Satb1 is an activity-modulated transcription factor required for the terminal differentiation and connectivity of medial ganglionic eminence-derived cortical interneurons
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Although previous work identified transcription factors crucial for the specification and migration of parvalbumin (PV)-expressing and somatostatin (SST)-expressing interneurons, the intrinsic factors required for the terminal differentiation, connectivity, and survival of these cell types remain uncharacterized. Here we demonstrate that, within subpopulations of cortical interneurons, Satb1 (special AT-rich binding protein) promotes terminal differentiation, connectivity, and survival in interneurons that express PV and SST. We find that conditional removal of Satb1 in mouse interneurons results in the loss of a majority of SST-expressing cells across all cortical layers, as well as some PV-expressing cells in layers IV and VI, by postnatal day 21. SST-expressing cells initially migrate to the cortex in Satb1 mutant mice, but receive reduced levels of afferent input and begin to die during the first postnatal week. Electrophysiological characterization indicates that loss of Satb1 function in interneurons results in a loss of functional inhibition of excitatory principal cells. These data suggest that Satb1 is required for medial ganglionic eminence-derived interneuron differentiation, connectivity, and survival.
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Decreasing interneuron excitability by overexpressing Kir2.1 cell-autonomously reduces survival.
“while decreasing the excitability of interneurons through the overexpression of the inward-rectifying potassium channel Kir2.1 cell-autonomously diminishes their survival (Close et al., 2012; Priya et al., 2018) (Figure 6B).”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Close et al., 2012
Cell-autonomous manipulation of cortical interneuron excitability influences their survival.
“Second, cell-autonomous manipulation of the excitability of cortical interneurons influence their survival.”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Close et al., 2012
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References 74 · Cited by 141
Research works printed but not linked: 2
- Butt SJ Cobos I Golden J Kessaris N Pachnis V Anderson S Transcriptional regulation of cortical interneuron development J Neurosci 2007 27 11847 11850 17978022 PMC6673372
- Gelman DM Martini FJ Nobrega-Pereira S Pierani A Kessaris N Marin O J Neuroscience 2009 29 9380 9 PMC6665570 19625528
- Authors
- Close, J., Xu, H., De Marco García, N., Batista-Brito, R., Rossignol, E., Rudy, B., & Fishell, G.
- Affiliations
- NYU Langone Health (US)
- Corresponding author
- Rudy, Bernardo
- Fishell, Gord
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-12-05
- Volume
- 32
- Issue
- 49
- Pages
- 17690-17705
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC3654406
- OpenAlex
- W2007091385
- Cited by
- 141
- References
- 74
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 7 · 2023: 12 · 2022: 9 · 2021: 14 · 2020: 9 · 2019: 10 · 2018: 18 · 2017: 11 · 2016: 8 · 2015: 10 · 2014: 8 · 2013: 8
- FWCI
- 2.80
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R00MH095825, R01MH071679, R37MH071679)
- National Institute of Neurological Disorders and Stroke (R01NS081297)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- SATB1, cortical interneurons, parvalbumin interneurons, somatostatin interneurons, medial ganglionic eminence, interneuron connectivity, conditional gene deletion, afferent input, functional inhibition, interneuron migration
- MeSH terms
- Animals, Cell Differentiation, Cell Movement, Cell Survival, Cerebral Cortex, Interneurons, Mice, Inbred C57BL, Mice, Transgenic, Neural Inhibition, Parvalbumins, Somatostatin, Transcription Factors, Presynaptic Terminals, Gene Expression Regulation, Developmental, Excitatory Postsynaptic Potentials, Matrix Attachment Region Binding Proteins, Mice, Brain Waves
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