rat CNS

Atkinson, L., Batten, T. F. C., Moores, T. S., Varoqui, H., Erickson, J. D., & Deuchars, J. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2003.08.065 · Cited by 80 · see citing works

p75NTR immunoreactivity in the rat dentate gyrus is mostly within presynaptic profiles but is also found in some astrocytic and postsynaptic profiles

Dougherty, K. D., & Milner, T. A. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990428)407:1 · Cited by 76 · see citing works

Purinergic receptor regulation of LPS-induced signaling and pathophysiology

Guerra, A. N., Fisette, P. L., Pfeiffer, Z. A., Quinchia-Rios, B. H., Prabhu, U., Aga, M., Denlinger, L. C., Guadarrama, A. G., Abozeid, S. H., Sommer, J. A., et al. (2003) · Journal of Endotoxin Research · doi:10.1177/09680519030090040701 · Cited by 74 · see citing works

Synaptic P2X 7 and Oxygen/Glucose Deprivation in Organotypic Hippocampal Cultures

Cavaliere, F., Amadio, S., Sancesario, G., Bernardi, G., & Volonté, C. (2004) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200404000-00004 · Cited by 74 · see citing works

Novel P2X7 receptor antagonists

Alcaraz, L., Baxter, A., Bent, J., Bowers, K. C., Braddock, M., Cladingboel, D. E., Donald, D. K., Fagura, M., Furber, M., Laurent, C., et al. (2003) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2003.08.033 · Cited by 59 · see citing works

A standardized method of identification of raw and heat-processed fish by urea isoelectric focusing: A collaborative study

Etienne, M., Jérôme, M., Fleurence, J., Rehbein, H., Kündiger, R., Yman, I. M., Ferm, M., Craig, A., Mackie, I., Jessen, F., et al. (1999) · Electrophoresis · doi:10.1002/(sici)1522-2683(19990701)20:10 · Cited by 52 · see citing works

Stimulation of Ca2+ influx through ATP receptors on rat brain synaptosomes: identification of functional P2X7 receptor subtypes

Lundy, P. M., Hamilton, M. G., Mi, L., Gong, W., Vair, C., Sawyer, T. W., & Frew, R. (2002) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0704624 · Cited by 51 · see citing works

An ATP-gated ion channel at the cell nucleus

Atkinson, L., Milligan, C. J., Buckley, N. J., & Deuchars, J. (2002) · Nature · doi:10.1038/420042a · Cited by 51 · see citing works

Presynaptic Modulation Controlling Neuronal Excitability and Epileptogenesis: Role of Kainate, Adenosine and Neuropeptide Y Receptors

Malva, J. O., Silva, A. P., & Cunha, R. A. (2003) · Neurochemical Research · doi:10.1023/a:1025618324593 · Cited by 49 · see citing works

Inhibition of potassium and calcium currents in neurones by molecularly-defined P2Y receptors

Brown, D. A., Filippov, A. K., & Barnard, E. A. (2000) · Journal of the Autonomic Nervous System · doi:10.1016/s0165-1838(00)00150-8 · Cited by 44 · see citing works

ATP- and Adenosine-Mediated Signaling in the Central Nervous System: Synaptic Purinoceptors: the Stage for ATP to Play Its “Dual-Role”

Kato, F., Kawamura, M., Shigetomi, E., Tanaka, J.-I., & Inoue, K. (2004) · Journal of Pharmacological Sciences · doi:10.1254/jphs.94.107 · Cited by 39 · see citing works

Purinergic receptor regulation of LPS-induced signaling and pathophysiology

Guerra, A. N., Fisette, P. L., Pfeiffer, Z. A., et al. (2003) · Journal of Endotoxin Research · doi:10.1179/096805103225001468 · Cited by 29 · see citing works

Physiology of Astroglia

Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678 · see citing works

Astrocyte Control of Synaptic Transmission and Neurovascular Coupling

Haydon, P. G., & Carmignoto, G. (2006) · Physiological Reviews · doi:10.1152/physrev.00049.2005 · Cited by 1,326 · see citing works

