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Complete Pattern of Ocular Dominance Columns in Human Primary Visual Cortex
Open accessAbstract
The occipital lobes were obtained after death from six adult subjects with monocular visual loss. Flat-mounts were processed for cytochrome oxidase (CO) to reveal metabolic activity in the primary (V1) and secondary (V2) visual cortices. Mean V1 surface area was 2643 mm 2 (range, 1986–3477 mm 2 ). Ocular dominance columns were present in all cases, having a mean width of 863 μm. There were 78–126 column pairs along the V1 perimeter. Human column patterns were highly variable, but in at least one person they resembled a scaled-up version of macaque columns. CO patches in the upper layers were centered on ocular dominance columns in layer 4C, with one exception. In this individual, the columns in a local area resembled those present in the squirrel monkey, and no evidence was found for column/patch alignment. In every subject, the blind spot of the contralateral eye was conspicuous as an oval region without ocular dominance columns. It provided a precise landmark for delineating the central 15° of the visual field. A mean of 53.1% of striate cortex was devoted to the representation of the central 15°. This fraction was less than the proportion of striate cortex allocated to the representation of the central 15° in the macaque. Within the central 15°, each eye occupied an equal territory. Beyond this eccentricity, the contralateral eye predominated, occupying 63% of the cortex. In one subject, monocular visual loss began at age 4 months, causing shrinkage of ocular dominance columns. In V2, which had a larger surface area than V1, CO stripes were present but could not be classified as thick or thin.
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“Our predictions reflect the fact that orientation and on–off dominance columns are relatively large (> 2 mm for a full ocular dominance/pinwheel map41,42).”
From A virtual patient simulation modeling the neural and perceptual effects of human visual cortical stimulation, from pulse trains to percepts (2024) · cites this paper as [42]
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Cites
A Computational Approach to Edge Detection
Canny, J. (1986) · IEEE Transactions on Pattern Analysis and Machine Intelligence · doi:10.1109/tpami.1986.4767851 · Cited by 30,004
Borders of Multiple Visual Areas in Humans Revealed by Functional Magnetic Resonance Imaging
Sereno, M. I., Dale, A. M., Reppas, J. B., Kwong, K. K., Belliveau, J. W., Brady, T. J., Rosen, B. R., & Tootell, R. B. H. (1995) · Science · doi:10.1126/science.7754376 · Cited by 2,663
Ferrier lecture. Functional architecture of macaque monkey visual cortex
Hubel, D. H., & Wiesel, T. N. (1977) · Proceedings of the Royal Society of London. Series B. Biological Sciences · doi:10.1098/rspb.1977.0085 · Cited by 2,608
Wong‐Riley, M. T. T. (1979) · Brain Research · doi:10.1016/0006-8993(79)90728-5 · Cited by 1,853
Topography of ganglion cells in human retina
Curcio, C. A., & Allen, K. A. (1990) · The Journal of Comparative Neurology · doi:10.1002/cne.903000103 · Cited by 1,849
Plasticity of ocular dominance columns in monkey striate cortex
Hubel, D. H., Wiesel, T. N., LeVay, S., Barlow, H. B., & Gaze, R. M. (1977) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1977.0050 · Cited by 1,629
Retinotopic organization in human visual cortex and the spatial precision of functional MRI
Engel, S. A. (1997) · Cerebral Cortex · doi:10.1093/cercor/7.2.181 · Cited by 1,606
Mapping striate and extrastriate visual areas in human cerebral cortex.
