The DOI matches its Crossref record; 70 of the 70 references it cites were found in a registry or an index.
Fear Conditioning and Extinction Differentially Modify the Intrinsic Excitability of Infralimbic Neurons
Open accessAbstract
Extinction of conditioned fear is an active learning process involving inhibition of fear expression. It has been proposed that fear extinction potentiates neurons in the infralimbic (IL) prefrontal cortex, but the cellular mechanisms underlying this potentiation remain unknown. It is also not known whether this potentiation occurs locally in IL neurons as opposed to IL afferents. To determine whether extinction enhances the intrinsic excitability of IL pyramidal neurons in layers II/III and V, we performed whole-cell patch-clamp recordings in slices from naive, conditioned, or conditioned-extinguished rats. We observed that conditioning depressed IL excitability compared with slices from naive animals, as evidenced by a decreased number of spikes evoked by injected current and an increase in the slow afterhyperpolarizing potential (sAHP). Extinction reversed these conditioning-induced effects. Furthermore, IL neurons from extinguished rats showed increased burst spiking compared with naive rats, which was correlated with extinction recall. These changes were specific to IL prefrontal cortex and were not observed in prelimbic prefrontal cortex. Together, these findings suggest that IL intrinsic excitability is reduced to allow for expression of conditioning memory and enhanced for expression of extinction memory through the modulation of Ca 2+-gated K+channels underlying the sAHP. Inappropriate modulation of these intrinsic mechanisms may underlie anxiety disorders, characterized by exaggerated fear and deficient extinction.
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Cites
Neurons in medial prefrontal cortex signal memory for fear extinction
Milad, M. R., & Quirk, G. J. (2002) · Nature · doi:10.1038/nature01138 · Cited by 1,836 · cited 2×
“Moreover, extinction potentiates IL activity relative to conditioning, and this potentiation is correlated with expression of extinction memory (Herry and Garcia, 2002; Milad and Quirk, 2002; Barrett et al., 2003).”
BackgroundSelf-citationThe action potential in mammalian central neurons
Bean, B. P. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2148 · Cited by 1,785
Phelps, E. A., Delgado, M. R., Nearing, K. I., & LeDoux, J. E. (2004) · Neuron · doi:10.1016/j.neuron.2004.08.042 · Cited by 1,753
Bursts as a unit of neural information: making unreliable synapses reliable
Lisman, J. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10070-9 · Cited by 1,409
Rauch, S. L., Shin, L. M., & Phelps, E. A. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.06.004 · Cited by 1,397
Prefrontal cortex in the rat: Projections to subcortical autonomic, motor, and limbic centers
Gabbott, P. L. A., Warner, T. A., Jays, P. R. L., Salway, P., & Busby, S. J. (2005) · Journal of Comparative Neurology · doi:10.1002/cne.20738 · Cited by 1,227
Milad, M. R., Wright, C. I., Orr, S. P., Pitman, R. K., Quirk, G. J., & Rauch, S. L. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.10.011 · Cited by 1,197
Self-citationThe role of ventromedial prefrontal cortex in the recovery of extinguished fear
Quirk, G. J., Russo, G. K., Barron, J. L., & Lebron, K. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-16-06225.2000 · Cited by 957 · cited 2×
“Electrolytic lesions or pharmacological inactivation of IL had no effect on conditioning or extinction training but impaired subsequent recall of extinction memory (Morgan et al., 1993; Quirk et al., 2000; Lebron et al., 2004; Sierra-Mercado et al., 2006).”
BackgroundSelf-citationQuirk, G. J., Likhtik, E., Pelletier, J. G., & Paré, D. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-25-08800.2003 · Cited by 927
Self-citationExtinction of emotional learning: contribution of medial prefrontal cortex
Morgan, M. A., Romanski, L. M., & LeDoux, J. E. (1993) · Neuroscience Letters · doi:10.1016/0304-3940(93)90241-c · Cited by 897 · cited 2×
“Electrolytic lesions or pharmacological inactivation of IL had no effect on conditioning or extinction training but impaired subsequent recall of extinction memory (Morgan et al., 1993; Quirk et al., 2000; Lebron et al., 2004; Sierra-Mercado et al., 2006).”
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Cited by
Stress Effects on Neuronal Structure: Hippocampus, Amygdala, and Prefrontal Cortex
McEwen, B. S., Nasca, C., & Gray, J. D. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.171 · Cited by 1,574
Fear Extinction as a Model for Translational Neuroscience: Ten Years of Progress
Milad, M. R., & Quirk, G. J. (2012) · Annual Review of Psychology · doi:10.1146/annurev.psych.121208.131631 · Cited by 1,466
Self-citationPrefrontal control of fear: more than just extinction
Sotres-Bayon, F., & Quirk, G. J. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2010.02.005 · Cited by 625
“In support of the latter possibility, it was recently shown that conditioning and extinction decreased and increased, respectively, the intrinsic excitability of IL neurons [23 ].”
BackgroundSelf-citationThe Influence of Stress Hormones on Fear Circuitry
Rodrigues, S. M., LeDoux, J. E., & Sapolsky, R. M. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135620 · Cited by 556
Targeted electrode-based modulation of neural circuits for depression.
Mayberg, H. S. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38454 · Cited by 542
Metadata
- Authors
- Santini, E., Quirk, G. J., & Porter, J. T.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-04-09
- Volume
- 28
- Issue
- 15
- Pages
- 4028-4036
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1975341827
- Cited by
- 275
- References
- 70
- FWCI
- 9.42
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Santini, E., Quirk, G. J., & Porter, J. T. (2008). Fear Conditioning and Extinction Differentially Modify the Intrinsic Excitability of Infralimbic Neurons. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.2623-07.2008
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