The P2X7 Receptor in Infection and Inflammation

Di Virgilio, F., Dal Ben, D., Sarti, A. C., Giuliani, A. L., & Falzoni, S. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.020 · Cited by 1,267 · see citing works

Disruption of the P2X7 purinoceptor gene abolishes chronic inflammatory and neuropathic pain

Chessell, I. P., Hatcher, J. P., Bountra, C., Michel, A. D., Hughes, J. P., Green, P., Egerton, J., Murfin, M., Richardson, J. C., Peck, W. L., et al. (2005) · Pain · doi:10.1016/j.pain.2005.01.002 · Cited by 790 · see citing works

Signaling at Purinergic P2X Receptors

Surprenant, A., & North, R. A. (2008) · Annual Review of Physiology · doi:10.1146/annurev.physiol.70.113006.100630 · Cited by 547 · see citing works

P2X 7 Receptors Mediate ATP Release and Amplification of Astrocytic Intercellular Ca 2+ Signaling

Suadicani, S. O., Brosnan, C. F., & Scemes, E. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.3902-05.2006 · Cited by 512 · see citing works

Activation and Regulation of Purinergic P2X Receptor Channels

Coddou, C., Yan, Z., Obšil, T., Huidobro-Toro, J. P., & Stojilković, S. S. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.003129 · Cited by 493 · see citing works

A-740003 [N-(1-{[(Cyanoimino)(5-quinolinylamino) methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a Novel and Selective P2X7 Receptor Antagonist, Dose-Dependently Reduces Neuropathic Pain in the Rat

Honoré, P., Donnelly‐Roberts, D. L., Namovic, M. T., Hsieh, G. C., Zhu, C., Mikusa, J. P., Hernandez, G., Zhong, C., Gauvin, D. M., Chandran, P., et al. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.106.111559 · Cited by 418 · see citing works

Purinergic signalling: From normal behaviour to pathological brain function

Burnstock, G., Krügel, U., Abbracchio, M. P., & Illés, P. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.08.006 · Cited by 394 · see citing works

The P2X7 Receptor Channel: Recent Developments and the Use of P2X7 Antagonists in Models of Disease

Bartlett, R., Stokes, L., & Sluyter, R. (2014) · Pharmacological Reviews · doi:10.1124/pr.113.008003 · Cited by 395 · see citing works

P2X7 receptor: an emerging target in central nervous system diseases

Sperlágh, B., & Illes, P. (2014) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2014.08.002 · Cited by 390 · see citing works

P2X7 receptors in the nervous system

Sperlágh, B., Vizi, E. S., Wirkner, K., & Illés, P. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.03.007 · Cited by 374 · see citing works

ATP release through connexin hemichannels and gap junction transfer of second messengers propagate Ca 2+ signals across the inner ear

Anselmi, F., Hernández, V. H., Crispino, G., Seydel, A., Ortolano, S., Roper, S. D., Kessaris, N., Richardson, W. D., Rickheit, G., Filippov, M. A., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0800793105 · Cited by 342 · see citing works

Calcium-Permeable Ion Channels in Pain Signaling

Bourinet, E., Altier, C., Hildebrand, M. E., Trang, T., Salter, M. W., & Zamponi, G. W. (2014) · Physiological Reviews · doi:10.1152/physrev.00023.2013 · Cited by 335 · see citing works

The P2X 7 purinergic receptor: from physiology to neurological disorders

Skaper, S. D., Debetto, P., & Giusti, P. (2009) · The FASEB Journal · doi:10.1096/fj.09-138883 · Cited by 336 · see citing works

Pharmacology of P2X channels

Gever, J. R., Cockayne, D. A., Dillon, M. P., Burnstock, G., & Ford, A. P. D. W. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0070-9 · Cited by 298 · see citing works

Discovery of P2X7 receptor‐selective antagonists offers new insights into P2X7 receptor function and indicates a role in chronic pain states

Donnelly‐Roberts, D. L., & Jarvis, M. F. (2007) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0707265 · Cited by 267 · see citing works

P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder

Lucae, S., Salyakina, D., Barden, N., Harvey, M., Gagné, B., Labbé, M., Binder, E. B., Uhr, M., Paez-Pereda, M., Sillaber, I., et al. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl166 · Cited by 261 · see citing works