DeYoe, E. A., Carman, G. J., Bandettini, P. A., Glickman, S., Wieser, J., Cox, R. W., Miller, D. A., & Jay Neitz, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.6.2382 · Cited by 1,047
Essen, D. C. V., Newsome, W. T., & Maunsell, J. H. R. (1984) · Vision Research · doi:10.1016/0042-6989(84)90041-5 · Cited by 938
The Representation of the Visual Field in Human Striate Cortex
Horton, J. C. (1991) · Archives of Ophthalmology · doi:10.1001/archopht.1991.01080060080030 · Cited by 715
Self-citationVisual field representations and locations of visual areas V1/2/3 in human visual cortex
Dougherty, R. F., Koch, V. M., Brewer, A. A., Fischer, B., Jan Modersitzki, C., & Wandell, B. A. (2003) · Journal of Vision · doi:10.1167/3.10.1 · Cited by 538
Functional anatomy of macaque striate cortex. II. Retinotopic organization
Tootell, R. B. H., Switkes, E., Silverman, M. S., & Hamilton, S. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-05-01531.1988 · Cited by 511
Functional anatomy of macaque striate cortex. III. Color
Tootell, R. B. H., Silverman, M. S., Hamilton, S., Valois, R. L. D., & Switkes, E. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-05-01569.1988 · Cited by 472
Segregation of efferent connections and receptive field properties in visual area V2 of the macaque
DeYoe, E. A., & Essen, D. C. V. (1985) · Nature · doi:10.1038/317058a0 · Cited by 465
Segregation of pathways leading from area V2 to areas V4 and V5 of macaque monkey visual cortex
Shipp, S. D., & Zeki, S. (1985) · Nature · doi:10.1038/315322a0 · Cited by 446
Wiesel, T. N., Hubel, D. H., & Lam, D. M.-K. (1974) · Brain Research · doi:10.1016/0006-8993(74)90416-8 · Cited by 432
The topography and variability of the primary visual cortex in man
Stensaas, S. S., Eddington, D. K., & Dobelle, W. H. (1974) · Journal of neurosurgery · doi:10.3171/jns.1974.40.6.0747 · Cited by 420
Cytochrome oxidase patches: a new cytoarchitectonic feature of monkey visual cortex
Horton, J. C. (1984) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1984.0021 · Cited by 407
Self-citationCortical magnification within human primary visual cortex correlates with acuity thresholds
Duncan, R. O., & Boynton, G. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00265-4 · Cited by 385
Human Ocular Dominance Columns as Revealed by High-Field Functional Magnetic Resonance Imaging
Cheng, K., Waggoner, R. A., & Tanaka, K. (2001) · Neuron · doi:10.1016/s0896-6273(01)00477-9 · Cited by 383
Correlated Size Variations in Human Visual Cortex, Lateral Geniculate Nucleus, and Optic Tract
Andrews, T. J., Halpern, S. D., & Purves, D. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-08-02859.1997 · Cited by 380
Anatomical Demonstration of Columns in the Monkey Striate Cortex
Hubel, D. H., & Wiesel, T. N. (1969) · Nature · doi:10.1038/221747a0 · Cited by 373
Spatial Relationships among Three Columnar Systems in Cat Area 17
Hübener, M., Shoham, D., Grinvald, A., & Bonhoeffer, T. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-23-09270.1997 · Cited by 372
Geometry of orientation and ocular dominance columns in monkey striate cortex
Obermayer, K., & Blasdel, G. (1993) · The Journal of Neuroscience · doi:10.1523/jneurosci.13-10-04114.1993 · Cited by 330
Functional Organization of the Second Cortical Visual Area in Primates
Tootell, R. B. H., Silverman, M. S., Valois, R. L. D., & Jacobs, G. H. (1983) · Science · doi:10.1126/science.6301017 · Cited by 295
Spatio-temporal point-spread function of fMRI signal in human gray matter at 7 Tesla
Shmuel, A., Yacoub, E., Chaimow, D., Logothetis, N. K., & Ugurbil, K. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2006.12.030 · Cited by 294
Ocular Dominance in Human V1 Demonstrated by Functional Magnetic Resonance Imaging
Menon, R. S., Ogawa, S., Strupp, J., & Uǧurbil, K. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.77.5.2780 · Cited by 293
LeVay, S., Connolly, M. B., Houde, J., & Essen, D. C. V. (1985) · Journal of Neuroscience · doi:10.1523/jneurosci.05-02-00486.1985 · Cited by 270
Anatomical Evidence for MT and Additional Cortical Visual Areas in Humans
Tootell, R. B. H., & Taylor, J. B. (1995) · Cerebral Cortex · doi:10.1093/cercor/5.1.39 · Cited by 253
Mapping of cytochrome oxidase patches and ocular dominance columns in human visual cortex
Horton, J. C., & Hedley‐Whyte, E. T. (1984) · Philosophical transactions of the Royal Society of London. Series B, Biological sciences · doi:10.1098/rstb.1984.0022 · Cited by 241
Self-citationHolmes, G. M., & Lister, W. T. (1916) · Brain · doi:10.1093/brain/39.1-2.34 · Cited by 232
The determination of molecular orbitals
Lennard-Jones, J. E. (1949) · Proceedings of the Royal Society of London A Mathematical and Physical Sciences · doi:10.1098/rspa.1949.0083 · Cited by 206
Intrinsic Variability of Ocular Dominance Column Periodicity in Normal Macaque Monkeys
Horton, J. C., & Hocking, D. R. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-22-07228.1996 · Cited by 156
Self-citationClark, V. P., Courchesne, E., & Grafe, M. R. (1992) · Cerebral Cortex · doi:10.1093/cercor/2.5.417 · Cited by 150
Gender-Specific Left–Right Asymmetries in Human Visual Cortex
Amunts, K., Armstrong, E., Maliković, A., Hömke, L., Mohlberg, H., Schleicher, A., & Zilles, K. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.4753-06.2007 · Cited by 142
Brief visual stimulation allows mapping of ocular dominance in visual cortex using fMRI
Goodyear, B. G., & Menon, R. S. (2001) · Human Brain Mapping · doi:10.1002/hbm.1053 · Cited by 142
The overall pattern of ocular dominance bands in cat visual cortex
Anderson, P., Olavarría, J. F., & Sluyters, R. C. V. (1988) · Journal of Neuroscience · doi:10.1523/jneurosci.08-06-02183.1988 · Cited by 139
Inouye, T. (1909) · W. Engelmann eBooks · Cited by 130
Arrangement of Ocular Dominance Columns in Human Visual Cortex
Horton, J. C. (1990) · Archives of Ophthalmology · doi:10.1001/archopht.1990.01070090127054 · Cited by 125
Self-citationFunctional Retinotopy of Monkey Visual Cortex
Blasdel, G. G., & Campbell, D. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-20-08286.2001 · Cited by 122
Moon, C.-H., Fukuda, M., Park, S., & Kim, S.-G. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.0445-07.2007 · Cited by 106
Representation of the visual field in the occipital striate cortex.
