The DOI matches its Crossref record; 62 of the 63 references it cites were found in a registry or an index.
No Evidence for Chronic Demyelination in Spared Axons after Spinal Cord Injury in a Mouse
Open accessAbstract
The pattern of remyelination after traumatic spinal cord injury remains elusive, with animal and human studies reporting partial to complete demyelination followed by incomplete remyelination. In the present study, we found that spared rubrospinal tract (RST) axons of passage traced with actively transported dextrans and examined caudally to the lesion 12 weeks after mouse spinal cord contusion injury were fully remyelinated. Spared axons exhibited a marginally reduced myelin thickness and significantly shorter internodes. CASPR (contactin-associated protein) and K(v)1.2 channels were used to identify internodes and paranodal protein distribution properties were used as an index of myelin integrity. This is the first time the CNS myelin internode length was measured in a mouse. To better understand the significance of shortened internodes and thinner myelin in spared axons, we modeled conduction properties using McIntyre's et al. model of myelinated axons. Mathematical modeling predicted a 21% decrease in the conduction velocity of remyelinated RST axons attributable to shortened internodes. To determine whether demyelination could be present on axons exhibiting a pathological transport system, we used the retroviral reporter system. Virally delivered green fluorescent protein unveiled a small population of dystrophic RST axons that persist chronically with evident demyelination or abnormal remyelination. Collectively, these data show that lasting demyelination in spared axons is rare and that remyelination of axons of passage occurs in the chronically injured mouse spinal cord.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“It is well documented that myelin formed during repair of experimental demyelination or during demyelinating injury or disease is thinner on average (larger g-ratio) than myelin that is formed during normal development (e.g., Lasiene et al., 2008), although this is less pronounced for smaller-diameter axons such as those in the optic nerve (Stidworthy et al., 2003).”
From Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling (2013) · cites this paper as Lasiene et al., 2008
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A Third-Generation Lentivirus Vector with a Conditional Packaging System
Dull, T., Zufferey, R., Kelly, M., Mandel, R. J., Nguyen, M., Trono, D., & Naldini, L. (1998) · Journal of Virology · doi:10.1128/jvi.72.11.8463-8471.1998 · Cited by 3,341
The NEURON Simulation Environment
Hines, M. L., & Carnevale, N. T. (1997) · Neural Computation · doi:10.1162/neco.1997.9.6.1179 · Cited by 2,630
Keirstead, H. S., Nistor, G., Bernal, G. M., Totoiu, M. O., Cloutier, F., Sharp, K. L., & Steward, O. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0311-05.2005 · Cited by 1,263
Apoptosis and delayed degeneration after spinal cord injury in rats and monkeys
Crowe, M. J., Bresnahan, J. C., Shuman, S. L., Masters, J. N., & Beattie, M. S. (1997) · Nature Medicine · doi:10.1038/nm0197-73 · Cited by 1,153
Axonal Swellings and Degeneration in Mice Lacking the Major Proteolipid of Myelin
Griffiths, I., Klugmann, M., Anderson, T., Yool, D., Thomson, C., Schwab, M. H., Schneider, A., Zimmermann, F., McCulloch, M., Nadon, N., et al. (1998) · Science · doi:10.1126/science.280.5369.1610 · Cited by 889
Repair of Adult Rat Corticospinal Tract by Transplants of Olfactory Ensheathing Cells
Li, Y., Field, P. M., & Raisman, G. (1997) · Science · doi:10.1126/science.277.5334.2000 · Cited by 875
McIntyre, C. C., Richardson, A. G., & Grill, W. M. (2002) · Journal of Neurophysiology · doi:10.1152/jn.00353.2001 · Cited by 764
Human neural stem cells differentiate and promote locomotor recovery in spinal cord-injured mice
Cummings, B. J., Uchida, N., Tamaki, S. J., Salazar, D. L., Hooshmand, M. J., Summers, R. G., Gage, F. H., & Anderson, A. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507063102 · Cited by 715
The local differentiation of myelinated axons at nodes of Ranvier
Poliak, S., & Peles, E. (2003) · Nature reviews. Neuroscience · doi:10.1038/nrn1253 · Cited by 650
The Pathology of Human Spinal Cord Injury: Defining the Problems
Norenberg, M. D., Smith, J., & Marcillo, A. E. (2004) · Journal of Neurotrauma · doi:10.1089/089771504323004575 · Cited by 634
Cited by
Sorted by citations
Remyelination in the CNS: from biology to therapy
Franklin, R. J. M., & ffrench-Constant, C. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2480 · Cited by 1,544
Cell transplantation therapy for spinal cord injury
Assinck, P., Duncan, G. J., Hilton, B. J., Plemel, J. R., & Tetzlaff, W. (2017) · Nature Neuroscience · doi:10.1038/nn.4541 · Cited by 960
Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling
Young, K. M., Psachoulia, K., Tripathi, R. B., Dunn, S.-J., Cossell, L., Attwell, D., Tohyama, K., & Richardson, W. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.006 · Cited by 919
“…engaged in myelin remodeling, either by replacing dying OLs in their entirety or by adding additional myelin internodes in such 874 Neuron 77, 873–885, March 6, 2013 ª2013 Elsevier Inc. a way that the total number of OLs increases without a concomitant increase in the total length of myelin sheath.”
BackgroundRowland, J. W., Hawryluk, G. W. J., Kwon, B. K., & Fehlings, M. G. (2008) · Neurosurgical FOCUS · doi:10.3171/foc.2008.25.11.e2 · Cited by 843
Glial Cells as Progenitors and Stem Cells: New Roles in the Healthy and Diseased Brain
Dimou, L., & Götz, M. (2014) · Physiological Reviews · doi:10.1152/physrev.00036.2013 · Cited by 285
Metadata
- Authors
- Lasiene, J., Shupe, L., Perlmutter, S., & Horner, P.
- Affiliations
- University of Washington (US)
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-04-09
- Volume
- 28
- Issue
- 15
- Pages
- 3887-3896
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC2631430
- OpenAlex
- W2000630772
- Cited by
- 133
- References
- 63
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 10 · 2022: 4 · 2021: 4 · 2020: 6 · 2019: 9 · 2018: 7 · 2017: 13 · 2016: 5 · 2015: 7 · 2014: 10 · 2013: 12 · 2012: 10
- FWCI
- 5.67
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Washington
- Università degli Studi di Sassari
- National Institutes of Health (NSO46724)
- U.S. Public Health Service (NSO46724)
- University of California, San Diego
- National Institute of Neurological Disorders and Stroke (NS040867, R01NS046724, R01NS040867)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Spinal Cord Injury Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Keywords
- spinal cord injury, remyelination, demyelination, rubrospinal tract, myelin thickness, Caspr, axonal transport, retrograde transport, conduction velocity, dystrophic axons, mouse model
- MeSH terms
- Animals, Axons, Female, Genetic Vectors, Mice, Inbred C57BL, Models, Neurological, Myelin Sheath, Nerve Regeneration, Neural Conduction, Reaction Time, Spinal Cord, Spinal Cord Injuries, Time Factors, Transfection, Cell Adhesion Molecules, Neuronal, Lentivirus, Microscopy, Immunoelectron, Green Fluorescent Proteins, Mice, Kv1.2 Potassium Channel
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