P2X7 Receptors: Channels, Pores and More

Volonté, C., Apolloni, S., Skaper, S. D., & Burnstock, G. (2012) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152712803581137 · Cited by 254 · see citing works

Involvement of P2 receptors in the growth and survival of neurons in the CNS

Franke, H., & Illés, P. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.06.002 · Cited by 240 · see citing works

Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes

Elliott, J. I., Surprenant, A., Marelli‐Berg, F. M., Cooper, J. C., Cassady-Cain, R. L., Wooding, C., Linton, K. J., Alexander, D. R., & Higgins, C. F. (2005) · Nature Cell Biology · doi:10.1038/ncb1279 · Cited by 228 · see citing works

Molecular and functional properties of P2X receptors—recent progress and persisting challenges

Kaczmarek-Hájek, K., Lörinczi, É., Hausmann, R., & Nicke, A. (2012) · Purinergic Signalling · doi:10.1007/s11302-012-9314-7 · Cited by 223 · see citing works

Purinoceptors on Neuroglia

Verkhratsky, A., Krishtal, O., & Burnstock, G. (2009) · Molecular Neurobiology · doi:10.1007/s12035-009-8063-2 · Cited by 218 · see citing works

P2X7 Interactions and Signaling – Making Head or Tail of It

Kopp, R., Krautloher, A., Ramírez-Fernández, A., & Nicke, A. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00183 · Cited by 217 · see citing works

Dual Presynaptic Control by ATP of Glutamate Release via Facilitatory P2X 1 , P2X 2/3 , and P2X 3 and Inhibitory P2Y 1 , P2Y 2 , and/or P2Y 4 Receptors in the Rat Hippocampus

Rodrigues, R. J., Almeida, T., Richardson, P. J., Oliveira, C. R., & Cunha, R. A. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0628-05.2005 · Cited by 214 · see citing works

Re-evaluation of neuronal P2X7 expression using novel mouse models and a P2X7-specific nanobody

Kaczmarek-Hájek, K., Zhang, J., Kopp, R., Grosche, A., Rissiek, B., Saul, A., Bruzzone, S., Engel, T., Jooss, T., Durner, A., et al. (2018) · eLife · doi:10.7554/elife.36217 · Cited by 210 · see citing works

Emerging challenges of assigning P2X7 receptor function and immunoreactivity in neurons

Anderson, C. M., & Nedergaard, M. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.03.003 · Cited by 207 · see citing works

Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder

Barden, N., Harvey, M., Gagné, B., Shink, É., Tremblay, M., Raymond, C., Labbé, M., Villeneuve, A., Rochette, D., Bordeleau, L., et al. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30303 · Cited by 201 · see citing works

The role of microglial P2X7: modulation of cell death and cytokine release

He, Y., Taylor, N., Fourgeaud, L., & Bhattacharya, A. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0904-8 · Cited by 194 · see citing works

P2X receptors

North, R. A. (2016) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2015.0427 · Cited by 191 · see citing works

Adenosine and ATP Receptors in the Brain

Burnstock, G., Fredholm, B. B., & Verkhratsky, A. (2011) · Current Topics in Medicinal Chemistry · doi:10.2174/156802611795347627 · Cited by 188 · see citing works

A Functional P2X7 Splice Variant with an Alternative Transmembrane Domain 1 Escapes Gene Inactivation in P2X7 Knock-out Mice

Nicke, A., Kuan, Y., Masin, M., Rettinger, J., Marquez-Klaka, B., Bender, O., Górecki, D. C., Murrell‐Lagnado, R. D., & Soto, F. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.033134 · Cited by 187 · see citing works

P2 receptors and neuronal injury

Franke, H., Krügel, U., & Illés, P. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0071-8 · Cited by 184 · see citing works

Altered Hippocampal Synaptic Potentiation in P2X4Knock-Out Mice

Sim, J. A., Chaumont‐Dubel, S., Jo, J., Ulmann, L., Young, M. T., Cho, K., Buell, G. N., North, R. A., & Rassendren, F. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2370-06.2006 · Cited by 180 · see citing works

Neuronal P2X7 Receptors Revisited: Do They Really Exist?