McFadzean, R. M., Brosnahan, D. M., Hadley, D. M., & Mutlukan, E. (1994) · British Journal of Ophthalmology · doi:10.1136/bjo.78.3.185 · Cited by 104
Capricious expression of cortical columns in the primate brain
Adams, D. L., & Horton, J. C. (2003) · Nature Neuroscience · doi:10.1038/nn1004 · Cited by 103
Self-citationSpatial specificity of cerebral blood volume-weighted fMRI responses at columnar resolution
Zhao, F., Wang, P., Hendrich, K. S., & Kim, S. (2005) · NeuroImage · doi:10.1016/j.neuroimage.2005.04.011 · Cited by 102
Anatomical Demonstration of Ocular Dominance Columns in Striate Cortex of the Squirrel Monkey
Horton, J. C., & Hocking, D. R. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-17-05510.1996 · Cited by 90
Self-citationProjection into the visual field of ocular dominance columns in macaque monkey
Hubel, D. H., & Freeman, D. (1977) · Brain Research · doi:10.1016/0006-8993(77)90299-2 · Cited by 84
Complete flatmounting of the macaque cerebral cortex
Sincich, L. C., Adams, D. L., & Horton, J. C. (2003) · Visual Neuroscience · doi:10.1017/s0952523803206088 · Cited by 80
Self-citationOcular dominance columns: evidence for their presence in humans
Hitchcock, P. F., & Hickey, T. L. (1980) · Brain Research · doi:10.1016/0006-8993(80)90841-0 · Cited by 79
Unfolding and flattening the cortex of gyrencephalic brains
Olavarría, J. F., & Sluyters, R. C. V. (1985) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(85)90098-6 · Cited by 75
Lister, W. T., & Holmes, G. M. (1916) · Proceedings of the Royal Society of Medicine · doi:10.1177/003591571600901711 · Cited by 74
Horton, J. C., & Stryker, M. P. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.12.5494 · Cited by 73
Self-citationCytochrome-oxidase blobs in cat primary visual cortex
Murphy, K., Jones, D., & Sluyters, R. V. (1995) · Journal of Neuroscience · doi:10.1523/jneurosci.15-06-04196.1995 · Cited by 71
Genetic Influence on Quantitative Features of Neocortical Architecture
Kaschube, M., Wolf, F., Geisel, T., & Löwel, S. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-16-07206.2002 · Cited by 71
The pattern of ocular dominance columns in flat-mounts of the cat visual cortex
Löwel, S., & Singer, W. (1987) · Experimental Brain Research · doi:10.1007/bf00249809 · Cited by 64
Xu, X., Bosking, W. H., WHITE, L. E., Fitzpatrick, D., & Casagrande, V. A. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00354.2005 · Cited by 63
Two methods for flat-mounting cortical tissue
Tootell, R. B. H., & Silverman, M. S. (1985) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(85)90097-4 · Cited by 62
Dyck, R. H., & Cynader, M. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.19.9066 · Cited by 61
Direct mapping of ocular dominance columns in human primary visual cortex
Dechent, P., & Frahm, J. (2000) · Neuroreport · doi:10.1097/00001756-200009280-00039 · Cited by 59
Florence, S. L., & Kaas, J. H. (1992) · Visual Neuroscience · doi:10.1017/s0952523800004958 · Cited by 58
Horton, J. C., & Hocking, D. R. (1998) · Visual Neuroscience · doi:10.1017/s0952523898152124 · Cited by 55
Self-citationComplete pattern of ocular dominance stripes in V1 of a New World monkey, Cebus apella
Rosa, M. G. P., Gattass, R., & Fiorani, M. (1988) · Experimental Brain Research · doi:10.1007/bf00250609 · Cited by 55
Swindale, N. V. (1988) · The Journal of Comparative Neurology · doi:10.1002/cne.902670403 · Cited by 55
Mu�oz, A., Liu, X.-B., & Jones, E. G. (1999) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19990712)409:4 · Cited by 50
Representation of the Visual Field in the Human Occipital Cortex
WONG, A. M. F. (1999) · Archives of Ophthalmology · doi:10.1001/archopht.117.2.208 · Cited by 50
Computational Studies of the Spatial Architecture of Primate Visual Cortex
Schwartz, E. L. (1994) · Cerebral cortex · doi:10.1007/978-1-4757-9628-5_9 · Cited by 48
STUDIES ON THE CENTRAL VISUAL SYSTEM
PUTNAM, T. J. (1926) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1926.02200300003001 · Cited by 43
Korogi, Y., Takahashi, M., Hirai, T., Ikushima, I., Kitajima, M., Sugahara, T., Shigematsu, Y., Okajima, T., & Mukuno, K. (1997) · PubMed Central · Cited by 41
Behavioral perimetry in monkeys.
