The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
A Cre-Dependent GCaMP3 Reporter Mouse for Neuronal Imaging In Vivo
Open accessAbstract
Fluorescent calcium indicator proteins, such as GCaMP3, allow imaging of activity in genetically defined neuronal populations. GCaMP3 can be expressed using various gene delivery methods, such as viral infection or electroporation. However, these methods are invasive and provide inhomogeneous and nonstationary expression. Here, we developed a genetic reporter mouse, Ai38, which expresses GCaMP3 in a Cre-dependent manner from the ROSA26 locus, driven by a strong CAG promoter. Crossing Ai38 with appropriate Cre mice produced robust GCaMP3 expression in defined cell populations in the retina, cortex, and cerebellum. In the primary visual cortex, visually evoked GCaMP3 signals showed normal orientation and direction selectivity. GCaMP3 signals were rapid, compared with virally expressed GCaMP3 and synthetic calcium indicators. In the retina, Ai38 allowed imaging spontaneous calcium waves in starburst amacrine cells during development, and light-evoked responses in ganglion cells in adult tissue. Our results show that the Ai38 reporter mouse provides a flexible method for targeted expression of GCaMP3.
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Komiyama, T., Sato, T. R., O’Connor, D. H., Zhang, Y.-X., Huber, D., Hooks, B. M., Gabitto, M., & Svoboda, K. (2010) · Nature · doi:10.1038/nature08897 · Cited by 447
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Chen, T.-W., Wardill, T. J., Sun, Y., Pulver, S. R., Renninger, S. L., Baohan, A., Schreiter, E. R., Kerr, R. A., Orger, M. B., Jayaraman, V., et al. (2013) · Nature · doi:10.1038/nature12354 · Cited by 6,474
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Madisen, L., Garner, A. R., Shimaoka, D., Chuong, A. S., Klapoetke, N. C., Li, L., van der Bourg, A., Niino, Y., Egolf, L., Monetti, C., et al. (2015) · Neuron · doi:10.1016/j.neuron.2015.02.022 · Cited by 1,114
Self-citationDaigle, T. L., Madisen, L., Hage, T. A., Valley, M. T., Knoblich, U., Larsen, R. S., Takeno, M. M., Huang, L., Gu, H., Larsen, R., et al. (2018) · Cell · doi:10.1016/j.cell.2018.06.035 · Cited by 817
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Metadata
- Authors
- Zariwala, H. A., Borghuis, B. G., Hoogland, T. M., Madisen, L., Tian, L., De Zeeuw, C. I., Zeng, H., Looger, L. L., Svoboda, K., & Chen, T.-W.
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2012-02-29
- Volume
- 32
- Issue
- 9
- Pages
- 3131-3141
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- OpenAlex
- W1989470236
- Cited by
- 353
- References
- 6
- FWCI
- 17.99
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Zariwala, H. A., Borghuis, B. G., Hoogland, T. M., Madisen, L., Tian, L., De Zeeuw, C. I., Zeng, H., Looger, L. L., Svoboda, K., & Chen, T.-W. (2012). A Cre-Dependent GCaMP3 Reporter Mouse for Neuronal Imaging In Vivo. The Journal of Neuroscience. https://doi.org/10.1523/jneurosci.4469-11.2012
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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