Illes, P., Khan, T. M., & Rubini, P. (2017) · The Journal of Neuroscience · doi:10.1523/jneurosci.3103-16.2017 · Cited by 179 · see citing works

Molecular properties of P2X receptors

Roberts, J. A., Vial, C., Digby, H. R., Agboh, K. C., Wen, H., Atterbury-Thomas, A. E., & Evans, R. J. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0073-6 · Cited by 176 · see citing works

P2X7 receptor signaling contributes to tissue factor–dependent thrombosis in mice

Furlan-Freguia, C., Marchese, P., Gruber, A., Ruggeri, Z. M., & Ruf, W. (2011) · Journal of Clinical Investigation · doi:10.1172/jci46129 · Cited by 169 · see citing works

P2x7 deficiency suppresses development of experimental autoimmune encephalomyelitis

Sharp, A. J., Polak, P. E., Simonini, M. V., Lin, S. X., Richardson, J. C., Bongarzone, E. R., & Feinstein, D. L. (2008) · Journal of Neuroinflammation · doi:10.1186/1742-2094-5-33 · Cited by 167 · see citing works

Purinergic Receptors Mediate Two Distinct Glutamate Release Pathways in Hippocampal Astrocytes

Fellin, T., Pozzan, T., & Carmignoto, G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m510679200 · Cited by 165 · see citing works

The P2X7 Receptor: Central Hub of Brain Diseases

Andrejew, R., Oliveira-Giacomelli, Á., Ribeiro, D. E., Glaser, T., Arnaud-Sampaio, V. F., Lameu, C., & Ulrich, H. (2020) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2020.00124 · Cited by 162 · see citing works

Transient P2X7 Receptor Antagonism Produces Lasting Reductions in Spontaneous Seizures and Gliosis in Experimental Temporal Lobe Epilepsy

Jimenez‐Pacheco, A., Dı́az-Hernández, M., Arribas-Blázquez, M., Sanz‐Rodriguez, A., Olivos-Oré, L. A., Artalejo, A. R., Alves, M., Letavic, M. A., Miras‐Portugal, M. T., Conroy, R. M., et al. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.4009-15.2016 · Cited by 161 · see citing works

Effect of Lead (Pb) on Inflammatory Processes in the Brain

Chibowska, K., Baranowska‐Bosiacka, I., Falkowska, A., Gutowska, I., Goschorska, M., & Chlubek, D. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17122140 · Cited by 154 · see citing works

P2X receptors and synaptic plasticity

Pankratov, Y. V., Lalo, U., Krishtal, O., & Verkhratsky, A. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.03.076 · Cited by 155 · see citing works

Molecular Targets for PET Imaging of Activated Microglia: The Current Situation and Future Expectations

Tronel, C., Largeau, B., Ribeiro, M. J., Guilloteau, D., Dupont, A.-C., & Arlicot, N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18040802 · Cited by 154 · see citing works

Neuronal P2X7 Receptor: Involvement in Neuronal Physiology and Pathology

Miras‐Portugal, M. T., Sebastián‐Serrano, Á., García, L. D. D., & Dı́az-Hernández, M. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.3104-16.2017 · Cited by 154 · see citing works

Epileptogenic roles of astroglial death and regeneration in the dentate gyrus of experimental temporal lobe epilepsy

Kang, T., Kim, D., Kwak, S., Kim, J., Won, M. H., Kim, D. W., Choi, S., & Kwon, O. (2006) · Glia · doi:10.1002/glia.20380 · Cited by 142 · see citing works

Characterization of 11 C-GSK1482160 for Targeting the P2X7 Receptor as a Biomarker for Neuroinflammation

Territo, P. R., Meyer, J. A., Peters, J. S., Riley, A. K., McCarthy, B. P., Gao, M., Wang, M., Green, M. A., Zheng, Q., & Hutchins, G. D. (2016) · Journal of Nuclear Medicine · doi:10.2967/jnumed.116.181354 · Cited by 138 · see citing works

P2X7 Receptors Amplify CNS Damage in Neurodegenerative Diseases

Illés, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21175996 · Cited by 141 · see citing works

Acute retinal ganglion cell injury caused by intraocular pressure spikes is mediated by endogenous extracellular ATP

Resta, V., Novelli, E., Vozzi, G., Scarpa, C., Caleo, M., Ahluwalia, A. D., Solini, A., Santini, E., Parisi, V., Virgilio, F. D., et al. (2007) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2007.05528.x · Cited by 137 · see citing works

P2X7 receptors: Properties and relevance to CNS function

Duan, S., & Neary, J. T. (2006) · Glia · doi:10.1002/glia.20397 · Cited by 136 · see citing works

P2X7 receptor: Death or life?

