Cited by 198Neural dynamics and brain functionVisual perception and processing mechanismsNeuroscience and Neuropharmacology Research

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Cortical State Determines Global Variability and Correlations in Visual Cortex

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Schölvinck, Marieke L., Saleem, Aman B., Benucci, Andrea, Harris, Kenneth D., Carandini, Matteo·2015·The Journal of Neuroscience

DOI 10.1523/jneurosci.4994-13.2015PMC PMC4287140

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Abstract

The response of neurons in sensory cortex to repeated stimulus presentations is highly variable. To investigate the nature of this variability, we compared the spike activity of neurons in the primary visual cortex (V1) of cats with that of their afferents from lateral geniculate nucleus (LGN), in response to similar stimuli. We found variability to be much higher in V1 than in LGN. To investigate the sources of the additional variability, we measured the spiking activity of large V1 populations and found that much of the variability was shared across neurons: the variable portion of the responses of one neuron could be well predicted from the summed activity of the rest of the neurons. Variability thus mostly reflected global fluctuations affecting all neurons. The size and prevalence of these fluctuations, both in responses to stimuli and in ongoing activity, depended on cortical state, being larger in synchronized states than in more desynchronized states. Contrary to previous reports, these fluctuations invested the overall population, regardless of preferred orientation. The global fluctuations substantially increased variability in single neurons and correlations among pairs of neurons. Once this effect was removed, pairwise correlations were reduced and were similar regardless of cortical state. These results highlight the importance of cortical state in controlling cortical operation and can help reconcile previous studies, which differed widely in their estimate of neuronal variability and pairwise correlations.

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Authors: Schölvinck, M. L., Saleem, A. B., Benucci, A., Harris, K. D., & Carandini, M.
Affiliations: University College London (GB)
UCL Queen Square Institute of Neurology (GB)
ORCID: Schölvinck, Marieke L.
Saleem, Aman B.
Benucci, Andrea
Harris, Kenneth D.
Carandini, Matteo
Venue: The Journal of Neuroscience
Publisher: Society for Neuroscience
Published: 2015-01-07
Volume: 35
Issue: 1
Pages: 170-178
ISSN: 0270-6474 (ISSN-L)
1529-2401
DOI: 10.1523/jneurosci.4994-13.2015
PMC: PMC4287140
OpenAlex: W1969233644
Cited by: 198
References: 61
Citations by year: 2026: 2 · 2025: 6 · 2024: 13 · 2023: 10 · 2022: 12 · 2021: 16 · 2020: 21 · 2019: 21 · 2018: 26 · 2017: 27 · 2016: 28 · 2015: 16
FWCI: 19.46
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
creativecommons.org/licenses/by-nc-sa/4.0/ (vor, 181 d)
Locations: Journal of Neuroscience (publishedVersion, cc-by)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
MPG.PuRe (Max Planck Society) (submittedVersion, cc-by)
UCL Discovery (University College London) (submittedVersion)
Funders: GlaxoSmithKline
Wellcome Trust (095668, 095669)
Engineering and Physical Sciences Research Council (EP/I005102/1, EP/I005102/2, EP/K015141/1)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Life Sciences › Neuroscience › Cognitive Neuroscience › Visual perception and processing mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: neural variability, cortical state, primary visual cortex, lateral geniculate nucleus, spike train correlations, global fluctuations, cortical synchronization, population coding, crystallographic texture
MeSH terms: Animals, Cats, Female, Nerve Net, Photic Stimulation, Random Allocation, Visual Cortex, Visual Pathways

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Cortical State Determines Global Variability and Correlations in Visual Cortex

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