The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Vascular Endothelial Growth Factor Overexpression Delays Neurodegeneration and Prolongs Survival in Amyotrophic Lateral Sclerosis Mice
Open accessAbstract
We sought genetic evidence for the involvement of neuronal vascular endothelial growth factor (VEGF) in amyotrophic lateral sclerosis (ALS). Mice expressing human ALS mutant superoxide dismutase-1 (SOD1) were crossed with mice that overexpress VEGF in neurons (VEGF+/+). We report that SOD1 G93A/VEGF+/+double-transgenic mice show delayed motor neuron loss, delayed motor impairment, and prolonged survival compared with SOD1 G93A single transgenics. These findings indicate that neuronal VEGF protects against motor neuron degeneration, and may have therapeutic implications for ALS.
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Cites
Rosen, D. R., Siddique, T., Patterson, D., Figlewicz, D. A., Sapp, P., Hentati, A., Donaldson, D., Goto, J., O'Regan, J. P., Deng, H.-X., et al. (1993) · Nature · doi:10.1038/362059a0 · Cited by 7,062
Wang, Y. (2004) · Brain · doi:10.1093/brain/awh325 · Cited by 221
Self-citation
Cited by
Current hypotheses for the underlying biology of amyotrophic lateral sclerosis
Rothstein, J. D. (2009) · Annals of Neurology · doi:10.1002/ana.21543 · Cited by 703
Saint-Geniez, M., Maharaj, A. S. R., Walshe, T. E., Tucker, B. A., Sekiyama, E., Kurihara, T., Darland, D. C., Young, M. J., & D'Amore, P. A. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003554 · Cited by 616
Role and Therapeutic Potential of VEGF in the Nervous System
Ruiz de Almodovar, C., Lambrechts, D., Mazzone, M., & Carmeliet, P. (2009) · Physiological Reviews · doi:10.1152/physrev.00031.2008 · Cited by 448
Therapeutic potential of mood stabilizers lithium and valproic acid:Beyond bipolar disorder
Chiu, C.-T., Wang, Z., Hunsberger, J. G., & Chuang, D.-M. (2013) · Pharmacological Reviews · doi:10.1124/pr.111.005512 · Cited by 404
Vascular endothelial growth factor: a neurovascular target in neurological diseases
Lange, C., Storkebaum, E., de Almodóvar, C. R., Dewerchin, M., & Carmeliet, P. (2016) · Nature Reviews Neurology · doi:10.1038/nrneurol.2016.88 · Cited by 382
Metadata
- Authors
- Wang, Y., Ou Mao, X., Xie, L., Banwait, S., Marti, H. H., Greenberg, D. A., & Jin, K.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2007-01-10
- Volume
- 27
- Issue
- 2
- Pages
- 304-307
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W2083959138
- Cited by
- 168
- References
- 2
- FWCI
- 12.49
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: Vascular Endothelial Growth Factor Overexpression Delays Neurodegeneration and Prolongs Survival in Amyotrophic Lateral Sclerosis Mice. https://app.cochat.ai/papers/10.1523/jneurosci.4433-06.2007
- The paper
- Wang, Y., Ou Mao, X., Xie, L., Banwait, S., Marti, H. H., Greenberg, D. A., & Jin, K. (2007). Vascular Endothelial Growth Factor Overexpression Delays Neurodegeneration and Prolongs Survival in Amyotrophic Lateral Sclerosis Mice. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.4433-06.2007
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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