Adinolfi, E., Pizzirani, C., Idzko, M., Panther, E., Norgauer, J., Virgilio, F. D., & Ferrari, D. (2005) · Purinergic Signalling · doi:10.1007/s11302-005-6322-x · Cited by 136 · see citing works

Characterization of a selective and potent antagonist of human P2X7receptors, AZ11645373

Stokes, L., Jiang, L., Alcaraz, L., Bent, J., Bowers, K., Fagura, M., Furber, M., Mortimore, M., Lawson, M., Theaker, J., et al. (2006) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706933 · Cited by 134 · see citing works

Cellular localization of P2X7 receptor mRNA in the rat brain

Yu, Y., Ugawa, S., Ueda, T., Ishida, Y., Inoue, K., Kyaw Nyunt, A., Umemura, A., Mase, M., Yamada, K., & Shimada, S. (2008) · Brain Research · doi:10.1016/j.brainres.2007.11.064 · Cited by 132 · see citing works

Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions

Roger, S., Mei, Z.-Z., Baldwin, J. M., Dong, L., Bradley, H., Baldwin, S. A., Surprenant, A., & Jiang, L. (2009) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.10.005 · Cited by 131 · see citing works

Stimulation of P2X 7 Receptors Elevates Ca 2+ and Kills Retinal Ganglion Cells

Zhang, X., Zhang, M., Laties, A. M., & Mitchell, C. H. (2005) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.05-0052 · Cited by 130 · see citing works

P2X7 Receptor Signaling in Stress and Depression

Ribeiro, D. E., Roncalho, A. L., Glaser, T., Ulrich, H., Wegener, G., & Joca, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20112778 · Cited by 129 · see citing works

Biophysics of P2X receptors

Egan, T. M., Samways, D. S. K., & Li, Z. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0078-1 · Cited by 128 · see citing works

Expression of P2 nucleotide receptors varies with age and sex in murine brain microglia

Crain, J. M., Nikodémová, M., & Watters, J. J. (2009) · Journal of Neuroinflammation · doi:10.1186/1742-2094-6-24 · Cited by 122 · see citing works

P2X Receptors and Their Roles in Astroglia in the Central and Peripheral Nervous System

Illés, P., Verkhratsky, A., Burnstock, G., & Franke, H. (2011) · The Neuroscientist · doi:10.1177/1073858411418524 · Cited by 121 · see citing works

P2X7 on Mouse T Cells: One Channel, Many Functions

Rissiek, B., Haag, F., Boyer, O., Koch-Nolte, F., & Adriouch, S. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00204 · Cited by 116 · see citing works

Involvement of microglial P2X7 receptors and downstream signaling pathways in long-term potentiation of spinal nociceptive responses

Chu, Y., Zhang, Y., Zhang, Y., & Zhao, Z.-Q. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.06.001 · Cited by 117 · see citing works

The antihyperalgesic activity of a selective P2X7 receptor antagonist, A-839977, is lost in IL-1αβ knockout mice

Honoré, P., Donnelly‐Roberts, D. L., Namovic, M. T., Zhong, C., Wade, C. L., Chandran, P., Zhu, C., Carroll, W. A., Perez‐Medrano, A., Iwakura, Y., et al. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.05.018 · Cited by 116 · see citing works

P2X7 Receptor Signaling Pathway as a Therapeutic Target for Neurodegenerative Diseases

Takenouchi, T., Sekiyama, K., Sekigawa, A., Fujita, M., Waragai, M., Sugama, S., Iwamaru, Y., Kitani, H., & Hashimoto, M. (2010) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-010-0069-y · Cited by 116 · see citing works

