VSDI: a new era in functional imaging of cortical dynamics
Abstract
During the last few decades, neuroscientists have benefited from the emergence of many powerful functional imaging techniques that cover broad spatial and temporal scales. We can now image single molecules controlling cell differentiation, growth and death; single cells and their neurites processing electrical inputs and sending outputs; neuronal circuits performing neural computations in vitro; and the intact brain. At present, imaging based on voltage-sensitive dyes (VSDI) offers the highest spatial and temporal resolution for imaging neocortical functions in the living brain, and has paved the way for a new era in the functional imaging of cortical dynamics. It has facilitated the exploration of fundamental mechanisms that underlie neocortical development, function and plasticity at the fundamental level of the cortical column.
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In two animals using voltage sensitive dyes, somatosensory cortex function was present 40-90 min after reperfusion.
“To further examine this issue, in two animals using voltage sensitive dyes that directly measure sensory-evoked depolarization (Grinvald and Hildesheim, 2004;Ferezou et al., 2006), we confirmed that somatosensory cortex function was present 40 -90 min after reperfusion (supplemental Fig. 2, available at www.jneurosci.org as supplemental material).”
From Two-Photon Imaging of Stroke Onset<i>In Vivo</i>Reveals That NMDA-Receptor Independent Ischemic Depolarization Is the Major Cause of Rapid Reversible Damage to Dendrites and Spines (2008) · cites this paper as Grinvald and Hildesheim, 2004
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“Since the dye we used responds to membrane depolarization by an increase in fluorescence (Grinvald and Hildesheim, 2004), this point process effectively extracts epochs of simultaneously increased activation (i.e., depolarization) in local population activity (see Figs.”
Background
- Authors
- Grinvald, A., & Hildesheim, R.
- Affiliations
- Weizmann Institute of Science (IL)
- Corresponding author
- Grinvald, Amiram
- ORCID
- Grinvald, Amiram
- Venue
- Nature Reviews Neuroscience
- Published
- 2004-11
- Volume
- 5
- Issue
- 11
- Pages
- 874-885
- ISSN
- 1471-003X (ISSN-L)
- 1471-0048
- OpenAlex
- W2019475363
- Cited by
- 618
- References
- 7
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 11 · 2023: 18 · 2022: 16 · 2021: 22 · 2020: 16 · 2019: 53 · 2018: 29 · 2017: 30 · 2016: 25 · 2015: 42 · 2014: 35 · 2013: 38 · 2012: 47
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biophysics › Advanced Fluorescence Microscopy Techniques
- Keywords
- voltage-sensitive dyes, cortical dynamics, neocortex, functional imaging, cortical columns, neocortex development, neuroplasticity, single-cell imaging, neural circuits
- MeSH terms
- Animals, Brain Mapping, Cerebral Cortex, Coloring Agents, Electrophysiology, Neurology
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