Cited by 261Memory and Neural MechanismsMemory Processes and InfluencesSleep and Wakefulness Research

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Memory Retrieval and the Passage of Time: From Reconsolidation and Strengthening to Extinction

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Inda, Maria Carmen, Muravieva, Elizaveta V., Alberini, Cristina M.·2011·The Journal of Neuroscience

DOI 10.1523/jneurosci.4736-10.2011PMC PMC3069643

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Abstract

An established memory can be made transiently labile if retrieved or reactivated. Over time, it becomes again resistant to disruption and this process that renders the memory stable is termed reconsolidation. The reasons why a memory becomes labile after retrieval and reconsolidates still remains debated. Here, using inhibitory avoidance learning in rats, we provide evidence that retrievals of a young memory, which are accompanied by its reconsolidation, result in memory strengthening and contribute to its overall consolidation. This function associated to reconsolidation is temporally limited. With the passage of time, the stored memory undergoes important changes, as revealed by the behavioral outcomes of its retrieval. Over time, without explicit retrievals, memory first strengthens and becomes refractory to both retrieval-dependent interference and strengthening. At later times, the same retrievals that lead to reconsolidation of a young memory extinguish an older memory. We conclude that the storage of information is very dynamic and that its temporal evolution regulates behavioral outcomes. These results are important for potential clinical applications.

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Authors: Inda, M. C., Muravieva, E. V., & Alberini, C. M.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
Corresponding author: Alberini, Cristina M.
ORCID: Alberini, Cristina M.
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2011-02-02
Volume: 31
Issue: 5
Pages: 1635-1643
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.4736-10.2011
PMC: PMC3069643
OpenAlex: W2013517273
Cited by: 261
References: 57
Citations by year: 2026: 7 · 2025: 9 · 2024: 17 · 2023: 6 · 2022: 10 · 2021: 8 · 2020: 14 · 2019: 9 · 2018: 18 · 2017: 19 · 2016: 26 · 2015: 27 · 2014: 28 · 2013: 29 · 2012: 24
FWCI: 14.61
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-sa
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 181 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Mental Health (R01MH074736)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Keywords: memory reconsolidation, memory retrieval, memory enhancement, memory extinction, passive avoidance, memory consolidation, temporal dynamics of memory
MeSH terms: Animals, Avoidance Learning, Cycloheximide, Extinction, Psychological, Inhibition, Psychological, Injections, Intraperitoneal, Male, Memory, Neuropsychological Tests, Protein Synthesis Inhibitors, Mental Recall, Retention, Psychology, Time Factors, Protein Biosynthesis, Rats, Long-Evans, Rats

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Memory Retrieval and the Passage of Time: From Reconsolidation and Strengthening to Extinction

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