Interleukin-1β and Signaling of Interleukin-1 in Vascular Wall and Circulating Cells Modulates the Extent of Neointima Formation in Mice

Chamberlain, J., EVANS, D. B., King, A. R., Dewberry, R. M., Dower, S., Crossman, D. C., & Francis, S. (2006) · American Journal Of Pathology · doi:10.2353/ajpath.2006.051054 · Cited by 116 · see citing works

Expression, assembly and function of novel C‐terminal truncated variants of the mouse P2X7 receptor: re‐evaluation of P2X7 knockouts

Masin, M., Young, C., Lim, K., Barnes, S. J., Xu, X., Marschall, V., Brutkowski, W., Mooney, E. R., Górecki, D. C., & Murrell‐Lagnado, R. D. (2011) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2011.01624.x · Cited by 112 · see citing works

[3H]A-804598 ([3H]2-cyano-1-[(1S)-1-phenylethyl]-3-quinolin-5-ylguanidine) is a novel, potent, and selective antagonist radioligand for P2X7 receptors

Donnelly‐Roberts, D. L., Namovic, M. T., Surber, B. W., Vaidyanathan, S. X., Perez‐Medrano, A., Wang, Y., Carroll, W. A., & Jarvis, M. F. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.06.012 · Cited by 111 · see citing works

Pharmacokinetic and pharmacodynamic profiling of a P2X7 receptor allosteric modulator GSK1482160 in healthy human subjects

Ali, Z., Laurijssens, B. E., Ostenfeld, T., McHugh, S. M., Stylianou, A., Scott‐Stevens, P., Hosking, L. K., Dewit, O., Richardson, J. C., & Chen, C. (2012) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04320.x · Cited by 111 · see citing works

Homotrimeric complexes are the dominant assembly state of native P2X7 subunits

Nicke, A. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.10.042 · Cited by 110 · see citing works

Expression, signaling, and function of P2X7 receptors in bone

Grol, M. W., Panupinthu, N., Korčok, J., Sims, S. M., & Dixon, S. J. (2009) · Purinergic Signalling · doi:10.1007/s11302-009-9139-1 · Cited by 110 · see citing works

Spinal P2X7 receptor mediates microglia activation-induced neuropathic pain in the sciatic nerve injury rat model

He, W., Cui, J. G., Du, L., Zhao, Y., Burnstock, G., Zhou, H., & Ruan, H. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.09.015 · Cited by 107 · see citing works

Purinergic receptor P2X7: A novel target for anti-inflammatory therapy

Mehta, N., Kaur, M., Singh, M., Chand, S., Vyas, B., Silakari, P., Bahia, M. S., & Silakari, O. (2013) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2013.10.054 · Cited by 103 · see citing works

Understanding the roles of the P2X7 receptor in solid tumour progression and therapeutic perspectives

Roger, S., Jelassi, B., Couillin, I., Pelegrı́n, P., Besson, P., & Jiang, L. (2014) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2014.10.029 · Cited by 101 · see citing works

Lack of ATP-evoked GABA and glutamate release in the hippocampus of P2X7 receptor-/- mice

Papp, L., Vizi, E. S., & Sperlágh, B. (2004) · Neuroreport · doi:10.1097/00001756-200410250-00017 · Cited by 102 · see citing works

The ATP-Gated P2X7 Receptor As a Target for the Treatment of Drug-Resistant Epilepsy

Beamer, E. H., Fischer, W., & Engel, T. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00021 · Cited by 100 · see citing works

Direct Excitation of Inhibitory Interneurons by Extracellular ATP Mediated by P2Y1Receptors in the Hippocampal Slice

Kawamura, M., Gachet, C., Inoue, K., & Kato, F. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3028-04.2004 · Cited by 98 · see citing works

The purinergic P2X7 receptor as a potential drug target to combat neuroinflammation in neurodegenerative diseases

Calzaferri, F., Ruiz‐Ruiz, C., de Diego, A. M. G., de Pascual, R., Méndez‐López, I., Cano‐Abad, M. F., Maneu, V., Rı́os, C. D. L., Gandı́a, L., & de Diego, A. M. G. (2020) · Medicinal Research Reviews · doi:10.1002/med.21710 · Cited by 98 · see citing works