Harwerth, R. S., Smith, E. L., & DeSantis, L. M. (1993) · PubMed · Cited by 37
STUDIES ON THE CENTRAL VISUAL CONNECTIONS
PUTNAM, T. J. (1926) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1926.02200290029003 · Cited by 34
Monocular Cells Without Ocular Dominance Columns
Adams, D. L., & Horton, J. C. (2006) · Journal of Neurophysiology · doi:10.1152/jn.00131.2006 · Cited by 30
Self-citationCytochrome Oxidase and Neurofilament Reactivity in Monocularly Deprived Human Primary Visual Cortex
Duffy, K. R., Murphy, K. M., Frosch, M. P., & Livingstone, M. S. (2006) · Cerebral Cortex · doi:10.1093/cercor/bhl038 · Cited by 22
Lia, B., & Olavarría, J. F. (1996) · Visual Neuroscience · doi:10.1017/s0952523800008130 · Cited by 15
Ocular dominance columns in strabismus
Adams, D. L., & Horton, J. C. (2006) · Visual Neuroscience · doi:10.1017/s0952523806230116 · Cited by 13
Self-citationComparison between monkey and human visual fields using a personal computer system
Sasaoka, M., Hara, H., & Nakamura, K. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.02.009 · Cited by 10
An albino-like decussation error in the optic chiasm revealed by anomalous ocular dominance columns
Sincich, L. C., & Horton, J. C. (2002) · Visual Neuroscience · doi:10.1017/s0952523802194132 · Cited by 7
Self-citation
Research works printed but not linked: 3
- Brodmann, 1918, Individuelle Variationen der Sehsphäre und ihr Bedeutung für die Klinik der Hinterhauptschüsse, Allgz Psychiat (Berlin), 74, 564
- Filimonoff, 1932, Über die Variabilität der Grosshirnrindenstruktur. Regio occipitalis beim erwachsenen Menschen, J Psychol Neurol, 44, 1
- Popoff, 1927, Zur Kenntnis der Grösse der Area striate und die Methodik ihrer Ausmessung, J Psychol Neurol, 34, 238
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Metadata
- Authors
- Adams, D. L., Sincich, L. C., & Horton, J. C.
- Affiliations
- University of California, San Francisco (US)
- Corresponding author
- Horton, Jonathan C.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-09-26
- Volume
- 27
- Issue
- 39
- Pages
- 10391-10403
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6673158
- OpenAlex
- W2041587140
- Cited by
- 212
- References
- 76
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 13 · 2023: 11 · 2022: 14 · 2021: 9 · 2020: 12 · 2019: 13 · 2018: 7 · 2017: 17 · 2016: 12 · 2015: 13 · 2014: 8 · 2013: 8 · 2012: 13
- FWCI
- 5.38
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Iris (University of Trento) (submittedVersion)
- Funders
- National Eye Institute (EY02162, P30EY002162, R01EY010217)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Life Sciences › Neuroscience › Cognitive Neuroscience › Tactile and Sensory Interactions
- Keywords
- ocular dominance columns, primary visual cortex, secondary visual cortex, cytochrome c oxidase, monocular visual loss, visual field representation, blind spots, column width, squirrel monkey
- MeSH terms
- Adult, Aged, Animals, Blindness, Cadaver, Electron Transport Complex IV, Humans, Macaca, Male, Visual Cortex, Visual Fields, Vision, Binocular, Vision, Monocular, Eye Enucleation, Dominance, Ocular
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