On the role of P2X7 receptors in dopamine nerve cell degeneration in a rat model of Parkinson’s disease: studies with the P2X7 receptor antagonist A-438079

Marcellino, D., Suárez-Boomgaard, D., Sánchez-Reina, M. D., Aguirre, J. A., Yoshitake, T., Yoshitake, S., Hagman, B., Kehr, J., Agnati, L. F., Fuxe, K., et al. (2010) · Journal of Neural Transmission · doi:10.1007/s00702-010-0400-0 · Cited by 97 · see citing works

P2X7 Receptor: A Potential Therapeutic Target for Depression?

Deussing, J. M., & Arzt, E. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.07.005 · Cited by 97 · see citing works

P2RX7 Purinoceptor as a Therapeutic Target—The Second Coming?

Young, C., & Górecki, D. C. (2018) · Frontiers in Chemistry · doi:10.3389/fchem.2018.00248 · Cited by 95 · see citing works

Selective P2X7 receptor antagonists for chronic inflammation and pain

Carroll, W. A., Donnelly‐Roberts, D. L., & Jarvis, M. F. (2008) · Purinergic Signalling · doi:10.1007/s11302-008-9110-6 · Cited by 94 · see citing works

Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice

Metzger, M. W., Walser, S. M., Aprile-Garcia, F., Dedic, N., Chen, A., Holsboer, F., ARZT, E. S., Wurst, W., & Deussing, J. M. (2016) · Purinergic Signalling · doi:10.1007/s11302-016-9546-z · Cited by 92 · see citing works

Supersensitivity of P2X₇ receptors in cerebrocortical cell cultures after <i>in vitro</i> ischemia

Wirkner, K., Köfalvi, A., Fischer, W., Günther, A., Franke, H., Gröger‐Arndt, H., Nörenberg, W., Madarász, E., Vizi, E. S., Schneider, D., et al. (2005) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03465.x · Cited by 89 · see citing works

Pore properties and pharmacological features of the P2X receptor channel in airway ciliated cells

Ma, W., Korngreen, A., Weil, S., Cohen, E. B.-T., Priel, A., Kuzin, L., & Silberberg, S. D. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.103408 · Cited by 87 · see citing works

P2X7 receptor-deficient mice are susceptible to bone cancer pain

Hansen, R. R., Nielsen, C. K., Nasser, A., Thomsen, S. I. M., Eghorn, L. F., Pham, Y., Schulenburg, C., Syberg, S., Ding, M. L., Stojilković, S. S., et al. (2011) · Pain · doi:10.1016/j.pain.2011.03.024 · Cited by 86 · see citing works

P2 Receptors for Extracellular Nucleotides in the Central Nervous System: Role of P2X7 and P2Y2 Receptor Interactions in Neuroinflammation

Weisman, G. A., Camden, J. M., Peterson, T. S., Ajit, D., Woods, L. T., & Erb, L. (2012) · Molecular Neurobiology · doi:10.1007/s12035-012-8263-z · Cited by 85 · see citing works

Adenosine and ATP Receptors

Sawynok, J. (2007) · Springer eBooks · doi:10.1007/978-3-540-33823-9_11 · Cited by 82 · see citing works

Functional expression of P2X7 receptors in non-neuronal cells of rat dorsal root ganglia

Zhang, X.-F., Han, P., Faltynek, C. R., Jarvis, M. F., & Shieh, C. (2005) · Brain Research · doi:10.1016/j.brainres.2005.06.022 · Cited by 82 · see citing works

Rodent Cortical Astroglia Express In Situ Functional P2X7 Receptors Sensing Pathologically High ATP Concentrations

Oliveira, J. F., Riedel, T., Leichsenring, A., Heine, C., Franke, H., Krügel, U., Nörenberg, W., & Illés, P. (2010) · Cerebral Cortex · doi:10.1093/cercor/bhq154 · Cited by 81 · see citing works

Critical Evaluation of P2X7 Receptor Antagonists in Selected Seizure Models

Fischer, W., Franke, H., Krügel, U., Müller, H., Dinkel, K., Lord, B., Letavic, M. A., Henshall, D. C., & Engel, T. (2016) · PLoS ONE · doi:10.1371/journal.pone.0156468 · Cited by 81 · see citing works

Lack of P2X receptor mediated currents in astrocytes and GluR type glial cells of the hippocampal CA1 region

Jabs, R., Matthias, K., Grote, A., Grauer, M., Seifert, G., & Steinhäuser, C. (2007) · Glia · doi:10.1002/glia.20580 · Cited by 81 · see citing works

Purinoceptors in microglia and neuropathic pain

Trang, T., Beggs, S., & Salter, M. W. (2006) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-006-0074-5 · Cited by 80 · see citing works

Purinergic P2X7 Receptors Mediate ATP-induced Saliva Secretion by the Mouse Submandibular Gland

Nakamoto, T., Brown, D. A., Catalán, M. A., González–Begne, M., Romanenko, V. G., & Melvin, J. E. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m808597200 · Cited by 79 · see citing works

Carbenoxolone and mefloquine suppress tremor in the harmaline mouse model of essential tremor

Martin, F. C., & Handforth, A. (2006) · Movement Disorders · doi:10.1002/mds.20940 · Cited by 79 · see citing works

Regulation of P2X7 receptor expression and function in the brain

Jimenez-Mateos, E. M., Smith, J., Nicke, A., & Engel, T. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.12.008 · Cited by 79 · see citing works

P2X2 and P2X5 Subunits Define a New Heteromeric Receptor with P2X7-Like Properties

Compan, V., Ulmann, L., Stelmashenko, O., Chemin, J., Chaumont‐Dubel, S., & Rassendren, F. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.6332-11.2012 · Cited by 76 · see citing works

C-terminal Calmodulin-binding Motif Differentially Controls Human and Rat P2X7 Receptor Current Facilitation

Roger, S., Gillet, L., Baroja‐Mazo, A., Surprenant, A., & Pelegrı́n, P. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.053082 · Cited by 76 · see citing works

The role of P2X7 in pain and inflammation

Hughes, J. P., Hatcher, J. P., & Chessell, I. P. (2007) · Purinergic Signalling · doi:10.1007/s11302-006-9031-1 · Cited by 77 · see citing works

Site-Specific Regulation of P2X7 Receptor Function in Microglia Gates Morphine Analgesic Tolerance

Leduc‐Pessah, H., Weilinger, N. L., Fan, C. Y., Burma, N. E., Thompson, R. J., & Trang, T. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0852-17.2017 · Cited by 74 · see citing works

P2X7 as a scavenger receptor for innate phagocytosis in the brain

Gu, B. J., & Wiley, J. S. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14470 · Cited by 73 · see citing works

Characterization of a functional P2X7‐like receptor in cerebellar granule neurons from P2X7 knockout mice

Sánchez‐Nogueiro, J., Marín‐García, P., & Miras‐Portugal, M. T. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.05.073 · Cited by 74 · see citing works

Cellular/Molecular Reanalysis of P2X 7 Receptor Expression in Rodent Brain

Sim, J. A., Young, M. T., Sung, H.-Y., North, R. A., & Surprenant, A. (2013)

The P2X 7 purinergic receptor: from physiology to neurological disorders

Skaper, S. D., Debetto, P., & Giusti, P. (2009) · The FASEB Journal · doi:10.1096/fj.09-138883 · Cited by 336 · see citing works

P2X7 Receptors: Channels, Pores and More

Volonté, C., Apolloni, S., Skaper, S. D., & Burnstock, G. (2012) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/187152712803581137 · Cited by 254 · see citing works

Characterization of a P2X7 BAC reporter mouse model and investigation of the P2X4/P2X7 interaction in mouse lung tissue

Ramírez-Fernández, A. (2023) · doi:10.5282/edoc.32890

The neuronal P2X7R controversy: Revisiting evidence, methods, and unresolved questions

Kachappilly, N., Pizzo, P., & Basso, E. (2026) · Neuropharmacology · doi:10.1016/j.neuropharm.2026.110876 · Cited by 2 · see citing works